GREMLIN Database
KPYK2 - Pyruvate kinase II
UniProt: P21599 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10803
Length: 480 (468)
Sequences: 4189 (2406)
Seq/√Len: 111.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
139_L149_E4.3821.00
25_E60_K4.2981.00
222_A243_S4.2221.00
237_D272_R4.0341.00
48_K52_D3.4231.00
21_D56_E3.3941.00
236_M269_L3.3461.00
137_K149_E3.2101.00
205_N242_A3.1601.00
12_T32_A3.0291.00
82_K106_D2.9651.00
69_G185_A2.9351.00
230_V265_I2.8651.00
261_E340_G2.8041.00
282_T312_T2.7621.00
204_L222_A2.7511.00
32_A35_V2.7311.00
137_K151_T2.7291.00
140_E147_F2.6631.00
66_A418_A2.6571.00
208_R220_I2.6471.00
23_N26_K2.6031.00
93_K147_F2.5631.00
20_R23_N2.5411.00
48_K188_I2.4671.00
82_K104_E2.4641.00
89_N92_D2.4551.00
80_T159_N2.4171.00
93_K139_L2.4051.00
204_L220_I2.3171.00
46_D50_R2.2901.00
260_P336_R2.2621.00
94_F110_V2.2171.00
241_L276_L2.2011.00
19_D50_R2.1851.00
28_I65_V2.1831.00
202_E206_Y2.1801.00
29_A61_L2.1671.00
408_S414_L2.1611.00
51_A188_I2.1521.00
292_T325_Q2.1391.00
182_I193_L2.1031.00
257_I265_I2.0571.00
92_D107_K2.0551.00
116_G119_A2.0281.00
380_T455_D2.0211.00
142_Q145_K2.0211.00
221_V245_V1.9881.00
267_K310_D1.9821.00
209_R213_D1.9771.00
335_A339_L1.9651.00
315_V338_C1.9511.00
21_D53_K1.9421.00
84_G158_N1.9341.00
129_L156_L1.9301.00
189_G412_R1.8601.00
93_K149_E1.8601.00
85_K155_P1.8591.00
186_A218_A1.8491.00
99_N144_M1.8441.00
23_N328_S1.8321.00
88_L150_V1.8101.00
123_P141_V1.7981.00
270_I282_T1.7971.00
51_A67_I1.7671.00
25_E29_A1.7621.00
126_I135_Q1.7571.00
236_M240_I1.7431.00
219_K416_L1.7411.00
109_K145_K1.7401.00
443_N447_D1.7371.00
202_E205_N1.7291.00
87_F155_P1.7271.00
383_I457_V1.7171.00
183_K214_A1.7161.00
96_L136_L1.7051.00
55_R58_A1.6981.00
176_E180_A1.6951.00
120_D170_S1.6941.00
37_M51_A1.6881.00
372_A474_T1.6821.00
95_L147_F1.6801.00
201_G238_D1.6731.00
21_D60_K1.6601.00
136_L148_T1.6541.00
414_L427_H1.6441.00
227_A231_C1.6421.00
195_V207_A1.6291.00
92_D150_V1.6191.00
56_E60_K1.6141.00
33_N63_R1.6091.00
168_G228_E1.6091.00
94_F148_T1.6061.00
11_V281_I1.6011.00
45_E48_K1.5941.00
26_K29_A1.5941.00
14_L24_L1.5911.00
246_V269_L1.5851.00
268_A272_R1.5741.00
329_E332_A1.5601.00
180_A183_K1.5571.00
99_N109_K1.5511.00
179_K183_K1.5491.00
34_V68_L1.5451.00
86_V107_K1.5441.00
71_L75_K1.5441.00
177_K181_D1.5431.00
126_I137_K1.5421.00
95_L145_K1.5311.00
28_I57_I1.5231.00
122_V125_D1.5161.00
221_V281_I1.4921.00
35_V54_V1.4891.00
11_V34_V1.4811.00
21_D57_I1.4751.00
69_G190_V1.4701.00
179_K206_Y1.4651.00
326_Y329_E1.4601.00
25_E61_L1.4561.00
444_L447_D1.4551.00
98_A118_P1.4191.00
49_M52_D1.4161.00
99_N145_K1.4051.00
291_I319_A1.4031.00
81_F158_N1.3891.00
97_D109_K1.3821.00
48_K187_L1.3761.00
6_R335_A1.3681.00
417_T420_Y1.3641.00
379_V458_I1.3601.00
43_S46_D1.3601.00
376_L379_V1.3551.00
42_G47_H1.3541.00
67_I190_V1.3501.00
30_A332_A1.3451.00
259_D333_A1.3401.00
44_P184_T1.3341.00
262_L302_M1.3301.00
444_L448_K1.3241.00
49_M53_K1.3221.00
57_I61_L1.3211.00
141_V146_V1.3181.00
235_A238_D1.3171.00
118_P146_V1.3130.99
130_D133_R1.3050.99
446_R453_S1.2930.99
386_T406_A1.2910.99
125_D167_G1.2900.99
23_N27_V1.2820.99
217_D412_R1.2810.99
37_M54_V1.2690.99
308_V338_C1.2670.99
332_A336_R1.2630.99
78_V110_V1.2600.99
79_S111_G1.2580.99
142_Q147_F1.2570.99
179_K210_L1.2560.99
52_D56_E1.2470.99
12_T35_V1.2470.99
272_R276_L1.2410.99
22_N25_E1.2340.99
90_I153_G1.2340.99
78_V134_V1.2330.99
340_G343_K1.2320.99
129_L136_L1.2280.99
185_A190_V1.2240.99
201_G242_A1.2240.99
14_L50_R1.2160.99
226_R229_A1.2110.99
5_L339_L1.2100.99
121_V146_V1.2010.99
288_E292_T1.1980.99
18_T23_N1.1980.99
361_V456_L1.1960.99
186_A211_A1.1890.99
205_N209_R1.1860.99
27_V331_V1.1850.99
20_R53_K1.1820.99
26_K332_A1.1770.99
265_I269_L1.1750.99
186_A214_A1.1670.99
37_M190_V1.1650.99
89_N153_G1.1630.99
53_K56_E1.1590.99
456_L478_T1.1580.99
115_K118_P1.1530.99
183_K187_L1.1520.99
240_I272_R1.1520.99
19_D49_M1.1510.99
47_H50_R1.1490.99
25_E57_I1.1480.99
86_V156_L1.1250.98
364_A372_A1.1240.98
406_A417_T1.1230.98
372_A476_I1.1200.98
99_N103_G1.1150.98
80_T104_E1.1140.98
201_G205_N1.1100.98
212_R216_C1.1100.98
8_T338_C1.1060.98
19_D53_K1.1040.98
28_I63_R1.1020.98
270_I312_T1.0940.98
433_D436_A1.0910.98
201_G235_A1.0900.98
44_P181_D1.0830.98
97_D145_K1.0820.98
211_A216_C1.0810.98
51_A184_T1.0760.98
85_K157_S1.0750.98
406_A423_V1.0750.98
59_A411_E1.0730.98
18_T27_V1.0680.98
187_L214_A1.0610.98
363_E397_R1.0610.98
26_K328_S1.0610.98
14_L18_T1.0590.98
286_M304_V1.0550.98
461_Q473_T1.0530.98
384_T395_T1.0530.98
381_A405_F1.0520.98
89_N107_K1.0510.98
37_M67_I1.0510.98
135_Q151_T1.0450.97
53_K57_I1.0420.97
206_Y209_R1.0420.97
288_E291_I1.0420.97
183_K213_D1.0400.97
21_D25_E1.0380.97
116_G120_D1.0360.97
264_G309_L1.0350.97
72_Q75_K1.0340.97
96_L112_I1.0330.97
191_D415_N1.0290.97
164_K167_G1.0270.97
39_F69_G1.0250.97
139_L147_F1.0200.97
393_L420_Y1.0150.97
54_V67_I1.0120.97
136_L150_V1.0100.97
294_P326_Y1.0090.97
118_P141_V1.0040.97
106_D109_K1.0020.97
14_L54_V1.0010.97
288_E319_A0.9970.97
304_V337_V0.9890.96
93_K140_E0.9870.96
11_V314_A0.9810.96
367_M371_Y0.9810.96
176_E179_K0.9720.96
259_D301_V0.9660.96
174_L179_K0.9660.96
301_V337_V0.9650.96
80_T158_N0.9650.96
52_D188_I0.9620.96
182_I207_A0.9620.96
126_I151_T0.9600.96
51_A190_V0.9580.96
150_V153_G0.9570.96
8_T308_V0.9510.96
199_R228_E0.9430.95
34_V314_A0.9420.95
200_C203_D0.9410.95
243_S246_V0.9390.95
396_S420_Y0.9390.95
208_R244_D0.9370.95
46_D49_M0.9370.95
87_F153_G0.9330.95
129_L148_T0.9310.95
380_T452_M0.9270.95
90_I325_Q0.9200.95
78_V157_S0.9110.94
110_V156_L0.9100.94
236_M272_R0.9040.94
230_V253_L0.9030.94
461_Q464_V0.9010.94
179_K209_R0.8990.94
407_M428_F0.8980.94
164_K169_L0.8980.94
68_L194_A0.8980.94
105_G110_V0.8950.94
130_D157_S0.8940.94
75_K226_R0.8900.94
190_V218_A0.8900.94
227_A261_E0.8890.94
48_K184_T0.8850.93
240_I276_L0.8850.93
24_L57_I0.8830.93
81_F94_F0.8830.93
135_Q295_M0.8820.93
114_Y120_D0.8750.93
117_L146_V0.8730.93
83_E86_V0.8720.93
405_F445_L0.8710.93
96_L127_L0.8680.93
72_Q177_K0.8670.93
30_A331_V0.8650.93
130_D288_E0.8640.93
72_Q181_D0.8630.93
464_V472_N0.8580.92
237_D276_L0.8570.92
192_Y221_V0.8570.92
287_M330_T0.8560.92
271_R275_Q0.8560.92
211_A218_A0.8520.92
96_L110_V0.8510.92
238_D241_L0.8500.92
91_G149_E0.8480.92
112_I162_I0.8480.92
45_E49_M0.8460.92
326_Y330_T0.8450.92
240_I273_A0.8440.92
81_F156_L0.8440.92
237_D240_I0.8420.92
81_F157_S0.8420.92
30_A328_S0.8370.91
442_V457_V0.8330.91
57_I60_K0.8310.91
123_P140_E0.8280.91
56_E59_A0.8250.91
163_N256_E0.8250.91
44_P48_K0.8240.91
328_S332_A0.8220.91
61_L64_H0.8210.91
66_A192_Y0.8180.91
365_I460_T0.8150.90
270_I280_V0.8140.90
121_V127_L0.8100.90
304_V315_V0.8080.90
64_H425_P0.8080.90
28_I61_L0.8070.90
97_D103_G0.8050.90
413_T417_T0.8040.90
204_L243_S0.8030.90
264_G341_A0.8030.90
24_L54_V0.8010.90
392_A406_A0.7960.89
309_L344_I0.7940.89
64_H414_L0.7920.89
123_P139_L0.7900.89
411_E427_H0.7890.89
18_T321_T0.7880.89
14_L37_M0.7870.89
366_A395_T0.7870.89
96_L148_T0.7860.89
139_L148_T0.7860.89
367_M375_H0.7830.88
103_G109_K0.7820.88
438_A459_V0.7810.88
365_I474_T0.7800.88
369_A373_A0.7790.88
69_G75_K0.7780.88
125_D138_V0.7770.88
184_T188_I0.7750.88
75_K161_G0.7740.88
186_A193_L0.7740.88
93_K108_E0.7730.88
90_I149_E0.7730.88
445_L451_L0.7710.88
116_G170_S0.7710.88
130_D161_G0.7700.88
95_L109_K0.7680.88
208_R212_R0.7640.87
393_L416_L0.7640.87
236_M268_A0.7640.87
438_A475_R0.7630.87
371_Y375_H0.7610.87
412_R416_L0.7610.87
122_V141_V0.7580.87
24_L53_K0.7560.87
112_I116_G0.7550.87
82_K107_K0.7530.86
78_V162_I0.7520.86
408_S427_H0.7500.86
34_V66_A0.7500.86
124_G137_K0.7500.86
182_I210_L0.7490.86
381_A451_L0.7470.86
25_E56_E0.7450.86
40_S181_D0.7440.86
390_R394_M0.7430.86
130_D319_A0.7420.86
131_D161_G0.7410.86
58_A65_V0.7360.85
44_P180_A0.7360.85
411_E415_N0.7340.85
245_V279_A0.7320.85
221_V419_L0.7300.85
88_L134_V0.7290.85
240_I269_L0.7280.85
75_K229_A0.7230.84
258_G262_L0.7220.84
183_K186_A0.7200.84
58_A61_L0.7200.84
171_A175_T0.7200.84
236_M273_A0.7180.84
134_V150_V0.7170.84
131_D285_Q0.7140.83
286_M334_M0.7140.83
363_E394_M0.7140.83
443_N446_R0.7130.83
169_L172_E0.7120.83
18_T328_S0.7100.83
387_E430_S0.7100.83
86_V110_V0.7090.83
78_V81_F0.7020.82
39_F181_D0.7020.82
11_V32_A0.7020.82
166_G227_A0.6980.82
28_I58_A0.6980.82
14_L35_V0.6960.82
387_E410_H0.6950.82
186_A216_C0.6950.82
43_S159_N0.6940.82
386_T392_A0.6940.82
237_D268_A0.6930.82
54_V58_A0.6930.82
274_R313_D0.6920.82
340_G344_I0.6900.81
387_E409_R0.6880.81
459_V477_L0.6880.81
383_I451_L0.6870.81
133_R293_N0.6860.81
66_A415_N0.6840.81
306_N310_D0.6820.81
407_M445_L0.6820.81
384_T391_T0.6820.81
279_A419_L0.6790.80
442_V477_L0.6780.80
81_F110_V0.6780.80
92_D108_E0.6780.80
71_L226_R0.6770.80
165_L256_E0.6770.80
286_M315_V0.6740.80
224_V230_V0.6740.80
335_A338_C0.6740.80
183_K210_L0.6740.80
26_K30_A0.6720.80
373_A382_I0.6720.80
264_G344_I0.6710.79
362_E390_R0.6700.79
51_A54_V0.6690.79
241_L278_R0.6650.79
28_I54_V0.6650.79
23_N53_K0.6620.79
369_A458_I0.6610.78
134_V156_L0.6610.78
185_A193_L0.6580.78
308_V315_V0.6570.78
72_Q319_A0.6560.78
94_F105_G0.6560.78
446_R451_L0.6560.78
384_T392_A0.6550.78
103_G111_G0.6540.78
418_A425_P0.6540.78
414_L425_P0.6540.78
309_L345_P0.6540.78
323_A330_T0.6530.78
224_V236_M0.6530.78
92_D136_L0.6520.78
265_I268_A0.6520.78
10_I331_V0.6520.78
157_S323_A0.6510.77
81_F134_V0.6500.77
369_A460_T0.6500.77
376_L456_L0.6480.77
254_G295_M0.6480.77
20_R27_V0.6470.77
79_S113_D0.6450.77
95_L98_A0.6440.77
207_A220_I0.6440.77
114_Y117_L0.6440.77
102_K115_K0.6440.77
272_R275_Q0.6420.76
309_L341_A0.6420.76
173_A198_P0.6420.76
118_P144_M0.6410.76
71_L195_V0.6410.76
42_G46_D0.6400.76
268_A344_I0.6390.76
262_L301_V0.6390.76
192_Y420_Y0.6380.76
379_V476_I0.6380.76
14_L53_K0.6380.76
37_M47_H0.6360.76
410_H413_T0.6360.76
192_Y419_L0.6360.76
267_K306_N0.6350.76
372_A376_L0.6340.76
156_L159_N0.6330.75
185_A189_G0.6330.75
19_D24_L0.6310.75
469_G472_N0.6310.75
99_N102_K0.6310.75
29_A60_K0.6290.75
236_M246_V0.6290.75
404_I423_V0.6280.75
29_A63_R0.6280.75
247_M318_S0.6280.75
119_A144_M0.6270.75
189_G218_A0.6260.75
321_T334_M0.6260.75
96_L129_L0.6250.75
210_L213_D0.6240.74
19_D46_D0.6240.74
369_A382_I0.6240.74
229_A240_I0.6230.74
210_L214_A0.6230.74
41_H252_D0.6220.74
121_V138_V0.6220.74
264_G340_G0.6210.74
333_A337_V0.6200.74
90_I326_Y0.6190.74
39_F47_H0.6170.74
47_H185_A0.6170.74
10_I334_M0.6170.74
193_L211_A0.6150.73
206_Y210_L0.6120.73
374_N401_G0.6110.73
81_F105_G0.6100.73
85_K158_N0.6090.73
38_N41_H0.6080.73
381_A403_P0.6080.73
192_Y219_K0.6070.72
201_G224_V0.6070.72
274_R282_T0.6050.72
119_A170_S0.6050.72
399_S421_R0.6050.72
27_V328_S0.6040.72
94_F106_D0.6030.72
134_V154_G0.6020.72
88_L92_D0.5980.71
54_V65_V0.5970.71
287_M333_A0.5960.71
207_A210_L0.5960.71
460_T471_T0.5950.71
224_V269_L0.5940.71
277_N397_R0.5930.71
308_V341_A0.5920.71
362_E394_M0.5920.71
361_V384_T0.5920.71
424_T450_Y0.5920.71
114_Y199_R0.5900.70
369_A379_V0.5900.70
200_C235_A0.5890.70
6_R33_N0.5890.70
14_L19_D0.5890.70
174_L210_L0.5870.70
58_A63_R0.5870.70
94_F111_G0.5860.70
370_M400_S0.5850.70
76_I162_I0.5850.70
345_P350_S0.5850.70
34_V418_A0.5840.69
75_K171_A0.5840.69
219_K393_L0.5840.69
286_M318_S0.5840.69
279_A313_D0.5780.69
94_F150_V0.5770.69
277_N400_S0.5770.69
392_A425_P0.5770.69
431_A436_A0.5760.68
209_R212_R0.5760.68
78_V96_L0.5760.68
81_F85_K0.5750.68
360_N363_E0.5750.68
155_P292_T0.5740.68
385_M437_A0.5730.68
95_L144_M0.5720.68
134_V153_G0.5720.68
69_G184_T0.5710.68
314_A419_L0.5700.68
463_D475_R0.5700.68
321_T330_T0.5700.68
452_M455_D0.5690.68
395_T460_T0.5690.68
198_P222_A0.5680.67
27_V35_V0.5670.67
259_D302_M0.5650.67
333_A336_R0.5650.67
391_T462_G0.5640.67
24_L27_V0.5640.67
10_I335_A0.5620.67
202_E238_D0.5610.66
27_V32_A0.5600.66
97_D118_P0.5600.66
76_I177_K0.5600.66
458_I474_T0.5600.66
72_Q226_R0.5590.66
247_M316_M0.5560.66
58_A415_N0.5560.66
58_A64_H0.5550.66
95_L142_Q0.5540.65
51_A55_R0.5540.65
197_F252_D0.5530.65
120_D199_R0.5530.65
174_L182_I0.5520.65
200_C238_D0.5520.65
50_R53_K0.5510.65
406_A425_P0.5490.65
88_L129_L0.5490.65
195_V198_P0.5480.65
182_I215_G0.5470.64
125_D166_G0.5460.64
197_F256_E0.5460.64
179_K213_D0.5460.64
268_A271_R0.5450.64
432_N436_A0.5450.64
244_D278_R0.5450.64
400_S404_I0.5440.64
442_V451_L0.5440.64
14_L32_A0.5430.64
376_L458_I0.5420.64
286_M312_T0.5420.64
26_K107_K0.5410.64
33_N418_A0.5410.64
347_I351_K0.5400.64
329_E333_A0.5390.63
315_V335_A0.5390.63
130_D160_K0.5390.63
247_M283_A0.5380.63
171_A198_P0.5370.63
462_G471_T0.5370.63
94_F107_K0.5360.63
222_A246_V0.5360.63
48_K51_A0.5350.63
22_N26_K0.5350.63
88_L156_L0.5330.63
263_V421_R0.5330.63
462_G469_G0.5320.62
78_V160_K0.5320.62
94_F157_S0.5320.62
192_Y314_A0.5320.62
360_N394_M0.5310.62
281_I316_M0.5310.62
68_L192_Y0.5300.62
458_I476_I0.5290.62
434_G473_T0.5280.62
88_L94_F0.5280.62
405_F450_Y0.5280.62
208_R242_A0.5280.62
217_D410_H0.5280.62
128_L194_A0.5270.62
119_A141_V0.5270.62
92_D153_G0.5250.61
174_L207_A0.5240.61
173_A199_R0.5240.61
139_L142_Q0.5220.61
39_F190_V0.5220.61
261_E336_R0.5220.61
373_A379_V0.5210.61
40_S69_G0.5200.61
383_I407_M0.5180.60
22_N53_K0.5170.60
93_K137_K0.5170.60
252_D283_A0.5160.60
383_I445_L0.5160.60
161_G255_V0.5150.60
282_T311_G0.5140.60
408_S413_T0.5140.60
37_M42_G0.5140.60
14_L20_R0.5140.60
260_P340_G0.5130.60
39_F44_P0.5120.59
131_D322_A0.5120.59
71_L161_G0.5120.59
308_V363_E0.5110.59
394_M438_A0.5110.59
163_N175_T0.5100.59
224_V245_V0.5100.59
131_D252_D0.5100.59
202_E209_R0.5090.59
98_A143_G0.5090.59
6_R302_M0.5090.59
86_V92_D0.5080.59
112_I164_K0.5080.59
157_S160_K0.5080.59
43_S80_T0.5080.59
126_I166_G0.5080.59
245_V419_L0.5070.59
83_E107_K0.5070.59
389_G406_A0.5070.59
246_V276_L0.5070.59
18_T53_K0.5060.59
211_A219_K0.5060.59
19_D22_N0.5040.58
364_A368_S0.5040.58
461_Q475_R0.5040.58
141_V144_M0.5040.58
210_L215_G0.5030.58
431_A437_A0.5030.58
117_L127_L0.5030.58
397_R469_G0.5030.58
172_E206_Y0.5020.58
257_I261_E0.5020.58
429_D432_N0.5020.58
72_Q229_A0.5010.58
83_E106_D0.5010.58
43_S180_A0.5010.58
105_G109_K0.5000.58
135_Q152_V0.5000.58
376_L476_I0.5000.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3t05A 3 0.9771 100 0.14 Contact Map
2e28A 3 0.9812 100 0.141 Contact Map
3gr4A 4 0.9896 100 0.141 Contact Map
1a3wA 3 0.9792 100 0.147 Contact Map
3khdA 3 0.9896 100 0.147 Contact Map
3gg8A 3 0.9854 100 0.147 Contact Map
1e0tA 3 0.9229 100 0.148 Contact Map
4kctB 3 0.9896 100 0.166 Contact Map
4drsA 3 0.9625 100 0.179 Contact Map
3qtgA 3 0.9292 100 0.19 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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