ASNB - ECOLI - GREMLIN Contacts

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ASNB - Asparagine synthetase B [glutamine-hydrolyzing]

UniProt:	P22106	Sequences: MCSIFGVFDIKTDAVELRKKALELSRLMRHRGPDWSGIYASDNAILAHERLSIVDVNAGAQPLYNQQKTHVLAVNGEIYNHQALRAEYGDRYQFQTGSDCEVILALYQEKGPEFLDDLQGMFAFALYDSEKDAYLIGRDHLGIIPLYMGYDEHGQLYVASEMKALVPVCRTIKEFPAGSYLWSQDGEIRSYYHRDWFDYDAVKDNVTDKNELRQALEDSVKSHLMSDVPYGVLLSGGLDSSIISAITKKYAARRVEDQERSEAWWPQLHSFAVGLPGSPDLKAAQEVANHLGTVHHEIHFTVQEGLDAIRDVIYHIETYDVTTIRASTPMYLMSRKIKAMGIKMVLSGEGSDEVFGGYLYFHKAPNAKELHEETVRKLLALHMYDCARANKAMSAWGVEARVPFLDKKFLDVAMRINPQDKMCGNGKMEKHILRECFEAYLPASVAWRQKEQFSDGVGYSWIDTLKEVAAQQVSDQQLETARFRFPYNTPTSKEAYLYREIFEELFPLPSAAECVPGGPSVACSSAKAIEWDEAFKKMDDPSGRAVGVHQSAYK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10092
Length:	554 (484)
Sequences:	5120 (3664)
Seq/√Len:	166.6

ECOLI - ASNB
BACSU - ASNH ASNB ASNO

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
35_W	60_A	3.800	1.00
269_H	294_V	3.741	1.00
25_S	47_A	3.500	1.00
113_E	116_D	3.282	1.00
64_Y	71_V	3.278	1.00
133_A	184_Q	3.244	1.00
90_D	109_E	3.216	1.00
242_I	437_F	3.177	1.00
92_Y	109_E	3.158	1.00
21_A	45_I	3.087	1.00
285_Q	297_E	2.994	1.00
215_A	412_V	2.980	1.00
87_E	117_D	2.963	1.00
133_A	182_W	2.934	1.00
106_L	110_K	2.899	1.00
286_E	444_S	2.851	1.00
217_E	249_K	2.818	1.00
232_V	244_S	2.788	1.00
141_L	410_L	2.776	1.00
336_K	339_A	2.742	1.00
231_G	342_I	2.706	1.00
143_I	402_V	2.691	1.00
136_I	146_L	2.684	1.00
213_R	439_A	2.664	1.00
59_G	98_S	2.526	1.00
435_E	438_E	2.520	1.00
204_D	207_T	2.484	1.00
216_L	246_I	2.468	1.00
106_L	114_F	2.455	1.00
110_K	117_D	2.410	1.00
205_N	435_E	2.335	1.00
36_S	49_E	2.306	1.00
393_M	400_A	2.269	1.00
125_A	136_I	2.265	1.00
163_K	317_E	2.231	1.00
218_D	408_K	2.218	1.00
285_Q	289_N	2.140	1.00
269_H	296_H	2.139	1.00
175_F	181_L	2.113	1.00
65_N	108_Q	2.108	1.00
72_L	100_C	2.060	1.00
140_H	407_K	2.032	1.00
114_F	118_L	2.027	1.00
65_N	69_T	2.011	1.00
115_L	180_Y	2.009	1.00
180_Y	191_Y	1.989	1.00
92_Y	105_A	1.983	1.00
41_S	129_S	1.947	1.00
443_A	447_W	1.932	1.00
119_Q	222_S	1.915	1.00
69_T	130_E	1.895	1.00
270_S	293_T	1.859	1.00
334_S	393_M	1.823	1.00
423_C	431_H	1.816	1.00
211_E	215_A	1.816	1.00
119_Q	408_K	1.815	1.00
438_E	447_W	1.811	1.00
6_G	158_V	1.809	1.00
112_P	191_Y	1.806	1.00
176_P	179_S	1.804	1.00
355_F	413_A	1.780	1.00
82_Q	225_M	1.770	1.00
205_N	420_D	1.759	1.00
222_S	408_K	1.759	1.00
107_Y	126_L	1.750	1.00
159_A	164_A	1.744	1.00
244_S	293_T	1.723	1.00
30_H	161_E	1.718	1.00
156_L	183_S	1.711	1.00
54_V	81_H	1.706	1.00
221_K	250_Y	1.705	1.00
122_F	137_G	1.703	1.00
338_K	343_K	1.693	1.00
212_L	355_F	1.689	1.00
143_I	223_H	1.679	1.00
335_R	339_A	1.670	1.00
136_I	181_L	1.668	1.00
211_E	214_Q	1.655	1.00
205_N	431_H	1.650	1.00
213_R	436_C	1.648	1.00
70_H	104_L	1.647	1.00
112_P	182_W	1.642	1.00
6_G	125_A	1.631	1.00
176_P	190_S	1.620	1.00
115_L	137_G	1.618	1.00
431_H	435_E	1.611	1.00
119_Q	407_K	1.606	1.00
67_Q	108_Q	1.605	1.00
224_L	247_T	1.604	1.00
351_S	404_F	1.602	1.00
71_V	129_S	1.600	1.00
241_S	287_V	1.598	1.00
65_N	105_A	1.598	1.00
124_F	137_G	1.590	1.00
103_I	118_L	1.586	1.00
179_S	190_S	1.585	1.00
148_M	173_K	1.584	1.00
40_A	45_I	1.578	1.00
311_D	335_R	1.577	1.00
209_K	435_E	1.567	1.00
132_D	185_D	1.564	1.00
407_K	411_D	1.558	1.00
303_Q	307_D	1.555	1.00
179_S	192_Y	1.552	1.00
283_A	448_R	1.551	1.00
284_A	288_A	1.550	1.00
217_E	246_I	1.533	1.00
121_M	143_I	1.524	1.00
119_Q	406_D	1.521	1.00
70_H	108_Q	1.518	1.00
272_A	284_A	1.517	1.00
218_D	222_S	1.514	1.00
270_S	295_H	1.501	1.00
203_K	211_E	1.497	1.00
121_M	223_H	1.495	1.00
128_D	131_K	1.489	1.00
203_K	208_D	1.489	1.00
127_Y	132_D	1.487	1.00
74_V	100_C	1.479	1.00
174_E	318_T	1.478	1.00
439_A	443_A	1.477	1.00
213_R	440_Y	1.477	1.00
107_Y	135_L	1.473	1.00
271_F	341_G	1.470	1.00
217_E	250_Y	1.469	1.00
114_F	135_L	1.467	1.00
135_L	182_W	1.452	1.00
205_N	209_K	1.447	1.00
208_D	416_I	1.440	1.00
106_L	118_L	1.439	1.00
215_A	409_F	1.425	1.00
74_V	78_I	1.422	1.00
315_H	395_A	1.418	1.00
115_L	135_L	1.415	1.00
150_Y	173_K	1.408	1.00
481_A	503_E	1.405	1.00
151_D	154_G	1.403	1.00
361_F	377_K	1.397	1.00
5_F	24_L	1.389	1.00
219_S	223_H	1.388	1.00
212_L	412_V	1.386	1.00
53_I	344_M	1.373	1.00
438_E	443_A	1.368	1.00
484_R	492_S	1.362	1.00
28_M	164_A	1.361	1.00
119_Q	218_D	1.360	1.00
127_Y	134_Y	1.356	1.00
218_D	221_K	1.354	1.00
205_N	423_C	1.351	1.00
408_K	411_D	1.335	1.00
211_E	412_V	1.335	1.00
209_K	436_C	1.333	1.00
213_R	217_E	1.332	1.00
181_L	188_I	1.315	1.00
21_A	47_A	1.314	1.00
22_L	26_R	1.305	1.00
107_Y	114_F	1.302	1.00
301_T	304_E	1.299	1.00
81_H	225_M	1.293	1.00
5_F	25_S	1.292	1.00
78_I	103_I	1.290	1.00
135_L	180_Y	1.290	1.00
25_S	49_E	1.288	1.00
28_M	49_E	1.285	1.00
222_S	225_M	1.278	1.00
85_R	94_F	1.270	1.00
22_L	36_S	1.268	1.00
466_K	470_A	1.265	1.00
276_P	299_H	1.264	1.00
347_S	400_A	1.264	1.00
72_L	104_L	1.252	1.00
244_S	291_L	1.249	1.00
485_F	491_T	1.248	1.00
246_I	440_Y	1.239	1.00
276_P	301_T	1.226	1.00
316_I	392_A	1.223	1.00
25_S	38_I	1.220	1.00
485_F	488_N	1.213	1.00
105_A	108_Q	1.210	1.00
151_D	155_Q	1.207	1.00
5_F	47_A	1.206	1.00
103_I	114_F	1.205	1.00
232_V	270_S	1.202	1.00
39_Y	71_V	1.197	1.00
115_L	124_F	1.195	1.00
208_D	420_D	1.188	1.00
72_L	126_L	1.184	1.00
57_N	96_T	1.175	1.00
157_Y	165_L	1.172	1.00
29_R	49_E	1.172	1.00
412_V	416_I	1.171	1.00
54_V	225_M	1.169	1.00
349_E	388_R	1.162	1.00
112_P	135_L	1.159	1.00
210_N	439_A	1.157	1.00
119_Q	223_H	1.147	1.00
215_A	408_K	1.144	1.00
281_L	297_E	1.137	1.00
203_K	207_T	1.135	1.00
69_T	129_S	1.130	1.00
6_G	136_I	1.125	1.00
87_E	110_K	1.124	1.00
247_T	346_L	1.124	1.00
356_G	422_M	1.121	1.00
485_F	489_T	1.121	1.00
478_L	481_A	1.118	1.00
81_H	102_V	1.113	1.00
114_F	124_F	1.111	1.00
69_T	108_Q	1.111	1.00
22_L	38_I	1.109	1.00
241_S	441_L	1.107	1.00
248_K	291_L	1.103	1.00
310_R	504_E	1.097	1.00
233_L	337_I	1.095	1.00
192_Y	195_D	1.094	1.00
137_G	180_Y	1.083	1.00
126_L	135_L	1.083	1.00
304_E	307_D	1.082	1.00
82_Q	97_G	1.074	1.00
65_N	68_K	1.074	1.00
267_Q	294_V	1.072	1.00
369_E	372_E	1.070	0.99
212_L	413_A	1.070	0.99
242_I	436_C	1.070	0.99
304_E	335_R	1.067	0.99
356_G	374_T	1.061	0.99
476_Q	480_T	1.060	0.99
72_L	124_F	1.060	0.99
333_M	337_I	1.058	0.99
165_L	172_I	1.056	0.99
210_N	214_Q	1.054	0.99
43_N	132_D	1.053	0.99
244_S	270_S	1.051	0.99
223_H	402_V	1.050	0.99
274_G	281_L	1.046	0.99
29_R	36_S	1.040	0.99
416_I	432_I	1.039	0.99
226_S	230_Y	1.033	0.99
162_M	172_I	1.029	0.99
337_I	345_V	1.027	0.99
389_A	400_A	1.024	0.99
8_F	44_A	1.024	0.99
66_Q	105_A	1.021	0.99
63_L	100_C	1.021	0.99
26_R	49_E	1.019	0.99
2_C	75_N	1.018	0.99
423_C	426_G	1.017	0.99
66_Q	108_Q	1.017	0.99
331_Y	396_W	1.013	0.99
243_I	346_L	1.010	0.99
230_Y	344_M	1.009	0.99
326_A	329_P	1.007	0.99
54_V	226_S	1.004	0.99
484_R	489_T	1.002	0.99
287_V	445_V	0.997	0.99
69_T	131_K	0.995	0.99
46_L	158_V	0.993	0.99
468_V	471_Q	0.990	0.99
350_G	405_L	0.984	0.99
86_A	89_G	0.982	0.99
220_V	246_I	0.981	0.99
35_W	48_H	0.978	0.99
212_L	409_F	0.978	0.99
46_L	73_A	0.977	0.99
349_E	389_A	0.974	0.99
286_E	289_N	0.972	0.99
184_Q	187_E	0.972	0.99
375_V	379_L	0.968	0.99
178_G	194_R	0.962	0.99
8_F	134_Y	0.959	0.99
147_Y	391_K	0.955	0.99
183_S	188_I	0.954	0.99
216_L	404_F	0.948	0.99
308_A	335_R	0.947	0.99
87_E	90_D	0.945	0.99
70_H	130_E	0.944	0.99
324_I	388_R	0.944	0.99
5_F	159_A	0.943	0.99
371_H	421_K	0.936	0.99
90_D	110_K	0.936	0.99
368_K	418_P	0.930	0.99
194_R	411_D	0.929	0.99
4_I	73_A	0.923	0.99
131_K	184_Q	0.919	0.98
63_L	104_L	0.919	0.98
56_V	227_D	0.918	0.98
215_A	218_D	0.916	0.98
37_G	60_A	0.914	0.98
484_R	490_P	0.913	0.98
298_I	336_K	0.912	0.98
212_L	216_L	0.911	0.98
485_F	492_S	0.909	0.98
247_T	268_L	0.907	0.98
283_A	287_V	0.903	0.98
404_F	433_L	0.897	0.98
428_M	434_R	0.894	0.98
175_F	190_S	0.893	0.98
91_R	109_E	0.893	0.98
216_L	242_I	0.892	0.98
91_R	94_F	0.890	0.98
354_V	410_L	0.890	0.98
18_R	22_L	0.890	0.98
124_F	135_L	0.882	0.98
92_Y	108_Q	0.880	0.98
243_I	404_F	0.880	0.98
274_G	299_H	0.879	0.98
70_H	107_Y	0.879	0.98
311_D	314_Y	0.878	0.98
4_I	48_H	0.875	0.98
81_H	85_R	0.875	0.98
83_A	225_M	0.873	0.98
219_S	406_D	0.869	0.98
3_S	28_M	0.868	0.98
26_R	36_S	0.868	0.98
94_F	102_V	0.866	0.98
103_I	124_F	0.863	0.98
3_S	31_R	0.862	0.98
209_K	439_A	0.861	0.98
316_I	320_D	0.860	0.98
59_G	96_T	0.860	0.98
317_E	391_K	0.860	0.98
81_H	97_G	0.854	0.98
475_D	479_E	0.853	0.98
483_F	486_P	0.851	0.97
478_L	482_R	0.851	0.97
245_A	440_Y	0.849	0.97
198_D	414_M	0.848	0.97
439_A	446_A	0.847	0.97
163_K	314_Y	0.845	0.97
125_A	134_Y	0.840	0.97
326_A	388_R	0.839	0.97
121_M	144_I	0.838	0.97
83_A	222_S	0.837	0.97
468_V	472_Q	0.836	0.97
370_L	374_T	0.829	0.97
107_Y	128_D	0.829	0.97
55_D	58_A	0.828	0.97
125_A	158_V	0.825	0.97
68_K	95_Q	0.822	0.97
409_F	413_A	0.821	0.97
232_V	247_T	0.818	0.97
281_L	299_H	0.818	0.97
241_S	283_A	0.812	0.97
29_R	397_G	0.812	0.97
231_G	337_I	0.811	0.97
308_A	332_L	0.810	0.97
482_R	503_E	0.810	0.97
72_L	103_I	0.809	0.97
474_S	478_L	0.807	0.97
492_S	495_A	0.805	0.96
283_A	286_E	0.803	0.96
21_A	38_I	0.803	0.96
204_D	208_D	0.803	0.96
209_K	213_R	0.803	0.96
79_Y	121_M	0.803	0.96
233_L	334_S	0.801	0.96
475_D	478_L	0.800	0.96
252_A	267_Q	0.792	0.96
296_H	341_G	0.792	0.96
413_A	416_I	0.791	0.96
41_S	44_A	0.790	0.96
195_D	379_L	0.788	0.96
112_P	133_A	0.785	0.96
214_Q	217_E	0.785	0.96
201_A	208_D	0.784	0.96
436_C	439_A	0.778	0.96
458_G	493_K	0.777	0.96
7_V	157_Y	0.776	0.96
471_Q	474_S	0.774	0.96
149_G	165_L	0.772	0.96
216_L	437_F	0.772	0.96
417_N	420_D	0.772	0.96
19_K	23_E	0.770	0.95
331_Y	395_A	0.770	0.95
28_M	159_A	0.765	0.95
64_Y	68_K	0.765	0.95
5_F	21_A	0.764	0.95
141_L	378_L	0.764	0.95
148_M	156_L	0.763	0.95
146_L	175_F	0.762	0.95
345_V	400_A	0.761	0.95
20_K	23_E	0.761	0.95
213_R	246_I	0.758	0.95
311_D	315_H	0.757	0.95
156_L	181_L	0.755	0.95
216_L	409_F	0.754	0.95
245_A	291_L	0.753	0.95
79_Y	144_I	0.753	0.95
217_E	221_K	0.752	0.95
249_K	440_Y	0.747	0.95
52_S	56_V	0.747	0.95
56_V	228_V	0.745	0.95
63_L	96_T	0.745	0.95
330_M	389_A	0.743	0.95
21_A	40_A	0.742	0.94
88_Y	94_F	0.742	0.94
205_N	208_D	0.741	0.94
360_Y	377_K	0.739	0.94
113_E	117_D	0.738	0.94
428_M	447_W	0.738	0.94
356_G	370_L	0.737	0.94
69_T	128_D	0.736	0.94
316_I	327_S	0.734	0.94
462_I	485_F	0.733	0.94
324_I	327_S	0.730	0.94
286_E	290_H	0.730	0.94
208_D	412_V	0.730	0.94
110_K	114_F	0.729	0.94
477_Q	480_T	0.728	0.94
5_F	28_M	0.726	0.94
208_D	417_N	0.726	0.94
25_S	28_M	0.725	0.94
106_L	117_D	0.724	0.94
409_F	412_V	0.724	0.94
212_L	433_L	0.724	0.94
25_S	36_S	0.723	0.94
471_Q	475_D	0.723	0.94
41_S	127_Y	0.722	0.94
96_T	101_E	0.720	0.94
105_A	109_E	0.720	0.94
231_G	345_V	0.719	0.93
9_D	155_Q	0.716	0.93
456_G	460_S	0.715	0.93
387_A	391_K	0.713	0.93
353_E	358_Y	0.713	0.93
443_A	446_A	0.712	0.93
65_N	70_H	0.710	0.93
220_V	243_I	0.709	0.93
35_W	52_S	0.704	0.93
310_R	468_V	0.703	0.93
313_I	501_I	0.703	0.93
486_P	489_T	0.699	0.93
112_P	180_Y	0.698	0.92
271_F	342_I	0.697	0.92
477_Q	482_R	0.697	0.92
39_Y	127_Y	0.697	0.92
323_T	326_A	0.697	0.92
270_S	297_E	0.696	0.92
156_L	175_F	0.696	0.92
150_Y	156_L	0.696	0.92
54_V	96_T	0.696	0.92
54_V	98_S	0.696	0.92
200_D	415_R	0.696	0.92
437_F	440_Y	0.694	0.92
34_D	343_K	0.693	0.92
114_F	137_G	0.693	0.92
37_G	49_E	0.687	0.92
67_Q	70_H	0.686	0.92
219_S	222_S	0.684	0.92
73_A	125_A	0.684	0.92
78_I	118_L	0.682	0.92
251_A	267_Q	0.682	0.92
377_K	385_D	0.681	0.92
168_V	318_T	0.680	0.91
323_T	498_Y	0.678	0.91
320_D	326_A	0.678	0.91
451_E	454_S	0.678	0.91
332_L	335_R	0.678	0.91
329_P	332_L	0.677	0.91
284_A	297_E	0.677	0.91
140_H	194_R	0.674	0.91
324_I	329_P	0.673	0.91
279_P	282_K	0.672	0.91
80_N	83_A	0.670	0.91
413_A	432_I	0.669	0.91
24_L	27_L	0.666	0.91
53_I	343_K	0.666	0.91
206_V	209_K	0.666	0.91
68_K	129_S	0.665	0.91
208_D	211_E	0.663	0.90
245_A	441_L	0.663	0.90
411_D	415_R	0.662	0.90
144_I	390_N	0.661	0.90
26_R	29_R	0.659	0.90
33_P	51_L	0.656	0.90
209_K	212_L	0.656	0.90
150_Y	155_Q	0.655	0.90
368_K	372_E	0.655	0.90
308_A	311_D	0.655	0.90
494_E	498_Y	0.654	0.90
125_A	181_L	0.653	0.90
467_E	471_Q	0.653	0.90
19_K	22_L	0.650	0.90
162_M	169_C	0.649	0.89
345_V	398_V	0.649	0.89
211_E	415_R	0.649	0.89
479_E	482_R	0.649	0.89
147_Y	382_H	0.649	0.89
16_E	45_I	0.647	0.89
66_Q	95_Q	0.647	0.89
289_N	292_G	0.647	0.89
106_L	109_E	0.646	0.89
212_L	436_C	0.646	0.89
483_F	487_Y	0.645	0.89
9_D	12_T	0.645	0.89
205_N	432_I	0.645	0.89
234_L	270_S	0.645	0.89
39_Y	64_Y	0.645	0.89
200_D	203_K	0.643	0.89
384_Y	387_A	0.643	0.89
80_N	84_L	0.642	0.89
150_Y	154_G	0.641	0.89
70_H	105_A	0.641	0.89
175_F	179_S	0.641	0.89
330_M	392_A	0.640	0.89
390_N	394_S	0.639	0.89
144_I	394_S	0.638	0.89
499_R	503_E	0.637	0.89
412_V	432_I	0.636	0.89
374_T	378_L	0.633	0.88
173_K	190_S	0.632	0.88
12_T	17_L	0.632	0.88
217_E	440_Y	0.631	0.88
150_Y	171_T	0.630	0.88
103_I	126_L	0.630	0.88
85_R	102_V	0.629	0.88
88_Y	110_K	0.628	0.88
21_A	25_S	0.626	0.88
224_L	251_A	0.625	0.88
478_L	503_E	0.625	0.88
149_G	154_G	0.623	0.88
66_Q	69_T	0.621	0.87
75_N	399_E	0.621	0.87
69_T	105_A	0.620	0.87
251_A	268_L	0.619	0.87
323_T	327_S	0.619	0.87
207_T	211_E	0.618	0.87
330_M	349_E	0.618	0.87
182_W	189_R	0.617	0.87
216_L	243_I	0.616	0.87
468_V	500_E	0.616	0.87
364_A	367_A	0.615	0.87
123_A	146_L	0.614	0.87
269_H	342_I	0.614	0.87
2_C	77_E	0.613	0.87
325_R	329_P	0.613	0.87
181_L	190_S	0.612	0.87
103_I	115_L	0.612	0.87
94_F	101_E	0.611	0.86
214_Q	221_K	0.610	0.86
35_W	59_G	0.610	0.86
345_V	393_M	0.609	0.86
320_D	349_E	0.609	0.86
72_L	115_L	0.607	0.86
236_G	272_A	0.607	0.86
195_D	375_V	0.606	0.86
44_A	134_Y	0.605	0.86
203_K	412_V	0.605	0.86
308_A	328_T	0.604	0.86
435_E	447_W	0.604	0.86
192_Y	379_L	0.604	0.86
466_K	486_P	0.604	0.86
212_L	432_I	0.604	0.86
147_Y	162_M	0.603	0.86
274_G	284_A	0.602	0.86
70_H	126_L	0.602	0.86
58_A	98_S	0.601	0.86
483_F	489_T	0.601	0.86
232_V	243_I	0.601	0.86
374_T	421_K	0.599	0.85
272_A	281_L	0.597	0.85
290_H	444_S	0.596	0.85
151_D	157_Y	0.596	0.85
77_E	399_E	0.595	0.85
242_I	439_A	0.595	0.85
228_V	343_K	0.594	0.85
23_E	26_R	0.593	0.85
149_G	172_I	0.592	0.85
122_F	140_H	0.592	0.85
50_R	59_G	0.592	0.85
330_M	454_S	0.591	0.85
148_M	181_L	0.590	0.85
370_L	418_P	0.590	0.85
124_F	136_I	0.590	0.85
7_V	155_Q	0.590	0.85
27_L	164_A	0.588	0.84
338_K	341_G	0.587	0.84
371_H	418_P	0.587	0.84
90_D	93_Q	0.585	0.84
500_E	504_E	0.584	0.84
83_A	86_A	0.583	0.84
324_I	349_E	0.583	0.84
136_I	156_L	0.579	0.83
27_L	314_Y	0.579	0.83
129_S	132_D	0.578	0.83
450_K	453_F	0.578	0.83
476_Q	479_E	0.577	0.83
288_A	293_T	0.577	0.83
209_K	432_I	0.576	0.83
448_R	451_E	0.576	0.83
64_Y	129_S	0.576	0.83
204_D	420_D	0.572	0.83
233_L	345_V	0.571	0.83
116_D	191_Y	0.571	0.83
136_I	158_V	0.571	0.83
238_L	434_R	0.569	0.82
251_A	266_P	0.566	0.82
169_C	172_I	0.566	0.82
330_M	388_R	0.566	0.82
233_L	324_I	0.565	0.82
213_R	437_F	0.565	0.82
458_G	462_I	0.564	0.82
82_Q	102_V	0.564	0.82
214_Q	218_D	0.564	0.82
302_V	464_T	0.564	0.82
241_S	448_R	0.564	0.82
178_G	193_H	0.563	0.82
216_L	433_L	0.563	0.82
485_F	490_P	0.563	0.82
246_I	250_Y	0.563	0.82
412_V	415_R	0.563	0.82
150_Y	153_H	0.562	0.82
75_N	358_Y	0.561	0.82
291_L	295_H	0.560	0.81
150_Y	188_I	0.559	0.81
330_M	347_S	0.558	0.81
281_L	284_A	0.557	0.81
337_I	342_I	0.557	0.81
335_R	396_W	0.557	0.81
2_C	50_R	0.556	0.81
360_Y	363_K	0.555	0.81
33_P	397_G	0.554	0.81
35_W	73_A	0.554	0.81
82_Q	86_A	0.553	0.81
437_F	441_L	0.553	0.81
361_F	374_T	0.553	0.81
312_V	392_A	0.552	0.80
428_M	431_H	0.552	0.80
115_L	126_L	0.551	0.80
51_L	75_N	0.551	0.80
141_L	194_R	0.551	0.80
66_Q	92_Y	0.550	0.80
184_Q	189_R	0.550	0.80
41_S	71_V	0.550	0.80
73_A	158_V	0.548	0.80
2_C	53_I	0.548	0.80
327_S	332_L	0.548	0.80
233_L	388_R	0.547	0.80
458_G	491_T	0.545	0.80
229_P	343_K	0.545	0.80
491_T	495_A	0.545	0.80
2_C	358_Y	0.545	0.80
311_D	395_A	0.544	0.80
347_S	392_A	0.543	0.79
18_R	40_A	0.543	0.79
282_K	286_E	0.543	0.79
140_H	223_H	0.542	0.79
55_D	227_D	0.541	0.79
25_S	29_R	0.541	0.79
140_H	193_H	0.541	0.79
281_L	285_Q	0.540	0.79
93_Q	105_A	0.540	0.79
220_V	247_T	0.539	0.79
316_I	387_A	0.538	0.79
65_N	104_L	0.537	0.79
70_H	131_K	0.537	0.79
381_L	385_D	0.536	0.79
390_N	399_E	0.535	0.78
54_V	82_Q	0.534	0.78
9_D	16_E	0.533	0.78
70_H	128_D	0.532	0.78
143_I	387_A	0.532	0.78
63_L	72_L	0.532	0.78
312_V	331_Y	0.532	0.78
218_D	407_K	0.531	0.78
242_I	355_F	0.531	0.78
146_L	156_L	0.531	0.78
145_P	160_S	0.531	0.78
308_A	312_V	0.529	0.78
141_L	404_F	0.529	0.78
368_K	371_H	0.528	0.77
209_K	431_H	0.527	0.77
273_V	298_I	0.527	0.77
104_L	126_L	0.525	0.77
180_Y	189_R	0.524	0.77
167_P	172_I	0.524	0.77
307_D	310_R	0.523	0.77
287_V	293_T	0.523	0.77
80_N	102_V	0.523	0.77
162_M	167_P	0.522	0.77
484_R	491_T	0.522	0.77
66_Q	109_E	0.521	0.77
84_L	106_L	0.520	0.76
491_T	494_E	0.520	0.76
220_V	346_L	0.520	0.76
325_R	360_Y	0.519	0.76
230_Y	343_K	0.517	0.76
1_M	4_I	0.517	0.76
233_L	330_M	0.516	0.76
55_D	96_T	0.516	0.76
88_Y	109_E	0.516	0.76
140_H	411_D	0.516	0.76
233_L	398_V	0.516	0.76
248_K	251_A	0.514	0.76
333_M	336_K	0.513	0.75
18_R	38_I	0.513	0.75
84_L	118_L	0.513	0.75
472_Q	504_E	0.513	0.75
115_L	193_H	0.513	0.75
354_V	413_A	0.512	0.75
190_S	193_H	0.511	0.75
329_P	388_R	0.511	0.75
8_F	183_S	0.511	0.75
78_I	81_H	0.510	0.75
298_I	304_E	0.510	0.75
107_Y	115_L	0.509	0.75
163_K	315_H	0.509	0.75
48_H	394_S	0.508	0.75
7_V	17_L	0.506	0.74
382_H	385_D	0.506	0.74
72_L	107_Y	0.505	0.74
477_Q	481_A	0.505	0.74
88_Y	91_R	0.504	0.74
325_R	457_V	0.504	0.74
226_S	344_M	0.504	0.74
74_V	124_F	0.503	0.74
48_H	74_V	0.503	0.74
437_F	446_A	0.502	0.74
128_D	133_A	0.501	0.74
287_V	290_H	0.501	0.74
296_H	336_K	0.501	0.74
326_A	389_A	0.501	0.74
228_V	344_M	0.501	0.74
432_I	436_C	0.500	0.74
434_R	447_W	0.500	0.74
58_A	97_G	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ct9A	2	0.8971	100	0.236	Contact Map
1q15A	3	0.8087	100	0.361	Contact Map
1jgtA	2	0.8141	100	0.382	Contact Map
1ao0A	3	0.6931	100	0.697	Contact Map
1xffA	2	0.3556	100	0.73	Contact Map
1ecfA	4	0.713	100	0.735	Contact Map
1te5A	2	0.3159	100	0.737	Contact Map
4amvA	2	0.8971	100	0.741	Contact Map
3mdnA	4	0.2996	100	0.769	Contact Map
4zflA	5	0.3285	100	0.786	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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