GREMLIN Database
ACPH - Acyl carrier protein phosphodiesterase
UniProt: P21515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11095
Length: 193 (188)
Sequences: 745 (541)
Seq/√Len: 39.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
83_H170_Y5.2831.00
61_A81_W3.9141.00
86_S98_L3.7501.00
64_W176_R3.3731.00
8_H181_Y3.3441.00
131_Q134_V3.1931.00
84_F170_Y3.0621.00
79_V145_V2.9421.00
106_R131_Q2.8391.00
96_F104_Y2.6821.00
145_V148_G2.6751.00
76_T162_S2.4991.00
86_S102_V2.4821.00
13_A37_D2.4741.00
80_M166_L2.4521.00
44_M48_I2.3871.00
10_A16_S2.3841.00
7_L105_A2.3401.00
61_A176_R2.3091.00
55_L183_R2.2280.99
79_V149_M2.1770.99
52_T180_F2.1330.99
47_R187_Q2.1090.99
28_G46_R2.0630.99
144_N148_G1.9690.99
102_V134_V1.9170.98
88_H174_E1.8780.98
92_L178_W1.8690.98
51_L183_R1.8320.98
36_P40_A1.7410.97
20_N41_G1.7330.97
169_H172_A1.6680.96
57_E183_R1.6340.96
88_H178_W1.5920.95
57_E60_E1.5890.95
127_L132_W1.5800.95
182_P185_M1.5730.95
7_L21_L1.4950.93
50_V54_N1.4460.92
120_F124_N1.4250.91
2_N6_H1.4200.91
83_H125_N1.4080.91
31_E34_F1.3920.90
118_P171_D1.3800.90
37_D40_A1.3620.89
61_A173_L1.3460.89
138_D141_F1.3400.89
14_E111_T1.3390.89
69_T161_D1.3170.88
139_M167_D1.3160.88
93_S96_F1.2810.86
124_N128_W1.2790.86
16_S20_N1.2630.85
148_G151_S1.2620.85
27_R38_V1.2500.85
65_F73_A1.2470.85
122_N126_Y1.2440.85
87_R174_E1.2410.84
79_V142_I1.2330.84
45_H49_D1.2310.84
1_M6_H1.2260.84
91_Q178_W1.2210.83
5_A53_D1.1870.82
61_A64_W1.1850.81
31_E43_H1.1750.81
175_T179_Q1.1680.81
32_E39_V1.1640.80
51_L180_F1.1560.80
15_S37_D1.1530.80
77_L81_W1.1510.80
178_W182_P1.1250.78
164_Y167_D1.1060.77
64_W169_H1.1040.77
60_E179_Q1.0910.76
106_R132_W1.0830.75
10_A20_N1.0660.74
67_S188_A1.0480.73
60_E176_R1.0370.72
90_S171_D1.0060.70
34_F42_I1.0030.69
98_L102_V0.9930.69
76_T166_L0.9900.68
17_L105_A0.9840.68
58_V81_W0.9830.68
1_M4_L0.9770.67
18_S21_L0.9760.67
96_F179_Q0.9750.67
9_L185_M0.9740.67
65_F166_L0.9720.67
117_P148_G0.9690.67
57_E179_Q0.9630.66
49_D78_D0.9540.65
45_H78_D0.9500.65
29_N34_F0.9340.64
48_I162_S0.9120.62
62_R73_A0.9110.62
81_W176_R0.9110.62
171_D175_T0.9080.62
89_W177_F0.9070.62
123_L132_W0.9020.61
69_T165_D0.8960.61
165_D169_H0.8870.60
58_V158_A0.8790.59
25_F120_F0.8780.59
26_V42_I0.8760.59
80_M173_L0.8600.57
24_D45_H0.8520.57
100_E118_P0.8510.57
45_H53_D0.8450.56
23_A27_R0.8450.56
167_D171_D0.8430.56
91_Q99_Q0.8380.55
11_H44_M0.8330.55
24_D49_D0.8310.55
66_R165_D0.8310.55
65_F89_W0.8280.55
147_N160_R0.8270.54
51_L187_Q0.8220.54
49_D53_D0.8210.54
120_F125_N0.8200.54
95_D103_C0.8180.54
64_W173_L0.8180.54
80_M84_F0.8120.53
153_R157_D0.8120.53
153_R156_L0.7960.52
118_P122_N0.7960.52
110_M128_W0.7910.51
39_V43_H0.7890.51
75_I155_R0.7880.51
8_H185_M0.7870.51
164_Y168_A0.7860.51
15_S112_I0.7850.51
139_M166_L0.7830.50
18_S116_S0.7800.50
174_E178_W0.7780.50
126_Y130_E0.7700.49
171_D189_S0.7670.49
22_L117_P0.7640.49
65_F77_L0.7630.49
5_A52_T0.7590.48
74_P109_V0.7580.48
106_R110_M0.7550.48
113_L121_I0.7440.47
93_S98_L0.7410.47
26_V120_F0.7390.46
52_T58_V0.7380.46
8_H17_L0.7340.46
99_Q102_V0.7300.46
4_L98_L0.7280.45
30_P39_V0.7240.45
89_W92_L0.7210.45
145_V149_M0.7190.45
122_N171_D0.7180.45
70_R138_D0.7180.45
74_P137_R0.7170.44
185_M189_S0.7170.44
58_V184_M0.7140.44
34_F72_V0.7120.44
71_R173_L0.7120.44
86_S178_W0.7110.44
10_A13_A0.7070.44
90_S115_D0.6990.43
96_F107_E0.6970.43
100_E139_M0.6950.42
61_A65_F0.6930.42
143_Q146_L0.6930.42
37_D168_A0.6930.42
150_A165_D0.6910.42
69_T73_A0.6910.42
88_H177_F0.6900.42
59_R107_E0.6880.42
12_L15_S0.6870.42
105_A109_V0.6860.42
163_W167_D0.6840.41
34_F154_P0.6810.41
9_L58_V0.6810.41
54_N59_R0.6790.41
21_L89_W0.6760.41
149_M153_R0.6760.41
158_A161_D0.6740.41
36_P39_V0.6680.40
84_F174_E0.6660.40
18_S38_V0.6650.40
6_H9_L0.6620.40
88_H91_Q0.6610.39
72_V84_F0.6590.39
122_N168_A0.6590.39
157_D160_R0.6570.39
90_S99_Q0.6570.39
142_I146_L0.6560.39
39_V81_W0.6490.38
71_R75_I0.6420.38
57_E176_R0.6420.38
7_L133_L0.6410.38
97_P100_E0.6340.37
53_D78_D0.6340.37
84_F173_L0.6340.37
72_V153_R0.6340.37
26_V66_R0.6310.37
91_Q103_C0.6300.37
51_L55_L0.6280.37
142_I148_G0.6280.37
37_D186_A0.6260.36
125_N170_Y0.6250.36
71_R182_P0.6230.36
32_E145_V0.6230.36
11_H86_S0.6190.36
44_M188_A0.6190.36
20_N84_F0.6180.36
60_E168_A0.6170.36
25_F150_A0.6160.36
27_R46_R0.6160.36
4_L127_L0.6140.35
52_T184_M0.6100.35
83_H136_Y0.6060.35
65_F76_T0.6050.35
109_V120_F0.6040.35
80_M176_R0.6040.35
72_V181_Y0.6030.35
13_A16_S0.6020.34
61_A77_L0.6020.34
162_S180_F0.5970.34
18_S105_A0.5950.34
60_E175_T0.5940.34
7_L128_W0.5920.34
98_L101_F0.5910.34
23_A159_L0.5900.33
132_W152_R0.5880.33
38_V101_F0.5880.33
68_E164_Y0.5870.33
66_R71_R0.5860.33
150_A160_R0.5850.33
24_D78_D0.5850.33
7_L101_F0.5820.33
65_F80_M0.5790.33
26_V34_F0.5790.33
135_R138_D0.5740.32
75_I159_L0.5730.32
97_P119_R0.5720.32
84_F180_F0.5690.32
152_R159_L0.5680.32
15_S38_V0.5670.32
109_V131_Q0.5660.32
58_V137_R0.5570.31
143_Q163_W0.5550.31
32_E118_P0.5550.31
65_F69_T0.5550.31
100_E186_A0.5530.31
60_E100_E0.5510.30
7_L181_Y0.5510.30
86_S125_N0.5500.30
107_E121_I0.5490.30
106_R109_V0.5470.30
62_R70_R0.5460.30
16_S44_M0.5460.30
59_R62_R0.5450.30
88_H184_M0.5450.30
117_P150_A0.5450.30
147_N186_A0.5440.30
163_W166_L0.5360.29
59_R70_R0.5320.29
168_A175_T0.5270.29
62_R74_P0.5270.29
102_V149_M0.5240.28
47_R50_V0.5200.28
99_Q134_V0.5200.28
97_P179_Q0.5170.28
48_I146_L0.5160.28
1_M9_L0.5140.28
19_G24_D0.5120.27
159_L166_L0.5110.27
8_H65_F0.5110.27
23_A30_P0.5100.27
65_F71_R0.5090.27
32_E144_N0.5060.27
109_V128_W0.5050.27
91_Q104_Y0.5050.27
14_E17_L0.5030.27
72_V158_A0.5030.27
36_P43_H0.5020.27
10_A70_R0.5000.27
10_A15_S0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ebfX 1 0.9119 39 0.951 Contact Map
2jqtA 1 0.2642 18.9 0.958 Contact Map
1wa5C 1 0.8653 14.5 0.96 Contact Map
2bmbA 1 0.3523 8.6 0.964 Contact Map
1v54E 1 0.4663 6.2 0.966 Contact Map
4g3aA 1 0.4197 5.3 0.967 Contact Map
3rk6A 1 0.513 4.8 0.968 Contact Map
4n78D 1 0.2798 4.1 0.969 Contact Map
1ciyA 1 0.6321 3.8 0.969 Contact Map
1u8vA 3 0.7202 3.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0074 seconds.