GREMLIN Database
LPXD - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase
UniProt: P21645 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10316
Length: 341 (289)
Sequences: 4812 (3312)
Seq/√Len: 194.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_E147_K3.4531.00
151_G169_N3.3781.00
262_G281_D3.3161.00
264_Y282_K2.8921.00
150_A168_Q2.8301.00
15_A23_I2.7621.00
260_K278_E2.7381.00
160_I164_I2.7181.00
37_G57_S2.6821.00
169_N206_R2.6301.00
127_G145_N2.6201.00
139_G157_N2.5691.00
131_G150_A2.4731.00
147_K165_Q2.4331.00
263_R281_D2.4161.00
11_Q22_D2.4011.00
240_N264_Y2.3921.00
132_D150_A2.3851.00
134_V152_S2.3791.00
149_G168_Q2.3361.00
215_I218_G2.1771.00
41_F63_Q2.1221.00
231_I235_C2.0991.00
134_V168_Q2.0941.00
281_D298_P2.0801.00
205_D222_D2.0791.00
112_L116_V2.0711.00
201_V215_I2.0711.00
278_E294_P2.0191.00
225_I231_I1.9951.00
113_G132_D1.9741.00
267_I273_I1.9491.00
280_C298_P1.9251.00
227_N245_D1.8581.00
133_N151_G1.8561.00
15_A74_L1.8431.00
125_E144_K1.8371.00
128_V142_V1.8191.00
288_M305_I1.7521.00
222_D239_H1.6991.00
115_N133_N1.6831.00
172_I176_T1.6741.00
204_G227_N1.6541.00
121_N139_G1.6521.00
245_D263_R1.6481.00
152_S170_C1.6101.00
274_N277_M1.5961.00
27_G38_H1.5711.00
111_K129_E1.5621.00
246_N264_Y1.5371.00
209_I215_I1.5271.00
175_G212_C1.5251.00
142_V146_S1.5231.00
37_G63_Q1.5071.00
203_I207_V1.5051.00
223_T263_R1.5031.00
113_G116_V1.4971.00
166_I170_C1.4891.00
242_V260_K1.4881.00
162_H180_A1.4881.00
226_G245_D1.4761.00
262_G278_E1.4701.00
137_G153_R1.4531.00
156_A174_S1.4511.00
185_Y205_D1.4491.00
76_V82_T1.4461.00
110_A113_G1.4421.00
202_I219_A1.4381.00
220_L225_I1.4301.00
200_R217_R1.4231.00
152_S168_Q1.4171.00
239_H263_R1.4121.00
122_A136_I1.4041.00
200_R222_D1.4031.00
225_I229_V1.3751.00
296_T300_V1.3741.00
134_V150_A1.3741.00
271_S285_V1.3671.00
77_K86_M1.3631.00
111_K114_N1.3601.00
204_G222_D1.3551.00
128_V146_S1.3521.00
282_K299_G1.3501.00
280_C283_V1.3471.00
19_G22_D1.3451.00
285_V291_V1.3411.00
250_A272_V1.3301.00
131_G149_G1.2961.00
167_G185_Y1.2881.00
125_E128_V1.2831.00
87_A196_P1.2821.00
143_G161_Y1.2761.00
272_V290_M1.2711.00
286_T303_S1.2681.00
140_C154_L1.2671.00
280_C294_P1.2631.00
131_G168_Q1.2581.00
295_I302_S1.2501.00
153_R171_L1.2471.00
157_N175_G1.2431.00
279_I283_V1.2221.00
176_T213_T1.2201.00
266_M284_T1.2131.00
109_T127_G1.2071.00
212_C234_Q1.1951.00
270_A288_M1.1931.00
130_L134_V1.1811.00
237_I243_I1.1761.00
236_Q260_K1.1721.00
166_I172_I1.1641.00
214_T234_Q1.1621.00
160_I166_I1.1581.00
280_C296_T1.1571.00
117_S120_A1.1551.00
305_I308_Q1.1531.00
34_A65_D1.1501.00
136_I140_C1.1431.00
226_G242_V1.1361.00
114_N132_D1.1311.00
184_G202_I1.1311.00
205_D227_N1.1291.00
223_T241_V1.1281.00
259_L273_I1.1261.00
148_I152_S1.1211.00
283_V295_I1.1171.00
31_M40_T1.1141.00
20_D23_I1.1121.00
109_T126_S1.1071.00
131_G134_V1.1051.00
169_N186_A1.1041.00
194_K211_A1.1031.00
277_M291_V1.0961.00
204_G219_A1.0861.00
164_I178_V1.0821.00
63_Q77_K1.0801.00
265_C281_D1.0771.00
252_G270_A1.0621.00
267_I285_V1.0541.00
223_T232_D1.0531.00
228_G232_D1.0501.00
220_L223_T1.0391.00
181_D194_K1.0371.00
38_H59_V1.0321.00
229_V232_D1.0231.00
110_A115_N1.0201.00
304_G307_L1.0171.00
135_I153_R1.0051.00
265_C283_V1.0031.00
225_I232_D1.0031.00
37_G41_F1.0021.00
227_N232_D0.9991.00
223_T229_V0.9881.00
161_Y174_S0.9850.99
110_A130_L0.9840.99
184_G205_D0.9830.99
193_V211_A0.9810.99
309_P312_V0.9750.99
178_V181_D0.9740.99
182_G202_I0.9720.99
226_G229_V0.9680.99
229_V263_R0.9660.99
151_G168_Q0.9650.99
283_V298_P0.9640.99
225_I228_G0.9620.99
42_M59_V0.9550.99
168_Q185_Y0.9540.99
224_I232_D0.9530.99
303_S313_W0.9520.99
227_N230_I0.9510.99
34_A37_G0.9480.99
44_N51_L0.9480.99
112_L115_N0.9340.99
116_V120_A0.9300.99
265_C298_P0.9280.99
208_E226_G0.9270.99
164_I200_R0.9230.99
149_G152_S0.9200.99
218_G231_I0.9200.99
224_I230_I0.9140.99
167_G205_D0.9110.99
16_E47_Y0.9100.99
112_L118_I0.9090.99
134_V148_I0.9070.99
125_E143_G0.9040.99
226_G231_I0.9020.99
114_N120_A0.9020.99
42_M54_C0.8980.99
224_I242_V0.8970.99
228_G231_I0.8880.99
247_T265_C0.8860.99
228_G246_N0.8840.99
218_G222_D0.8840.99
170_C205_D0.8820.99
218_G235_C0.8820.99
130_L136_I0.8770.99
261_I265_C0.8690.99
223_T231_I0.8680.99
286_T302_S0.8610.99
34_A38_H0.8600.99
286_T310_N0.8590.99
152_S167_G0.8550.99
111_K115_N0.8540.99
215_I231_I0.8530.99
155_W171_L0.8530.99
303_S310_N0.8520.99
34_A56_A0.8510.99
194_K208_E0.8470.98
188_D191_N0.8440.98
152_S166_I0.8430.98
223_T228_G0.8430.98
136_I142_V0.8420.98
186_A206_R0.8420.98
16_E63_Q0.8370.98
259_L275_G0.8360.98
225_I230_I0.8340.98
224_I227_N0.8320.98
289_G307_L0.8320.98
241_V255_M0.8320.98
114_N117_S0.8310.98
85_R88_Q0.8300.98
249_V261_I0.8290.98
29_A38_H0.8230.98
267_I271_S0.8170.98
229_V247_T0.8160.98
115_N120_A0.8160.98
183_F195_I0.8090.98
10_A61_M0.8050.98
223_T230_I0.8030.98
130_L142_V0.7960.98
121_N157_N0.7940.98
148_I160_I0.7940.98
221_D239_H0.7880.98
285_V289_G0.7870.98
130_L148_I0.7870.98
180_A211_A0.7830.97
124_I136_I0.7820.97
81_L96_P0.7810.97
115_N132_D0.7790.97
51_L59_V0.7770.97
137_G140_C0.7750.97
34_A60_V0.7740.97
15_A76_V0.7740.97
226_G232_D0.7730.97
8_D11_Q0.7620.97
142_V148_I0.7620.97
227_N246_N0.7590.97
203_I209_I0.7540.97
241_V265_C0.7530.97
307_L313_W0.7490.97
241_V263_R0.7490.97
219_A236_Q0.7470.97
160_I172_I0.7430.96
32_Q36_T0.7410.96
89_I92_T0.7390.96
122_A140_C0.7390.96
44_N47_Y0.7370.96
116_V134_V0.7360.96
25_I58_A0.7350.96
144_K162_H0.7350.96
123_V138_A0.7340.96
165_Q182_G0.7320.96
38_H56_A0.7300.96
168_Q205_D0.7290.96
250_A266_M0.7280.96
96_P112_L0.7270.96
223_T226_G0.7260.96
131_G152_S0.7250.96
206_R222_D0.7230.96
95_Q117_S0.7210.96
146_S160_I0.7150.96
9_L69_A0.7120.96
231_I249_V0.7120.96
92_T96_P0.7070.95
224_I231_I0.7010.95
283_V300_V0.7000.95
173_Q176_T0.7000.95
58_A62_T0.7000.95
138_A156_A0.6990.95
274_N287_G0.6960.95
42_M56_A0.6950.95
147_K150_A0.6940.95
142_V154_L0.6890.95
237_I241_V0.6890.95
41_F59_V0.6870.95
170_C187_N0.6860.95
224_I228_G0.6860.95
247_T263_R0.6850.94
143_G159_T0.6820.94
134_V149_G0.6800.94
308_Q311_K0.6780.94
248_A266_M0.6770.94
306_P309_P0.6770.94
282_K298_P0.6770.94
247_T261_I0.6770.94
79_P112_L0.6760.94
15_A82_T0.6750.94
284_T301_Y0.6740.94
227_N231_I0.6730.94
254_I272_V0.6700.94
12_Q89_I0.6670.94
265_C279_I0.6660.94
131_G147_K0.6660.94
250_A269_G0.6650.94
18_H75_V0.6650.94
141_F156_A0.6630.93
23_I57_S0.6600.93
125_E141_F0.6600.93
110_A116_V0.6580.93
13_L22_D0.6540.93
80_Y186_A0.6540.93
149_G165_Q0.6540.93
173_Q181_D0.6530.93
162_H179_G0.6490.93
170_C185_Y0.6480.93
111_K116_V0.6470.93
247_T271_S0.6460.93
271_S279_I0.6460.93
177_V180_A0.6460.93
211_A214_T0.6450.93
195_I201_V0.6430.92
109_T113_G0.6390.92
224_I229_V0.6380.92
118_I122_A0.6370.92
123_V141_F0.6350.92
86_M90_L0.6350.92
304_G308_Q0.6340.92
235_C249_V0.6330.92
204_G226_G0.6320.92
35_Q38_H0.6320.92
32_Q50_H0.6310.92
274_N290_M0.6290.92
272_V287_G0.6290.92
26_T37_G0.6280.92
84_A120_A0.6270.91
223_T227_N0.6250.91
94_P124_I0.6230.91
178_V201_V0.6220.91
60_V86_M0.6220.91
64_D67_P0.6200.91
154_L160_I0.6200.91
128_V143_G0.6180.91
280_C295_I0.6180.91
274_N292_M0.6180.91
247_T267_I0.6130.91
249_V253_V0.6130.91
154_L158_V0.6120.90
215_I220_L0.6100.90
253_V271_S0.6080.90
226_G230_I0.6060.90
33_S221_D0.6020.90
249_V267_I0.6020.90
124_I128_V0.6020.90
145_N162_H0.6010.90
28_V39_I0.5970.89
262_G298_P0.5960.89
207_V215_I0.5940.89
170_C184_G0.5940.89
140_C158_V0.5940.89
129_E145_N0.5930.89
137_G143_G0.5870.89
165_Q202_I0.5860.88
31_M50_H0.5810.88
202_I222_D0.5800.88
123_V139_G0.5770.88
139_G159_T0.5770.88
243_I249_V0.5770.88
238_A250_A0.5750.88
241_V259_L0.5750.88
215_I225_I0.5740.87
255_M259_L0.5740.87
75_V85_R0.5730.87
308_Q312_V0.5730.87
226_G247_T0.5710.87
164_I177_V0.5710.87
187_N191_N0.5710.87
81_L84_A0.5700.87
181_D201_V0.5700.87
122_A142_V0.5680.87
149_G167_G0.5680.87
61_M67_P0.5670.87
207_V221_D0.5660.87
173_Q188_D0.5650.87
113_G130_L0.5640.87
88_Q91_D0.5640.87
110_A114_N0.5640.87
116_V130_L0.5600.86
217_R236_Q0.5590.86
36_T55_Q0.5580.86
279_I291_V0.5570.86
252_G288_M0.5570.86
173_Q180_A0.5540.86
192_W248_A0.5530.85
302_S310_N0.5520.85
279_I285_V0.5490.85
256_A274_N0.5440.85
183_F187_N0.5430.84
293_R306_P0.5420.84
40_T59_V0.5410.84
291_V307_L0.5400.84
307_L312_V0.5370.84
167_G182_G0.5370.84
146_S200_R0.5360.84
203_I215_I0.5340.83
193_V209_I0.5310.83
124_I130_L0.5310.83
307_L311_K0.5300.83
66_L70_K0.5290.83
35_Q55_Q0.5280.83
37_G40_T0.5250.82
201_V225_I0.5220.82
81_L112_L0.5210.82
127_G144_K0.5210.82
223_T239_H0.5200.82
237_I261_I0.5200.82
9_L86_M0.5190.82
141_F159_T0.5190.82
261_I267_I0.5170.81
272_V289_G0.5150.81
247_T250_A0.5140.81
51_L54_C0.5140.81
253_V267_I0.5130.81
8_D61_M0.5100.81
17_L48_R0.5090.80
47_Y80_Y0.5080.80
159_T177_V0.5060.80
85_R89_I0.5060.80
75_V89_I0.5050.80
273_I279_I0.5050.80
79_P83_Y0.5050.80
159_T175_G0.5050.80
149_G185_Y0.5050.80
308_Q313_W0.5020.80
9_L61_M0.5020.80
117_S136_I0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pmoA 3 0.9853 100 0.321 Contact Map
2iu8A 3 0.9971 100 0.329 Contact Map
4e79A 3 0.9971 100 0.336 Contact Map
4ihfA 4 0.9912 100 0.369 Contact Map
3t57A 3 0.6921 100 0.578 Contact Map
4g3qA 3 0.9062 100 0.636 Contact Map
2pigA 1 0.7566 100 0.638 Contact Map
4r36A 3 0.6364 100 0.64 Contact Map
4eqyA 3 0.6422 100 0.643 Contact Map
3fs8A 3 0.6422 100 0.644 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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