GREMLIN Database
YAHA - Cyclic di-GMP phosphodiesterase YahA
UniProt: P21514 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11236
Length: 362 (352)
Sequences: 20076 (16071)
Seq/√Len: 856.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
140_C352_F3.8601.00
132_A338_L3.8001.00
174_R214_E3.3771.00
216_L255_H3.1061.00
173_T205_C3.0661.00
286_K290_Q2.8951.00
126_I183_I2.8381.00
230_V281_F2.7981.00
123_K147_E2.7811.00
16_T19_L2.7741.00
253_H280_D2.7641.00
178_K221_K2.7461.00
344_S347_V2.7271.00
131_C134_T2.5721.00
105_H158_Q2.5341.00
188_K228_K2.5281.00
329_L333_K2.4821.00
310_R336_H2.4151.00
185_M189_H2.3561.00
324_Q328_D2.3061.00
112_A148_H2.2561.00
327_A343_Y2.2141.00
183_I349_G2.2061.00
175_Q179_Q2.1861.00
260_A281_F2.1321.00
303_D311_K2.0991.00
148_H152_G2.0771.00
275_Q298_S2.0061.00
179_Q182_D1.9891.00
115_L119_N1.9601.00
163_A172_M1.9541.00
147_E153_I1.9391.00
321_V338_L1.9381.00
299_G329_L1.9031.00
144_V176_L1.8871.00
323_T326_Q1.8851.00
129_V337_F1.8711.00
179_Q183_I1.8211.00
181_A218_L1.8141.00
327_A338_L1.8131.00
123_K153_I1.8121.00
125_W348_P1.7991.00
120_H179_Q1.7971.00
230_V260_A1.7821.00
303_D333_K1.7771.00
106_H165_S1.7751.00
178_K218_L1.7581.00
201_V211_F1.7331.00
348_P351_K1.7271.00
281_F317_V1.7181.00
129_V281_F1.7101.00
225_D228_K1.7071.00
249_F259_F1.6961.00
183_I187_V1.6791.00
327_A331_I1.6771.00
196_H258_T1.6711.00
124_P176_L1.6671.00
184_L224_N1.6671.00
73_I76_W1.6371.00
130_F343_Y1.6341.00
303_D307_E1.6231.00
293_S299_G1.6221.00
218_L222_L1.6081.00
258_T280_D1.6041.00
178_K222_L1.5931.00
282_I309_A1.5871.00
71_S80_F1.5801.00
148_H151_T1.5701.00
306_V335_V1.5611.00
4_C7_R1.5611.00
324_Q342_L1.5601.00
129_V230_V1.5591.00
91_T97_R1.5491.00
125_W153_I1.5461.00
196_H230_V1.5451.00
219_V257_I1.5381.00
88_I97_R1.5211.00
327_A342_L1.5141.00
293_S325_E1.5111.00
315_S336_H1.5071.00
138_T337_F1.5061.00
8_V56_I1.4971.00
315_S337_F1.4911.00
286_K320_G1.4871.00
306_V333_K1.4751.00
190_L353_I1.4741.00
57_S62_Q1.4481.00
24_S30_R1.4461.00
122_F144_V1.4441.00
187_V349_G1.4301.00
201_V231_L1.4191.00
275_Q291_M1.4181.00
121_E148_H1.4071.00
8_V11_Q1.4011.00
261_L279_V1.4001.00
341_Y346_P1.3871.00
281_F315_S1.3721.00
144_V172_M1.3681.00
188_K225_D1.3601.00
5_D65_E1.3451.00
129_V139_G1.3381.00
293_S329_L1.3231.00
124_P175_Q1.3201.00
217_N221_K1.3121.00
182_D222_L1.3091.00
170_V208_A1.3091.00
246_R250_D1.2951.00
318_A335_V1.2851.00
186_P190_L1.2571.00
11_Q14_G1.2531.00
9_F52_S1.2451.00
180_T197_I1.2431.00
292_A329_L1.2431.00
121_E146_W1.2381.00
219_V226_K1.2321.00
82_Q86_E1.2311.00
4_C59_Q1.2251.00
87_I90_A1.2251.00
131_C138_T1.2191.00
214_E218_L1.2151.00
338_L343_Y1.2111.00
194_N228_K1.2091.00
309_A316_I1.2081.00
246_R276_A1.2001.00
105_H151_T1.1941.00
33_L44_E1.1911.00
184_L197_I1.1891.00
112_A151_T1.1891.00
151_T158_Q1.1851.00
8_V12_E1.1831.00
80_F104_Y1.1751.00
328_D331_I1.1741.00
216_L251_S1.1741.00
183_I186_P1.1711.00
87_I91_T1.1681.00
230_V258_T1.1641.00
115_L121_E1.1531.00
307_E311_K1.1521.00
76_W80_F1.1461.00
293_S323_T1.1441.00
135_G331_I1.1351.00
216_L220_N1.1311.00
129_V198_G1.1291.00
198_G230_V1.1291.00
212_E216_L1.1231.00
144_V175_Q1.1231.00
347_V351_K1.1221.00
87_I97_R1.1191.00
139_G196_H1.1191.00
131_C136_V1.1181.00
295_D298_S1.1141.00
51_R54_K1.1141.00
324_Q327_A1.1121.00
88_I95_S1.1061.00
38_Q41_S1.1031.00
4_C8_V1.1001.00
187_V353_I1.0991.00
132_A327_A1.0951.00
281_F337_F1.0841.00
250_D254_Q1.0821.00
178_K182_D1.0821.00
279_V314_L1.0771.00
185_M222_L1.0731.00
328_D332_G1.0671.00
49_R96_H1.0671.00
300_H311_K1.0651.00
108_V112_A1.0641.00
292_A302_V1.0641.00
207_L240_P1.0641.00
52_S67_L1.0591.00
185_M188_K1.0571.00
212_E251_S1.0531.00
215_C231_L1.0491.00
156_P159_F1.0451.00
122_F175_Q1.0371.00
215_C252_L1.0371.00
113_I163_A1.0361.00
149_P152_G1.0361.00
231_L257_I1.0351.00
329_L332_G1.0321.00
212_E248_I1.0241.00
304_N311_K1.0141.00
46_S50_N1.0141.00
248_I251_S1.0131.00
141_E200_N1.0121.00
109_T162_L1.0101.00
244_E248_I1.0081.00
166_S170_V1.0061.00
123_K348_P0.9991.00
184_L188_K0.9991.00
242_T277_F0.9971.00
306_V316_I0.9901.00
349_G353_I0.9851.00
129_V196_H0.9811.00
12_E56_I0.9771.00
129_V317_V0.9691.00
112_A150_Q0.9691.00
181_A229_L0.9661.00
164_E169_I0.9661.00
49_R69_I0.9641.00
36_L41_S0.9641.00
171_I174_R0.9631.00
203_A236_R0.9621.00
142_V197_I0.9611.00
180_T199_I0.9551.00
218_L221_K0.9531.00
38_Q42_V0.9531.00
120_H175_Q0.9511.00
133_Q336_H0.9501.00
239_I273_Y0.9491.00
110_P114_S0.9481.00
317_V337_F0.9441.00
26_S86_E0.9401.00
251_S254_Q0.9351.00
182_D186_P0.9341.00
131_C336_H0.9331.00
168_L171_I0.9331.00
7_R11_Q0.9331.00
185_M223_G0.9281.00
151_T154_I0.9271.00
118_E171_I0.9261.00
293_S326_Q0.9211.00
110_P166_S0.9201.00
13_F21_L0.9171.00
183_I353_I0.9161.00
157_D286_K0.9161.00
114_S168_L0.9151.00
68_G93_S0.9131.00
177_M218_L0.9091.00
99_I103_H0.9081.00
53_A94_N0.9051.00
140_C195_F0.9051.00
45_I69_I0.9051.00
210_G214_E0.9021.00
45_I96_H0.9011.00
66_K70_Q0.8991.00
124_P180_T0.8961.00
44_E47_Q0.8951.00
76_W79_I0.8921.00
208_A214_E0.8921.00
37_M41_S0.8911.00
160_I169_I0.8911.00
148_H154_I0.8911.00
83_Y103_H0.8901.00
27_E89_S0.8881.00
115_L118_E0.8881.00
211_F215_C0.8881.00
126_I349_G0.8881.00
120_H178_K0.8871.00
241_V244_E0.8851.00
66_K94_N0.8791.00
306_V310_R0.8691.00
114_S171_I0.8641.00
45_I49_R0.8631.00
50_N53_A0.8591.00
124_P142_V0.8581.00
126_I142_V0.8571.00
232_E283_K0.8561.00
177_M215_C0.8521.00
196_H228_K0.8521.00
126_I140_C0.8521.00
321_V330_M0.8511.00
174_R178_K0.8471.00
214_E217_N0.8451.00
116_A121_E0.8451.00
133_Q331_I0.8451.00
186_P349_G0.8371.00
57_S60_K0.8361.00
174_R218_L0.8361.00
247_A251_S0.8331.00
100_N103_H0.8241.00
186_P189_H0.8201.00
213_K251_S0.8191.00
128_P344_S0.8151.00
52_S56_I0.8141.00
121_E149_P0.8141.00
213_K217_N0.8131.00
124_P144_V0.8121.00
130_F137_L0.8101.00
250_D278_P0.8081.00
142_V180_T0.8081.00
25_V28_K0.8061.00
36_L42_V0.8041.00
170_V205_C0.8031.00
144_V159_F0.8021.00
91_T95_S0.7991.00
116_A122_F0.7991.00
321_V327_A0.7941.00
181_A224_N0.7891.00
28_K82_Q0.7881.00
163_A169_I0.7871.00
71_S77_R0.7841.00
10_L21_L0.7811.00
276_A297_I0.7801.00
135_G327_A0.7801.00
300_H303_D0.7801.00
113_I122_F0.7771.00
58_H63_L0.7761.00
15_T51_R0.7751.00
62_Q115_L0.7751.00
290_Q326_Q0.7741.00
275_Q301_I0.7741.00
307_E310_R0.7711.00
247_A250_D0.7691.00
291_M298_S0.7691.00
177_M199_I0.7671.00
244_E247_A0.7671.00
181_A222_L0.7651.00
258_T315_S0.7631.00
318_A330_M0.7621.00
330_M335_V0.7591.00
224_N229_L0.7521.00
128_P347_V0.7501.00
289_V292_A0.7471.00
291_M294_V0.7441.00
234_T263_D0.7431.00
110_P162_L0.7421.00
263_D319_E0.7401.00
299_G303_D0.7391.00
310_R316_I0.7341.00
264_F305_I0.7341.00
188_K194_N0.7311.00
242_T246_R0.7311.00
30_R78_D0.7281.00
246_R278_P0.7271.00
209_A244_E0.7231.00
117_L175_Q0.7201.00
5_D56_I0.7191.00
296_E299_G0.7121.00
80_F99_I0.7101.00
46_S49_R0.7071.00
341_Y345_P0.7061.00
192_P195_F0.7061.00
157_D161_P0.7041.00
70_Q84_N0.7011.00
347_V352_F0.7001.00
155_P158_Q0.6981.00
298_S326_Q0.6971.00
16_T44_E0.6971.00
92_G95_S0.6951.00
186_P353_I0.6901.00
16_T47_Q0.6891.00
108_V151_T0.6831.00
128_P137_L0.6821.00
166_S169_I0.6791.00
284_I335_V0.6771.00
19_L33_L0.6751.00
113_I116_A0.6711.00
9_F13_F0.6711.00
147_E152_G0.6701.00
330_M338_L0.6681.00
113_I168_L0.6661.00
258_T281_F0.6641.00
306_V330_M0.6641.00
178_K214_E0.6601.00
195_F228_K0.6581.00
49_R94_N0.6571.00
184_L228_K0.6561.00
229_L257_I0.6541.00
282_I314_L0.6541.00
289_V318_A0.6531.00
9_F56_I0.6521.00
322_E341_Y0.6491.00
242_T245_A0.6481.00
19_L44_E0.6481.00
206_F248_I0.6461.00
235_E265_G0.6441.00
299_G333_K0.6441.00
12_E55_T0.6431.00
135_G324_Q0.6391.00
291_M295_D0.6371.00
316_I336_H0.6371.00
206_F237_N0.6361.00
251_S255_H0.6361.00
200_N262_D0.6341.00
213_K216_L0.6341.00
125_W147_E0.6341.00
70_Q81_F0.6331.00
140_C197_I0.6321.00
14_G21_L0.6321.00
169_I204_G0.6291.00
43_T47_Q0.6221.00
261_L273_Y0.6221.00
4_C58_H0.6191.00
23_G27_E0.6181.00
130_F135_G0.6151.00
174_R205_C0.6141.00
212_E255_H0.6141.00
289_V302_V0.6141.00
296_E300_H0.6131.00
199_I229_L0.6121.00
219_V222_L0.6101.00
132_A331_I0.6091.00
122_F146_W0.6091.00
137_L344_S0.6081.00
2_N26_S0.6061.00
305_I309_A0.6051.00
64_F114_S0.6041.00
300_H304_N0.6001.00
187_V352_F0.5991.00
215_C218_L0.5971.00
163_A167_G0.5971.00
37_M40_M0.5971.00
139_G198_G0.5971.00
215_C257_I0.5961.00
197_I224_N0.5961.00
31_L48_Y0.5951.00
266_T288_F0.5951.00
99_I104_Y0.5941.00
113_I172_M0.5941.00
125_W346_P0.5941.00
184_L194_N0.5941.00
112_A146_W0.5901.00
174_R217_N0.5901.00
112_A115_L0.5891.00
114_S118_E0.5881.00
141_E283_K0.5871.00
188_K191_L0.5851.00
170_V174_R0.5831.00
204_G207_L0.5811.00
109_T112_A0.5801.00
12_E51_R0.5801.00
58_H61_K0.5791.00
39_G42_V0.5781.00
49_R53_A0.5781.00
266_T287_S0.5771.00
11_Q15_T0.5761.00
147_E151_T0.5751.00
107_I111_E0.5721.00
177_M181_A0.5721.00
143_L200_N0.5711.00
86_E89_S0.5701.00
322_E326_Q0.5701.00
224_N228_K0.5691.00
203_A237_N0.5691.00
55_T62_Q0.5681.00
184_L229_L0.5681.00
242_T276_A0.5671.00
309_A314_L0.5671.00
83_Y104_Y0.5661.00
231_L259_F0.5661.00
248_I252_L0.5651.00
275_Q295_D0.5641.00
72_D76_W0.5641.00
259_F280_D0.5631.00
68_G88_I0.5621.00
87_I103_H0.5611.00
2_N6_F0.5591.00
177_M201_V0.5591.00
82_Q85_P0.5581.00
123_K179_Q0.5581.00
284_I305_I0.5561.00
7_R10_L0.5561.00
272_R287_S0.5551.00
304_N308_L0.5551.00
325_E328_D0.5541.00
20_S32_L0.5541.00
252_L257_I0.5511.00
141_E262_D0.5501.00
174_R210_G0.5501.00
135_G343_Y0.5481.00
23_G26_S0.5471.00
219_V224_N0.5471.00
174_R208_A0.5471.00
105_H109_T0.5461.00
273_Y276_A0.5461.00
124_P179_Q0.5451.00
123_K350_N0.5451.00
250_D253_H0.5431.00
120_H182_D0.5421.00
227_I258_T0.5421.00
49_R67_L0.5411.00
185_M224_N0.5411.00
217_N220_N0.5401.00
273_Y277_F0.5401.00
292_A330_M0.5401.00
304_N307_E0.5381.00
167_G204_G0.5381.00
181_A219_V0.5381.00
164_E236_R0.5381.00
210_G213_K0.5361.00
111_E115_L0.5361.00
275_Q297_I0.5361.00
154_I161_P0.5341.00
25_V86_E0.5331.00
117_L172_M0.5321.00
20_S34_K0.5311.00
234_T319_E0.5311.00
113_I146_W0.5301.00
343_Y346_P0.5281.00
97_R103_H0.5281.00
226_K257_I0.5271.00
200_N283_K0.5271.00
173_T176_L0.5271.00
308_L312_P0.5271.00
209_A248_I0.5251.00
172_M176_L0.5251.00
112_A149_P0.5241.00
56_I65_E0.5241.00
239_I242_T0.5231.00
173_T202_S0.5221.00
220_N255_H0.5211.00
211_F214_E0.5201.00
164_E202_S0.5201.00
203_A239_I0.5191.00
239_I245_A0.5191.00
302_V318_A0.5181.00
46_S96_H0.5161.00
108_V150_Q0.5141.00
249_F278_P0.5141.00
259_F279_V0.5141.00
243_P276_A0.5131.00
296_E313_G0.5121.00
130_F344_S0.5121.00
350_N353_I0.5111.00
184_L222_L0.5111.00
71_S76_W0.5111.00
243_P247_A0.5101.00
299_G332_G0.5101.00
177_M214_E0.5091.00
331_I338_L0.5061.00
170_V204_G0.5061.00
42_V45_I0.5051.00
108_V111_E0.5041.00
297_I313_G0.5021.00
203_A273_Y0.5021.00
253_H259_F0.5011.00
205_C211_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4rnhA 2 0.9862 100 0.091 Contact Map
4j40A 2 0.6878 100 0.106 Contact Map
3pjxA 1 0.9392 100 0.124 Contact Map
4hjfA 1 0.7072 100 0.191 Contact Map
3gfzA 2 0.9006 100 0.236 Contact Map
4kieA 1 0.721 100 0.264 Contact Map
4hu4A 1 0.674 100 0.269 Contact Map
2r6oA 2 0.7072 100 0.275 Contact Map
4rniA 2 0.6961 100 0.275 Contact Map
3sy8A 6 0.8978 100 0.287 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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