GREMLIN Database
CYSQ - 3'(2'),5'-bisphosphate nucleotidase CysQ
UniProt: P22255 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10043
Length: 246 (222)
Sequences: 10117 (7212)
Seq/√Len: 484.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
213_A218_A4.1181.00
116_Y123_M3.4501.00
78_R106_D3.2791.00
127_A130_K3.1781.00
77_Q107_H3.0251.00
210_H214_A2.8841.00
117_A120_M2.6971.00
8_L51_G2.6811.00
11_N51_G2.5731.00
29_V42_I2.3651.00
15_A47_V2.3571.00
13_G116_Y2.2141.00
79_Y105_I2.1811.00
78_R104_L2.1701.00
125_S132_W2.1671.00
109_K128_E2.1101.00
98_F119_V2.1021.00
222_D226_K2.0901.00
39_A43_A2.0471.00
45_H63_S1.9701.00
19_V40_A1.9381.00
56_T59_V1.9151.00
16_I44_A1.9071.00
46_T50_D1.9051.00
51_G54_T1.8671.00
106_D111_I1.8641.00
81_L105_I1.8511.00
152_V192_A1.8181.00
105_I110_P1.7941.00
59_V78_R1.7891.00
49_M53_R1.7791.00
113_G211_A1.7771.00
133_K189_E1.7621.00
211_A215_A1.7291.00
47_V51_G1.6841.00
122_V133_K1.6801.00
124_Y189_E1.6641.00
126_A215_A1.6581.00
49_M61_V1.6521.00
9_A102_I1.6341.00
17_M119_V1.6321.00
99_T181_S1.6241.00
115_V185_C1.6031.00
6_C125_S1.5761.00
117_A182_L1.5621.00
5_V80_W1.5441.00
4_Q56_T1.5061.00
132_W137_G1.4951.00
4_Q8_L1.4741.00
103_A207_A1.4701.00
128_E215_A1.4681.00
185_C212_V1.4591.00
4_Q55_L1.4531.00
146_D149_P1.4441.00
15_A18_Q1.4391.00
101_N181_S1.4261.00
9_A114_V1.4251.00
77_Q106_D1.4231.00
129_G215_A1.4151.00
59_V80_W1.4141.00
20_Y98_F1.4081.00
122_V191_Q1.4061.00
122_V189_E1.4011.00
38_T92_I1.3641.00
7_Q55_L1.3601.00
50_D54_T1.3581.00
82_V102_I1.3491.00
164_K168_Q1.3491.00
51_G55_L1.3271.00
6_C10_R1.3091.00
10_R123_M1.3091.00
48_I82_V1.3061.00
80_W104_L1.3021.00
109_K214_A1.2871.00
16_I85_L1.2841.00
46_T66_D1.2841.00
128_E214_A1.2731.00
36_P92_I1.2711.00
36_P89_K1.2571.00
184_F209_G1.2471.00
7_Q11_N1.2391.00
6_C123_M1.2381.00
16_I98_F1.2271.00
17_M98_F1.2191.00
43_A46_T1.2111.00
95_N178_I1.2041.00
186_L191_Q1.1991.00
45_H66_D1.1891.00
11_N47_V1.1881.00
131_A138_V1.1861.00
48_I102_I1.1851.00
210_H220_V1.1831.00
111_I128_E1.1741.00
138_V142_I1.1711.00
145_R148_R1.1711.00
165_E169_Q1.1681.00
52_L59_V1.1451.00
49_M63_S1.1311.00
45_H49_M1.1311.00
62_L81_L1.1211.00
126_A211_A1.1151.00
214_A227_P1.1131.00
81_L207_A1.0941.00
15_A43_A1.0901.00
116_Y121_N1.0671.00
18_Q22_G1.0641.00
42_I46_T1.0611.00
14_D18_Q1.0591.00
166_Y169_Q1.0531.00
166_Y170_L1.0501.00
16_I40_A1.0481.00
49_M66_D1.0341.00
7_Q51_G1.0331.00
8_L48_I1.0321.00
73_R76_W1.0051.00
104_L112_L1.0041.00
103_A110_P0.9991.00
110_P211_A0.9931.00
19_V43_A0.9871.00
182_L186_L0.9821.00
62_L79_Y0.9801.00
131_A215_A0.9771.00
20_Y119_V0.9771.00
8_L47_V0.9691.00
19_V39_A0.9591.00
15_A19_V0.9551.00
11_N14_D0.9471.00
97_E186_L0.9361.00
131_A212_V0.9331.00
110_P210_H0.9271.00
32_A35_S0.9271.00
184_F213_A0.9231.00
201_T206_T0.9201.00
165_E168_Q0.9111.00
151_L194_L0.9091.00
31_K38_T0.9021.00
78_R111_I0.8961.00
115_V212_V0.8931.00
137_G142_I0.8921.00
41_D65_E0.8861.00
27_D39_A0.8781.00
152_V155_S0.8711.00
101_N115_V0.8681.00
112_L127_A0.8611.00
90_E176_T0.8601.00
44_A48_I0.8581.00
44_A85_L0.8551.00
38_T88_T0.8541.00
10_R121_N0.8481.00
104_L111_I0.8471.00
4_Q52_L0.8471.00
20_Y94_R0.8441.00
163_L166_Y0.8391.00
154_I157_S0.8381.00
65_E88_T0.8381.00
124_Y185_C0.8331.00
63_S66_D0.8311.00
64_E88_T0.8291.00
60_P79_Y0.8171.00
155_S158_H0.8131.00
101_N208_A0.8111.00
103_A211_A0.8041.00
52_L56_T0.7921.00
31_K37_V0.7901.00
115_V209_G0.7861.00
141_Q144_V0.7841.00
10_R116_Y0.7821.00
105_I207_A0.7801.00
15_A44_A0.7771.00
109_K227_P0.7761.00
128_E211_A0.7741.00
17_M121_N0.7721.00
6_C114_V0.7711.00
45_H67_P0.7691.00
56_T80_W0.7621.00
134_E138_V0.7621.00
5_V114_V0.7571.00
10_R14_D0.7551.00
62_L204_W0.7551.00
127_A215_A0.7531.00
26_M39_A0.7491.00
143_Q149_P0.7471.00
161_A165_E0.7441.00
135_E138_V0.7341.00
47_V50_D0.7281.00
44_A100_V0.7281.00
187_V192_A0.7261.00
141_Q193_Q0.7241.00
41_D88_T0.7241.00
138_V189_E0.7231.00
184_F220_V0.7231.00
19_V22_G0.7221.00
222_D225_G0.7201.00
52_L104_L0.7201.00
139_R142_I0.7201.00
101_N209_G0.7201.00
12_A44_A0.7191.00
122_V134_E0.7191.00
40_A44_A0.7161.00
134_E137_G0.7111.00
39_A42_I0.7091.00
5_V112_L0.7081.00
149_P193_Q0.7061.00
213_A220_V0.7041.00
163_L167_L0.7031.00
214_A219_H0.6961.00
163_L170_L0.6931.00
209_G212_V0.6921.00
40_A91_F0.6911.00
188_A212_V0.6841.00
117_A124_Y0.6841.00
103_A113_G0.6831.00
10_R13_G0.6821.00
7_Q10_R0.6821.00
99_T117_A0.6801.00
5_V59_V0.6791.00
126_A212_V0.6781.00
93_K173_H0.6781.00
12_A47_V0.6771.00
52_L80_W0.6751.00
156_R159_A0.6711.00
176_T179_G0.6681.00
206_T228_L0.6651.00
147_A150_P0.6641.00
12_A100_V0.6641.00
43_A47_V0.6641.00
99_T182_L0.6621.00
8_L12_A0.6601.00
49_M67_P0.6571.00
16_I91_F0.6551.00
106_D109_K0.6551.00
151_L154_I0.6521.00
65_E83_D0.6521.00
126_A131_A0.6511.00
151_L156_R0.6491.00
154_I158_H0.6481.00
151_L155_S0.6461.00
83_D88_T0.6451.00
41_D64_E0.6431.00
9_A100_V0.6391.00
53_R69_G0.6341.00
125_S135_E0.6291.00
105_I203_I0.6281.00
69_G73_R0.6261.00
15_A40_A0.6261.00
117_A122_V0.6241.00
152_V157_S0.6231.00
177_S180_S0.6231.00
62_L68_P0.6211.00
141_Q146_D0.6211.00
41_D83_D0.6211.00
22_G25_P0.6190.99
162_E165_E0.6100.99
197_R201_T0.6080.99
18_Q21_D0.6050.99
89_K93_K0.6050.99
102_I114_V0.6010.99
97_E182_L0.6010.99
206_T210_H0.6000.99
64_E83_D0.5990.99
203_I231_T0.5980.99
28_V92_I0.5940.99
114_V123_M0.5930.99
142_I146_D0.5920.99
130_K215_A0.5910.99
97_E178_I0.5900.99
99_T180_S0.5890.99
210_H230_Y0.5860.99
60_P76_W0.5860.99
163_L169_Q0.5840.99
122_V186_L0.5840.99
19_V85_L0.5840.99
115_V208_A0.5820.99
180_S183_K0.5790.99
153_V156_R0.5780.99
174_Q177_S0.5750.99
13_G17_M0.5730.99
64_E84_P0.5730.99
132_W215_A0.5730.99
12_A16_I0.5710.99
158_H161_A0.5680.99
73_R231_T0.5660.99
64_E205_D0.5640.99
14_D17_M0.5590.99
86_D205_D0.5570.99
30_S33_D0.5560.99
131_A216_A0.5550.99
221_H225_G0.5550.99
143_Q148_R0.5550.99
81_L103_A0.5550.99
8_L55_L0.5550.99
105_I108_G0.5540.99
61_V82_V0.5480.99
183_K195_Y0.5480.99
133_K191_Q0.5470.99
19_V91_F0.5460.99
195_Y201_T0.5450.99
52_L55_L0.5450.99
9_A116_Y0.5450.99
99_T115_V0.5440.99
44_A47_V0.5440.99
214_A220_V0.5440.99
151_L157_S0.5440.99
65_E205_D0.5430.99
42_I66_D0.5430.99
184_F187_V0.5420.99
97_E120_M0.5410.99
164_K169_Q0.5380.99
41_D205_D0.5330.98
133_K136_C0.5320.98
213_A216_A0.5310.98
177_S183_K0.5300.98
187_V195_Y0.5290.98
16_I100_V0.5280.98
142_I145_R0.5270.98
80_W112_L0.5260.98
4_Q51_G0.5190.98
152_V158_H0.5190.98
6_C135_E0.5190.98
31_K35_S0.5170.98
79_Y108_G0.5170.98
110_P207_A0.5150.98
219_H227_P0.5140.98
48_I51_G0.5140.98
81_L110_P0.5140.98
84_P88_T0.5130.98
22_G39_A0.5080.98
183_K192_A0.5080.98
135_E140_K0.5080.98
8_L11_N0.5070.98
29_V39_A0.5030.98
20_Y96_G0.5000.98
28_V31_K0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n81A 2 0.9593 100 0.13 Contact Map
3lv0A 2 0.9797 100 0.142 Contact Map
2pcrA 3 0.8902 100 0.145 Contact Map
2fvzA 2 0.9187 100 0.147 Contact Map
3t0jA 3 0.9634 100 0.147 Contact Map
2qflA 1 0.9878 100 0.148 Contact Map
2p3nA 4 0.9553 100 0.151 Contact Map
3b8bA 1 0.9593 100 0.154 Contact Map
4i3yA 2 0.9675 100 0.16 Contact Map
4o7iA 1 0.9919 100 0.161 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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