GREMLIN Database
SRMB - ATP-dependent RNA helicase SrmB
UniProt: P21507 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10975
Length: 444 (359)
Sequences: 38378 (21923)
Seq/√Len: 1157.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_L96_A4.3771.00
62_A79_I3.8981.00
38_A185_L3.4641.00
276_C299_V3.2141.00
293_R298_R3.1641.00
83_T92_V3.0291.00
292_K296_E2.7711.00
289_E293_R2.7341.00
258_R281_E2.6881.00
255_V261_V2.6581.00
132_A137_L2.6481.00
30_I46_G2.5871.00
265_A275_N2.5181.00
274_N300_N2.5071.00
93_S97_R2.4671.00
21_D102_H2.4381.00
276_C293_R2.4241.00
240_V271_A2.4121.00
262_H277_Y2.3181.00
265_A277_Y2.3071.00
265_A269_R2.2671.00
168_A171_I2.2471.00
108_A127_Q2.2201.00
140_Y145_N2.2011.00
336_I348_A2.1791.00
168_A172_E2.1771.00
42_R208_V2.1341.00
93_S107_I2.1231.00
255_V264_L2.0561.00
251_S319_H2.0031.00
255_V303_V1.9971.00
78_R152_E1.9851.00
273_I301_V1.9731.00
288_N292_K1.9611.00
106_D128_D1.9461.00
249_T318_S1.9261.00
93_S109_T1.9211.00
261_V279_E1.8991.00
276_C290_A1.8891.00
169_Q172_E1.8821.00
260_R324_D1.8811.00
79_I153_T1.8731.00
65_H153_T1.8581.00
95_H98_E1.8551.00
167_F171_I1.8191.00
304_A308_A1.8031.00
267_W271_A1.7971.00
159_A186_L1.7951.00
319_H349_I1.7941.00
238_L241_H1.7811.00
283_V286_K1.7751.00
268_L303_V1.7691.00
325_M350_S1.7331.00
224_Q336_I1.7271.00
24_F56_A1.7251.00
115_A118_N1.7231.00
236_T267_W1.7151.00
96_A129_I1.7041.00
261_V277_Y1.6991.00
64_Q68_D1.6731.00
223_H347_T1.6681.00
58_Y187_F1.6511.00
308_A312_I1.6381.00
225_W347_T1.6361.00
322_N336_I1.6281.00
38_A44_V1.6141.00
197_Q201_E1.6121.00
58_Y155_I1.6031.00
39_L64_Q1.5931.00
172_E202_R1.5801.00
76_P150_A1.5741.00
316_D344_R1.5651.00
46_G187_F1.5551.00
90_M288_N1.5531.00
250_R316_D1.5531.00
170_D173_H1.5501.00
117_M121_E1.5301.00
160_D310_R1.5211.00
78_R128_D1.5181.00
264_L323_F1.5161.00
62_A155_I1.4981.00
251_S321_F1.4841.00
260_R263_E1.4771.00
224_Q332_Y1.4731.00
34_A57_A1.4681.00
257_K260_R1.4571.00
251_S301_V1.4541.00
88_L311_G1.4501.00
239_L323_F1.4481.00
239_L321_F1.4461.00
49_P52_T1.4371.00
96_A107_I1.4361.00
320_V339_T1.4361.00
219_R222_I1.4351.00
37_P44_V1.4331.00
161_R164_D1.4311.00
32_A36_P1.4281.00
326_P332_Y1.4251.00
62_A153_T1.4221.00
360_L364_G1.4101.00
90_M94_D1.4061.00
154_L184_T1.3991.00
244_K271_A1.3851.00
282_M290_A1.3741.00
240_V244_K1.3731.00
108_A122_V1.3721.00
138_L173_H1.3711.00
197_Q209_E1.3691.00
94_D98_E1.3621.00
89_A109_T1.3561.00
322_N350_S1.3551.00
265_A303_V1.3461.00
142_K173_H1.3401.00
269_R275_N1.3371.00
80_L151_V1.3321.00
21_D101_K1.3301.00
37_P208_V1.3011.00
83_T89_A1.2931.00
322_N335_R1.2881.00
264_L303_V1.2871.00
38_A61_P1.2871.00
82_L132_A1.2841.00
82_L137_L1.2841.00
169_Q173_H1.2781.00
19_L24_F1.2751.00
127_Q130_V1.2731.00
65_H152_E1.2701.00
290_A299_V1.2681.00
22_K98_E1.2601.00
108_A130_V1.2401.00
293_R299_V1.2271.00
20_Q25_T1.2251.00
242_L349_I1.2201.00
141_I177_E1.2111.00
241_H245_Q1.2051.00
286_K290_A1.2021.00
121_E124_S1.1941.00
319_H347_T1.1921.00
328_S331_T1.1881.00
253_V301_V1.1871.00
261_V303_V1.1861.00
37_P40_D1.1801.00
173_H177_E1.1761.00
224_Q227_Y1.1761.00
286_K289_E1.1631.00
195_A198_D1.1571.00
250_R297_G1.1521.00
235_K324_D1.1461.00
248_A251_S1.1451.00
154_L175_A1.1391.00
175_A178_T1.1361.00
242_L321_F1.1331.00
95_H313_D1.1321.00
66_L79_I1.1281.00
262_H279_E1.1281.00
171_I174_I1.1241.00
278_L308_A1.1221.00
29_A33_A1.1211.00
238_L242_L1.1161.00
93_S131_V1.1151.00
94_D97_R1.1111.00
58_Y92_V1.1001.00
55_T92_V1.0971.00
96_A131_V1.0931.00
294_L302_L1.0891.00
374_R378_E1.0691.00
242_L245_Q1.0681.00
77_P152_E1.0671.00
222_I340_A1.0651.00
282_M286_K1.0631.00
35_I39_L1.0611.00
279_E282_M1.0551.00
375_V378_E1.0541.00
119_H122_V1.0541.00
240_V267_W1.0491.00
63_L100_A1.0461.00
65_H183_Q1.0441.00
48_A52_T1.0391.00
236_T271_A1.0381.00
278_L307_V1.0301.00
172_E176_G1.0241.00
237_A240_V1.0231.00
244_K273_I1.0211.00
290_A302_L1.0171.00
236_T240_V1.0111.00
117_M120_A1.0091.00
120_A124_S1.0021.00
47_S211_S1.0011.00
377_D380_R0.9961.00
378_E381_P0.9961.00
236_T323_F0.9891.00
359_L362_K0.9841.00
225_W228_R0.9841.00
289_E292_K0.9831.00
120_A145_N0.9711.00
261_V265_A0.9701.00
357_H361_G0.9691.00
41_G183_Q0.9681.00
36_P40_D0.9651.00
266_N269_R0.9641.00
248_A300_N0.9471.00
173_H176_G0.9471.00
297_G300_N0.9431.00
29_A32_A0.9371.00
34_A46_G0.9341.00
91_Q313_D0.9301.00
138_L170_D0.9281.00
66_L128_D0.9271.00
259_E263_E0.9261.00
57_A61_P0.9261.00
273_I300_N0.9261.00
26_R32_A0.9241.00
44_V185_L0.9241.00
266_N270_E0.9231.00
224_Q229_A0.9221.00
56_A95_H0.9161.00
46_G185_L0.9161.00
171_I175_A0.9151.00
362_K365_R0.9121.00
254_F335_R0.9001.00
362_K366_Y0.8991.00
242_L319_H0.8901.00
200_A204_L0.8891.00
378_E382_K0.8881.00
89_A131_V0.8881.00
167_F170_D0.8871.00
43_D205_E0.8831.00
292_K295_T0.8821.00
243_L251_S0.8801.00
116_Y120_A0.8781.00
226_Y229_A0.8761.00
167_F172_E0.8721.00
139_Q143_E0.8711.00
221_K345_K0.8681.00
224_Q228_R0.8661.00
267_W270_E0.8651.00
189_A337_G0.8651.00
198_D201_E0.8641.00
253_V321_F0.8621.00
116_Y143_E0.8601.00
252_I304_A0.8581.00
153_T183_Q0.8571.00
230_D234_H0.8551.00
377_D381_P0.8501.00
214_P217_R0.8491.00
79_I155_I0.8491.00
66_L105_L0.8481.00
361_G364_G0.8441.00
364_G368_E0.8421.00
62_A96_A0.8381.00
88_L91_Q0.8361.00
119_H123_F0.8361.00
309_A331_T0.8351.00
236_T263_E0.8321.00
160_D334_H0.8291.00
62_A129_I0.8241.00
213_N216_T0.8231.00
322_N326_P0.8221.00
95_H99_L0.8201.00
306_D335_R0.8201.00
284_Q288_N0.8171.00
41_G65_H0.8151.00
153_T185_L0.8141.00
196_I200_A0.8141.00
291_I314_I0.8081.00
79_I129_I0.8061.00
326_P335_R0.8041.00
357_H360_L0.7971.00
374_R381_P0.7941.00
239_L264_L0.7931.00
37_P42_R0.7931.00
371_I375_V0.7911.00
35_I60_L0.7901.00
374_R377_D0.7891.00
168_A175_A0.7871.00
33_A37_P0.7861.00
80_L154_L0.7841.00
110_I119_H0.7831.00
290_A293_R0.7801.00
81_I96_A0.7781.00
56_A60_L0.7781.00
256_R327_R0.7781.00
218_E221_K0.7761.00
118_N121_E0.7711.00
294_L317_V0.7701.00
243_L273_I0.7701.00
192_E196_I0.7691.00
114_V119_H0.7661.00
360_L371_I0.7621.00
238_L351_L0.7601.00
239_L253_V0.7591.00
138_L142_K0.7591.00
363_V367_I0.7591.00
118_N122_V0.7571.00
50_T189_A0.7541.00
190_T334_H0.7541.00
42_R206_D0.7531.00
134_T156_L0.7521.00
234_H237_A0.7501.00
64_Q67_L0.7491.00
85_T310_R0.7481.00
132_A146_F0.7481.00
61_P153_T0.7471.00
148_C151_V0.7471.00
155_I185_L0.7471.00
223_H345_K0.7451.00
377_D382_K0.7451.00
285_G289_E0.7421.00
360_L363_V0.7421.00
67_L78_R0.7411.00
197_Q200_A0.7381.00
317_V339_T0.7381.00
364_G370_P0.7381.00
120_A140_Y0.7371.00
237_A241_H0.7371.00
45_L191_L0.7371.00
67_L103_T0.7361.00
179_R182_K0.7361.00
262_H266_N0.7321.00
274_N299_V0.7311.00
363_V366_Y0.7311.00
193_G198_D0.7291.00
90_M109_T0.7211.00
310_R334_H0.7181.00
235_K242_L0.7181.00
306_D331_T0.7141.00
43_D184_T0.7071.00
250_R300_N0.7071.00
171_I178_T0.7061.00
19_L56_A0.7061.00
34_A38_A0.7051.00
235_K238_L0.7031.00
167_F174_I0.7021.00
63_L67_L0.7001.00
136_R139_Q0.6981.00
240_V273_I0.6971.00
37_P210_V0.6961.00
36_P39_L0.6951.00
172_E175_A0.6941.00
375_V379_L0.6931.00
204_L207_P0.6931.00
46_G57_A0.6921.00
212_A216_T0.6901.00
76_P128_D0.6901.00
227_Y238_L0.6871.00
368_E371_I0.6851.00
295_T316_D0.6831.00
111_T114_V0.6821.00
364_G367_I0.6811.00
161_R310_R0.6801.00
291_I294_L0.6761.00
250_R294_L0.6751.00
250_R318_S0.6751.00
241_H244_K0.6751.00
90_M111_T0.6731.00
86_R113_G0.6731.00
105_L128_D0.6721.00
50_T337_G0.6711.00
92_V131_V0.6711.00
278_L282_M0.6681.00
141_I148_C0.6681.00
253_V323_F0.6671.00
62_A81_I0.6661.00
252_I302_L0.6651.00
364_G371_I0.6641.00
237_A267_W0.6641.00
348_A352_V0.6631.00
30_I48_A0.6631.00
100_A107_I0.6621.00
358_L362_K0.6621.00
60_L63_L0.6611.00
295_T315_P0.6611.00
100_A103_T0.6591.00
291_I295_T0.6551.00
379_L383_T0.6551.00
237_A271_A0.6491.00
252_I317_V0.6481.00
346_G353_E0.6481.00
211_S215_S0.6471.00
83_T133_T0.6471.00
119_H140_Y0.6451.00
260_R323_F0.6431.00
356_D360_L0.6431.00
85_T135_G0.6411.00
188_S191_L0.6401.00
211_S214_P0.6391.00
380_R383_T0.6381.00
262_H281_E0.6371.00
374_R379_L0.6361.00
236_T264_L0.6361.00
263_E267_W0.6351.00
365_R368_E0.6351.00
119_H136_R0.6291.00
121_E125_E0.6271.00
360_L370_P0.6271.00
379_L382_K0.6261.00
229_A238_L0.6261.00
216_T220_K0.6251.00
287_R291_I0.6201.00
106_D126_N0.6201.00
217_R220_K0.6191.00
169_Q174_I0.6181.00
170_D174_I0.6171.00
346_G349_I0.6161.00
274_N293_R0.6161.00
258_R262_H0.6161.00
58_Y83_T0.6141.00
174_I178_T0.6101.00
208_V211_S0.6101.00
80_L132_A0.6091.00
43_D186_L0.6091.00
77_P151_V0.6081.00
369_E372_K0.6081.00
65_H68_D0.6071.00
353_E356_D0.6061.00
253_V303_V0.6041.00
277_Y290_A0.6031.00
256_R260_R0.6001.00
210_V216_T0.6001.00
110_I130_V0.6001.00
170_D175_A0.5991.00
107_I110_I0.5981.00
297_G316_D0.5951.00
96_A100_A0.5951.00
318_S344_R0.5941.00
208_V213_N0.5931.00
358_L361_G0.5921.00
225_W230_D0.5901.00
109_T112_G0.5901.00
97_R101_K0.5901.00
254_F320_V0.5901.00
77_P150_A0.5871.00
322_N325_M0.5851.00
236_T239_L0.5841.00
338_R341_R0.5831.00
114_V122_V0.5821.00
47_S191_L0.5821.00
116_Y119_H0.5811.00
208_V212_A0.5811.00
56_A99_L0.5781.00
90_M93_S0.5761.00
256_R324_D0.5761.00
371_I374_R0.5751.00
364_G373_A0.5751.00
43_D183_Q0.5721.00
78_R150_A0.5711.00
253_V264_L0.5711.00
114_V118_N0.5691.00
45_L186_L0.5691.00
250_R317_V0.5671.00
58_Y61_P0.5661.00
213_N217_R0.5651.00
277_Y282_M0.5641.00
272_G275_N0.5621.00
43_D204_L0.5621.00
207_P210_V0.5601.00
116_Y140_Y0.5591.00
176_G204_L0.5591.00
376_I380_R0.5581.00
374_R380_R0.5571.00
235_K239_L0.5551.00
175_A182_K0.5531.00
367_I370_P0.5521.00
169_Q176_G0.5491.00
87_E278_L0.5491.00
214_P218_E0.5481.00
225_W349_I0.5461.00
218_E222_I0.5451.00
249_T319_H0.5431.00
216_T219_R0.5431.00
89_A111_T0.5411.00
63_L103_T0.5411.00
19_L23_G0.5391.00
159_A191_L0.5391.00
132_A136_R0.5391.00
192_E195_A0.5391.00
28_T342_A0.5381.00
226_Y230_D0.5381.00
94_D295_T0.5381.00
280_G287_R0.5371.00
278_L304_A0.5371.00
48_A57_A0.5351.00
156_L171_I0.5351.00
160_D163_L0.5341.00
221_K340_A0.5331.00
258_R279_E0.5331.00
359_L364_G0.5321.00
366_Y369_E0.5321.00
243_L268_L0.5321.00
361_G365_R0.5281.00
122_V127_Q0.5271.00
376_I381_P0.5271.00
231_D234_H0.5261.00
60_L99_L0.5261.00
211_S217_R0.5261.00
78_R130_V0.5251.00
34_A37_P0.5251.00
97_R107_I0.5241.00
276_C302_L0.5231.00
212_A217_R0.5211.00
246_P249_T0.5211.00
275_N303_V0.5211.00
94_D292_K0.5191.00
168_A176_G0.5181.00
322_N348_A0.5181.00
259_E262_H0.5181.00
367_I371_I0.5171.00
235_K323_F0.5171.00
59_L107_I0.5171.00
222_I348_A0.5171.00
224_Q231_D0.5151.00
332_Y336_I0.5141.00
352_V360_L0.5141.00
337_G340_A0.5131.00
171_I176_G0.5131.00
163_L198_D0.5121.00
366_Y370_P0.5121.00
376_I379_L0.5121.00
252_I339_T0.5111.00
27_P35_I0.5111.00
172_E178_T0.5101.00
27_P60_L0.5091.00
290_A294_L0.5081.00
87_E307_V0.5081.00
311_G338_R0.5071.00
363_V368_E0.5071.00
299_V302_L0.5061.00
86_R284_Q0.5061.00
50_T61_P0.5061.00
154_L182_K0.5051.00
223_H226_Y0.5051.00
359_L363_V0.5041.00
254_F339_T0.5041.00
198_D202_R0.5021.00
209_E212_A0.5021.00
68_D78_R0.5011.00
35_I61_P0.5001.00
260_R264_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4pxaA 1 0.8581 100 0.278 Contact Map
4c9bA 1 0.8446 100 0.278 Contact Map
4nhoA 1 0.8446 100 0.28 Contact Map
4ljyA 1 0.8874 100 0.28 Contact Map
3eiqA 1 0.8018 100 0.288 Contact Map
2db3A 1 0.8468 100 0.292 Contact Map
4d25A 1 0.8491 100 0.292 Contact Map
1fuuA 2 0.8401 100 0.298 Contact Map
1s2mA 1 0.8491 100 0.3 Contact Map
3fmpB 1 0.4617 100 0.303 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0126 seconds.