LPXD - ECOLI - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

LPXD - UDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase

UniProt:	P21645	Sequences: MPSIRLADLAQQLDAELHGDGDIVITGVASMQSAQTGHITFMVNPKYREHLGLCQASAVVMTQDDLPFAKSAALVVKNPYLTYARMAQILDTTPQPAQNIAPSAVIDATAKLGNNVSIGANAVIESGVELGDNVIIGAGCFVGKNSKIGAGSRLWANVTIYHEIQIGQNCLIQSGTVVGADGFGYANDRGNWVKIPQIGRVIIGDRVEIGACTTIDRGALDDTIIGNGVIIDNQCQIAHNVVIGDNTAVAGGVIMAGSLKIGRYCMIGGASVINGHMEICDKVTVTGMGMVMRPITEPGVYSSGIPLQPNKVWRKTAALVMNIDDMSKRLKSLERKVNQQD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10316
Length:	341 (289)
Sequences:	4812 (3312)
Seq/√Len:	194.8

ECOLI - LPXD LPXA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
129_E	147_K	3.453	1.00
151_G	169_N	3.378	1.00
262_G	281_D	3.316	1.00
264_Y	282_K	2.892	1.00
150_A	168_Q	2.830	1.00
15_A	23_I	2.762	1.00
260_K	278_E	2.738	1.00
160_I	164_I	2.718	1.00
37_G	57_S	2.682	1.00
169_N	206_R	2.630	1.00
127_G	145_N	2.620	1.00
139_G	157_N	2.569	1.00
131_G	150_A	2.473	1.00
147_K	165_Q	2.433	1.00
263_R	281_D	2.416	1.00
11_Q	22_D	2.401	1.00
240_N	264_Y	2.392	1.00
132_D	150_A	2.385	1.00
134_V	152_S	2.379	1.00
149_G	168_Q	2.336	1.00
215_I	218_G	2.177	1.00
41_F	63_Q	2.122	1.00
231_I	235_C	2.099	1.00
134_V	168_Q	2.094	1.00
281_D	298_P	2.080	1.00
205_D	222_D	2.079	1.00
112_L	116_V	2.071	1.00
201_V	215_I	2.071	1.00
278_E	294_P	2.019	1.00
225_I	231_I	1.995	1.00
113_G	132_D	1.974	1.00
267_I	273_I	1.949	1.00
280_C	298_P	1.925	1.00
227_N	245_D	1.858	1.00
133_N	151_G	1.856	1.00
15_A	74_L	1.843	1.00
125_E	144_K	1.837	1.00
128_V	142_V	1.819	1.00
288_M	305_I	1.752	1.00
222_D	239_H	1.699	1.00
115_N	133_N	1.683	1.00
172_I	176_T	1.674	1.00
204_G	227_N	1.654	1.00
121_N	139_G	1.652	1.00
245_D	263_R	1.648	1.00
152_S	170_C	1.610	1.00
274_N	277_M	1.596	1.00
27_G	38_H	1.571	1.00
111_K	129_E	1.562	1.00
246_N	264_Y	1.537	1.00
209_I	215_I	1.527	1.00
175_G	212_C	1.525	1.00
142_V	146_S	1.523	1.00
37_G	63_Q	1.507	1.00
203_I	207_V	1.505	1.00
223_T	263_R	1.503	1.00
113_G	116_V	1.497	1.00
166_I	170_C	1.489	1.00
242_V	260_K	1.488	1.00
162_H	180_A	1.488	1.00
226_G	245_D	1.476	1.00
262_G	278_E	1.470	1.00
137_G	153_R	1.453	1.00
156_A	174_S	1.451	1.00
185_Y	205_D	1.449	1.00
76_V	82_T	1.446	1.00
110_A	113_G	1.442	1.00
202_I	219_A	1.438	1.00
220_L	225_I	1.430	1.00
200_R	217_R	1.423	1.00
152_S	168_Q	1.417	1.00
239_H	263_R	1.412	1.00
122_A	136_I	1.404	1.00
200_R	222_D	1.403	1.00
225_I	229_V	1.375	1.00
296_T	300_V	1.374	1.00
134_V	150_A	1.374	1.00
271_S	285_V	1.367	1.00
77_K	86_M	1.363	1.00
111_K	114_N	1.360	1.00
204_G	222_D	1.355	1.00
128_V	146_S	1.352	1.00
282_K	299_G	1.350	1.00
280_C	283_V	1.347	1.00
19_G	22_D	1.345	1.00
285_V	291_V	1.341	1.00
250_A	272_V	1.330	1.00
131_G	149_G	1.296	1.00
167_G	185_Y	1.288	1.00
125_E	128_V	1.283	1.00
87_A	196_P	1.282	1.00
143_G	161_Y	1.276	1.00
272_V	290_M	1.271	1.00
286_T	303_S	1.268	1.00
140_C	154_L	1.267	1.00
280_C	294_P	1.263	1.00
131_G	168_Q	1.258	1.00
295_I	302_S	1.250	1.00
153_R	171_L	1.247	1.00
157_N	175_G	1.243	1.00
279_I	283_V	1.222	1.00
176_T	213_T	1.220	1.00
266_M	284_T	1.213	1.00
109_T	127_G	1.207	1.00
212_C	234_Q	1.195	1.00
270_A	288_M	1.193	1.00
130_L	134_V	1.181	1.00
237_I	243_I	1.176	1.00
236_Q	260_K	1.172	1.00
166_I	172_I	1.164	1.00
214_T	234_Q	1.162	1.00
160_I	166_I	1.158	1.00
280_C	296_T	1.157	1.00
117_S	120_A	1.155	1.00
305_I	308_Q	1.153	1.00
34_A	65_D	1.150	1.00
136_I	140_C	1.143	1.00
226_G	242_V	1.136	1.00
114_N	132_D	1.131	1.00
184_G	202_I	1.131	1.00
205_D	227_N	1.129	1.00
223_T	241_V	1.128	1.00
259_L	273_I	1.126	1.00
148_I	152_S	1.121	1.00
283_V	295_I	1.117	1.00
31_M	40_T	1.114	1.00
20_D	23_I	1.112	1.00
109_T	126_S	1.107	1.00
131_G	134_V	1.105	1.00
169_N	186_A	1.104	1.00
194_K	211_A	1.103	1.00
277_M	291_V	1.096	1.00
204_G	219_A	1.086	1.00
164_I	178_V	1.082	1.00
63_Q	77_K	1.080	1.00
265_C	281_D	1.077	1.00
252_G	270_A	1.062	1.00
267_I	285_V	1.054	1.00
223_T	232_D	1.053	1.00
228_G	232_D	1.050	1.00
220_L	223_T	1.039	1.00
181_D	194_K	1.037	1.00
38_H	59_V	1.032	1.00
229_V	232_D	1.023	1.00
110_A	115_N	1.020	1.00
304_G	307_L	1.017	1.00
135_I	153_R	1.005	1.00
265_C	283_V	1.003	1.00
225_I	232_D	1.003	1.00
37_G	41_F	1.002	1.00
227_N	232_D	0.999	1.00
223_T	229_V	0.988	1.00
161_Y	174_S	0.985	0.99
110_A	130_L	0.984	0.99
184_G	205_D	0.983	0.99
193_V	211_A	0.981	0.99
309_P	312_V	0.975	0.99
178_V	181_D	0.974	0.99
182_G	202_I	0.972	0.99
226_G	229_V	0.968	0.99
229_V	263_R	0.966	0.99
151_G	168_Q	0.965	0.99
283_V	298_P	0.964	0.99
225_I	228_G	0.962	0.99
42_M	59_V	0.955	0.99
168_Q	185_Y	0.954	0.99
224_I	232_D	0.953	0.99
303_S	313_W	0.952	0.99
227_N	230_I	0.951	0.99
34_A	37_G	0.948	0.99
44_N	51_L	0.948	0.99
112_L	115_N	0.934	0.99
116_V	120_A	0.930	0.99
265_C	298_P	0.928	0.99
208_E	226_G	0.927	0.99
164_I	200_R	0.923	0.99
149_G	152_S	0.920	0.99
218_G	231_I	0.920	0.99
224_I	230_I	0.914	0.99
167_G	205_D	0.911	0.99
16_E	47_Y	0.910	0.99
112_L	118_I	0.909	0.99
134_V	148_I	0.907	0.99
125_E	143_G	0.904	0.99
226_G	231_I	0.902	0.99
114_N	120_A	0.902	0.99
42_M	54_C	0.898	0.99
224_I	242_V	0.897	0.99
228_G	231_I	0.888	0.99
247_T	265_C	0.886	0.99
228_G	246_N	0.884	0.99
218_G	222_D	0.884	0.99
170_C	205_D	0.882	0.99
218_G	235_C	0.882	0.99
130_L	136_I	0.877	0.99
261_I	265_C	0.869	0.99
223_T	231_I	0.868	0.99
286_T	302_S	0.861	0.99
34_A	38_H	0.860	0.99
286_T	310_N	0.859	0.99
152_S	167_G	0.855	0.99
111_K	115_N	0.854	0.99
215_I	231_I	0.853	0.99
155_W	171_L	0.853	0.99
303_S	310_N	0.852	0.99
34_A	56_A	0.851	0.99
194_K	208_E	0.847	0.98
188_D	191_N	0.844	0.98
152_S	166_I	0.843	0.98
223_T	228_G	0.843	0.98
136_I	142_V	0.842	0.98
186_A	206_R	0.842	0.98
16_E	63_Q	0.837	0.98
259_L	275_G	0.836	0.98
225_I	230_I	0.834	0.98
224_I	227_N	0.832	0.98
289_G	307_L	0.832	0.98
241_V	255_M	0.832	0.98
114_N	117_S	0.831	0.98
85_R	88_Q	0.830	0.98
249_V	261_I	0.829	0.98
29_A	38_H	0.823	0.98
267_I	271_S	0.817	0.98
229_V	247_T	0.816	0.98
115_N	120_A	0.816	0.98
183_F	195_I	0.809	0.98
10_A	61_M	0.805	0.98
223_T	230_I	0.803	0.98
130_L	142_V	0.796	0.98
121_N	157_N	0.794	0.98
148_I	160_I	0.794	0.98
221_D	239_H	0.788	0.98
285_V	289_G	0.787	0.98
130_L	148_I	0.787	0.98
180_A	211_A	0.783	0.97
124_I	136_I	0.782	0.97
81_L	96_P	0.781	0.97
115_N	132_D	0.779	0.97
51_L	59_V	0.777	0.97
137_G	140_C	0.775	0.97
34_A	60_V	0.774	0.97
15_A	76_V	0.774	0.97
226_G	232_D	0.773	0.97
8_D	11_Q	0.762	0.97
142_V	148_I	0.762	0.97
227_N	246_N	0.759	0.97
203_I	209_I	0.754	0.97
241_V	265_C	0.753	0.97
307_L	313_W	0.749	0.97
241_V	263_R	0.749	0.97
219_A	236_Q	0.747	0.97
160_I	172_I	0.743	0.96
32_Q	36_T	0.741	0.96
89_I	92_T	0.739	0.96
122_A	140_C	0.739	0.96
44_N	47_Y	0.737	0.96
116_V	134_V	0.736	0.96
25_I	58_A	0.735	0.96
144_K	162_H	0.735	0.96
123_V	138_A	0.734	0.96
165_Q	182_G	0.732	0.96
38_H	56_A	0.730	0.96
168_Q	205_D	0.729	0.96
250_A	266_M	0.728	0.96
96_P	112_L	0.727	0.96
223_T	226_G	0.726	0.96
131_G	152_S	0.725	0.96
206_R	222_D	0.723	0.96
95_Q	117_S	0.721	0.96
146_S	160_I	0.715	0.96
9_L	69_A	0.712	0.96
231_I	249_V	0.712	0.96
92_T	96_P	0.707	0.95
224_I	231_I	0.701	0.95
283_V	300_V	0.700	0.95
173_Q	176_T	0.700	0.95
58_A	62_T	0.700	0.95
138_A	156_A	0.699	0.95
274_N	287_G	0.696	0.95
42_M	56_A	0.695	0.95
147_K	150_A	0.694	0.95
142_V	154_L	0.689	0.95
237_I	241_V	0.689	0.95
41_F	59_V	0.687	0.95
170_C	187_N	0.686	0.95
224_I	228_G	0.686	0.95
247_T	263_R	0.685	0.94
143_G	159_T	0.682	0.94
134_V	149_G	0.680	0.94
308_Q	311_K	0.678	0.94
248_A	266_M	0.677	0.94
306_P	309_P	0.677	0.94
282_K	298_P	0.677	0.94
247_T	261_I	0.677	0.94
79_P	112_L	0.676	0.94
15_A	82_T	0.675	0.94
284_T	301_Y	0.674	0.94
227_N	231_I	0.673	0.94
254_I	272_V	0.670	0.94
12_Q	89_I	0.667	0.94
265_C	279_I	0.666	0.94
131_G	147_K	0.666	0.94
250_A	269_G	0.665	0.94
18_H	75_V	0.665	0.94
141_F	156_A	0.663	0.93
23_I	57_S	0.660	0.93
125_E	141_F	0.660	0.93
110_A	116_V	0.658	0.93
13_L	22_D	0.654	0.93
80_Y	186_A	0.654	0.93
149_G	165_Q	0.654	0.93
173_Q	181_D	0.653	0.93
162_H	179_G	0.649	0.93
170_C	185_Y	0.648	0.93
111_K	116_V	0.647	0.93
247_T	271_S	0.646	0.93
271_S	279_I	0.646	0.93
177_V	180_A	0.646	0.93
211_A	214_T	0.645	0.93
195_I	201_V	0.643	0.92
109_T	113_G	0.639	0.92
224_I	229_V	0.638	0.92
118_I	122_A	0.637	0.92
123_V	141_F	0.635	0.92
86_M	90_L	0.635	0.92
304_G	308_Q	0.634	0.92
235_C	249_V	0.633	0.92
204_G	226_G	0.632	0.92
35_Q	38_H	0.632	0.92
32_Q	50_H	0.631	0.92
274_N	290_M	0.629	0.92
272_V	287_G	0.629	0.92
26_T	37_G	0.628	0.92
84_A	120_A	0.627	0.91
223_T	227_N	0.625	0.91
94_P	124_I	0.623	0.91
178_V	201_V	0.622	0.91
60_V	86_M	0.622	0.91
64_D	67_P	0.620	0.91
154_L	160_I	0.620	0.91
128_V	143_G	0.618	0.91
280_C	295_I	0.618	0.91
274_N	292_M	0.618	0.91
247_T	267_I	0.613	0.91
249_V	253_V	0.613	0.91
154_L	158_V	0.612	0.90
215_I	220_L	0.610	0.90
253_V	271_S	0.608	0.90
226_G	230_I	0.606	0.90
33_S	221_D	0.602	0.90
249_V	267_I	0.602	0.90
124_I	128_V	0.602	0.90
145_N	162_H	0.601	0.90
28_V	39_I	0.597	0.89
262_G	298_P	0.596	0.89
207_V	215_I	0.594	0.89
170_C	184_G	0.594	0.89
140_C	158_V	0.594	0.89
129_E	145_N	0.593	0.89
137_G	143_G	0.587	0.89
165_Q	202_I	0.586	0.88
31_M	50_H	0.581	0.88
202_I	222_D	0.580	0.88
123_V	139_G	0.577	0.88
139_G	159_T	0.577	0.88
243_I	249_V	0.577	0.88
238_A	250_A	0.575	0.88
241_V	259_L	0.575	0.88
215_I	225_I	0.574	0.87
255_M	259_L	0.574	0.87
75_V	85_R	0.573	0.87
308_Q	312_V	0.573	0.87
226_G	247_T	0.571	0.87
164_I	177_V	0.571	0.87
187_N	191_N	0.571	0.87
81_L	84_A	0.570	0.87
181_D	201_V	0.570	0.87
122_A	142_V	0.568	0.87
149_G	167_G	0.568	0.87
61_M	67_P	0.567	0.87
207_V	221_D	0.566	0.87
173_Q	188_D	0.565	0.87
113_G	130_L	0.564	0.87
88_Q	91_D	0.564	0.87
110_A	114_N	0.564	0.87
116_V	130_L	0.560	0.86
217_R	236_Q	0.559	0.86
36_T	55_Q	0.558	0.86
279_I	291_V	0.557	0.86
252_G	288_M	0.557	0.86
173_Q	180_A	0.554	0.86
192_W	248_A	0.553	0.85
302_S	310_N	0.552	0.85
279_I	285_V	0.549	0.85
256_A	274_N	0.544	0.85
183_F	187_N	0.543	0.84
293_R	306_P	0.542	0.84
40_T	59_V	0.541	0.84
291_V	307_L	0.540	0.84
307_L	312_V	0.537	0.84
167_G	182_G	0.537	0.84
146_S	200_R	0.536	0.84
203_I	215_I	0.534	0.83
193_V	209_I	0.531	0.83
124_I	130_L	0.531	0.83
307_L	311_K	0.530	0.83
66_L	70_K	0.529	0.83
35_Q	55_Q	0.528	0.83
37_G	40_T	0.525	0.82
201_V	225_I	0.522	0.82
81_L	112_L	0.521	0.82
127_G	144_K	0.521	0.82
223_T	239_H	0.520	0.82
237_I	261_I	0.520	0.82
9_L	86_M	0.519	0.82
141_F	159_T	0.519	0.82
261_I	267_I	0.517	0.81
272_V	289_G	0.515	0.81
247_T	250_A	0.514	0.81
51_L	54_C	0.514	0.81
253_V	267_I	0.513	0.81
8_D	61_M	0.510	0.81
17_L	48_R	0.509	0.80
47_Y	80_Y	0.508	0.80
159_T	177_V	0.506	0.80
85_R	89_I	0.506	0.80
75_V	89_I	0.505	0.80
273_I	279_I	0.505	0.80
79_P	83_Y	0.505	0.80
159_T	175_G	0.505	0.80
149_G	185_Y	0.505	0.80
308_Q	313_W	0.502	0.80
9_L	61_M	0.502	0.80
117_S	136_I	0.500	0.79

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3pmoA	3	0.9853	100	0.321	Contact Map
2iu8A	3	0.9971	100	0.329	Contact Map
4e79A	3	0.9971	100	0.336	Contact Map
4ihfA	4	0.9912	100	0.369	Contact Map
3t57A	3	0.6921	100	0.578	Contact Map
4g3qA	3	0.9062	100	0.636	Contact Map
2pigA	1	0.7566	100	0.638	Contact Map
4r36A	3	0.6364	100	0.64	Contact Map
4eqyA	3	0.6422	100	0.643	Contact Map
3fs8A	3	0.6422	100	0.644	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0099 seconds.