GREMLIN Database
RNR - Ribonuclease R
UniProt: P21499 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11259
Length: 813 (693)
Sequences: 3636 (2230)
Seq/√Len: 84.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
261_V369_K4.9951.00
360_S364_R4.8371.00
349_D376_S4.6371.00
648_K707_E4.5391.00
244_Q311_P4.3381.00
108_L139_A4.1321.00
195_E209_K3.9781.00
274_E384_T3.8181.00
264_R349_D3.7241.00
646_V707_E3.6391.00
238_P241_V3.4741.00
286_E294_R3.4661.00
290_G358_T3.4331.00
292_G358_T3.3291.00
239_Q243_Q3.1621.00
266_L286_E3.1051.00
352_C375_M3.0241.00
123_Q146_V2.8721.00
298_A354_V2.8631.00
482_L613_G2.8591.00
464_I560_L2.7041.00
564_A578_L2.6391.00
87_G99_L2.6391.00
268_L375_M2.6281.00
108_L126_A2.5671.00
307_R310_T2.5651.00
372_E583_K2.5541.00
709_R723_S2.5481.00
156_Y163_G2.5391.00
156_Y183_I2.5091.00
102_E123_Q2.4971.00
111_S114_Q2.4851.00
649_G661_V2.4821.00
706_V724_L2.4751.00
125_L143_R2.4601.00
387_W391_Q2.4431.00
651_I700_Y2.3891.00
268_L378_H2.3571.00
387_W453_N2.3401.00
283_V459_I2.3391.00
261_V371_Y2.3321.00
356_E371_Y2.3251.00
89_V115_M2.3241.00
294_R356_E2.3231.00
256_A259_G2.2781.00
127_Q140_R2.2741.00
345_N348_V2.2681.00
253_P256_A2.2631.00
323_V623_A2.2311.00
321_T619_A2.2161.00
212_E229_R2.2151.00
659_F672_V2.2091.00
679_N682_Y2.2071.00
485_I549_D2.2011.00
317_R612_L2.1911.00
439_N443_R2.1761.00
77_A82_L2.1701.00
648_K705_R2.1381.00
303_S576_L2.1271.00
320_G619_A2.1251.00
190_F216_D2.1251.00
241_V315_E2.1211.00
288_K292_G2.1121.00
154_G165_V2.0961.00
487_D553_R2.0701.00
358_T367_G2.0661.00
86_K123_Q2.0631.00
296_W356_E2.0561.00
352_C373_A2.0491.00
372_E587_A2.0471.00
646_V709_R2.0451.00
275_D435_K2.0431.00
263_L356_E2.0351.00
485_I553_R2.0271.00
99_L110_L2.0141.00
501_L535_L1.9951.00
528_D532_A1.9881.00
419_K423_E1.9881.00
397_R408_E1.9721.00
354_V373_A1.9621.00
683_R694_E1.9581.00
168_D191_V1.9531.00
468_I560_L1.9501.00
246_A336_V1.9451.00
711_E723_S1.9171.00
250_E336_V1.9171.00
238_P315_E1.9091.00
292_G361_S1.9011.00
672_V706_V1.8921.00
179_P182_Q1.8531.00
182_Q209_K1.8391.00
574_P616_C1.8261.00
614_Q618_M1.8261.00
359_V465_L1.8241.00
657_F671_L1.8121.00
642_Q645_N1.8091.00
354_V371_Y1.7961.00
321_T574_P1.7931.00
415_K454_D1.7901.00
482_L577_T1.7861.00
317_R615_H1.7681.00
123_Q145_L1.7651.00
245_V336_V1.7601.00
657_F660_F1.7581.00
279_F380_R1.7571.00
176_I208_G1.7551.00
151_Q195_E1.7541.00
244_Q310_T1.7411.00
86_K125_L1.7381.00
482_L616_C1.7371.00
287_K412_N1.7351.00
194_V208_G1.7221.00
288_K294_R1.7151.00
268_L352_C1.7121.00
298_A373_A1.6981.00
359_V365_L1.6961.00
674_V691_L1.6961.00
497_F539_L1.6821.00
453_N456_H1.6761.00
619_A622_R1.6711.00
267_P406_H1.6681.00
296_W354_V1.6551.00
90_I100_R1.6501.00
634_L637_D1.6501.00
326_P630_V1.6461.00
411_H415_K1.6431.00
276_A279_F1.6371.00
292_G366_T1.6341.00
285_C409_E1.6251.00
680_D693_G1.6231.00
284_Y298_A1.6181.00
267_P378_H1.6161.00
346_P377_S1.6131.00
364_R420_A1.6111.00
126_A141_I1.6051.00
288_K291_G1.5931.00
389_I404_V1.5891.00
287_K409_E1.5851.00
40_L55_L1.5821.00
651_I659_F1.5681.00
437_I448_E1.5571.00
636_C713_V1.5531.00
197_T209_K1.5401.00
62_M67_Q1.5301.00
347_Q376_S1.5291.00
497_F501_L1.5191.00
257_K264_R1.5181.00
263_L373_A1.5080.99
418_D461_E1.5060.99
385_K399_Q1.4870.99
248_L341_L1.4870.99
285_C410_L1.4850.99
439_N445_E1.4820.99
411_H414_Y1.4810.99
165_V210_I1.4680.99
664_D705_R1.4660.99
443_R637_D1.4600.99
152_I194_V1.4490.99
99_L126_A1.4470.99
524_E527_A1.4440.99
269_V406_H1.4410.99
297_V357_M1.4400.99
713_V720_I1.4380.99
538_M689_Q1.4320.99
257_K374_V1.4300.99
357_M469_S1.4290.99
670_G722_F1.4250.99
379_A399_Q1.4250.99
271_I458_L1.4210.99
358_T366_T1.4200.99
288_K358_T1.4110.99
294_R358_T1.4090.99
418_D457_K1.4060.99
313_D573_Y1.4020.99
545_Q621_R1.4010.99
365_L469_S1.4010.99
437_I446_R1.3980.99
640_L715_M1.3980.99
615_H619_A1.3940.99
46_I55_L1.3880.99
293_W409_E1.3770.99
88_T123_Q1.3760.99
368_Y473_F1.3730.99
150_S195_E1.3690.99
227_A633_W1.3680.99
164_F175_D1.3640.99
487_D547_I1.3640.99
191_V226_I1.3630.99
335_E339_N1.3630.99
340_G345_N1.3610.99
89_V97_G1.3580.99
398_E401_A1.3570.99
313_D580_R1.3560.99
659_F677_L1.3430.99
390_L408_E1.3430.99
370_F469_S1.3420.99
283_V410_L1.3340.99
682_Y693_G1.3310.99
584_Y601_G1.3240.99
385_K400_Y1.3220.99
368_Y469_S1.3200.99
685_D688_G1.3180.99
410_L462_C1.3120.99
290_G366_T1.3110.99
355_C469_S1.3100.99
353_M372_E1.3100.99
387_W456_H1.3070.99
244_Q307_R1.3070.99
59_L76_Y1.3070.99
409_E412_N1.3060.99
353_M583_K1.3020.98
353_M582_I1.3020.98
320_G616_C1.3020.98
199_R206_A1.3000.98
712_A721_D1.2970.98
273_G386_V1.2950.98
654_V659_F1.2930.98
284_Y296_W1.2880.98
310_T314_R1.2880.98
321_T623_A1.2880.98
706_V725_I1.2820.98
98_F107_D1.2810.98
365_L465_L1.2800.98
418_D422_E1.2800.98
355_C370_F1.2790.98
521_E525_S1.2760.98
268_L298_A1.2710.98
228_L330_I1.2680.98
682_Y698_Q1.2670.98
646_V725_I1.2660.98
351_L374_V1.2640.98
99_L124_V1.2590.98
381_L403_L1.2530.98
169_D230_T1.2520.98
564_A581_A1.2460.98
690_R699_T1.2420.98
360_S366_T1.2360.98
193_V212_E1.2360.98
658_G671_L1.2340.98
293_W416_V1.2300.98
636_C720_I1.2280.98
501_L506_L1.2270.98
165_V192_V1.2260.98
506_L531_D1.2240.98
473_F477_A1.2190.98
404_V408_E1.2120.98
526_V535_L1.2060.98
287_K361_S1.2050.97
288_K366_T1.2020.97
156_Y165_V1.2010.97
382_T385_K1.1970.97
583_K587_A1.1950.97
91_G115_M1.1940.97
315_E318_N1.1900.97
118_C141_I1.1890.97
323_V626_A1.1880.97
97_G141_I1.1870.97
165_V194_V1.1860.97
264_R374_V1.1840.97
231_H629_D1.1840.97
390_L411_H1.1810.97
28_L68_L1.1780.97
230_T629_D1.1770.97
490_S544_K1.1770.97
124_V141_I1.1750.97
414_Y461_E1.1750.97
411_H454_D1.1700.97
274_E385_K1.1650.97
709_R725_I1.1640.97
454_D458_L1.1640.97
285_C406_H1.1620.97
673_H676_S1.1610.97
53_E56_R1.1570.97
518_D521_E1.1420.97
234_P622_R1.1410.97
85_V126_A1.1390.96
63_E70_F1.1390.96
243_Q246_A1.1390.96
284_Y378_H1.1310.96
27_H35_A1.1290.96
284_Y354_V1.1280.96
84_L125_L1.1260.96
550_P613_G1.1250.96
708_V722_F1.1230.96
165_V208_G1.1220.96
710_V720_I1.1200.96
381_L407_L1.1190.96
100_R107_D1.1190.96
233_I330_I1.1160.96
678_D682_Y1.1160.96
389_I407_L1.1150.96
648_K664_D1.1140.96
27_H43_E1.1130.96
125_L145_L1.1110.96
269_V381_L1.1090.96
523_L526_V1.1040.96
471_A578_L1.1040.96
581_A585_L1.0990.96
66_G69_V1.0950.96
114_Q129_L1.0940.96
321_T616_C1.0940.96
649_G663_L1.0890.95
322_S329_V1.0870.95
421_R461_E1.0870.95
63_E76_Y1.0830.95
195_E211_V1.0810.95
389_I400_Y1.0740.95
672_V676_S1.0720.95
190_F213_V1.0720.95
101_V104_R1.0720.95
268_L283_V1.0720.95
336_V341_L1.0710.95
233_I626_A1.0710.95
261_V356_E1.0700.95
573_Y580_R1.0700.95
216_D219_G1.0680.95
661_V672_V1.0660.95
241_V245_V1.0660.95
176_I194_V1.0660.95
501_L522_L1.0650.95
245_V310_T1.0630.95
498_R508_L1.0630.95
192_V210_I1.0620.95
223_A634_L1.0620.95
436_F631_A1.0560.95
527_A532_A1.0550.95
254_E257_K1.0530.95
654_V691_L1.0530.95
151_Q211_V1.0500.94
157_F166_V1.0480.94
31_R35_A1.0480.94
269_V407_L1.0440.94
63_E68_L1.0440.94
164_F177_L1.0440.94
268_L284_Y1.0410.94
610_L614_Q1.0350.94
194_V210_I1.0330.94
268_L296_W1.0270.94
295_L359_V1.0260.94
403_L407_L1.0260.94
99_L141_I1.0230.94
347_Q377_S1.0210.94
485_I547_I1.0180.93
393_D397_R1.0160.93
474_V578_L1.0140.93
616_C619_A1.0140.93
650_V664_D1.0140.93
472_R476_K1.0130.93
454_D457_K1.0080.93
298_A356_E1.0070.93
126_A139_A1.0070.93
273_G382_T1.0070.93
608_E612_L1.0040.93
64_R67_Q1.0020.93
92_H95_G1.0000.93
270_T279_F0.9960.93
381_L400_Y0.9930.93
272_D281_D0.9920.93
37_R56_R0.9920.93
292_G360_S0.9920.93
391_Q453_N0.9900.93
472_R562_S0.9880.92
346_P379_A0.9860.92
424_R468_I0.9860.92
349_D374_V0.9850.92
474_V582_I0.9850.92
88_T100_R0.9820.92
370_F470_A0.9820.92
227_A626_A0.9790.92
291_G361_S0.9740.92
370_F473_F0.9740.92
253_P259_G0.9700.92
165_V178_I0.9700.92
35_A43_E0.9690.92
281_D332_M0.9690.92
110_L139_A0.9650.92
79_P82_L0.9650.92
279_F345_N0.9640.91
256_A304_Y0.9630.91
389_I408_E0.9610.91
266_L284_Y0.9610.91
263_L268_L0.9600.91
36_S39_E0.9590.91
291_G358_T0.9590.91
70_F74_Q0.9560.91
187_R216_D0.9560.91
89_V99_L0.9550.91
253_P304_Y0.9540.91
118_C124_V0.9530.91
263_L371_Y0.9520.91
158_T163_G0.9520.91
96_Y109_Y0.9510.91
274_E382_T0.9510.91
500_V538_M0.9500.91
701_R704_D0.9450.91
388_H394_Q0.9450.91
168_D226_I0.9440.91
248_L336_V0.9430.91
713_V717_E0.9420.91
526_V536_Q0.9410.90
548_Y565_H0.9400.90
198_Q207_V0.9380.90
252_V257_K0.9380.90
473_F585_L0.9340.90
363_G413_L0.9320.90
38_D42_V0.9310.90
381_L389_I0.9270.90
89_V118_C0.9270.90
58_R61_A0.9260.90
660_F671_L0.9250.90
141_I144_V0.9190.89
224_V630_V0.9180.89
28_L40_L0.9130.89
279_F335_E0.9110.89
450_T456_H0.9100.89
266_L296_W0.9100.89
474_V481_A0.9080.89
278_D570_I0.9070.89
452_R456_H0.9060.89
84_L142_V0.9050.89
108_L128_P0.9040.89
242_E246_A0.9040.89
242_E245_V0.8970.88
424_R560_L0.8950.88
659_F706_V0.8900.88
91_G173_S0.8890.88
149_T199_R0.8890.88
90_I120_H0.8880.88
281_D383_Y0.8870.88
56_R60_R0.8840.88
233_I622_R0.8820.87
713_V716_D0.8810.87
672_V724_L0.8800.87
332_M383_Y0.8790.87
388_H392_G0.8760.87
296_W371_Y0.8760.87
71_T75_C0.8750.87
463_M486_H0.8750.87
447_I668_I0.8690.87
41_A55_L0.8680.87
61_A64_R0.8640.86
387_W454_D0.8630.86
125_L142_V0.8610.86
659_F676_S0.8600.86
659_F700_Y0.8600.86
268_L354_V0.8600.86
390_L454_D0.8590.86
295_L462_C0.8580.86
187_R335_E0.8560.86
434_A667_F0.8540.86
284_Y373_A0.8520.86
499_S687_V0.8500.85
81_R84_L0.8490.85
303_S583_K0.8470.85
477_A585_L0.8430.85
435_K450_T0.8410.85
390_L407_L0.8390.85
471_A564_A0.8390.85
684_F689_Q0.8370.85
475_E483_F0.8340.84
287_K405_K0.8340.84
162_V177_L0.8330.84
516_P519_Y0.8290.84
62_M65_D0.8290.84
437_I445_E0.8280.84
475_E562_S0.8270.84
46_I51_Q0.8250.84
379_A403_L0.8230.84
647_F710_V0.8210.83
710_V722_F0.8200.83
304_Y372_E0.8200.83
97_G115_M0.8190.83
311_P314_R0.8190.83
128_P137_R0.8170.83
426_G431_S0.8150.83
452_R457_K0.8150.83
284_Y356_E0.8140.83
532_A536_Q0.8140.83
315_E319_R0.8110.83
32_E35_A0.8100.83
60_R63_E0.8090.82
147_P199_R0.8070.82
326_P444_I0.8060.82
638_F642_Q0.8030.82
281_D324_Y0.8030.82
663_L708_V0.8010.82
263_L375_M0.8010.82
693_G696_S0.8000.82
154_G194_V0.8000.82
156_Y210_I0.8000.82
159_E162_V0.8000.82
266_L356_E0.7980.82
392_G395_D0.7970.81
55_L59_L0.7970.81
89_V141_I0.7970.81
241_V244_Q0.7910.81
187_R190_F0.7910.81
27_H40_L0.7910.81
443_R641_D0.7890.81
386_V390_L0.7880.81
381_L385_K0.7850.81
175_D205_K0.7830.80
470_A564_A0.7830.80
412_N416_V0.7810.80
406_H409_E0.7810.80
651_I706_V0.7800.80
238_P318_N0.7800.80
605_S608_E0.7790.80
384_T388_H0.7790.80
35_A40_L0.7760.80
379_A385_K0.7720.79
679_N698_Q0.7720.79
163_G188_M0.7710.79
120_H171_R0.7710.79
312_L654_V0.7700.79
533_E662_R0.7690.79
714_N717_E0.7690.79
164_F205_K0.7690.79
343_S570_I0.7680.79
28_L32_E0.7680.79
636_C718_R0.7680.79
320_G615_H0.7670.79
639_M710_V0.7670.79
32_E36_S0.7670.79
289_R292_G0.7660.79
48_G51_Q0.7660.79
50_E54_G0.7660.79
249_K256_A0.7650.79
280_D383_Y0.7650.79
178_I208_G0.7650.79
227_A630_V0.7630.79
466_A566_F0.7630.79
186_A210_I0.7610.78
668_I720_I0.7610.78
70_F76_Y0.7600.78
245_V248_L0.7600.78
519_Y542_S0.7580.78
223_A633_W0.7570.78
257_K352_C0.7570.78
55_L58_R0.7560.78
119_I149_T0.7560.78
119_I172_L0.7550.78
240_A311_P0.7550.78
253_P257_K0.7540.78
681_Y694_E0.7540.78
357_M465_L0.7520.78
268_L285_C0.7510.78
368_Y472_R0.7500.77
413_L462_C0.7480.77
379_A402_P0.7480.77
685_D690_R0.7470.77
566_F579_H0.7470.77
363_G416_V0.7440.77
178_I186_A0.7370.76
269_V403_L0.7370.76
83_D127_Q0.7370.76
92_H96_Y0.7360.76
414_Y418_D0.7350.76
59_L62_M0.7330.76
243_Q247_G0.7320.76
272_D324_Y0.7320.76
234_P318_N0.7320.76
62_M68_L0.7300.75
265_D378_H0.7300.75
370_F582_I0.7290.75
420_A423_E0.7290.75
256_A351_L0.7280.75
175_D206_A0.7260.75
179_P186_A0.7250.75
578_L581_A0.7250.75
273_G380_R0.7250.75
78_L82_L0.7240.75
244_Q247_G0.7230.75
155_R191_V0.7230.75
530_P705_R0.7210.75
506_L529_R0.7210.75
270_T377_S0.7200.74
484_R546_A0.7200.74
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218_M223_A0.7130.74
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281_D463_M0.7120.74
85_V101_V0.7120.74
416_V419_K0.7120.74
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27_H44_L0.7110.74
37_R41_A0.7100.73
362_K416_V0.7100.73
611_Q615_H0.7100.73
119_I148_K0.7100.73
193_V229_R0.7090.73
357_M365_L0.7090.73
516_P520_A0.7080.73
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484_R572_R0.7070.73
613_G616_C0.7070.73
649_G706_V0.7050.73
192_V213_V0.7050.73
393_D408_E0.7050.73
707_E725_I0.7040.73
541_R628_R0.7040.73
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280_D571_R0.7020.73
280_D324_Y0.7000.72
281_D571_R0.7000.72
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158_T183_I0.6970.72
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163_G183_I0.6940.72
299_I343_S0.6930.72
257_K351_L0.6930.72
325_F630_V0.6920.72
421_R426_G0.6920.72
53_E57_R0.6920.72
264_R376_S0.6910.71
58_R65_D0.6910.71
290_G367_G0.6900.71
241_V318_N0.6900.71
294_R354_V0.6880.71
109_Y112_S0.6870.71
304_Y583_K0.6860.71
153_V226_I0.6850.71
155_R217_N0.6850.71
186_A192_V0.6840.71
519_Y522_L0.6830.71
269_V285_C0.6820.70
287_K293_W0.6810.70
309_S314_R0.6800.70
342_C463_M0.6800.70
463_M568_S0.6780.70
676_S711_E0.6760.70
322_S331_P0.6760.70
278_D460_E0.6760.70
550_P609_M0.6750.70
252_V256_A0.6750.70
384_T453_N0.6750.70
64_R69_V0.6750.70
197_T207_V0.6740.70
626_A630_V0.6730.69
483_F552_N0.6730.69
277_R339_N0.6730.69
295_L410_L0.6720.69
272_D383_Y0.6720.69
114_Q138_E0.6700.69
228_L328_Q0.6700.69
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270_T346_P0.6690.69
552_N562_S0.6680.69
426_G464_I0.6680.69
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293_W412_N0.6680.69
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506_L522_L0.6650.69
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278_D281_D0.6600.68
272_D571_R0.6600.68
639_M668_I0.6600.68
346_P380_R0.6580.68
92_H107_D0.6580.68
98_F109_Y0.6570.68
628_R658_G0.6570.68
343_S568_S0.6570.68
342_C546_A0.6560.67
35_A39_E0.6560.67
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272_D460_E0.6360.65
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383_Y570_I0.6320.65
299_I570_I0.6310.64
91_G97_G0.6300.64
42_V47_E0.6300.64
27_H32_E0.6300.64
559_A639_M0.6290.64
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324_Y332_M0.6260.64
278_D383_Y0.6250.64
257_K349_D0.6250.64
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649_G720_I0.6250.64
387_W392_G0.6240.64
272_D332_M0.6220.63
252_V351_L0.6210.63
62_M66_G0.6210.63
384_T455_A0.6200.63
276_A380_R0.6200.63
309_S317_R0.6190.63
577_T612_L0.6190.63
252_V259_G0.6180.63
633_W715_M0.6170.63
272_D342_C0.6170.63
37_R48_G0.6170.63
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292_G367_G0.6160.63
418_D428_S0.6140.62
97_G101_V0.6140.62
673_H721_D0.6130.62
141_I148_K0.6130.62
343_S383_Y0.6120.62
325_F330_I0.6120.62
270_T380_R0.6110.62
120_H149_T0.6100.62
271_I281_D0.6100.62
272_D546_A0.6100.62
278_D463_M0.6090.62
661_V670_G0.6090.62
155_R168_D0.6090.62
152_I176_I0.6060.61
76_Y79_P0.6050.61
413_L416_V0.6050.61
411_H458_L0.6040.61
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482_L609_M0.6030.61
275_D329_V0.6020.61
69_V77_A0.6020.61
189_G216_D0.6010.61
329_V339_N0.6000.61
414_Y454_D0.6000.61
481_A564_A0.5990.60
266_L378_H0.5990.60
302_V484_R0.5990.60
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463_M570_I0.5960.60
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299_I332_M0.5950.60
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317_R616_C0.5950.60
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95_G109_Y0.5940.60
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78_L81_R0.5930.60
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169_D172_L0.5920.60
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233_I544_K0.5910.59
278_D342_C0.5910.59
548_Y566_F0.5910.59
197_T200_P0.5890.59
417_L420_A0.5880.59
659_F724_L0.5870.59
332_M571_R0.5870.59
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359_V416_V0.5750.57
228_L535_L0.5740.57
31_R43_E0.5740.57
225_D328_Q0.5730.57
658_G670_G0.5720.57
31_R34_P0.5720.57
129_L140_R0.5720.57
177_L207_V0.5710.57
649_G710_V0.5710.57
77_A84_L0.5700.57
58_R67_Q0.5700.57
308_P604_Y0.5700.57
474_V585_L0.5690.57
692_M699_T0.5690.57
302_V570_I0.5690.57
497_F557_G0.5690.57
267_P403_L0.5690.57
60_R64_R0.5690.57
298_A352_C0.5680.56
45_H51_Q0.5680.56
277_R570_I0.5680.56
377_S381_L0.5680.56
456_H560_L0.5680.56
84_L127_Q0.5680.56
392_G408_E0.5670.56
487_D617_S0.5660.56
431_S624_D0.5660.56
680_D694_E0.5660.56
348_V377_S0.5650.56
403_L406_H0.5640.56
434_A447_I0.5640.56
647_F708_V0.5640.56
149_T152_I0.5630.56
604_Y608_E0.5630.56
355_C470_A0.5630.56
110_L114_Q0.5630.56
30_K725_I0.5620.56
300_A570_I0.5620.56
285_C298_A0.5620.56
484_R489_P0.5620.56
496_S686_Q0.5610.56
332_M570_I0.5610.56
130_G133_R0.5610.56
216_D335_E0.5610.56
134_K138_E0.5600.55
141_I351_L0.5590.55
71_T78_L0.5590.55
324_Y463_M0.5590.55
484_R548_Y0.5580.55
33_K36_S0.5580.55
162_V207_V0.5580.55
426_G461_E0.5570.55
317_R608_E0.5560.55
55_L62_M0.5560.55
539_L543_M0.5550.55
284_Y406_H0.5550.55
446_R665_D0.5550.55
409_E416_V0.5540.55
276_A375_M0.5540.55
401_A405_K0.5530.54
241_V311_P0.5530.54
164_F176_I0.5520.54
540_L620_E0.5520.54
269_V386_V0.5520.54
249_K336_V0.5510.54
290_G294_R0.5500.54
565_H572_R0.5490.54
226_I326_P0.5490.54
387_W455_A0.5490.54
377_S458_L0.5490.54
153_V193_V0.5480.54
37_R59_L0.5480.54
300_A383_Y0.5460.54
69_V79_P0.5460.54
324_Y570_I0.5460.54
176_I699_T0.5460.54
671_L721_D0.5450.53
71_T79_P0.5440.53
148_K172_L0.5440.53
57_R60_R0.5440.53
355_C466_A0.5440.53
632_D669_D0.5430.53
263_L266_L0.5430.53
239_Q242_E0.5430.53
252_V348_V0.5430.53
333_L337_L0.5420.53
654_V674_V0.5420.53
89_V124_V0.5410.53
44_L61_A0.5400.53
286_E289_R0.5400.53
57_R68_L0.5400.53
271_I332_M0.5400.53
356_E373_A0.5390.53
473_F582_I0.5390.53
414_Y462_C0.5380.53
325_F456_H0.5380.53
420_A424_R0.5380.53
279_F346_P0.5380.53
355_C368_Y0.5370.52
401_A404_V0.5370.52
385_K388_H0.5360.52
278_D344_L0.5360.52
324_Y460_E0.5360.52
670_G693_G0.5360.52
69_V82_L0.5360.52
254_E258_A0.5350.52
222_M226_I0.5340.52
273_G456_H0.5330.52
77_A81_R0.5330.52
577_T609_M0.5320.52
460_E570_I0.5320.52
680_D696_S0.5320.52
484_R566_F0.5320.52
494_I519_Y0.5310.52
212_E318_N0.5310.52
359_V417_L0.5310.52
336_V340_G0.5300.51
143_R169_D0.5300.51
49_E56_R0.5300.51
416_V420_A0.5290.51
36_S42_V0.5280.51
210_I544_K0.5280.51
237_W241_V0.5270.51
267_P402_P0.5270.51
685_D692_M0.5270.51
87_G124_V0.5270.51
481_A578_L0.5270.51
611_Q614_Q0.5260.51
42_V45_H0.5260.51
120_H169_D0.5260.51
369_K373_A0.5260.51
34_P77_A0.5250.51
300_A463_M0.5250.51
137_R231_H0.5240.51
119_I199_R0.5240.51
98_F101_V0.5240.51
272_D570_I0.5240.51
392_G402_P0.5230.51
543_M556_F0.5220.50
386_V411_H0.5210.50
397_R400_Y0.5210.50
163_G210_I0.5210.50
119_I146_V0.5210.50
653_S689_Q0.5210.50
642_Q710_V0.5210.50
276_A331_P0.5210.50
214_L229_R0.5210.50
280_D570_I0.5210.50
101_V108_L0.5200.50
493_A647_F0.5200.50
323_V330_I0.5200.50
278_D332_M0.5190.50
446_R642_Q0.5170.50
548_Y572_R0.5170.50
438_F445_E0.5170.50
273_G340_G0.5170.50
354_V372_E0.5170.50
296_W444_I0.5160.50
99_L115_M0.5160.50
66_G70_F0.5160.50
280_D332_M0.5150.49
281_D568_S0.5150.49
271_I407_L0.5150.49
620_E627_T0.5140.49
445_E448_E0.5130.49
506_L526_V0.5130.49
279_F455_A0.5120.49
175_D179_P0.5120.49
35_A42_V0.5110.49
314_R317_R0.5100.49
617_S620_E0.5100.49
267_P379_A0.5100.49
72_R77_A0.5100.49
356_E369_K0.5100.49
189_G196_L0.5090.49
581_A609_M0.5090.49
298_A633_W0.5090.49
676_S723_S0.5090.49
390_L458_L0.5090.49
156_Y178_I0.5090.49
707_E728_E0.5080.49
353_M370_F0.5080.49
421_R464_I0.5080.49
273_G459_I0.5080.49
278_D571_R0.5070.48
280_D486_H0.5060.48
244_Q312_L0.5060.48
232_E619_A0.5060.48
151_Q193_V0.5060.48
495_T499_S0.5060.48
484_R565_H0.5050.48
637_D640_L0.5050.48
400_Y404_V0.5050.48
617_S621_R0.5050.48
144_V147_P0.5050.48
77_A86_K0.5040.48
312_L338_S0.5040.48
289_R366_T0.5040.48
219_G686_Q0.5030.48
337_L570_I0.5030.48
272_D338_S0.5020.48
299_I568_S0.5010.48
252_V374_V0.5010.48
506_L510_G0.5010.48
87_G208_G0.5000.47
35_A48_G0.5000.47
300_A324_Y0.5000.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vnuD 1 0.7811 100 0.234 Contact Map
4ifdJ 1 0.8499 100 0.234 Contact Map
2id0A 1 0.7724 100 0.247 Contact Map
4pmwA 1 0.786 100 0.248 Contact Map
4ro1A 1 0.6519 100 0.253 Contact Map
2r7dA 1 0.5609 100 0.481 Contact Map
3bzcA 1 0.7245 99.9 0.886 Contact Map
1e3pA 3 0.4945 99.8 0.914 Contact Map
1go3E 1 0.2153 99.8 0.916 Contact Map
4qjfA 1 0.2177 99.7 0.924 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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