GREMLIN Database
KDPD - Sensor protein KdpD
UniProt: P21865 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10516
Length: 894 (848)
Sequences: 1127 (735)
Seq/√Len: 25.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
57_V72_L8.0671.00
98_A106_I7.3761.00
54_D101_R6.5841.00
413_T432_Y6.1991.00
93_F98_A5.4481.00
120_R130_E5.2191.00
785_L814_V5.0311.00
90_I116_A4.7721.00
96_D120_R4.6201.00
107_L141_T4.5831.00
284_V328_V4.5331.00
191_L196_V4.4701.00
852_C863_I4.2871.00
78_L93_F4.0441.00
821_L829_I3.8851.00
413_T462_F3.8221.00
309_A314_A3.7231.00
78_L98_A3.7021.00
412_I435_G3.6851.00
76_A101_R3.6261.00
58_G98_A3.5971.00
29_F144_V3.5461.00
93_F106_I3.4481.00
812_L877_V3.4211.00
856_V877_V3.3821.00
108_M131_L3.3821.00
56_V101_R3.3581.00
686_A707_I3.2421.00
85_Y116_A3.1171.00
58_G106_I3.0741.00
53_L105_L2.9801.00
49_R76_A2.9621.00
781_V856_V2.9451.00
80_L91_S2.9031.00
57_V77_V2.8601.00
785_L877_V2.8341.00
855_I859_H2.8041.00
535_S638_V2.7560.99
95_L121_H2.7180.99
247_W336_N2.6890.99
72_L77_V2.6300.99
823_P826_E2.6060.99
95_L131_L2.5960.99
562_T565_Q2.5850.99
342_L371_L2.5520.99
82_R91_S2.5330.99
853_R857_D2.5020.99
816_D820_G2.4960.99
56_V76_A2.4260.99
659_E662_Q2.4190.98
95_L99_L2.4090.98
773_V778_F2.3990.98
129_E133_E2.3810.98
185_D212_K2.3710.98
96_D130_E2.3390.98
57_V75_L2.3150.98
460_D464_I2.3110.98
782_L786_L2.3100.98
749_L760_I2.3080.98
825_Q828_T2.2990.98
264_E304_S2.2910.98
57_V369_Q2.2800.98
810_L881_Q2.2790.98
778_F877_V2.2760.98
160_I163_R2.2600.98
172_D225_R2.2490.98
257_I263_S2.2350.97
408_L435_G2.2350.97
317_A331_Y2.2350.97
328_V340_I2.2260.97
110_E164_E2.2210.97
781_V863_I2.2130.97
866_F874_C2.2110.97
237_W243_E2.1940.97
270_A283_A2.1820.97
781_V852_C2.1780.97
93_F131_L2.1590.97
744_V773_V2.1560.97
682_L711_V2.1520.97
143_N197_Y2.1210.96
827_Q853_R2.1090.96
54_D76_A2.1080.96
83_Q760_I2.0880.96
189_Q193_E2.0720.96
321_D327_A2.0690.96
48_L53_L2.0600.96
561_L564_P2.0450.96
773_V859_H2.0430.96
798_E817_N2.0270.95
826_E867_N2.0270.95
745_V812_L2.0240.95
271_A283_A2.0190.95
99_L131_L2.0070.95
121_H130_E1.9940.95
339_K370_V1.9910.95
238_R336_N1.9840.95
797_A817_N1.9450.94
69_A73_E1.9330.94
255_L266_L1.9240.94
93_F108_M1.9220.94
28_F139_F1.9090.94
198_I201_Q1.9050.94
48_L139_F1.9020.94
197_Y205_A1.8990.93
683_F712_L1.8930.93
85_Y90_I1.8930.93
815_W874_C1.8880.93
474_D477_Y1.8820.93
188_R206_I1.8710.93
864_T876_R1.8560.93
41_M107_L1.8530.93
213_G243_E1.8500.93
145_Q164_E1.8440.92
741_L803_A1.8360.92
480_T484_M1.8270.92
26_K178_V1.8270.92
655_R659_E1.8130.92
714_T725_A1.8100.92
92_E113_H1.8100.92
461_L469_T1.7840.91
456_V484_M1.7790.91
399_I403_V1.7780.91
256_C328_V1.7680.91
48_L105_L1.7660.91
822_P825_Q1.7460.90
441_L499_R1.7460.90
213_G237_W1.7410.90
231_D249_T1.7360.90
188_R192_K1.7360.90
738_W770_L1.7120.89
813_D876_R1.7050.89
528_P642_L1.6980.89
748_A801_I1.6920.89
437_V491_I1.6840.88
418_Q470_L1.6720.88
856_V863_I1.6670.88
402_C446_W1.6660.88
211_R237_W1.6500.87
745_V801_I1.6480.87
344_R357_A1.6430.87
867_N873_A1.6420.87
781_V877_V1.6380.87
243_E336_N1.6310.87
456_V477_Y1.6310.87
95_L108_M1.6300.87
527_S530_D1.6280.87
474_D791_K1.6220.86
57_V80_L1.6150.86
661_E682_L1.6130.86
202_A205_A1.6120.86
856_V861_G1.6080.86
787_E791_K1.5960.86
164_E197_Y1.5870.85
406_A450_V1.5820.85
46_Q73_E1.5780.85
595_V599_I1.5760.85
761_N798_E1.5650.84
243_E247_W1.5580.84
420_L467_R1.5540.84
238_R246_V1.5470.84
28_F519_S1.5460.84
460_D477_Y1.5360.83
53_L193_E1.5360.83
686_A704_A1.5350.83
863_I877_V1.5240.83
724_M845_V1.5160.82
231_D234_M1.5130.82
46_Q71_M1.5130.82
257_I283_A1.5110.82
576_Q580_D1.5090.82
67_D195_K1.5050.82
414_L418_Q1.5030.82
46_Q50_A1.4990.82
62_T69_A1.4980.82
794_G797_A1.4960.82
65_R197_Y1.4930.81
457_V470_L1.4900.81
690_T708_R1.4890.81
267_V436_V1.4870.81
29_F33_A1.4840.81
430_M484_M1.4770.81
696_E699_P1.4700.80
456_V855_I1.4560.80
282_H335_H1.4550.80
741_L812_L1.4550.80
685_Q706_E1.4530.80
91_S95_L1.4490.79
518_M638_V1.4460.79
402_C447_P1.4390.79
558_L564_P1.4330.79
407_A795_A1.4310.79
110_E143_N1.4190.78
53_L104_A1.4180.78
620_R623_M1.4180.78
48_L51_Q1.4160.78
257_I305_A1.4140.78
223_L226_T1.4120.78
604_S607_K1.4090.77
364_A367_L1.4010.77
472_V484_M1.4010.77
110_E197_Y1.3990.77
123_K143_N1.3970.77
470_L650_S1.3920.77
146_H164_E1.3870.76
560_P563_H1.3860.76
256_C791_K1.3850.76
151_N165_T1.3730.76
125_W711_V1.3670.75
83_Q90_I1.3660.75
652_E655_R1.3660.75
177_V226_T1.3630.75
464_I472_V1.3630.75
24_K745_V1.3550.75
809_N878_T1.3520.74
748_A781_V1.3470.74
344_R371_L1.3460.74
83_Q116_A1.3440.74
430_M481_F1.3440.74
57_V60_V1.3420.74
77_V80_L1.3410.74
211_R243_E1.3340.73
147_L342_L1.3330.73
323_A359_R1.3320.73
51_Q195_K1.3290.73
26_K183_P1.3240.73
176_D182_L1.3230.73
681_V706_E1.3190.73
283_A309_A1.3170.72
71_M74_G1.3080.72
84_A87_G1.3060.72
781_V785_L1.3060.72
763_S802_D1.3020.72
123_K145_Q1.2980.71
114_S123_K1.2960.71
811_Q878_T1.2920.71
866_F876_R1.2900.71
682_L707_I1.2870.71
97_A803_A1.2800.70
46_Q74_G1.2760.70
84_A827_Q1.2740.70
157_V336_N1.2710.70
59_V107_L1.2680.69
556_G860_G1.2670.69
429_V459_F1.2640.69
26_K139_F1.2610.69
65_R194_G1.2580.69
45_A107_L1.2560.69
145_Q205_A1.2500.68
82_R89_H1.2480.68
793_A797_A1.2480.68
257_I306_L1.2450.68
494_L797_A1.2400.68
844_G847_L1.2390.68
111_L140_T1.2380.68
807_G814_V1.2340.67
164_E205_A1.2330.67
66_K69_A1.2320.67
518_M817_N1.2300.67
21_H24_K1.2290.67
440_A448_S1.2260.67
251_D261_T1.2190.66
146_H205_A1.2190.66
460_D472_V1.2160.66
86_R90_I1.2140.66
106_I131_L1.2140.66
498_V502_A1.2130.66
254_L337_L1.2130.66
673_H677_T1.2110.66
404_V443_Y1.2110.66
267_V305_A1.2090.66
861_G879_L1.2030.65
208_H451_A1.1970.65
641_A680_T1.1970.65
83_Q119_S1.1960.65
246_V336_N1.1960.65
269_A372_V1.1940.65
676_R726_R1.1930.65
432_Y455_N1.1930.65
78_L106_I1.1920.65
524_V711_V1.1890.64
352_R362_R1.1830.64
92_E116_A1.1780.64
57_V319_L1.1780.64
143_N164_E1.1770.64
707_I711_V1.1770.64
113_H116_A1.1740.63
472_V477_Y1.1680.63
59_V62_T1.1670.63
273_L512_T1.1630.63
71_M688_I1.1630.63
670_A845_V1.1620.63
194_G205_A1.1620.63
271_A670_A1.1600.62
59_V373_A1.1550.62
263_S305_A1.1550.62
27_V320_S1.1530.62
56_V78_L1.1430.61
404_V442_F1.1410.61
105_L137_D1.1360.61
29_F171_F1.1320.60
341_I372_V1.1310.60
602_L610_G1.1290.60
123_K208_H1.1210.60
690_T705_S1.1170.59
140_T812_L1.1160.59
456_V480_T1.1130.59
102_R741_L1.1100.59
324_E356_F1.1090.59
256_C852_C1.1080.59
128_I767_P1.1080.59
192_K549_V1.1040.59
51_Q193_E1.1020.58
611_L614_V1.1020.58
49_R54_D1.0970.58
751_M780_R1.0960.58
233_Q724_M1.0960.58
672_S724_M1.0950.58
318_T410_A1.0950.58
556_G563_H1.0920.58
253_I281_W1.0880.57
778_F856_V1.0870.57
449_V743_E1.0870.57
84_A89_H1.0850.57
39_W71_M1.0850.57
765_P768_L1.0840.57
582_G603_K1.0830.57
427_N459_F1.0810.57
787_E851_I1.0810.57
254_L470_L1.0810.57
269_A368_D1.0800.57
140_T144_V1.0800.57
327_A330_R1.0770.57
194_G197_Y1.0730.56
197_Y210_F1.0660.56
284_V468_G1.0640.56
752_L811_Q1.0630.56
332_A340_I1.0590.55
27_V140_T1.0550.55
283_A305_A1.0520.55
434_L490_V1.0490.55
85_Y110_E1.0490.55
30_G35_V1.0470.54
28_F195_K1.0470.54
611_L615_E1.0450.54
644_R724_M1.0400.54
793_A817_N1.0400.54
672_S722_L1.0370.54
288_T295_P1.0370.54
738_W772_H1.0360.54
72_L83_Q1.0330.53
28_F44_E1.0290.53
284_V808_E1.0280.53
59_V64_G1.0280.53
173_A865_A1.0270.53
282_H337_L1.0260.53
401_G443_Y1.0260.53
452_T492_G1.0250.53
145_Q197_Y1.0230.53
76_A254_L1.0230.53
341_I786_L1.0210.53
100_A106_I1.0190.52
196_V267_V1.0120.52
781_V787_E1.0110.52
67_D71_M1.0080.52
429_V437_V1.0060.51
257_I853_R1.0040.51
29_F339_K1.0030.51
213_G247_W1.0030.51
585_A792_Y1.0020.51
43_A71_M1.0010.51
784_N788_N0.9980.51
668_L674_D0.9970.51
225_R228_D0.9970.51
811_Q876_R0.9960.51
314_A484_M0.9950.51
27_V142_V0.9940.51
423_F476_Q0.9920.50
751_M779_E0.9910.50
121_H126_Q0.9900.50
805_V881_Q0.9900.50
863_I875_F0.9880.50
150_L674_D0.9860.50
70_A73_E0.9860.50
520_K524_V0.9830.50
238_R247_W0.9830.50
237_W835_R0.9790.49
57_V84_A0.9780.49
697_G801_I0.9770.49
65_R205_A0.9760.49
349_R352_R0.9740.49
772_H882_Q0.9730.49
862_T881_Q0.9730.49
802_D815_W0.9720.49
743_E747_S0.9720.49
764_L771_I0.9710.49
400_Q403_V0.9710.49
518_M634_F0.9700.49
690_T696_E0.9690.49
250_R260_N0.9680.49
197_Y202_A0.9670.49
559_Q562_T0.9670.49
22_R25_L0.9640.48
745_V823_P0.9640.48
338_G537_Q0.9610.48
172_D875_F0.9590.48
514_H634_F0.9550.48
238_R245_K0.9550.48
411_V829_I0.9540.48
303_L488_G0.9540.48
182_L221_L0.9520.48
63_H197_Y0.9510.47
558_L562_T0.9500.47
46_Q49_R0.9500.47
182_L195_K0.9490.47
464_I477_Y0.9440.47
700_H703_Q0.9430.47
413_T463_F0.9430.47
562_T566_G0.9420.47
68_T146_H0.9420.47
502_A505_A0.9370.46
338_G370_V0.9370.46
793_A821_L0.9360.46
123_K164_E0.9360.46
704_A707_I0.9360.46
61_E151_N0.9350.46
366_D549_V0.9350.46
698_S775_G0.9340.46
85_Y201_Q0.9340.46
339_K368_D0.9330.46
186_D656_M0.9320.46
556_G562_T0.9310.46
538_F542_T0.9300.46
65_R68_T0.9290.46
63_H143_N0.9270.46
761_N800_G0.9260.46
481_F484_M0.9250.46
821_L873_A0.9240.45
61_E197_Y0.9220.45
133_E266_L0.9220.45
756_L790_V0.9200.45
745_V766_E0.9190.45
615_E618_N0.9190.45
288_T627_Q0.9160.45
530_D537_Q0.9160.45
438_V821_L0.9150.45
725_A780_R0.9140.45
95_L185_D0.9140.45
609_Y613_V0.9110.45
197_Y214_N0.9100.44
30_G34_G0.9080.44
20_P236_A0.9080.44
31_A62_T0.9030.44
407_A414_L0.9030.44
140_T712_L0.9000.44
46_Q419_W0.9000.44
114_S143_N0.8980.44
134_A676_R0.8970.44
599_I613_V0.8970.44
226_T508_R0.8960.43
868_R874_C0.8960.43
229_R283_A0.8950.43
201_Q456_V0.8950.43
411_V415_I0.8950.43
648_T853_R0.8950.43
97_A462_F0.8920.43
163_R375_D0.8900.43
50_A142_V0.8900.43
815_W868_R0.8880.43
429_V476_Q0.8880.43
56_V176_D0.8870.43
833_F847_L0.8840.43
612_V635_T0.8820.42
58_G133_E0.8810.42
27_V638_V0.8800.42
191_L469_T0.8800.42
328_V631_L0.8800.42
266_L342_L0.8770.42
23_G30_G0.8770.42
316_T552_P0.8770.42
778_F859_H0.8770.42
684_G780_R0.8720.42
683_F708_R0.8710.42
156_G365_P0.8710.42
54_D104_A0.8700.42
248_H338_G0.8700.42
252_A280_V0.8680.41
612_V616_P0.8680.41
457_V482_A0.8660.41
690_T701_A0.8650.41
234_M237_W0.8640.41
478_L803_A0.8640.41
518_M787_E0.8630.41
228_D368_D0.8630.41
157_V247_W0.8610.41
696_E700_H0.8610.41
558_L563_H0.8610.41
788_N846_G0.8590.41
78_L170_F0.8590.41
751_M851_I0.8570.41
209_F589_T0.8570.41
32_C60_V0.8560.41
61_E68_T0.8560.41
559_Q563_H0.8560.41
478_L786_L0.8550.41
283_A469_T0.8550.41
586_G589_T0.8520.40
302_I510_Q0.8520.40
490_V641_A0.8520.40
359_R363_I0.8520.40
262_G374_L0.8520.40
147_L523_A0.8510.40
826_E865_A0.8510.40
739_L773_V0.8500.40
429_V484_M0.8490.40
157_V243_E0.8490.40
607_K821_L0.8480.40
557_K560_P0.8470.40
147_L457_V0.8460.40
134_A726_R0.8460.40
728_Q832_K0.8450.40
316_T494_L0.8440.40
89_H380_R0.8400.40
751_M783_I0.8400.40
24_K807_G0.8370.39
821_L824_G0.8360.39
44_E47_R0.8350.39
401_G429_V0.8340.39
271_A314_A0.8310.39
741_L810_L0.8300.39
252_A538_F0.8290.39
836_G873_A0.8280.39
478_L633_T0.8270.39
637_L640_N0.8270.39
782_L821_L0.8260.39
629_R633_T0.8260.39
252_A282_H0.8260.39
238_R249_T0.8250.38
221_L574_I0.8240.38
166_V711_V0.8220.38
550_L857_D0.8200.38
189_Q195_K0.8190.38
171_F177_V0.8190.38
640_N821_L0.8180.38
804_H813_D0.8140.38
95_L130_E0.8140.38
59_V80_L0.8130.38
666_A723_D0.8130.38
344_R492_G0.8110.38
486_T551_L0.8100.37
112_A141_T0.8100.37
554_D558_L0.8090.37
75_L147_L0.8090.37
90_I209_F0.8070.37
685_Q688_I0.8060.37
783_I852_C0.8060.37
510_Q732_F0.8050.37
515_L532_A0.8050.37
228_D670_A0.8040.37
243_E367_L0.8040.37
710_H725_A0.8040.37
99_L108_M0.8030.37
321_D367_L0.8020.37
411_V827_Q0.7970.37
410_A414_L0.7970.37
273_L276_R0.7960.36
98_A131_L0.7960.36
598_Q628_Q0.7960.36
840_S851_I0.7950.36
472_V478_L0.7950.36
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445_R713_N0.5360.21
35_V65_R0.5360.21
151_N469_T0.5360.21
122_P423_F0.5360.21
85_Y164_E0.5360.21
128_I768_L0.5350.21
56_V59_V0.5350.21
137_D742_E0.5350.21
253_I264_E0.5340.21
126_Q209_F0.5340.21
191_L202_A0.5340.21
801_I805_V0.5340.21
656_M859_H0.5340.21
303_L356_F0.5340.21
682_L751_M0.5330.21
606_E609_Y0.5330.21
377_P482_A0.5330.21
319_L327_A0.5330.21
666_A826_E0.5320.21
24_K737_E0.5310.21
440_A453_V0.5310.21
412_I416_A0.5310.21
830_F872_G0.5300.21
40_A859_H0.5300.21
469_T472_V0.5300.21
372_V814_V0.5300.21
27_V417_M0.5300.21
35_V194_G0.5300.21
130_E738_W0.5300.21
851_I865_A0.5290.21
666_A713_N0.5290.21
186_D734_L0.5290.21
513_R517_E0.5280.21
234_M252_A0.5270.21
399_I520_K0.5260.21
415_I881_Q0.5250.21
200_G203_E0.5250.21
484_M680_T0.5240.21
698_S828_T0.5240.21
273_L353_R0.5240.21
286_V343_G0.5240.21
241_P283_A0.5240.21
771_I882_Q0.5230.21
72_L173_A0.5230.21
454_I464_I0.5230.21
577_W586_G0.5230.21
206_I458_S0.5230.21
724_M851_I0.5230.21
82_R142_V0.5220.21
453_V485_L0.5220.21
68_T143_N0.5220.21
470_L697_G0.5220.21
499_R832_K0.5210.20
199_A203_E0.5210.20
105_L491_I0.5210.20
321_D431_L0.5210.20
170_F175_D0.5200.20
110_E162_V0.5200.20
335_H356_F0.5200.20
147_L188_R0.5200.20
347_S356_F0.5200.20
314_A534_T0.5190.20
243_E280_V0.5190.20
90_I197_Y0.5190.20
183_P441_L0.5180.20
162_V197_Y0.5180.20
516_Y776_P0.5180.20
157_V166_V0.5180.20
110_E123_K0.5170.20
354_E362_R0.5170.20
805_V808_E0.5170.20
196_V356_F0.5170.20
677_T680_T0.5160.20
175_D264_E0.5160.20
238_R243_E0.5150.20
579_F582_G0.5150.20
314_A436_V0.5140.20
723_D726_R0.5130.20
152_D721_L0.5130.20
26_K212_K0.5130.20
288_T329_V0.5120.20
271_A275_S0.5120.20
432_Y538_F0.5120.20
480_T669_A0.5120.20
33_A80_L0.5110.20
28_F630_L0.5110.20
599_I602_L0.5110.20
63_H194_G0.5100.20
348_R361_A0.5090.20
57_V690_T0.5080.20
99_L617_G0.5080.20
258_G343_G0.5080.20
558_L561_L0.5070.20
656_M661_E0.5060.20
69_A199_A0.5060.20
736_K772_H0.5060.20
447_P776_P0.5060.20
285_Y635_T0.5050.20
323_A856_V0.5050.20
150_L664_R0.5050.20
461_L502_A0.5050.20
234_M538_F0.5050.20
144_V480_T0.5050.20
147_L319_L0.5040.20
673_H784_N0.5030.20
267_V300_R0.5030.20
285_Y302_I0.5020.20
164_E194_G0.5020.20
640_N663_I0.5020.20
63_H210_F0.5020.20
415_I560_P0.5020.20
685_Q862_T0.5020.20
250_R370_V0.5020.20
99_L489_L0.5020.20
348_R351_W0.5020.20
77_V199_A0.5010.20
48_L199_A0.5010.20
309_A316_T0.5010.20
81_K99_L0.5010.20
226_T659_E0.5010.20
252_A337_L0.5010.20
539_I681_V0.5010.20
488_G510_Q0.5000.20
220_E272_R0.5000.20
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.4206 100 0.859 Contact Map
4gczA 2 0.3993 100 0.87 Contact Map
3jz3A 2 0.1779 100 0.87 Contact Map
4q20A 2 0.255 100 0.871 Contact Map
2c2aA 2 0.2595 100 0.872 Contact Map
3a0rA 2 0.3647 100 0.872 Contact Map
4mpcA 2 0.3367 100 0.873 Contact Map
3d36A 2 0.2461 100 0.874 Contact Map
4e01A 3 0.3143 100 0.875 Contact Map
4ctiA 2 0.255 100 0.877 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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