MURE - ECOLI - GREMLIN Contacts

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MURE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase

UniProt:	P22188	Sequences: MADRNLRDLLAPWVPDAPSRALREMTLDSRVAAAGDLFVAVVGHQADGRRYIPQAIAQGVAAIIAEAKDEATDGEIREMHGVPVIYLSQLNERLSALAGRFYHEPSDNLRLVGVTGTNGKTTTTQLLAQWSQLLGEISAVMGTVGNGLLGKVIPTENTTGSAVDVQHELAGLVDQGATFCAMEVSSHGLVQHRVAALKFAASVFTNLSRDHLDYHGDMEHYEAAKWLLYSEHHCGQAIINADDEVGRRWLAKLPDAVAVSMEDHINPNCHGRWLKATEVNYHDSGATIRFSSSWGDGEIESHLMGAFNVSNLLLALATLLALGYPLADLLKTAARLQPVCGRMEVFTAPGKPTVVVDYAHTPDALEKALQAARLHCAGKLWCVFGCGGDRDKGKRPLMGAIAEEFADVAVVTDDNPRTEEPRAIINDILAGMLDAGHAKVMEGRAEAVTCAVMQAKENDVVLVAGKGHEDYQIVGNQRLDYSDRVTVARLLGVIA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10621
Length:	495 (402)
Sequences:	17445 (12898)
Seq/√Len:	643.3

ECOLI - MURE MURF MURC MPL MURD
BACSU - MURE MURF MURD MURC FOLC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
203_V	318_T	3.671	1.00
439_K	450_C	2.754	1.00
408_V	439_K	2.685	1.00
382_C	406_A	2.658	1.00
278_E	289_R	2.635	1.00
450_C	454_Q	2.627	1.00
325_P	328_D	2.601	1.00
133_L	335_R	2.594	1.00
110_R	200_A	2.568	1.00
316_L	329_L	2.515	1.00
345_V	353_T	2.503	1.00
441_M	450_C	2.497	1.00
443_G	446_E	2.471	1.00
203_V	314_L	2.466	1.00
201_A	318_T	2.449	1.00
408_V	454_Q	2.435	1.00
277_T	291_S	2.401	1.00
217_D	220_H	2.387	1.00
289_R	298_E	2.385	1.00
130_W	319_L	2.294	1.00
54_Q	58_Q	2.285	1.00
300_E	334_A	2.245	1.00
130_W	315_A	2.209	1.00
236_Q	321_A	2.189	1.00
366_E	370_Q	2.186	1.00
222_E	248_R	2.141	1.00
274_L	317_A	2.131	1.00
133_L	332_T	2.122	1.00
241_A	272_R	2.098	1.00
56_I	82_V	2.067	1.00
301_S	312_L	2.047	1.00
200_A	235_G	2.023	1.00
450_C	453_M	2.021	1.00
379_K	459_D	1.979	1.00
136_E	178_T	1.968	1.00
455_A	461_V	1.956	1.00
216_G	220_H	1.955	1.00
133_L	331_K	1.941	1.00
39_V	64_I	1.931	1.00
410_V	454_Q	1.931	1.00
370_Q	405_F	1.925	1.00
229_Y	237_A	1.907	1.00
134_L	328_D	1.890	1.00
112_V	322_L	1.851	1.00
261_M	314_L	1.850	1.00
113_G	199_F	1.842	1.00
54_Q	57_A	1.826	1.00
208_S	363_D	1.812	1.00
127_L	315_A	1.811	1.00
129_Q	335_R	1.808	1.00
381_W	454_Q	1.803	1.00
53_P	57_A	1.798	1.00
400_A	404_E	1.791	1.00
226_W	252_K	1.783	1.00
287_T	298_E	1.766	1.00
276_A	279_V	1.760	1.00
113_G	184_V	1.737	1.00
128_A	132_Q	1.727	1.00
388_G	391_D	1.724	1.00
128_A	140_V	1.722	1.00
379_K	408_V	1.719	1.00
276_A	313_L	1.708	1.00
320_L	326_L	1.699	1.00
312_L	333_A	1.695	1.00
345_V	355_V	1.673	1.00
381_W	408_V	1.671	1.00
422_R	426_N	1.651	1.00
222_E	245_V	1.649	1.00
288_I	312_L	1.639	1.00
114_V	127_L	1.638	1.00
127_L	319_L	1.635	1.00
127_L	318_T	1.632	1.00
410_V	450_C	1.622	1.00
291_S	296_D	1.610	1.00
289_R	296_D	1.605	1.00
134_L	324_Y	1.596	1.00
306_A	370_Q	1.590	1.00
201_A	322_L	1.582	1.00
472_Q	476_N	1.580	1.00
111_L	197_L	1.580	1.00
220_H	223_A	1.578	1.00
287_T	300_E	1.574	1.00
42_V	66_E	1.561	1.00
348_A	353_T	1.551	1.00
441_M	446_E	1.527	1.00
94_L	97_L	1.524	1.00
122_T	308_N	1.518	1.00
274_L	320_L	1.510	1.00
467_G	472_Q	1.507	1.00
110_R	179_F	1.491	1.00
473_I	476_N	1.490	1.00
423_A	426_N	1.489	1.00
202_S	228_L	1.489	1.00
367_K	370_Q	1.484	1.00
330_L	334_A	1.482	1.00
275_K	291_S	1.481	1.00
319_L	329_L	1.478	1.00
186_S	215_H	1.471	1.00
66_E	90_L	1.463	1.00
118_N	361_T	1.461	1.00
292_S	295_G	1.445	1.00
224_A	227_L	1.441	1.00
354_V	452_V	1.440	1.00
292_S	320_L	1.439	1.00
444_R	473_I	1.438	1.00
131_S	181_A	1.433	1.00
114_V	124_T	1.428	1.00
112_V	127_L	1.428	1.00
426_N	430_A	1.421	1.00
129_Q	332_T	1.402	1.00
352_P	455_A	1.387	1.00
331_K	335_R	1.382	1.00
179_F	322_L	1.380	1.00
92_E	96_A	1.370	1.00
131_S	322_L	1.367	1.00
126_L	303_L	1.362	1.00
328_D	331_K	1.357	1.00
280_N	287_T	1.352	1.00
383_V	412_T	1.345	1.00
263_D	306_A	1.345	1.00
381_W	410_V	1.344	1.00
288_I	309_V	1.343	1.00
427_D	430_A	1.340	1.00
201_A	321_A	1.336	1.00
277_T	289_R	1.336	1.00
123_T	205_T	1.323	1.00
204_F	207_L	1.320	1.00
302_H	337_Q	1.316	1.00
290_F	316_L	1.308	1.00
366_E	401_I	1.303	1.00
379_K	456_K	1.302	1.00
425_I	440_V	1.302	1.00
306_A	374_L	1.299	1.00
379_K	407_D	1.299	1.00
425_I	429_L	1.292	1.00
390_R	393_G	1.288	1.00
446_E	449_T	1.287	1.00
297_G	330_L	1.279	1.00
238_I	321_A	1.270	1.00
126_L	336_L	1.262	1.00
201_A	238_I	1.261	1.00
351_K	457_E	1.261	1.00
239_I	246_G	1.255	1.00
110_R	178_T	1.251	1.00
319_L	324_Y	1.250	1.00
240_N	310_S	1.245	1.00
410_V	447_A	1.243	1.00
46_A	50_R	1.237	1.00
370_Q	401_I	1.228	1.00
127_L	203_V	1.223	1.00
68_K	86_Y	1.223	1.00
345_V	348_A	1.219	1.00
207_L	222_E	1.217	1.00
131_S	179_F	1.206	1.00
331_K	334_A	1.205	1.00
412_T	447_A	1.204	1.00
104_E	107_D	1.203	1.00
121_T	339_V	1.195	1.00
219_E	223_A	1.194	1.00
223_A	252_K	1.193	1.00
198_K	235_G	1.189	1.00
139_A	142_G	1.174	1.00
449_T	453_M	1.171	1.00
131_S	324_Y	1.170	1.00
126_L	312_L	1.167	1.00
408_V	437_H	1.161	1.00
209_R	393_G	1.155	1.00
285_G	300_E	1.151	1.00
372_A	380_L	1.147	1.00
226_W	249_W	1.145	1.00
191_Q	230_S	1.143	1.00
343_M	355_V	1.140	1.00
340_C	344_E	1.139	1.00
306_A	310_S	1.133	1.00
138_S	142_G	1.133	1.00
248_R	251_A	1.120	1.00
42_V	67_A	1.119	1.00
420_E	423_A	1.119	1.00
227_L	230_S	1.114	1.00
387_G	414_D	1.114	1.00
365_L	464_A	1.112	1.00
52_I	63_I	1.112	1.00
209_R	212_L	1.112	1.00
343_M	372_A	1.106	1.00
411_V	440_V	1.103	1.00
276_A	309_V	1.098	1.00
137_I	178_T	1.096	1.00
184_V	194_V	1.094	1.00
241_A	247_R	1.090	1.00
274_L	292_S	1.083	1.00
396_P	400_A	1.082	1.00
112_V	318_T	1.063	1.00
48_G	56_I	1.058	1.00
269_C	272_R	1.057	1.00
219_E	245_V	1.055	1.00
423_A	427_D	1.051	1.00
327_A	331_K	1.050	1.00
52_I	56_I	1.048	1.00
445_A	449_T	1.045	1.00
242_D	310_S	1.042	1.00
422_R	440_V	1.039	1.00
136_E	179_F	1.039	1.00
222_E	226_W	1.037	1.00
245_V	248_R	1.034	1.00
139_A	172_L	1.031	1.00
394_K	397_L	1.025	1.00
117_T	210_D	1.024	1.00
108_N	173_V	1.024	1.00
344_E	356_V	1.024	1.00
78_E	82_V	1.022	1.00
428_I	432_M	1.021	1.00
456_K	459_D	1.018	1.00
288_I	299_I	1.017	1.00
200_A	232_H	1.012	1.00
446_E	450_C	1.011	1.00
209_R	218_M	1.011	1.00
381_W	459_D	1.008	1.00
277_T	296_D	1.007	1.00
308_N	311_N	1.006	1.00
130_W	332_T	1.002	1.00
80_H	83_P	1.001	1.00
129_Q	132_Q	1.000	1.00
204_F	229_Y	0.998	1.00
360_H	365_L	0.997	1.00
218_M	245_V	0.994	1.00
238_I	317_A	0.992	1.00
99_G	104_E	0.991	1.00
77_R	80_H	0.989	1.00
376_C	460_V	0.989	1.00
426_N	429_L	0.984	1.00
230_S	252_K	0.984	1.00
282_H	287_T	0.984	1.00
81_G	84_V	0.983	1.00
118_N	363_D	0.980	1.00
397_L	400_A	0.978	1.00
324_Y	328_D	0.978	1.00
201_A	236_Q	0.975	1.00
366_E	404_E	0.974	1.00
318_T	322_L	0.974	1.00
205_T	314_L	0.972	1.00
192_H	195_A	0.969	1.00
413_D	442_E	0.968	1.00
191_Q	214_Y	0.967	1.00
223_A	227_L	0.967	1.00
239_I	250_L	0.966	1.00
258_A	261_M	0.958	1.00
38_F	61_A	0.954	1.00
190_V	214_Y	0.953	1.00
410_V	451_A	0.953	1.00
429_L	432_M	0.952	1.00
79_M	82_V	0.951	1.00
439_K	454_Q	0.948	1.00
134_L	332_T	0.947	1.00
465_G	471_Y	0.944	1.00
365_L	384_F	0.941	1.00
272_R	275_K	0.940	1.00
220_H	224_A	0.937	1.00
192_H	224_A	0.935	1.00
89_Q	92_E	0.932	1.00
363_D	367_K	0.928	1.00
257_V	261_M	0.928	1.00
130_W	329_L	0.927	1.00
368_A	462_L	0.921	1.00
297_G	326_L	0.921	1.00
93_R	96_A	0.919	1.00
111_L	180_C	0.917	1.00
204_F	249_W	0.914	1.00
92_E	95_S	0.911	1.00
78_E	81_G	0.909	1.00
399_G	428_I	0.906	1.00
257_V	260_S	0.905	1.00
320_L	329_L	0.897	1.00
243_D	310_S	0.895	1.00
133_L	328_D	0.892	1.00
442_E	446_E	0.891	1.00
398_M	402_A	0.890	1.00
56_I	63_I	0.889	1.00
134_L	325_P	0.889	1.00
352_P	458_N	0.888	1.00
396_P	427_D	0.884	1.00
129_Q	336_L	0.878	1.00
244_E	248_R	0.877	1.00
410_V	441_M	0.873	1.00
65_A	84_V	0.872	1.00
348_A	352_P	0.867	1.00
190_V	224_A	0.867	1.00
110_R	322_L	0.864	1.00
48_G	52_I	0.862	1.00
411_V	425_I	0.862	1.00
421_P	424_I	0.860	1.00
115_T	225_K	0.852	1.00
79_M	84_V	0.849	1.00
422_R	442_E	0.842	1.00
282_H	285_G	0.839	1.00
369_L	405_F	0.836	1.00
210_D	361_T	0.834	1.00
410_V	439_K	0.834	1.00
49_R	52_I	0.830	1.00
40_A	65_A	0.829	1.00
451_A	455_A	0.829	1.00
226_W	230_S	0.828	1.00
359_A	464_A	0.826	1.00
382_C	464_A	0.825	1.00
355_V	372_A	0.823	1.00
429_L	438_A	0.820	1.00
92_E	192_H	0.815	1.00
128_A	138_S	0.814	1.00
90_L	93_R	0.811	1.00
93_R	97_L	0.810	1.00
258_A	262_E	0.810	1.00
129_Q	133_L	0.806	1.00
299_I	330_L	0.805	1.00
123_T	314_L	0.802	1.00
77_R	81_G	0.796	1.00
123_T	315_A	0.793	1.00
353_T	460_V	0.792	1.00
138_S	144_V	0.785	1.00
46_A	51_Y	0.784	1.00
399_G	403_E	0.783	1.00
255_D	259_V	0.783	1.00
326_L	330_L	0.781	1.00
429_L	440_V	0.780	1.00
401_I	405_F	0.780	1.00
386_C	469_E	0.779	1.00
447_A	451_A	0.778	1.00
329_L	332_T	0.777	1.00
125_Q	339_V	0.775	1.00
260_S	263_D	0.774	1.00
343_M	371_A	0.771	1.00
96_A	99_G	0.770	1.00
316_L	320_L	0.767	1.00
47_D	67_A	0.766	1.00
240_N	243_D	0.765	1.00
441_M	447_A	0.763	1.00
260_S	273_W	0.763	1.00
189_L	194_V	0.760	1.00
432_M	435_A	0.759	1.00
55_A	60_V	0.759	1.00
383_V	463_V	0.758	1.00
227_L	231_E	0.752	1.00
124_T	140_V	0.751	1.00
369_L	382_C	0.751	1.00
269_C	275_K	0.751	1.00
85_I	95_S	0.750	1.00
282_H	300_E	0.749	1.00
427_D	431_G	0.749	1.00
198_K	232_H	0.749	1.00
392_K	427_D	0.747	1.00
428_I	431_G	0.745	1.00
113_G	228_L	0.742	1.00
273_W	293_S	0.740	1.00
39_V	90_L	0.739	1.00
139_A	144_V	0.738	1.00
142_G	149_L	0.738	1.00
378_G	459_D	0.736	1.00
247_R	251_A	0.735	1.00
52_I	64_I	0.735	1.00
303_L	336_L	0.733	1.00
424_I	428_I	0.732	1.00
184_V	199_F	0.732	1.00
281_Y	286_A	0.732	1.00
63_I	82_V	0.731	1.00
348_A	351_K	0.731	1.00
248_R	252_K	0.728	1.00
208_S	218_M	0.728	1.00
91_N	95_S	0.726	1.00
241_A	246_G	0.726	1.00
341_G	356_V	0.726	1.00
86_Y	89_Q	0.723	1.00
125_Q	144_V	0.722	1.00
190_V	227_L	0.721	1.00
95_S	196_A	0.720	1.00
82_V	85_I	0.720	1.00
373_R	405_F	0.719	1.00
218_M	222_E	0.718	1.00
39_V	94_L	0.718	1.00
324_Y	329_L	0.716	1.00
395_R	399_G	0.715	1.00
87_L	93_R	0.713	1.00
219_E	222_E	0.711	1.00
43_G	48_G	0.710	1.00
354_V	461_V	0.708	1.00
238_I	318_T	0.706	1.00
262_E	310_S	0.706	1.00
396_P	430_A	0.706	1.00
355_V	460_V	0.705	1.00
376_C	380_L	0.704	1.00
95_S	192_H	0.704	1.00
128_A	139_A	0.703	1.00
209_R	363_D	0.703	1.00
192_H	214_Y	0.702	1.00
392_K	423_A	0.700	1.00
381_W	455_A	0.695	1.00
189_L	224_A	0.693	1.00
263_D	310_S	0.693	1.00
142_G	146_N	0.692	1.00
111_L	182_M	0.686	1.00
173_V	180_C	0.685	1.00
424_I	432_M	0.683	1.00
40_A	52_I	0.682	1.00
281_Y	306_A	0.679	1.00
80_H	84_V	0.679	1.00
385_G	465_G	0.678	1.00
368_A	464_A	0.675	1.00
173_V	177_A	0.674	1.00
279_V	282_H	0.670	1.00
186_S	190_V	0.670	1.00
83_P	86_Y	0.668	1.00
351_K	458_N	0.668	1.00
280_N	298_E	0.667	1.00
402_A	409_A	0.667	1.00
366_E	397_L	0.665	1.00
316_L	326_L	0.665	1.00
134_L	319_L	0.664	1.00
189_L	228_L	0.662	1.00
411_V	428_I	0.661	1.00
303_L	308_N	0.661	1.00
409_A	428_I	0.661	1.00
207_L	218_M	0.660	1.00
424_I	427_D	0.660	1.00
141_M	172_L	0.658	1.00
77_R	82_V	0.658	1.00
290_F	313_L	0.657	1.00
448_V	452_V	0.656	1.00
307_F	367_K	0.655	1.00
327_A	330_L	0.654	1.00
80_H	86_Y	0.654	1.00
215_H	224_A	0.653	1.00
128_A	181_A	0.653	1.00
191_Q	195_A	0.652	1.00
186_S	224_A	0.651	1.00
124_T	181_A	0.647	1.00
237_A	253_L	0.643	1.00
114_V	203_V	0.642	1.00
174_D	177_A	0.641	1.00
383_V	461_V	0.641	1.00
279_V	288_I	0.640	1.00
383_V	451_A	0.640	1.00
426_N	440_V	0.639	1.00
222_E	249_W	0.638	1.00
88_S	93_R	0.637	1.00
422_R	425_I	0.637	1.00
144_V	148_L	0.636	1.00
112_V	131_S	0.635	1.00
389_D	392_K	0.635	1.00
271_G	275_K	0.633	1.00
138_S	141_M	0.632	1.00
55_A	59_G	0.631	1.00
142_G	148_L	0.630	1.00
219_E	248_R	0.630	1.00
184_V	197_L	0.630	1.00
470_D	473_I	0.630	1.00
398_M	401_I	0.628	1.00
362_P	397_L	0.626	1.00
246_G	249_W	0.624	1.00
255_D	258_A	0.624	1.00
246_G	250_L	0.624	1.00
373_R	376_C	0.623	1.00
89_Q	93_R	0.621	1.00
381_W	451_A	0.621	1.00
130_W	134_L	0.618	1.00
53_P	56_I	0.617	1.00
118_N	208_S	0.614	1.00
84_V	91_N	0.614	1.00
406_A	409_A	0.613	1.00
171_G	175_Q	0.612	1.00
223_A	226_W	0.611	1.00
204_F	222_E	0.611	1.00
209_R	397_L	0.610	1.00
190_V	194_V	0.610	1.00
125_Q	129_Q	0.609	1.00
393_G	396_P	0.608	1.00
47_D	51_Y	0.607	1.00
395_R	398_M	0.607	1.00
400_A	403_E	0.605	1.00
286_A	309_V	0.604	1.00
127_L	181_A	0.604	1.00
90_L	94_L	0.604	1.00
41_V	91_N	0.604	1.00
347_T	353_T	0.603	1.00
350_G	457_E	0.603	1.00
241_A	269_C	0.602	1.00
412_T	444_R	0.602	1.00
394_K	398_M	0.601	1.00
56_I	61_A	0.601	1.00
378_G	460_V	0.601	1.00
359_A	368_A	0.601	1.00
48_G	51_Y	0.600	1.00
241_A	260_S	0.600	1.00
380_L	407_D	0.599	1.00
384_F	428_I	0.596	1.00
313_L	317_A	0.594	1.00
101_F	104_E	0.591	1.00
411_V	438_A	0.591	1.00
400_A	431_G	0.591	1.00
366_E	405_F	0.590	1.00
407_D	456_K	0.589	1.00
393_G	397_L	0.589	1.00
48_G	53_P	0.587	1.00
444_R	448_V	0.587	1.00
107_D	198_K	0.584	1.00
144_V	149_L	0.583	1.00
218_M	221_Y	0.583	1.00
378_G	458_N	0.582	1.00
109_L	173_V	0.581	1.00
388_G	392_K	0.579	1.00
273_W	276_A	0.578	1.00
306_A	309_V	0.577	1.00
278_E	298_E	0.577	1.00
138_S	177_A	0.577	1.00
145_G	148_L	0.575	1.00
301_S	333_A	0.574	1.00
239_I	260_S	0.574	1.00
421_P	425_I	0.574	1.00
316_L	333_A	0.574	1.00
383_V	447_A	0.573	1.00
366_E	400_A	0.573	1.00
373_R	380_L	0.572	1.00
78_E	83_P	0.571	1.00
105_P	198_K	0.571	1.00
305_G	308_N	0.570	1.00
413_D	425_I	0.567	1.00
142_G	145_G	0.567	1.00
63_I	84_V	0.567	1.00
425_I	438_A	0.566	1.00
372_A	460_V	0.563	1.00
297_G	327_A	0.562	1.00
49_R	66_E	0.561	1.00
47_D	50_R	0.561	1.00
270_H	275_K	0.558	1.00
263_D	269_C	0.556	1.00
145_G	149_L	0.554	1.00
370_Q	374_L	0.553	1.00
295_G	326_L	0.553	1.00
253_L	256_A	0.553	1.00
49_R	90_L	0.552	1.00
171_G	174_D	0.550	1.00
194_V	197_L	0.549	1.00
411_V	429_L	0.549	1.00
140_V	144_V	0.548	1.00
79_M	86_Y	0.548	1.00
44_H	64_I	0.548	1.00
309_V	313_L	0.548	1.00
365_L	401_I	0.547	1.00
279_V	309_V	0.545	1.00
212_L	217_D	0.545	1.00
237_A	255_D	0.544	1.00
88_S	91_N	0.543	1.00
99_G	198_K	0.543	1.00
382_C	409_A	0.543	1.00
109_L	180_C	0.542	1.00
326_L	329_L	0.542	1.00
91_N	94_L	0.541	1.00
132_Q	137_I	0.540	1.00
131_S	319_L	0.540	1.00
118_N	364_A	0.538	1.00
317_A	321_A	0.538	1.00
48_G	64_I	0.538	1.00
138_S	181_A	0.537	0.99
343_M	368_A	0.536	0.99
125_Q	340_C	0.536	0.99
420_E	424_I	0.535	0.99
137_I	177_A	0.534	0.99
292_S	326_L	0.533	0.99
361_T	364_A	0.532	0.99
316_L	330_L	0.532	0.99
122_T	126_L	0.531	0.99
384_F	411_V	0.529	0.99
193_R	196_A	0.529	0.99
194_V	231_E	0.527	0.99
449_T	452_V	0.526	0.99
40_A	63_I	0.526	0.99
365_L	382_C	0.525	0.99
403_E	432_M	0.525	0.99
407_D	459_D	0.523	0.99
130_W	324_Y	0.523	0.99
259_V	263_D	0.522	0.99
112_V	179_F	0.521	0.99
412_T	441_M	0.521	0.99
414_D	420_E	0.520	0.99
67_A	70_E	0.518	0.99
50_R	67_A	0.518	0.99
341_G	467_G	0.517	0.99
79_M	85_I	0.517	0.99
318_T	321_A	0.516	0.99
359_A	364_A	0.516	0.99
299_I	312_L	0.516	0.99
392_K	396_P	0.514	0.99
212_L	216_G	0.513	0.99
122_T	336_L	0.511	0.99
278_E	281_Y	0.510	0.99
198_K	231_E	0.510	0.99
187_H	214_Y	0.510	0.99
349_P	352_P	0.509	0.99
62_A	83_P	0.509	0.99
52_I	69_D	0.505	0.99
239_I	258_A	0.505	0.99
139_A	146_N	0.504	0.99
372_A	462_L	0.504	0.99
83_P	87_L	0.502	0.99
126_L	315_A	0.501	0.99
242_D	262_E	0.500	0.99
139_A	177_A	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4c12A	2	0.9697	100	0.178	Contact Map
4bubA	1	0.9535	100	0.189	Contact Map
1e8cA	1	0.9899	100	0.195	Contact Map
2wtzA	1	0.9778	100	0.212	Contact Map
4qdiA	1	0.8808	100	0.283	Contact Map
4cvkA	1	0.8545	100	0.285	Contact Map
3zm6A	1	0.8747	100	0.297	Contact Map
1gg4A	1	0.8586	100	0.299	Contact Map
3zl8A	1	0.8424	100	0.31	Contact Map
3lk7A	1	0.8323	100	0.397	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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