GREMLIN Database
YBHA - Pyridoxal phosphate phosphatase YbhA
UniProt: P21829 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11239
Length: 272 (254)
Sequences: 10809 (8874)
Seq/√Len: 556.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
256_G265_Q4.2151.00
17_P259_T3.5861.00
220_A234_A3.1231.00
257_D260_T2.8511.00
231_L237_G2.8291.00
4_R217_N2.8131.00
22_L261_D2.7561.00
24_S261_D2.5601.00
208_V218_V2.5391.00
245_D249_A2.4581.00
24_S268_Y2.4211.00
232_E250_R2.4131.00
16_T20_T2.3971.00
205_T233_A2.3911.00
8_L39_L2.3761.00
43_T50_I2.2741.00
215_M233_A2.0841.00
199_S229_S2.0311.00
81_E206_K1.9231.00
31_R34_E1.8991.00
225_F246_A1.8981.00
228_I247_V1.8931.00
237_G252_N1.8821.00
23_P27_E1.8611.00
225_F244_D1.8361.00
239_A251_A1.8291.00
29_L39_L1.8131.00
228_I250_R1.8041.00
32_A37_Y1.7631.00
86_P89_K1.7581.00
256_G260_T1.7501.00
31_R268_Y1.7421.00
5_V40_I1.7371.00
26_I56_A1.7131.00
245_D248_K1.7121.00
214_S217_N1.6991.00
3_T219_V1.6931.00
236_T253_I1.6671.00
7_A204_L1.6541.00
206_K210_A1.6501.00
205_T209_E1.6451.00
253_I270_H1.6451.00
31_R35_A1.6221.00
206_K209_E1.6071.00
238_V266_F1.5881.00
202_K205_T1.5851.00
236_T252_N1.5721.00
83_D206_K1.5491.00
201_G233_A1.5421.00
204_L230_M1.5341.00
22_L25_S1.5281.00
73_D76_A1.5241.00
247_V250_R1.5221.00
38_Q211_Q1.5191.00
10_L15_L1.5011.00
253_I266_F1.4951.00
3_T37_Y1.4871.00
8_L221_F1.4831.00
216_E235_G1.4621.00
97_L160_L1.4561.00
98_N115_E1.4511.00
27_E31_R1.4501.00
220_A230_M1.4471.00
24_S265_Q1.4411.00
221_F263_I1.4351.00
25_S261_D1.4341.00
26_I30_A1.4071.00
144_S147_E1.3841.00
33_R60_D1.3801.00
172_G176_E1.3721.00
3_T236_T1.3401.00
3_T217_N1.3291.00
221_F266_F1.3141.00
28_A264_A1.3121.00
239_A243_A1.2991.00
7_A42_V1.2931.00
228_I232_E1.2861.00
167_Q170_H1.2741.00
89_K92_Q1.2741.00
241_G257_D1.2741.00
82_A154_A1.2571.00
231_L247_V1.2551.00
215_M218_V1.2521.00
83_D195_R1.2491.00
79_V82_A1.2421.00
248_K254_V1.2411.00
96_M100_H1.2401.00
100_H174_H1.2381.00
182_E229_S1.2381.00
253_I269_S1.2351.00
82_A156_W1.2251.00
28_A268_Y1.2251.00
208_V215_M1.2211.00
87_V91_L1.1951.00
30_A34_E1.1941.00
246_A249_A1.1901.00
266_F270_H1.1701.00
92_Q178_E1.1651.00
6_I267_I1.1631.00
40_I207_W1.1581.00
5_V213_W1.1471.00
64_I203_R1.1471.00
24_S28_A1.1461.00
6_I32_A1.1351.00
218_V234_A1.1291.00
73_D77_K1.1281.00
220_A231_L1.1211.00
263_I267_I1.1151.00
16_T259_T1.1141.00
264_A268_Y1.1021.00
219_V270_H1.0881.00
5_V208_V1.0851.00
70_Y79_V1.0831.00
71_L206_K1.0821.00
242_N258_N1.0771.00
6_I37_Y1.0681.00
244_D247_V1.0671.00
62_P211_Q1.0491.00
89_K181_L1.0471.00
169_Q173_K1.0471.00
182_E197_G1.0451.00
30_A33_R1.0421.00
255_I266_F1.0381.00
17_P258_N1.0351.00
157_K192_D1.0331.00
23_P26_I1.0331.00
215_M235_G1.0281.00
199_S202_K1.0251.00
224_N244_D1.0211.00
142_V145_L1.0201.00
96_M99_E1.0141.00
240_M262_S1.0101.00
7_A218_V1.0101.00
71_L81_E1.0071.00
208_V233_A1.0071.00
10_L53_F1.0071.00
238_V253_I1.0061.00
204_L234_A1.0001.00
238_V255_I0.9981.00
30_A58_A0.9961.00
184_E194_A0.9901.00
14_L25_S0.9901.00
255_I262_S0.9901.00
266_F269_S0.9871.00
234_A237_G0.9841.00
219_V236_T0.9761.00
91_L95_E0.9631.00
84_P154_A0.9621.00
169_Q185_W0.9611.00
95_E99_E0.9571.00
219_V266_F0.9551.00
82_A109_D0.9521.00
265_Q269_S0.9481.00
69_T198_N0.9481.00
241_G248_K0.9471.00
5_V218_V0.9441.00
201_G229_S0.9421.00
219_V238_V0.9401.00
47_H65_C0.9401.00
170_H173_K0.9401.00
208_V213_W0.9391.00
207_W211_Q0.9381.00
162_H167_Q0.9301.00
83_D197_G0.9281.00
225_F228_I0.9271.00
195_R198_N0.9261.00
14_L29_L0.9241.00
8_L263_I0.9211.00
256_G262_S0.9181.00
243_A248_K0.9101.00
239_A247_V0.9081.00
205_T215_M0.9051.00
246_A250_R0.9001.00
265_Q268_Y0.8931.00
173_K176_E0.8931.00
162_H168_L0.8911.00
143_A146_A0.8881.00
241_G256_G0.8881.00
27_E30_A0.8751.00
71_L203_R0.8751.00
25_S264_A0.8741.00
174_H178_E0.8711.00
170_H174_H0.8671.00
194_A199_S0.8661.00
240_M255_I0.8621.00
140_T143_A0.8601.00
95_E146_A0.8581.00
85_M195_R0.8571.00
172_G185_W0.8531.00
65_C70_Y0.8511.00
119_G123_R0.8461.00
235_G252_N0.8441.00
143_A147_E0.8431.00
64_I207_W0.8421.00
169_Q172_G0.8401.00
119_G122_I0.8371.00
51_H55_Q0.8341.00
72_Y79_V0.8341.00
92_Q95_E0.8331.00
43_T65_C0.8331.00
32_A39_L0.8321.00
65_C72_Y0.8241.00
42_V64_I0.8231.00
47_H72_Y0.8221.00
218_V235_G0.8201.00
208_V235_G0.8181.00
80_L210_A0.8171.00
92_Q96_M0.8171.00
88_I92_Q0.8141.00
84_P156_W0.8141.00
25_S28_A0.8051.00
218_V233_A0.8041.00
7_A40_I0.8041.00
256_G269_S0.8001.00
231_L250_R0.7981.00
183_C193_I0.7981.00
96_M174_H0.7961.00
165_L169_Q0.7941.00
28_A31_R0.7871.00
241_G260_T0.7851.00
32_A267_I0.7851.00
16_T22_L0.7771.00
6_I219_V0.7761.00
8_L14_L0.7751.00
46_H66_C0.7721.00
99_E174_H0.7621.00
37_Y219_V0.7561.00
10_L41_I0.7541.00
94_I98_N0.7501.00
220_A237_G0.7491.00
24_S264_A0.7481.00
14_L21_L0.7471.00
231_L251_A0.7451.00
174_H177_H0.7381.00
202_K206_K0.7341.00
100_H170_H0.7251.00
96_M178_E0.7241.00
240_M243_A0.7231.00
204_L220_A0.7111.00
205_T208_V0.7061.00
217_N235_G0.7041.00
33_R61_T0.6981.00
50_I65_C0.6981.00
18_K259_T0.6971.00
111_A140_T0.6971.00
62_P207_W0.6931.00
16_T258_N0.6921.00
159_A192_D0.6901.00
67_N192_D0.6831.00
42_V230_M0.6821.00
182_E196_G0.6801.00
223_D243_A0.6771.00
198_N202_K0.6751.00
98_N104_G0.6741.00
91_L146_A0.6741.00
87_V154_A0.6721.00
221_F238_V0.6641.00
96_M179_L0.6641.00
229_S232_E0.6631.00
146_A149_A0.6621.00
243_A247_V0.6601.00
253_I265_Q0.6601.00
70_Y156_W0.6581.00
237_G247_V0.6571.00
253_I256_G0.6571.00
236_T266_F0.6561.00
14_L258_N0.6531.00
168_L172_G0.6461.00
24_S27_E0.6461.00
54_Y63_A0.6461.00
109_D154_A0.6451.00
41_I50_I0.6441.00
69_T195_R0.6431.00
182_E199_S0.6421.00
12_G240_M0.6401.00
120_H124_T0.6401.00
221_F255_I0.6391.00
165_L188_H0.6361.00
150_Q153_N0.6341.00
40_I62_P0.6331.00
47_H51_H0.6311.00
101_H167_Q0.6301.00
40_I61_T0.6291.00
60_D75_H0.6291.00
50_I63_A0.6281.00
223_D240_M0.6271.00
88_I91_L0.6251.00
173_K177_H0.6251.00
141_Q144_S0.6231.00
10_L50_I0.6201.00
237_G251_A0.6191.00
261_D264_A0.6161.00
139_F143_A0.6151.00
176_E180_G0.6141.00
228_I231_L0.6141.00
22_L264_A0.6121.00
142_V148_T0.6121.00
176_E183_C0.6121.00
94_I106_M0.6101.00
5_V207_W0.6081.00
90_A155_V0.6071.00
108_V153_N0.6071.00
225_F247_V0.6041.00
21_L26_I0.6011.00
183_C191_V0.5981.00
163_D166_P0.5951.00
261_D265_Q0.5951.00
121_V125_S0.5951.00
201_G205_T0.5921.00
242_N257_D0.5911.00
28_A32_A0.5911.00
240_M258_N0.5901.00
242_N248_K0.5891.00
255_I265_Q0.5891.00
10_L14_L0.5891.00
41_I54_Y0.5841.00
182_E194_A0.5791.00
146_A150_Q0.5760.99
197_G202_K0.5750.99
6_I221_F0.5720.99
143_A148_T0.5720.99
91_L150_Q0.5710.99
108_V155_V0.5690.99
157_K186_S0.5670.99
247_V251_A0.5650.99
122_I125_S0.5640.99
17_P257_D0.5630.99
25_S29_L0.5620.99
71_L207_W0.5610.99
52_P55_Q0.5610.99
187_W224_N0.5550.99
147_E150_Q0.5550.99
213_W218_V0.5540.99
74_Y77_K0.5530.99
38_Q62_P0.5520.99
37_Y217_N0.5510.99
29_L267_I0.5490.99
264_A267_I0.5480.99
165_L185_W0.5480.99
15_L258_N0.5470.99
120_H123_R0.5460.99
90_A94_I0.5460.99
92_Q179_L0.5450.99
66_C156_W0.5450.99
70_Y109_D0.5430.99
122_I126_N0.5390.99
138_T141_Q0.5380.99
71_L210_A0.5360.99
32_A264_A0.5350.99
143_A149_A0.5350.99
51_H54_Y0.5330.99
221_F267_I0.5310.99
159_A190_Q0.5310.99
239_A250_R0.5300.99
145_L148_T0.5290.99
63_A74_Y0.5280.99
5_V38_Q0.5270.99
106_M155_V0.5270.99
160_L193_I0.5270.99
256_G266_F0.5270.99
105_L159_A0.5260.99
33_R58_A0.5250.99
102_I160_L0.5210.99
50_I53_F0.5210.99
117_P122_I0.5200.99
166_P170_H0.5190.99
14_L41_I0.5180.99
52_P56_A0.5150.99
66_C69_T0.5150.99
109_D156_W0.5130.99
96_M175_V0.5120.99
213_W235_G0.5120.99
102_I171_F0.5080.99
3_T38_Q0.5080.99
4_R37_Y0.5050.99
244_D248_K0.5040.99
29_L33_R0.5030.99
16_T261_D0.5020.99
168_L185_W0.5010.99
213_W217_N0.5010.99
98_N146_A0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pgvA 3 0.9375 100 0.206 Contact Map
1nrwA 1 0.9853 100 0.209 Contact Map
2b30A 2 0.9632 100 0.232 Contact Map
1rkqA 1 0.9669 100 0.238 Contact Map
3l7yA 1 0.9522 100 0.242 Contact Map
4qjbA 1 0.9559 100 0.243 Contact Map
1nf2A 4 0.9559 100 0.247 Contact Map
4dw8A 1 0.9596 100 0.252 Contact Map
2pq0A 1 0.9412 100 0.256 Contact Map
3daoA 1 0.9559 100 0.259 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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