GREMLIN Database
MURE - UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase
UniProt: P22188 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10621
Length: 495 (402)
Sequences: 17445 (12898)
Seq/√Len: 643.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
203_V318_T3.6711.00
439_K450_C2.7541.00
408_V439_K2.6851.00
382_C406_A2.6581.00
278_E289_R2.6351.00
450_C454_Q2.6271.00
325_P328_D2.6011.00
133_L335_R2.5941.00
110_R200_A2.5681.00
316_L329_L2.5151.00
345_V353_T2.5031.00
441_M450_C2.4971.00
443_G446_E2.4711.00
203_V314_L2.4661.00
201_A318_T2.4491.00
408_V454_Q2.4351.00
277_T291_S2.4011.00
217_D220_H2.3871.00
289_R298_E2.3851.00
130_W319_L2.2941.00
54_Q58_Q2.2851.00
300_E334_A2.2451.00
130_W315_A2.2091.00
236_Q321_A2.1891.00
366_E370_Q2.1861.00
222_E248_R2.1411.00
274_L317_A2.1311.00
133_L332_T2.1221.00
241_A272_R2.0981.00
56_I82_V2.0671.00
301_S312_L2.0471.00
200_A235_G2.0231.00
450_C453_M2.0211.00
379_K459_D1.9791.00
136_E178_T1.9681.00
455_A461_V1.9561.00
216_G220_H1.9551.00
133_L331_K1.9411.00
39_V64_I1.9311.00
410_V454_Q1.9311.00
370_Q405_F1.9251.00
229_Y237_A1.9071.00
134_L328_D1.8901.00
112_V322_L1.8511.00
261_M314_L1.8501.00
113_G199_F1.8421.00
54_Q57_A1.8261.00
208_S363_D1.8121.00
127_L315_A1.8111.00
129_Q335_R1.8081.00
381_W454_Q1.8031.00
53_P57_A1.7981.00
400_A404_E1.7911.00
226_W252_K1.7831.00
287_T298_E1.7661.00
276_A279_V1.7601.00
113_G184_V1.7371.00
128_A132_Q1.7271.00
388_G391_D1.7241.00
128_A140_V1.7221.00
379_K408_V1.7191.00
276_A313_L1.7081.00
320_L326_L1.6991.00
312_L333_A1.6951.00
345_V355_V1.6731.00
381_W408_V1.6711.00
422_R426_N1.6511.00
222_E245_V1.6491.00
288_I312_L1.6391.00
114_V127_L1.6381.00
127_L319_L1.6351.00
127_L318_T1.6321.00
410_V450_C1.6221.00
291_S296_D1.6101.00
289_R296_D1.6051.00
134_L324_Y1.5961.00
306_A370_Q1.5901.00
201_A322_L1.5821.00
472_Q476_N1.5801.00
111_L197_L1.5801.00
220_H223_A1.5781.00
287_T300_E1.5741.00
42_V66_E1.5611.00
348_A353_T1.5511.00
441_M446_E1.5271.00
94_L97_L1.5241.00
122_T308_N1.5181.00
274_L320_L1.5101.00
467_G472_Q1.5071.00
110_R179_F1.4911.00
473_I476_N1.4901.00
423_A426_N1.4891.00
202_S228_L1.4891.00
367_K370_Q1.4841.00
330_L334_A1.4821.00
275_K291_S1.4811.00
319_L329_L1.4781.00
186_S215_H1.4711.00
66_E90_L1.4631.00
118_N361_T1.4611.00
292_S295_G1.4451.00
224_A227_L1.4411.00
354_V452_V1.4401.00
292_S320_L1.4391.00
444_R473_I1.4381.00
131_S181_A1.4331.00
114_V124_T1.4281.00
112_V127_L1.4281.00
426_N430_A1.4211.00
129_Q332_T1.4021.00
352_P455_A1.3871.00
331_K335_R1.3821.00
179_F322_L1.3801.00
92_E96_A1.3701.00
131_S322_L1.3671.00
126_L303_L1.3621.00
328_D331_K1.3571.00
280_N287_T1.3521.00
383_V412_T1.3451.00
263_D306_A1.3451.00
381_W410_V1.3441.00
288_I309_V1.3431.00
427_D430_A1.3401.00
201_A321_A1.3361.00
277_T289_R1.3361.00
123_T205_T1.3231.00
204_F207_L1.3201.00
302_H337_Q1.3161.00
290_F316_L1.3081.00
366_E401_I1.3031.00
379_K456_K1.3021.00
425_I440_V1.3021.00
306_A374_L1.2991.00
379_K407_D1.2991.00
425_I429_L1.2921.00
390_R393_G1.2881.00
446_E449_T1.2871.00
297_G330_L1.2791.00
238_I321_A1.2701.00
126_L336_L1.2621.00
201_A238_I1.2611.00
351_K457_E1.2611.00
239_I246_G1.2551.00
110_R178_T1.2511.00
319_L324_Y1.2501.00
240_N310_S1.2451.00
410_V447_A1.2431.00
46_A50_R1.2371.00
370_Q401_I1.2281.00
127_L203_V1.2231.00
68_K86_Y1.2231.00
345_V348_A1.2191.00
207_L222_E1.2171.00
131_S179_F1.2061.00
331_K334_A1.2051.00
412_T447_A1.2041.00
104_E107_D1.2031.00
121_T339_V1.1951.00
219_E223_A1.1941.00
223_A252_K1.1931.00
198_K235_G1.1891.00
139_A142_G1.1741.00
449_T453_M1.1711.00
131_S324_Y1.1701.00
126_L312_L1.1671.00
408_V437_H1.1611.00
209_R393_G1.1551.00
285_G300_E1.1511.00
372_A380_L1.1471.00
226_W249_W1.1451.00
191_Q230_S1.1431.00
343_M355_V1.1401.00
340_C344_E1.1391.00
306_A310_S1.1331.00
138_S142_G1.1331.00
248_R251_A1.1201.00
42_V67_A1.1191.00
420_E423_A1.1191.00
227_L230_S1.1141.00
387_G414_D1.1141.00
365_L464_A1.1121.00
52_I63_I1.1121.00
209_R212_L1.1121.00
343_M372_A1.1061.00
411_V440_V1.1031.00
276_A309_V1.0981.00
137_I178_T1.0961.00
184_V194_V1.0941.00
241_A247_R1.0901.00
274_L292_S1.0831.00
396_P400_A1.0821.00
112_V318_T1.0631.00
48_G56_I1.0581.00
269_C272_R1.0571.00
219_E245_V1.0551.00
423_A427_D1.0511.00
327_A331_K1.0501.00
52_I56_I1.0481.00
445_A449_T1.0451.00
242_D310_S1.0421.00
422_R440_V1.0391.00
136_E179_F1.0391.00
222_E226_W1.0371.00
245_V248_R1.0341.00
139_A172_L1.0311.00
394_K397_L1.0251.00
117_T210_D1.0241.00
108_N173_V1.0241.00
344_E356_V1.0241.00
78_E82_V1.0221.00
428_I432_M1.0211.00
456_K459_D1.0181.00
288_I299_I1.0171.00
200_A232_H1.0121.00
446_E450_C1.0111.00
209_R218_M1.0111.00
381_W459_D1.0081.00
277_T296_D1.0071.00
308_N311_N1.0061.00
130_W332_T1.0021.00
80_H83_P1.0011.00
129_Q132_Q1.0001.00
204_F229_Y0.9981.00
360_H365_L0.9971.00
218_M245_V0.9941.00
238_I317_A0.9921.00
99_G104_E0.9911.00
77_R80_H0.9891.00
376_C460_V0.9891.00
426_N429_L0.9841.00
230_S252_K0.9841.00
282_H287_T0.9841.00
81_G84_V0.9831.00
118_N363_D0.9801.00
397_L400_A0.9781.00
324_Y328_D0.9781.00
201_A236_Q0.9751.00
366_E404_E0.9741.00
318_T322_L0.9741.00
205_T314_L0.9721.00
192_H195_A0.9691.00
413_D442_E0.9681.00
191_Q214_Y0.9671.00
223_A227_L0.9671.00
239_I250_L0.9661.00
258_A261_M0.9581.00
38_F61_A0.9541.00
190_V214_Y0.9531.00
410_V451_A0.9531.00
429_L432_M0.9521.00
79_M82_V0.9511.00
439_K454_Q0.9481.00
134_L332_T0.9471.00
465_G471_Y0.9441.00
365_L384_F0.9411.00
272_R275_K0.9401.00
220_H224_A0.9371.00
192_H224_A0.9351.00
89_Q92_E0.9321.00
363_D367_K0.9281.00
257_V261_M0.9281.00
130_W329_L0.9271.00
368_A462_L0.9211.00
297_G326_L0.9211.00
93_R96_A0.9191.00
111_L180_C0.9171.00
204_F249_W0.9141.00
92_E95_S0.9111.00
78_E81_G0.9091.00
399_G428_I0.9061.00
257_V260_S0.9051.00
320_L329_L0.8971.00
243_D310_S0.8951.00
133_L328_D0.8921.00
442_E446_E0.8911.00
398_M402_A0.8901.00
56_I63_I0.8891.00
134_L325_P0.8891.00
352_P458_N0.8881.00
396_P427_D0.8841.00
129_Q336_L0.8781.00
244_E248_R0.8771.00
410_V441_M0.8731.00
65_A84_V0.8721.00
348_A352_P0.8671.00
190_V224_A0.8671.00
110_R322_L0.8641.00
48_G52_I0.8621.00
411_V425_I0.8621.00
421_P424_I0.8601.00
115_T225_K0.8521.00
79_M84_V0.8491.00
422_R442_E0.8421.00
282_H285_G0.8391.00
369_L405_F0.8361.00
210_D361_T0.8341.00
410_V439_K0.8341.00
49_R52_I0.8301.00
40_A65_A0.8291.00
451_A455_A0.8291.00
226_W230_S0.8281.00
359_A464_A0.8261.00
382_C464_A0.8251.00
355_V372_A0.8231.00
429_L438_A0.8201.00
92_E192_H0.8151.00
128_A138_S0.8141.00
90_L93_R0.8111.00
93_R97_L0.8101.00
258_A262_E0.8101.00
129_Q133_L0.8061.00
299_I330_L0.8051.00
123_T314_L0.8021.00
77_R81_G0.7961.00
123_T315_A0.7931.00
353_T460_V0.7921.00
138_S144_V0.7851.00
46_A51_Y0.7841.00
399_G403_E0.7831.00
255_D259_V0.7831.00
326_L330_L0.7811.00
429_L440_V0.7801.00
401_I405_F0.7801.00
386_C469_E0.7791.00
447_A451_A0.7781.00
329_L332_T0.7771.00
125_Q339_V0.7751.00
260_S263_D0.7741.00
343_M371_A0.7711.00
96_A99_G0.7701.00
316_L320_L0.7671.00
47_D67_A0.7661.00
240_N243_D0.7651.00
441_M447_A0.7631.00
260_S273_W0.7631.00
189_L194_V0.7601.00
432_M435_A0.7591.00
55_A60_V0.7591.00
383_V463_V0.7581.00
227_L231_E0.7521.00
124_T140_V0.7511.00
369_L382_C0.7511.00
269_C275_K0.7511.00
85_I95_S0.7501.00
282_H300_E0.7491.00
427_D431_G0.7491.00
198_K232_H0.7491.00
392_K427_D0.7471.00
428_I431_G0.7451.00
113_G228_L0.7421.00
273_W293_S0.7401.00
39_V90_L0.7391.00
139_A144_V0.7381.00
142_G149_L0.7381.00
378_G459_D0.7361.00
247_R251_A0.7351.00
52_I64_I0.7351.00
303_L336_L0.7331.00
424_I428_I0.7321.00
184_V199_F0.7321.00
281_Y286_A0.7321.00
63_I82_V0.7311.00
348_A351_K0.7311.00
248_R252_K0.7281.00
208_S218_M0.7281.00
91_N95_S0.7261.00
241_A246_G0.7261.00
341_G356_V0.7261.00
86_Y89_Q0.7231.00
125_Q144_V0.7221.00
190_V227_L0.7211.00
95_S196_A0.7201.00
82_V85_I0.7201.00
373_R405_F0.7191.00
218_M222_E0.7181.00
39_V94_L0.7181.00
324_Y329_L0.7161.00
395_R399_G0.7151.00
87_L93_R0.7131.00
219_E222_E0.7111.00
43_G48_G0.7101.00
354_V461_V0.7081.00
238_I318_T0.7061.00
262_E310_S0.7061.00
396_P430_A0.7061.00
355_V460_V0.7051.00
376_C380_L0.7041.00
95_S192_H0.7041.00
128_A139_A0.7031.00
209_R363_D0.7031.00
192_H214_Y0.7021.00
392_K423_A0.7001.00
381_W455_A0.6951.00
189_L224_A0.6931.00
263_D310_S0.6931.00
142_G146_N0.6921.00
111_L182_M0.6861.00
173_V180_C0.6851.00
424_I432_M0.6831.00
40_A52_I0.6821.00
281_Y306_A0.6791.00
80_H84_V0.6791.00
385_G465_G0.6781.00
368_A464_A0.6751.00
173_V177_A0.6741.00
279_V282_H0.6701.00
186_S190_V0.6701.00
83_P86_Y0.6681.00
351_K458_N0.6681.00
280_N298_E0.6671.00
402_A409_A0.6671.00
366_E397_L0.6651.00
316_L326_L0.6651.00
134_L319_L0.6641.00
189_L228_L0.6621.00
411_V428_I0.6611.00
303_L308_N0.6611.00
409_A428_I0.6611.00
207_L218_M0.6601.00
424_I427_D0.6601.00
141_M172_L0.6581.00
77_R82_V0.6581.00
290_F313_L0.6571.00
448_V452_V0.6561.00
307_F367_K0.6551.00
327_A330_L0.6541.00
80_H86_Y0.6541.00
215_H224_A0.6531.00
128_A181_A0.6531.00
191_Q195_A0.6521.00
186_S224_A0.6511.00
124_T181_A0.6471.00
237_A253_L0.6431.00
114_V203_V0.6421.00
174_D177_A0.6411.00
383_V461_V0.6411.00
279_V288_I0.6401.00
383_V451_A0.6401.00
426_N440_V0.6391.00
222_E249_W0.6381.00
88_S93_R0.6371.00
422_R425_I0.6371.00
144_V148_L0.6361.00
112_V131_S0.6351.00
389_D392_K0.6351.00
271_G275_K0.6331.00
138_S141_M0.6321.00
55_A59_G0.6311.00
142_G148_L0.6301.00
219_E248_R0.6301.00
184_V197_L0.6301.00
470_D473_I0.6301.00
398_M401_I0.6281.00
362_P397_L0.6261.00
246_G249_W0.6241.00
255_D258_A0.6241.00
246_G250_L0.6241.00
373_R376_C0.6231.00
89_Q93_R0.6211.00
381_W451_A0.6211.00
130_W134_L0.6181.00
53_P56_I0.6171.00
118_N208_S0.6141.00
84_V91_N0.6141.00
406_A409_A0.6131.00
171_G175_Q0.6121.00
223_A226_W0.6111.00
204_F222_E0.6111.00
209_R397_L0.6101.00
190_V194_V0.6101.00
125_Q129_Q0.6091.00
393_G396_P0.6081.00
47_D51_Y0.6071.00
395_R398_M0.6071.00
400_A403_E0.6051.00
286_A309_V0.6041.00
127_L181_A0.6041.00
90_L94_L0.6041.00
41_V91_N0.6041.00
347_T353_T0.6031.00
350_G457_E0.6031.00
241_A269_C0.6021.00
412_T444_R0.6021.00
394_K398_M0.6011.00
56_I61_A0.6011.00
378_G460_V0.6011.00
359_A368_A0.6011.00
48_G51_Y0.6001.00
241_A260_S0.6001.00
380_L407_D0.5991.00
384_F428_I0.5961.00
313_L317_A0.5941.00
101_F104_E0.5911.00
411_V438_A0.5911.00
400_A431_G0.5911.00
366_E405_F0.5901.00
407_D456_K0.5891.00
393_G397_L0.5891.00
48_G53_P0.5871.00
444_R448_V0.5871.00
107_D198_K0.5841.00
144_V149_L0.5831.00
218_M221_Y0.5831.00
378_G458_N0.5821.00
109_L173_V0.5811.00
388_G392_K0.5791.00
273_W276_A0.5781.00
306_A309_V0.5771.00
278_E298_E0.5771.00
138_S177_A0.5771.00
145_G148_L0.5751.00
301_S333_A0.5741.00
239_I260_S0.5741.00
421_P425_I0.5741.00
316_L333_A0.5741.00
383_V447_A0.5731.00
366_E400_A0.5731.00
373_R380_L0.5721.00
78_E83_P0.5711.00
105_P198_K0.5711.00
305_G308_N0.5701.00
413_D425_I0.5671.00
142_G145_G0.5671.00
63_I84_V0.5671.00
425_I438_A0.5661.00
372_A460_V0.5631.00
297_G327_A0.5621.00
49_R66_E0.5611.00
47_D50_R0.5611.00
270_H275_K0.5581.00
263_D269_C0.5561.00
145_G149_L0.5541.00
370_Q374_L0.5531.00
295_G326_L0.5531.00
253_L256_A0.5531.00
49_R90_L0.5521.00
171_G174_D0.5501.00
194_V197_L0.5491.00
411_V429_L0.5491.00
140_V144_V0.5481.00
79_M86_Y0.5481.00
44_H64_I0.5481.00
309_V313_L0.5481.00
365_L401_I0.5471.00
279_V309_V0.5451.00
212_L217_D0.5451.00
237_A255_D0.5441.00
88_S91_N0.5431.00
99_G198_K0.5431.00
382_C409_A0.5431.00
109_L180_C0.5421.00
326_L329_L0.5421.00
91_N94_L0.5411.00
132_Q137_I0.5401.00
131_S319_L0.5401.00
118_N364_A0.5381.00
317_A321_A0.5381.00
48_G64_I0.5381.00
138_S181_A0.5370.99
343_M368_A0.5360.99
125_Q340_C0.5360.99
420_E424_I0.5350.99
137_I177_A0.5340.99
292_S326_L0.5330.99
361_T364_A0.5320.99
316_L330_L0.5320.99
122_T126_L0.5310.99
384_F411_V0.5290.99
193_R196_A0.5290.99
194_V231_E0.5270.99
449_T452_V0.5260.99
40_A63_I0.5260.99
365_L382_C0.5250.99
403_E432_M0.5250.99
407_D459_D0.5230.99
130_W324_Y0.5230.99
259_V263_D0.5220.99
112_V179_F0.5210.99
412_T441_M0.5210.99
414_D420_E0.5200.99
67_A70_E0.5180.99
50_R67_A0.5180.99
341_G467_G0.5170.99
79_M85_I0.5170.99
318_T321_A0.5160.99
359_A364_A0.5160.99
299_I312_L0.5160.99
392_K396_P0.5140.99
212_L216_G0.5130.99
122_T336_L0.5110.99
278_E281_Y0.5100.99
198_K231_E0.5100.99
187_H214_Y0.5100.99
349_P352_P0.5090.99
62_A83_P0.5090.99
52_I69_D0.5050.99
239_I258_A0.5050.99
139_A146_N0.5040.99
372_A462_L0.5040.99
83_P87_L0.5020.99
126_L315_A0.5010.99
242_D262_E0.5000.99
139_A177_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c12A 2 0.9697 100 0.178 Contact Map
4bubA 1 0.9535 100 0.189 Contact Map
1e8cA 1 0.9899 100 0.195 Contact Map
2wtzA 1 0.9778 100 0.212 Contact Map
4qdiA 1 0.8808 100 0.283 Contact Map
4cvkA 1 0.8545 100 0.285 Contact Map
3zm6A 1 0.8747 100 0.297 Contact Map
1gg4A 1 0.8586 100 0.299 Contact Map
3zl8A 1 0.8424 100 0.31 Contact Map
3lk7A 1 0.8323 100 0.397 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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