GREMLIN Database
SYC - Cysteine--tRNA ligase
UniProt: P21888 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10196
Length: 461 (412)
Sequences: 20100 (11230)
Seq/√Len: 553.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
54_L59_Y5.1981.00
126_E130_A3.6701.00
341_R358_V3.6171.00
57_L343_I3.4991.00
84_S87_A3.2091.00
145_D148_T3.1931.00
35_L95_E3.0481.00
283_Y306_E3.0181.00
127_Q130_A3.0181.00
265_E271_L2.8801.00
49_V294_M2.8731.00
77_R80_E2.7881.00
22_E60_K2.7871.00
425_D429_A2.7821.00
101_D107_R2.7191.00
131_K244_C2.6901.00
55_R106_L2.6751.00
133_H148_T2.6731.00
385_R389_A2.6511.00
81_N91_R2.5931.00
145_D176_R2.5661.00
127_Q131_K2.4221.00
340_A344_E2.3351.00
188_K192_P2.3281.00
86_V90_D2.2791.00
95_E98_K2.2621.00
94_A98_K2.2451.00
139_N175_K2.1951.00
123_E127_Q2.1941.00
351_N354_E2.1931.00
344_E349_D2.1881.00
124_L245_A2.1401.00
51_A55_R2.1121.00
83_E91_R2.1041.00
53_Y57_L2.0931.00
346_M394_L2.0401.00
97_H101_D2.0121.00
54_L57_L2.0091.00
345_A354_E1.9971.00
222_D251_V1.9941.00
182_V185_K1.9871.00
83_E87_A1.9641.00
358_V361_D1.9521.00
141_D175_K1.8941.00
195_P200_A1.8931.00
421_Q425_D1.8411.00
162_Q165_A1.8241.00
279_D282_K1.7951.00
47_F225_G1.7921.00
102_A282_K1.7861.00
104_N397_E1.7761.00
51_A61_L1.7521.00
98_K102_A1.7361.00
83_E88_M1.7111.00
120_E215_K1.6741.00
418_A422_Q1.6561.00
345_A358_V1.6561.00
337_A341_R1.6441.00
206_H209_C1.6391.00
90_D94_A1.6251.00
213_N216_Q1.6241.00
417_E421_Q1.6151.00
278_R282_K1.6111.00
219_N242_S1.6051.00
50_V350_F1.6041.00
112_P115_T1.5691.00
128_L244_C1.5571.00
338_F362_M1.5331.00
343_I348_D1.5261.00
391_L399_E1.5251.00
280_V289_V1.5231.00
339_E386_K1.5191.00
53_Y343_I1.5051.00
206_H213_N1.4871.00
306_E310_K1.4771.00
208_E211_A1.4551.00
111_E114_A1.4431.00
75_I79_N1.4421.00
252_N350_F1.4411.00
323_L384_L1.4381.00
201_G206_H1.4251.00
44_F100_F1.4231.00
209_C213_N1.4141.00
418_A421_Q1.4131.00
168_R171_V1.4091.00
94_A97_H1.4041.00
203_P206_H1.4021.00
192_P196_S1.3931.00
262_V305_S1.3911.00
184_W187_S1.3811.00
54_L348_D1.3661.00
412_E415_E1.3661.00
147_P177_N1.3641.00
210_S213_N1.3641.00
202_R206_H1.3541.00
19_H24_G1.3491.00
212_M216_Q1.3481.00
336_E339_E1.3461.00
77_R81_N1.3351.00
288_T313_R1.3221.00
374_M377_A1.3211.00
276_T279_D1.3201.00
208_E213_N1.3191.00
193_S199_G1.3161.00
339_E343_I1.3111.00
87_A91_R1.3091.00
366_V383_H1.3051.00
386_K389_A1.3031.00
211_A215_K1.2971.00
341_R344_E1.2921.00
188_K191_E1.2911.00
102_A281_L1.2851.00
323_L402_L1.2761.00
67_I93_I1.2731.00
205_W208_E1.2721.00
76_K80_E1.2691.00
159_D162_Q1.2671.00
26_Y29_G1.2671.00
202_R205_W1.2641.00
45_V293_L1.2621.00
25_M51_A1.2521.00
204_G209_C1.2511.00
151_T154_V1.2511.00
355_A394_L1.2431.00
207_I210_S1.2421.00
208_E212_M1.2341.00
136_V177_N1.2341.00
192_P195_P1.2331.00
194_W198_W1.2261.00
127_Q245_A1.2251.00
67_I97_H1.2181.00
279_D283_Y1.2161.00
56_F389_A1.2121.00
211_A216_Q1.2111.00
382_S386_K1.2071.00
339_E390_V1.2031.00
88_M92_M1.1871.00
318_R363_A1.1861.00
209_C212_M1.1801.00
424_L428_K1.1781.00
193_S200_A1.1781.00
206_H212_M1.1751.00
212_M217_L1.1741.00
206_H210_S1.1731.00
190_G193_S1.1731.00
381_A385_R1.1671.00
43_T257_S1.1641.00
19_H22_E1.1631.00
409_D412_E1.1531.00
197_P200_A1.1501.00
219_N248_G1.1501.00
316_L395_E1.1481.00
346_M355_A1.1431.00
202_R210_S1.1401.00
98_K101_D1.1401.00
97_H107_R1.1341.00
126_E129_I1.1331.00
201_G205_W1.1331.00
406_A409_D1.1321.00
204_G207_I1.1301.00
44_F105_I1.1291.00
342_F355_A1.1271.00
91_R95_E1.1271.00
41_G103_L1.1271.00
212_M215_K1.1181.00
413_V417_E1.1181.00
206_H215_K1.1171.00
117_H216_Q1.1151.00
425_D428_K1.1151.00
211_A214_C1.1141.00
262_V307_E1.1141.00
69_D113_R1.1131.00
209_C216_Q1.1131.00
102_A278_R1.1081.00
338_F358_V1.0961.00
213_N217_L1.0931.00
141_D173_D1.0901.00
117_H120_E1.0901.00
21_G59_Y1.0891.00
53_Y346_M1.0841.00
201_G204_G1.0821.00
193_S196_S1.0811.00
423_R427_R1.0791.00
133_H186_M1.0791.00
206_H216_Q1.0781.00
368_R372_E1.0771.00
342_F346_M1.0761.00
307_E310_K1.0761.00
283_Y310_K1.0751.00
98_K278_R1.0751.00
123_E126_E1.0741.00
210_S217_L1.0711.00
35_L278_R1.0701.00
189_E193_S1.0661.00
194_W197_P1.0661.00
51_A106_L1.0661.00
235_H253_Y1.0651.00
422_Q426_A1.0591.00
202_R207_I1.0571.00
97_H111_E1.0541.00
207_I213_N1.0511.00
421_Q424_L1.0441.00
287_E320_Y1.0381.00
133_H244_C1.0381.00
158_Q163_L1.0351.00
183_L186_M1.0351.00
90_D113_R1.0301.00
153_G156_S1.0301.00
322_A363_A1.0271.00
307_E311_Q1.0261.00
363_A387_L1.0261.00
36_C40_H1.0231.00
414_A418_A1.0211.00
292_F308_N1.0161.00
261_M303_N1.0161.00
81_N88_M1.0141.00
93_I97_H1.0141.00
23_V59_Y1.0111.00
264_R303_N1.0081.00
190_G194_W1.0061.00
204_G210_S1.0051.00
207_I212_M1.0051.00
341_R345_A1.0051.00
87_A90_D1.0031.00
354_E357_S1.0021.00
386_K390_V0.9961.00
170_D173_D0.9881.00
52_R396_Q0.9871.00
218_G222_D0.9861.00
74_I85_F0.9831.00
393_L396_Q0.9781.00
390_V393_L0.9771.00
160_L163_L0.9771.00
315_A360_F0.9761.00
34_D40_H0.9761.00
205_W212_M0.9751.00
182_V186_M0.9741.00
313_R317_E0.9731.00
322_A366_V0.9701.00
60_K218_G0.9691.00
56_F392_G0.9691.00
172_V175_K0.9681.00
169_V172_V0.9671.00
202_R209_C0.9641.00
209_C217_L0.9621.00
152_Y155_L0.9611.00
202_R213_N0.9571.00
330_V381_A0.9571.00
388_S402_L0.9561.00
30_I33_Y0.9541.00
210_S215_K0.9531.00
99_D278_R0.9521.00
206_H211_A0.9511.00
187_S191_E0.9501.00
345_A355_A0.9461.00
408_A411_S0.9441.00
168_R172_V0.9421.00
201_G209_C0.9311.00
193_S197_P0.9291.00
203_P213_N0.9291.00
267_M273_N0.9271.00
194_W199_G0.9251.00
391_L395_E0.9201.00
50_V54_L0.9201.00
336_E340_A0.9131.00
426_A429_A0.9101.00
189_E194_W0.9091.00
407_Q410_D0.9081.00
419_L422_Q0.9071.00
161_D164_Q0.9071.00
189_E192_P0.9071.00
414_A417_E0.9021.00
202_R211_A0.8991.00
207_I211_A0.8951.00
205_W213_N0.8951.00
204_G208_E0.8871.00
428_K432_W0.8861.00
29_G33_Y0.8851.00
196_S199_G0.8851.00
189_E243_T0.8841.00
411_S414_A0.8841.00
120_E123_E0.8831.00
128_L241_Q0.8821.00
205_W216_Q0.8781.00
392_G399_E0.8701.00
92_M95_E0.8701.00
357_S361_D0.8691.00
147_P169_V0.8691.00
49_V346_M0.8681.00
108_P111_E0.8681.00
206_H214_C0.8641.00
356_Y394_L0.8641.00
341_R361_D0.8561.00
128_L131_K0.8561.00
210_S216_Q0.8511.00
281_L286_A0.8491.00
175_K178_P0.8481.00
45_V105_I0.8471.00
201_G212_M0.8461.00
139_N177_N0.8451.00
342_F359_L0.8431.00
202_R208_E0.8421.00
395_E398_P0.8401.00
205_W217_L0.8381.00
119_A123_E0.8331.00
209_C215_K0.8311.00
43_T256_H0.8291.00
204_G211_A0.8281.00
122_I126_E0.8271.00
159_D164_Q0.8271.00
262_V274_F0.8251.00
119_A122_I0.8241.00
171_V175_K0.8231.00
337_A340_A0.8211.00
202_R215_K0.8181.00
34_D77_R0.8171.00
378_N382_S0.8141.00
27_V225_G0.8131.00
342_F390_V0.8121.00
49_V352_T0.8111.00
181_F185_K0.8101.00
310_K313_R0.8101.00
365_E368_R0.8091.00
169_V173_D0.8081.00
42_R302_L0.8031.00
267_M274_F0.8001.00
388_S403_Q0.7991.00
53_Y348_D0.7971.00
249_Q252_N0.7951.00
231_M255_M0.7921.00
345_A349_D0.7901.00
424_L427_R0.7881.00
47_F63_Y0.7861.00
410_D413_V0.7841.00
285_D288_T0.7821.00
201_G213_N0.7811.00
201_G207_I0.7811.00
206_H217_L0.7801.00
213_N221_F0.7801.00
182_V187_S0.7791.00
183_L187_S0.7791.00
345_A351_N0.7771.00
205_W210_S0.7771.00
57_L348_D0.7741.00
248_G251_V0.7691.00
81_N84_S0.7681.00
180_D183_L0.7681.00
271_L274_F0.7671.00
139_N174_D0.7641.00
319_L388_S0.7641.00
196_S200_A0.7641.00
202_R216_Q0.7631.00
338_F342_F0.7601.00
129_I134_A0.7531.00
48_D52_R0.7531.00
194_W200_A0.7521.00
338_F341_R0.7521.00
207_I216_Q0.7521.00
195_P198_W0.7501.00
35_L92_M0.7491.00
201_G208_E0.7471.00
415_E431_D0.7471.00
202_R217_L0.7461.00
114_A121_I0.7451.00
415_E418_A0.7451.00
420_I424_L0.7441.00
74_I89_V0.7441.00
158_Q161_D0.7431.00
35_L99_D0.7421.00
308_N311_Q0.7421.00
204_G216_Q0.7411.00
220_H252_N0.7391.00
36_C99_D0.7381.00
202_R212_M0.7361.00
341_R354_E0.7321.00
415_E419_L0.7321.00
201_G216_Q0.7321.00
52_R106_L0.7321.00
50_V352_T0.7321.00
398_P401_F0.7311.00
144_F149_D0.7311.00
295_S356_Y0.7301.00
291_Y312_A0.7261.00
51_A63_Y0.7241.00
413_V416_I0.7241.00
223_I254_W0.7231.00
382_S385_R0.7221.00
205_W215_K0.7211.00
319_L363_A0.7201.00
192_P198_W0.7191.00
257_S260_V0.7191.00
210_S214_C0.7181.00
342_F358_V0.7171.00
201_G217_L0.7141.00
190_G196_S0.7131.00
422_Q425_D0.7121.00
359_L391_L0.7111.00
203_P210_S0.7101.00
209_C214_C0.7101.00
263_D303_N0.7081.00
146_V172_V0.7081.00
191_E194_W0.7071.00
91_R94_A0.7071.00
397_E400_A0.7041.00
100_F105_I0.7041.00
388_S399_E0.6971.00
371_A374_M0.6961.00
110_M116_H0.6961.00
160_L164_Q0.6941.00
219_N222_D0.6931.00
211_A217_L0.6931.00
417_E424_L0.6921.00
93_I113_R0.6911.00
208_E215_K0.6901.00
228_S259_M0.6901.00
71_D75_I0.6901.00
178_P182_V0.6901.00
204_G213_N0.6891.00
226_G235_H0.6891.00
325_G371_A0.6891.00
27_V47_F0.6881.00
310_K314_A0.6861.00
201_G210_S0.6841.00
50_V223_I0.6821.00
408_A412_E0.6821.00
296_G302_L0.6811.00
325_G329_T0.6801.00
94_A101_D0.6801.00
77_R88_M0.6791.00
40_H44_F0.6781.00
214_C246_H0.6761.00
291_Y356_Y0.6761.00
396_Q399_E0.6751.00
161_D165_A0.6741.00
22_E62_K0.6721.00
176_R181_F0.6721.00
223_I252_N0.6711.00
409_D413_V0.6691.00
392_G400_A0.6681.00
420_I423_R0.6671.00
41_G277_V0.6671.00
413_V424_L0.6671.00
143_M173_D0.6611.00
291_Y315_A0.6561.00
90_D93_I0.6511.00
109_D115_T0.6511.00
205_W211_A0.6491.00
416_I419_L0.6491.00
131_K247_D0.6491.00
228_S231_M0.6481.00
316_L398_P0.6481.00
168_R173_D0.6481.00
97_H109_D0.6471.00
292_F312_A0.6461.00
208_E216_Q0.6461.00
167_A196_S0.6451.00
188_K193_S0.6441.00
45_V294_M0.6441.00
104_N286_A0.6421.00
201_G211_A0.6421.00
354_E358_V0.6421.00
166_G171_V0.6411.00
38_I267_M0.6411.00
393_L398_P0.6411.00
383_H386_K0.6401.00
193_S198_W0.6391.00
157_R161_D0.6371.00
338_F390_V0.6351.00
24_G62_K0.6341.00
158_Q164_Q0.6341.00
368_R371_A0.6331.00
171_V174_D0.6331.00
38_I274_F0.6301.00
279_D306_E0.6281.00
181_F184_W0.6271.00
205_W209_C0.6271.00
291_Y295_S0.6261.00
264_R272_G0.6251.00
388_S394_L0.6241.00
93_I111_E0.6221.00
142_V151_T0.6201.00
427_R432_W0.6201.00
426_A431_D0.6191.00
81_N92_M0.6181.00
406_A411_S0.6181.00
262_V303_N0.6171.00
242_S246_H0.6151.00
203_P207_I0.6151.00
26_Y33_Y0.6151.00
321_T325_G0.6141.00
24_G222_D0.6131.00
208_E214_C0.6121.00
308_N312_A0.6111.00
35_L276_T0.6101.00
140_G180_D0.6091.00
153_G157_R0.6081.00
195_P199_G0.6081.00
295_S312_A0.6081.00
45_V49_V0.6071.00
419_L429_A0.6061.00
23_V26_Y0.6051.00
267_M275_F0.6051.00
291_Y395_E0.6021.00
23_V28_C0.6011.00
337_A413_V0.6011.00
268_S271_L0.6011.00
118_I122_I0.6001.00
243_T249_Q0.6001.00
181_F186_M0.6001.00
188_K198_W0.6001.00
224_H238_E0.5981.00
411_S415_E0.5981.00
178_P181_F0.5981.00
159_D163_L0.5971.00
152_Y157_R0.5971.00
407_Q413_V0.5971.00
136_V139_N0.5961.00
203_P209_C0.5961.00
161_D170_D0.5961.00
188_K195_P0.5931.00
46_A225_G0.5931.00
258_G261_M0.5931.00
62_K110_M0.5901.00
65_R111_E0.5891.00
50_V255_M0.5861.00
385_R388_S0.5861.00
325_G370_K0.5851.00
188_K194_W0.5831.00
176_R179_M0.5831.00
135_Y182_V0.5821.00
218_G221_F0.5811.00
110_M216_Q0.5811.00
294_M356_Y0.5800.99
185_K188_K0.5800.99
173_D176_R0.5790.99
412_E416_I0.5790.99
383_H387_L0.5790.99
204_G217_L0.5780.99
381_A384_L0.5770.99
284_Y310_K0.5770.99
167_A171_V0.5770.99
340_A343_I0.5760.99
24_G221_F0.5750.99
32_V44_F0.5750.99
223_I350_F0.5750.99
404_S407_Q0.5740.99
379_A383_H0.5680.99
28_C33_Y0.5670.99
214_C217_L0.5670.99
180_D185_K0.5660.99
344_E348_D0.5650.99
99_D276_T0.5640.99
228_S301_Q0.5640.99
274_F277_V0.5630.99
392_G403_Q0.5620.99
78_A85_F0.5600.99
412_E420_I0.5600.99
110_M114_A0.5590.99
24_G28_C0.5560.99
145_D167_A0.5560.99
203_P211_A0.5550.99
43_T47_F0.5540.99
407_Q412_E0.5520.99
413_V420_I0.5500.99
201_G214_C0.5470.99
397_E401_F0.5470.99
176_R180_D0.5460.99
329_T333_A0.5460.99
222_D252_N0.5460.99
419_L423_R0.5460.99
131_K246_H0.5450.99
160_L165_A0.5410.99
311_Q315_A0.5400.99
154_V157_R0.5390.99
204_G215_K0.5380.99
169_V175_K0.5380.99
55_R109_D0.5380.99
202_R214_C0.5370.99
265_E272_G0.5370.99
388_S395_E0.5370.99
189_E198_W0.5360.99
166_G169_V0.5340.99
280_V306_E0.5330.99
413_V421_Q0.5320.99
232_F236_E0.5240.99
95_E278_R0.5240.99
416_I420_I0.5240.99
389_A392_G0.5230.99
133_H185_K0.5220.99
423_R431_D0.5220.99
157_R160_L0.5210.99
175_K181_F0.5200.99
203_P216_Q0.5180.99
305_S308_N0.5170.99
428_K431_D0.5170.99
152_Y156_S0.5160.99
76_K79_N0.5150.99
410_D414_A0.5130.99
262_V306_E0.5130.99
158_Q162_Q0.5130.99
420_I426_A0.5130.99
355_A358_V0.5120.99
426_A430_K0.5110.99
326_T330_V0.5100.99
128_L134_A0.5100.99
20_A60_K0.5090.99
155_L158_Q0.5090.99
180_D184_W0.5090.99
373_D376_A0.5080.99
152_Y159_D0.5070.99
62_K109_D0.5060.99
417_E431_D0.5050.99
424_L431_D0.5030.99
324_R327_D0.5010.99
46_A294_M0.5010.99
51_A109_D0.5010.99
409_D415_E0.5010.99
388_S393_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1li5A 1 0.8373 100 0.186 Contact Map
3tqoA 1 0.8308 100 0.199 Contact Map
3sp1A 1 0.9024 100 0.242 Contact Map
1gaxA 1 0.9935 100 0.294 Contact Map
3ziuA 1 0.9588 100 0.297 Contact Map
1rqgA 2 0.9479 100 0.31 Contact Map
3kflA 1 0.9089 100 0.315 Contact Map
1ffyA 1 0.9913 100 0.315 Contact Map
4arcA 1 0.9262 100 0.334 Contact Map
2x1lA 1 0.898 100 0.337 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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