GREMLIN Database
MRAZ - Transcriptional regulator MraZ
UniProt: P22186 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11084
Length: 152 (133)
Sequences: 2444 (1655)
Seq/√Len: 143.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_E122_E4.1901.00
103_G124_T3.5051.00
52_E55_I3.1391.00
36_C45_L3.1021.00
109_M122_E3.0281.00
14_G99_R2.5621.00
122_E126_H2.5451.00
16_L110_L2.5301.00
47_L119_L2.4891.00
36_C94_I2.3071.00
47_L117_F2.2261.00
43_P124_T2.1251.00
105_T121_D2.0571.00
7_L109_M2.0351.00
75_R118_E2.0141.00
124_T127_Q1.9151.00
3_R57_E1.9121.00
35_V50_L1.8521.00
9_N107_E1.8441.00
42_H71_R1.8101.00
96_P100_Q1.7461.00
123_T127_Q1.7351.00
2_F117_F1.7301.00
121_D124_T1.6721.00
82_S95_A1.5811.00
33_Q83_E1.5501.00
50_L54_E1.5271.00
78_L114_F1.4681.00
16_L108_V1.4551.00
55_I58_Q1.4351.00
3_R83_E1.4301.00
64_S70_E1.3821.00
65_S74_Q1.3821.00
49_P52_E1.3671.00
84_C92_L1.3551.00
104_L121_D1.3451.00
48_Y56_I1.3311.00
7_L122_E1.3221.00
126_H130_K1.3121.00
33_Q50_L1.3041.00
3_R35_V1.3041.00
54_E58_Q1.2921.00
127_Q131_E1.2911.00
79_G125_W1.2861.00
46_L116_K1.2851.00
43_P101_H1.2771.00
52_E115_N1.2641.00
22_Y117_F1.2591.00
61_S114_F1.2501.00
10_L104_L1.2271.00
2_F22_Y1.2021.00
21_R83_E1.1991.00
35_V81_A1.1931.00
68_P72_R1.1921.00
99_R104_L1.1911.00
9_N106_K1.1711.00
38_I80_H1.1601.00
123_T126_H1.1530.99
135_A138_L1.1530.99
58_Q62_R1.1380.99
48_Y53_W1.1320.99
55_I59_K1.1280.99
46_L77_L1.1180.99
127_Q130_K1.1140.99
5_A80_H1.1030.99
51_P54_E1.0760.99
84_C95_A1.0760.99
6_T22_Y1.0480.99
57_E114_F1.0450.99
96_P99_R1.0390.99
18_V92_L1.0040.99
82_S97_V1.0030.99
17_S89_A0.9920.98
39_D46_L0.9680.98
69_V72_R0.9620.98
12_S88_G0.9540.98
110_L117_F0.9480.98
36_C84_C0.9310.98
58_Q61_S0.9140.97
131_E134_D0.9090.97
94_I119_L0.9050.97
111_V125_W0.8770.97
2_F49_P0.8770.97
44_C118_E0.8580.96
10_L108_V0.8450.96
43_P115_N0.8450.96
14_G104_L0.8410.96
36_C47_L0.8340.96
75_R113_Q0.8220.95
103_G121_D0.8170.95
8_V110_L0.8160.95
18_V110_L0.8120.95
54_E57_E0.8110.95
4_G81_A0.8100.95
8_V20_T0.8070.95
61_S115_N0.8050.95
44_C120_W0.8010.94
11_D15_R0.8010.94
27_L33_Q0.7930.94
33_Q85_Q0.7910.94
63_L70_E0.7850.94
28_E51_P0.7560.93
76_L129_V0.7460.92
12_S105_T0.7430.92
34_M47_L0.7350.92
50_L83_E0.7250.91
37_T81_A0.7140.90
8_V17_S0.7020.90
46_L113_Q0.7000.89
17_S23_R0.6990.89
2_F25_Q0.6960.89
21_R82_S0.6940.89
128_Q131_E0.6920.89
72_R128_Q0.6900.89
100_Q103_G0.6900.89
39_D71_R0.6750.88
5_A38_I0.6740.88
119_L126_H0.6730.88
67_N70_E0.6720.87
53_W75_R0.6690.87
73_V77_L0.6680.87
26_L34_M0.6650.87
17_S20_T0.6630.87
60_L74_Q0.6590.86
75_R120_W0.6590.86
57_E60_L0.6580.86
56_I77_L0.6560.86
106_K121_D0.6510.86
35_V83_E0.6500.86
24_E27_L0.6490.86
4_G37_T0.6420.85
74_Q132_D0.6370.85
39_D42_H0.6330.84
105_T123_T0.6280.84
79_G111_V0.6280.84
55_I115_N0.6280.84
23_R81_A0.6270.84
43_P103_G0.6260.84
12_S106_K0.6250.83
38_I45_L0.6250.83
86_M92_L0.6240.83
36_C92_L0.6210.83
55_I62_R0.6150.82
60_L63_L0.6140.82
55_I61_S0.6130.82
12_S93_L0.6070.82
12_S85_Q0.6040.81
78_L113_Q0.5940.80
74_Q116_K0.5940.80
24_E89_A0.5920.80
37_T53_W0.5900.80
23_R90_G0.5890.80
108_V122_E0.5860.79
100_Q126_H0.5780.78
40_I43_P0.5740.78
111_V128_Q0.5680.77
71_R74_Q0.5680.77
3_R60_L0.5670.77
93_L99_R0.5670.77
5_A109_M0.5630.77
38_I101_H0.5630.77
22_Y39_D0.5630.77
66_M73_V0.5620.76
40_I73_V0.5590.76
53_W81_A0.5530.75
68_P137_Q0.5530.75
60_L78_L0.5490.75
57_E78_L0.5480.75
53_W63_L0.5440.74
5_A125_W0.5420.74
34_M92_L0.5410.74
27_L34_M0.5400.74
48_Y52_E0.5360.73
76_L132_D0.5360.73
45_L98_L0.5320.72
80_H129_V0.5250.71
47_L92_L0.5240.71
51_P83_E0.5220.71
58_Q130_K0.5210.71
72_R132_D0.5210.71
81_A120_W0.5210.71
61_S78_L0.5210.71
22_Y110_L0.5190.71
74_Q79_G0.5190.71
16_L90_G0.5170.70
56_I65_S0.5160.70
130_K133_I0.5150.70
124_T128_Q0.5140.70
22_Y80_H0.5130.70
52_E56_I0.5090.69
42_H75_R0.5070.69
98_L102_A0.5050.69
35_V49_P0.5050.69
21_R112_G0.5040.68
68_P131_E0.5030.68
35_V44_C0.5020.68
72_R131_E0.5020.68
5_A79_G0.5010.68
77_L80_H0.5000.68
43_P102_A0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1n0eA 5 0.9013 100 0.083 Contact Map
2glwA 1 0.5987 99.7 0.628 Contact Map
1yfbA 2 0.3355 94.5 0.874 Contact Map
2w1tA 2 0.9276 94.5 0.874 Contact Map
2l66A 2 0.3421 91.3 0.887 Contact Map
1mvfD 1 0.2895 75.2 0.908 Contact Map
2mrnA 2 0.3355 54 0.921 Contact Map
3o27A 2 0.3355 27.9 0.933 Contact Map
3d55A 4 0.5197 18.7 0.938 Contact Map
3vkgA 2 0.9342 6.5 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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