GREMLIN Database
DBPA - ATP-dependent RNA helicase DbpA
UniProt: P21693 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10210
Length: 457 (363)
Sequences: 35691 (19530)
Seq/√Len: 1025.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
58_G91_L4.5151.00
61_L74_A3.9411.00
37_I181_L3.6041.00
269_L292_A3.2001.00
78_C87_V3.1781.00
286_R291_S3.0291.00
251_K274_D2.7591.00
29_V45_V2.7391.00
282_Q286_R2.7041.00
285_V289_N2.6941.00
128_A133_L2.6721.00
248_C254_C2.6491.00
258_C268_A2.5751.00
20_E97_F2.5301.00
41_K203_L2.5101.00
88_A92_R2.4751.00
233_Q264_V2.4441.00
269_L286_R2.4201.00
255_Q270_S2.3111.00
267_S293_R2.2951.00
88_A103_I2.2341.00
248_C257_V2.2301.00
258_C262_N2.2211.00
312_L342_I2.2051.00
329_I341_A2.1711.00
258_C270_S2.1651.00
248_C296_V2.1151.00
136_H141_T2.0681.00
266_Q294_V2.0381.00
73_Q148_N2.0381.00
281_D285_V2.0171.00
218_Q329_I1.9841.00
104_L123_P1.9711.00
217_E340_L1.9501.00
231_L234_R1.9451.00
253_D317_E1.9261.00
90_E93_R1.9061.00
88_A105_T1.9021.00
244_C312_L1.8951.00
229_I260_A1.8941.00
261_L296_V1.8891.00
269_L283_T1.8531.00
64_Q149_T1.8221.00
254_C272_H1.8141.00
318_L343_S1.8141.00
315_N343_S1.8071.00
57_F183_F1.7801.00
164_S168_D1.7791.00
254_C270_S1.7781.00
57_F151_V1.7691.00
23_Y55_A1.7561.00
242_S311_E1.7181.00
164_S167_I1.7161.00
297_A301_A1.7141.00
260_A264_V1.7101.00
218_Q325_H1.6971.00
219_Q340_L1.6951.00
168_D197_R1.6741.00
166_A169_D1.6701.00
301_A305_L1.6481.00
37_I43_V1.6381.00
71_Q146_A1.6321.00
85_D281_D1.6241.00
74_A149_T1.6221.00
91_L125_I1.6181.00
155_A182_L1.6121.00
309_S337_N1.6061.00
73_Q124_H1.5941.00
192_A204_A1.5901.00
45_V183_F1.5751.00
38_L63_Q1.5701.00
315_N329_I1.5671.00
194_I198_V1.5621.00
244_C314_V1.5411.00
276_E279_D1.5411.00
61_L151_V1.5371.00
21_L93_R1.5351.00
235_L342_I1.5321.00
156_D303_R1.5241.00
102_K124_H1.5151.00
20_E96_R1.5131.00
213_L216_I1.5101.00
157_R160_D1.5031.00
111_P114_M1.4981.00
91_L103_I1.4861.00
134_L169_D1.4811.00
77_L133_L1.4741.00
36_A203_L1.4711.00
244_C294_V1.4661.00
37_I60_G1.4571.00
312_L340_L1.4501.00
188_P191_I1.4491.00
319_A325_H1.4491.00
243_S309_S1.4471.00
253_D256_A1.4151.00
48_K51_S1.4101.00
61_L149_T1.4051.00
237_S264_V1.3831.00
36_A39_A1.3821.00
113_G117_D1.3781.00
250_T253_D1.3751.00
258_C296_V1.3741.00
165_D169_D1.3721.00
78_C84_A1.3711.00
232_L314_V1.3661.00
75_L147_L1.3641.00
232_L316_F1.3631.00
18_L23_Y1.3621.00
283_T292_A1.3541.00
257_V296_V1.3471.00
275_L283_T1.3371.00
233_Q237_S1.3361.00
257_V316_F1.3341.00
192_A196_G1.3251.00
150_L180_T1.3251.00
33_A56_A1.3101.00
286_R292_A1.3071.00
64_Q148_N1.3041.00
315_N328_R1.3001.00
262_N268_A1.2991.00
83_L304_G1.2961.00
89_G93_R1.2941.00
138_Q169_D1.2881.00
85_D89_G1.2841.00
77_L128_A1.2711.00
199_Q202_P1.2671.00
123_P126_I1.2661.00
321_D324_V1.2641.00
137_L173_F1.2631.00
84_A105_T1.2611.00
241_P244_C1.2611.00
229_I264_V1.2461.00
171_I174_A1.2441.00
246_V294_V1.2431.00
35_P39_A1.2411.00
163_F167_I1.2361.00
88_A127_V1.2331.00
165_D168_D1.2301.00
169_D172_R1.2251.00
354_N357_S1.2081.00
279_D283_T1.2071.00
91_L127_V1.2021.00
57_F87_V1.1931.00
104_L126_I1.1751.00
255_Q272_H1.1651.00
36_A43_V1.1641.00
254_C258_C1.1641.00
350_A354_N1.1621.00
189_E193_A1.1621.00
190_A193_A1.1611.00
235_L314_V1.1611.00
228_K317_E1.1571.00
313_V332_T1.1471.00
31_A35_P1.1451.00
169_D173_F1.1331.00
89_G92_R1.1261.00
104_L118_S1.1181.00
237_S266_Q1.1151.00
229_I316_F1.1141.00
233_Q260_A1.1101.00
150_L171_I1.1051.00
34_L38_L1.1051.00
235_L238_L1.1031.00
234_R238_L1.1021.00
28_P32_A1.0921.00
353_A357_S1.0911.00
271_L300_V1.0851.00
355_I359_M1.0831.00
225_S253_D1.0811.00
243_S290_G1.0771.00
271_L301_A1.0711.00
65_I74_A1.0641.00
46_Q206_E1.0591.00
116_R141_T1.0571.00
275_L279_D1.0501.00
215_P338_S1.0471.00
62_L95_A1.0471.00
254_C296_V1.0441.00
357_S360_L1.0391.00
54_T87_V1.0361.00
357_S363_K1.0361.00
47_A51_S1.0351.00
224_S227_G1.0241.00
64_Q179_Q1.0211.00
219_Q222_E1.0161.00
40_G179_Q1.0141.00
185_A330_G1.0031.00
231_L344_F1.0031.00
227_G230_P0.9991.00
216_I333_A0.9971.00
42_D200_R0.9971.00
368_T371_A0.9931.00
221_Y231_L0.9921.00
167_I170_V0.9821.00
134_L166_A0.9821.00
279_D282_Q0.9801.00
352_R355_I0.9781.00
287_F295_L0.9671.00
229_I233_Q0.9671.00
112_F139_K0.9651.00
90_E306_D0.9641.00
135_D139_K0.9581.00
282_Q285_V0.9511.00
231_L235_L0.9471.00
113_G116_R0.9361.00
19_N24_L0.9341.00
83_L86_Q0.9311.00
191_I194_I0.9301.00
339_G343_S0.9301.00
56_A60_G0.9271.00
230_P233_Q0.9261.00
191_I195_S0.9221.00
241_P293_R0.9131.00
45_V181_L0.9111.00
283_T295_L0.9111.00
33_A45_V0.9081.00
110_Q115_Q0.9061.00
40_G64_Q0.9051.00
245_V297_A0.9031.00
357_S361_Q0.8991.00
84_A127_V0.8991.00
41_K201_D0.8921.00
55_A90_E0.8921.00
112_F116_R0.8921.00
156_D327_H0.8891.00
252_K256_A0.8861.00
249_N320_W0.8781.00
193_A196_G0.8781.00
235_L344_F0.8761.00
229_I256_A0.8751.00
259_D262_N0.8741.00
236_L244_C0.8711.00
232_L246_V0.8711.00
65_I101_T0.8691.00
28_P31_A0.8671.00
168_D172_R0.8671.00
285_V288_A0.8641.00
360_L363_K0.8641.00
371_A374_S0.8601.00
356_I360_L0.8571.00
351_Q355_I0.8511.00
128_A142_V0.8511.00
235_L312_L0.8471.00
256_A260_A0.8461.00
34_L59_L0.8431.00
349_E352_R0.8421.00
74_A151_V0.8401.00
284_L307_I0.8381.00
351_Q354_N0.8371.00
255_Q259_D0.8371.00
55_A59_L0.8371.00
193_A197_R0.8331.00
25_T31_A0.8331.00
272_H275_L0.8311.00
107_C110_Q0.8311.00
355_I358_D0.8311.00
44_R187_W0.8211.00
218_Q222_E0.8161.00
230_P264_V0.8151.00
236_L266_Q0.8131.00
382_M386_C0.8121.00
315_N319_A0.8071.00
170_V174_A0.8061.00
247_F328_R0.8061.00
117_D121_H0.8041.00
49_T185_A0.8041.00
260_A263_E0.7991.00
302_A324_V0.7961.00
186_T327_H0.7951.00
66_D69_L0.7951.00
134_L138_Q0.7891.00
72_T148_N0.7891.00
372_N375_I0.7871.00
246_V316_F0.7851.00
359_M362_I0.7801.00
245_V295_L0.7781.00
144_L147_L0.7771.00
310_L332_T0.7771.00
32_A36_A0.7771.00
86_Q306_D0.7731.00
151_V181_L0.7711.00
61_L76_V0.7711.00
382_M385_L0.7711.00
266_Q293_R0.7711.00
259_D263_E0.7711.00
90_E94_L0.7681.00
371_A375_I0.7671.00
192_A195_S0.7661.00
190_A194_I0.7651.00
370_P373_S0.7651.00
287_F310_L0.7641.00
232_L257_V0.7641.00
277_Q281_D0.7621.00
299_D328_R0.7611.00
106_L115_Q0.7551.00
290_G293_R0.7551.00
75_L150_L0.7521.00
114_M118_S0.7511.00
49_T330_G0.7501.00
223_T231_L0.7491.00
220_F345_C0.7491.00
61_L91_L0.7471.00
85_D105_T0.7471.00
383_A386_C0.7461.00
36_A205_I0.7461.00
243_S311_E0.7461.00
167_I171_I0.7451.00
349_E360_L0.7441.00
265_G268_A0.7431.00
216_I341_A0.7371.00
95_A103_I0.7361.00
243_S293_R0.7341.00
18_L55_A0.7321.00
319_A328_R0.7311.00
149_T181_L0.7311.00
81_R109_G0.7301.00
318_L356_I0.7281.00
353_A364_L0.7271.00
116_R120_Q0.7271.00
149_T179_Q0.7241.00
175_P178_R0.7241.00
234_R237_S0.7241.00
74_A125_I0.7241.00
345_C353_A0.7231.00
42_D202_P0.7221.00
212_A218_Q0.7221.00
163_F166_A0.7221.00
364_L369_P0.7211.00
80_T303_R0.7181.00
36_A41_K0.7181.00
168_D174_A0.7161.00
112_F115_Q0.7151.00
42_D199_Q0.7141.00
299_D324_V0.7141.00
303_R327_H0.7141.00
78_C129_T0.7121.00
352_R356_I0.7121.00
346_A349_E0.7121.00
229_I257_V0.7121.00
357_S364_L0.7111.00
332_T339_G0.7101.00
184_S187_W0.7091.00
267_S292_A0.7081.00
92_R103_I0.7031.00
233_Q266_Q0.7031.00
95_A98_L0.7021.00
92_R96_R0.7001.00
356_I364_L0.7001.00
208_D211_D0.6981.00
219_Q342_I0.6981.00
230_P234_R0.6971.00
29_V47_A0.6971.00
103_I106_L0.6961.00
65_I124_H0.6941.00
117_D120_Q0.6931.00
331_R334_R0.6891.00
283_T286_R0.6891.00
76_V91_L0.6891.00
43_V181_L0.6851.00
71_Q124_H0.6851.00
42_D182_L0.6851.00
353_A360_L0.6831.00
364_L368_T0.6821.00
105_T108_G0.6801.00
106_L136_H0.6711.00
18_L22_G0.6711.00
171_I178_R0.6661.00
137_L144_L0.6651.00
246_V314_V0.6641.00
35_P38_L0.6641.00
359_M363_K0.6631.00
252_K255_Q0.6631.00
217_E338_S0.6621.00
40_G43_V0.6611.00
349_E355_I0.6611.00
368_T372_N0.6581.00
57_F60_G0.6581.00
110_Q114_M0.6571.00
157_R303_R0.6571.00
201_D204_A0.6571.00
228_K235_L0.6551.00
251_K272_H0.6551.00
361_Q364_L0.6541.00
225_S346_A0.6531.00
42_D180_T0.6511.00
314_V344_F0.6501.00
284_L287_F0.6451.00
114_M117_D0.6451.00
281_D284_L0.6441.00
367_Q371_A0.6431.00
57_F78_C0.6421.00
59_L62_L0.6421.00
369_P372_N0.6421.00
46_Q187_W0.6411.00
228_K232_L0.6411.00
284_L288_A0.6401.00
325_H329_I0.6401.00
62_L98_L0.6391.00
45_V56_A0.6391.00
278_R282_Q0.6391.00
353_A356_I0.6381.00
245_V310_L0.6371.00
228_K231_L0.6341.00
106_L126_I0.6321.00
215_P333_A0.6311.00
249_N253_D0.6311.00
207_I210_T0.6281.00
212_A215_P0.6281.00
132_R135_D0.6271.00
166_A170_V0.6271.00
202_P206_E0.6271.00
288_A309_S0.6261.00
270_S275_L0.6261.00
370_P374_S0.6261.00
61_L125_I0.6221.00
33_A37_I0.6211.00
352_R360_L0.6191.00
354_N358_D0.6161.00
356_I359_M0.6161.00
363_K368_T0.6131.00
194_I197_R0.6101.00
246_V296_V0.6101.00
204_A207_I0.6091.00
97_F100_N0.6091.00
193_A198_V0.6081.00
115_Q136_H0.6061.00
246_V257_V0.6051.00
116_R136_H0.6051.00
115_Q132_R0.6031.00
364_L367_Q0.6021.00
269_L295_L0.5971.00
242_S312_L0.5971.00
212_A216_I0.5941.00
249_N317_E0.5911.00
91_L95_A0.5901.00
151_V183_F0.5901.00
360_L364_L0.5901.00
363_K367_Q0.5891.00
80_T131_G0.5891.00
232_L236_L0.5891.00
367_Q370_P0.5891.00
18_L59_L0.5881.00
59_L63_Q0.5871.00
100_N103_I0.5871.00
243_S287_F0.5861.00
368_T375_I0.5841.00
87_V127_V0.5841.00
311_E337_N0.5831.00
85_D88_A0.5811.00
75_L174_A0.5801.00
251_K255_Q0.5801.00
340_L343_S0.5801.00
66_D124_H0.5791.00
55_A94_L0.5761.00
128_A132_R0.5751.00
150_L178_R0.5751.00
87_V90_E0.5741.00
26_M59_L0.5731.00
243_S310_L0.5731.00
57_F76_V0.5721.00
253_D316_F0.5721.00
280_R284_L0.5721.00
18_L21_L0.5701.00
290_G309_S0.5671.00
288_A308_K0.5651.00
172_R175_P0.5651.00
75_L128_A0.5641.00
168_D171_I0.5601.00
112_F136_H0.5591.00
255_Q275_L0.5571.00
318_L352_R0.5571.00
89_G288_A0.5561.00
49_T83_L0.5551.00
367_Q374_S0.5531.00
136_H140_G0.5531.00
27_T335_A0.5511.00
189_E192_A0.5511.00
115_Q118_S0.5501.00
165_D170_V0.5501.00
283_T287_F0.5501.00
93_R96_R0.5481.00
108_G111_P0.5461.00
298_T328_R0.5451.00
222_E347_P0.5441.00
138_Q166_A0.5441.00
143_S146_A0.5441.00
302_A328_R0.5421.00
75_L133_L0.5421.00
195_S198_V0.5411.00
358_D361_Q0.5411.00
60_G149_T0.5401.00
44_R195_S0.5401.00
42_D179_Q0.5401.00
350_A353_A0.5371.00
203_L207_I0.5371.00
213_L218_Q0.5361.00
320_W352_R0.5341.00
84_A107_C0.5331.00
155_A187_W0.5311.00
267_S286_R0.5301.00
271_L297_A0.5301.00
273_G300_V0.5301.00
339_G344_F0.5281.00
216_I219_Q0.5281.00
142_V145_D0.5281.00
267_S291_S0.5271.00
47_A56_A0.5261.00
362_I365_N0.5251.00
217_E365_N0.5251.00
72_T147_L0.5251.00
213_L221_Y0.5241.00
277_Q280_R0.5221.00
115_Q119_L0.5211.00
349_E359_M0.5201.00
364_L370_P0.5191.00
215_P218_Q0.5161.00
357_S362_I0.5161.00
194_I199_Q0.5161.00
78_C127_V0.5161.00
130_P152_M0.5141.00
167_I174_A0.5141.00
363_K366_W0.5141.00
101_T124_H0.5131.00
107_C111_P0.5121.00
227_G231_L0.5121.00
262_N269_L0.5111.00
255_Q274_D0.5101.00
86_Q90_E0.5091.00
82_E86_Q0.5091.00
358_D362_I0.5091.00
58_G103_I0.5081.00
315_N325_H0.5071.00
253_D257_V0.5061.00
304_G334_R0.5061.00
66_D70_F0.5051.00
190_A195_S0.5051.00
240_Q293_R0.5041.00
163_F170_V0.5041.00
167_I175_P0.5041.00
315_N341_A0.5031.00
214_P217_E0.5021.00
82_E300_V0.5021.00
83_L330_G0.5011.00
214_P218_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.8184 100 0.274 Contact Map
4nhoA 1 0.8074 100 0.274 Contact Map
4c9bA 1 0.8118 100 0.28 Contact Map
4ljyA 1 0.8468 100 0.281 Contact Map
4ct4B 1 0.8206 100 0.281 Contact Map
4d25A 1 0.8096 100 0.283 Contact Map
1s2mA 1 0.8249 100 0.284 Contact Map
2db3A 1 0.8074 100 0.287 Contact Map
3eiqA 1 0.7702 100 0.287 Contact Map
3fmpB 1 0.4464 100 0.293 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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