GREMLIN Database
GLPX2 - Fructose-1,6-bisphosphatase 2 class 2
UniProt: P21437 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11245
Length: 321 (307)
Sequences: 1112 (499)
Seq/√Len: 28.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
160_T173_A6.2071.00
142_L156_L4.0601.00
49_R78_E4.0141.00
139_T172_E3.9781.00
27_D30_K3.7791.00
135_S230_E3.3781.00
145_V203_V3.3251.00
33_G37_T3.2841.00
158_M203_V3.2271.00
221_K269_D3.1481.00
191_S216_S3.1101.00
170_I182_A3.0651.00
138_L205_Y3.0621.00
86_I284_V2.9571.00
234_F251_E2.8981.00
173_A178_V2.8921.00
78_E108_R2.8761.00
20_W295_Q2.8231.00
123_V220_V2.7381.00
49_R70_E2.7241.00
9_F304_T2.7021.00
51_R70_E2.6601.00
227_M268_L2.5790.99
133_D265_V2.4780.99
120_K230_E2.4720.99
51_R108_R2.4440.99
168_A172_E2.3890.99
130_G226_D2.3690.99
134_L265_V2.3580.99
135_S265_V2.2520.98
303_Q318_D2.2210.98
253_K257_A2.2020.98
207_I232_I2.1520.98
303_Q316_I2.0830.97
195_C220_V2.0500.97
127_L149_L2.0240.97
301_R318_D1.9040.95
128_A145_V1.8810.95
134_L230_E1.8520.95
145_V156_L1.8010.94
17_L300_V1.7960.94
171_E175_Q1.7920.94
169_A205_Y1.7870.93
142_L176_L1.7790.93
107_P276_D1.7630.93
136_L144_N1.7470.93
142_L203_V1.7330.92
122_L132_I1.6810.91
283_G287_G1.6630.91
308_G313_T1.6560.91
23_T285_T1.6350.90
136_L140_D1.6160.89
142_L153_L1.6160.89
234_F248_A1.5990.89
124_V203_V1.5880.89
161_L183_L1.5870.89
221_K272_V1.5490.87
81_I105_F1.5250.86
159_V183_L1.5110.86
8_L105_F1.4850.85
164_P167_S1.4830.85
19_A101_A1.4820.85
132_I145_V1.4710.84
159_V190_A1.4630.84
286_G291_N1.4600.84
293_I302_T1.4520.84
158_M205_Y1.4450.83
111_L272_V1.4160.82
252_R256_K1.4110.82
226_D268_L1.3930.81
296_T299_G1.3880.81
153_L178_V1.3860.81
114_A210_A1.3690.80
28_K59_I1.3590.79
10_R308_G1.3530.79
46_V108_R1.3500.79
58_E64_M1.3340.78
139_T175_Q1.3260.78
43_L103_M1.3250.77
40_R69_E1.3240.77
133_D228_Q1.3220.77
113_H117_M1.3130.77
167_S171_E1.3070.76
291_N318_D1.2980.76
308_G311_D1.2930.76
2_M308_G1.2820.75
139_T143_R1.2790.75
60_D89_T1.2790.75
160_T170_I1.2760.75
116_D210_A1.2660.74
67_I210_A1.2530.73
59_I234_F1.2420.73
160_T206_T1.2410.73
67_I113_H1.2390.72
152_P155_K1.2370.72
106_A110_S1.2360.72
266_Y270_E1.2320.72
114_A254_R1.2300.72
308_G315_N1.2290.72
60_D64_M1.2240.72
112_L210_A1.2050.70
261_D264_R1.1980.70
120_K207_I1.1920.69
60_D63_P1.1840.69
218_C277_I1.1830.69
134_L228_Q1.1800.69
22_Q34_L1.1650.68
90_R94_M1.1640.68
137_P141_N1.1540.67
104_A218_C1.1500.67
274_G309_G1.1480.67
47_A73_K1.1470.66
70_E108_R1.1470.66
63_P89_T1.1430.66
123_V227_M1.1380.66
67_I116_D1.1340.66
91_M184_P1.1330.65
181_F288_E1.1330.65
62_A89_T1.1320.65
233_D251_E1.1240.65
2_M7_P1.1190.65
59_I117_M1.1150.64
57_G60_D1.1150.64
107_P274_G1.1120.64
141_N144_N1.1050.64
151_K202_D1.1050.64
301_R320_L1.1040.63
67_I114_A1.1030.63
140_D144_N1.1020.63
228_Q265_V1.1010.63
124_V226_D1.1000.63
28_K83_V1.0930.63
56_E60_D1.0770.61
210_A213_G1.0710.61
129_A226_D1.0580.60
151_K309_G1.0570.60
128_A148_A1.0540.60
264_R270_E1.0520.60
89_T211_P1.0460.59
57_G63_P1.0440.59
85_P211_P1.0340.58
168_A171_E1.0310.58
10_R315_N1.0250.58
116_D254_R1.0240.58
167_S170_I1.0240.58
137_P140_D1.0150.57
98_N190_A1.0140.57
132_I141_N1.0130.57
58_E254_R1.0110.57
112_L116_D1.0110.57
32_D56_E1.0100.56
142_L173_A1.0100.56
142_L145_V1.0080.56
113_H258_M1.0040.56
117_M251_E0.9830.54
204_M215_I0.9820.54
31_I86_I0.9670.53
51_R113_H0.9650.53
29_N86_I0.9540.52
19_A318_D0.9490.52
3_S278_L0.9480.52
58_E63_P0.9450.51
250_Q253_K0.9390.51
90_R185_D0.9380.51
222_A307_I0.9320.50
282_T302_T0.9210.50
110_S273_R0.9160.49
229_A271_L0.9100.49
227_M271_L0.8980.48
86_I92_V0.8960.48
128_A204_M0.8950.48
31_I92_V0.8930.47
213_G229_A0.8910.47
87_E170_I0.8850.47
94_M222_A0.8830.47
95_G300_V0.8830.47
3_S304_T0.8760.46
64_M89_T0.8750.46
59_I86_I0.8740.46
252_R263_N0.8720.46
59_I210_A0.8700.46
120_K134_L0.8690.46
117_M210_A0.8680.46
122_L319_S0.8680.46
131_A144_N0.8650.45
114_A260_V0.8640.45
10_R313_T0.8640.45
8_L189_A0.8530.44
253_K256_K0.8490.44
141_N228_Q0.8490.44
215_I226_D0.8450.44
58_E89_T0.8410.43
98_N159_V0.8380.43
106_A111_L0.8380.43
115_P214_V0.8360.43
2_M10_R0.8360.43
250_Q319_S0.8350.43
260_V264_R0.8320.43
59_I116_D0.8290.43
84_D89_T0.8200.42
132_I148_A0.8190.42
67_I117_M0.8110.41
254_R258_M0.8090.41
22_Q30_K0.7990.40
94_M162_D0.7960.40
58_E62_A0.7950.40
123_V191_S0.7940.40
116_D258_M0.7920.40
97_S286_G0.7880.40
57_G64_M0.7870.39
36_V60_D0.7790.39
160_T169_A0.7780.39
210_A260_V0.7780.39
21_P295_Q0.7770.39
57_G62_A0.7730.38
162_D167_S0.7700.38
3_S8_L0.7690.38
151_K296_T0.7690.38
64_M67_I0.7690.38
67_I254_R0.7660.38
12_T282_T0.7660.38
96_Q101_A0.7630.38
277_I309_G0.7600.37
95_G99_A0.7590.37
87_E189_A0.7580.37
124_V227_M0.7520.37
249_E253_K0.7520.37
137_P144_N0.7510.37
64_M254_R0.7510.37
58_E67_I0.7500.37
226_D255_C0.7490.37
173_A176_L0.7470.37
7_P46_V0.7450.36
7_P107_P0.7440.36
15_A39_M0.7440.36
36_V58_E0.7410.36
5_A278_L0.7380.36
2_M188_V0.7370.36
192_V289_L0.7330.36
131_A226_D0.7320.35
12_T52_V0.7280.35
197_Q316_I0.7280.35
294_Q301_R0.7270.35
28_K89_T0.7250.35
136_L141_N0.7220.35
85_P89_T0.7210.35
216_S220_V0.7210.35
32_D60_D0.7210.35
47_A75_D0.7200.35
59_I83_V0.7190.35
10_R13_E0.7160.34
54_I62_A0.7160.34
30_K34_L0.7150.34
222_A277_I0.7150.34
103_M184_P0.7130.34
2_M311_D0.7120.34
155_K270_E0.7120.34
196_W223_L0.7120.34
96_Q184_P0.7100.34
116_D255_C0.7080.34
281_A290_V0.7080.34
151_K156_L0.7070.34
11_V43_L0.6970.33
43_L90_R0.6960.33
100_L159_V0.6940.33
36_V62_A0.6920.33
23_T95_G0.6920.33
88_G209_G0.6910.33
50_G71_V0.6900.33
113_H210_A0.6820.32
132_I157_R0.6820.32
96_Q304_T0.6810.32
181_F201_Y0.6800.32
67_I258_M0.6790.32
258_M262_V0.6760.32
101_A304_T0.6750.32
100_L281_A0.6740.31
32_D57_G0.6720.31
117_M258_M0.6690.31
150_G153_L0.6670.31
21_P300_V0.6660.31
107_P110_S0.6660.31
220_V268_L0.6660.31
58_E211_P0.6600.31
221_K270_E0.6590.30
60_D211_P0.6580.30
97_S193_L0.6570.30
145_V158_M0.6560.30
59_I67_I0.6550.30
207_I215_I0.6520.30
233_D262_V0.6500.30
71_V192_V0.6470.30
113_H116_D0.6450.30
122_L141_N0.6440.29
62_A102_V0.6410.29
46_V188_V0.6400.29
9_F105_F0.6350.29
134_L278_L0.6340.29
73_K76_G0.6330.29
163_K248_A0.6310.29
17_L48_F0.6270.28
47_A284_V0.6260.28
249_E258_M0.6250.28
9_F317_I0.6220.28
160_T180_V0.6220.28
131_A147_K0.6200.28
202_D318_D0.6190.28
95_G179_K0.6190.28
316_I320_L0.6180.28
183_L190_A0.6150.28
45_D286_G0.6150.28
92_V99_A0.6150.28
191_S204_M0.6140.28
23_T92_V0.6140.28
143_R152_P0.6130.28
8_L100_L0.6130.28
87_E232_I0.6110.27
248_A251_E0.6110.27
54_I60_D0.6100.27
117_M255_C0.6090.27
43_L92_V0.6080.27
221_K273_R0.6080.27
93_A190_A0.6070.27
132_I196_W0.6060.27
105_F319_S0.6060.27
126_R200_P0.6040.27
56_E118_Y0.6040.27
124_V131_A0.6020.27
60_D85_P0.6020.27
123_V158_M0.6020.27
138_L172_E0.6010.27
86_I255_C0.6010.27
311_D315_N0.6000.27
62_A211_P0.5980.27
163_K222_A0.5980.27
7_P10_R0.5950.26
54_I82_A0.5950.26
6_W9_F0.5940.26
52_V71_V0.5930.26
132_I144_N0.5920.26
75_D301_R0.5920.26
20_W92_V0.5920.26
90_R184_P0.5910.26
183_L232_I0.5870.26
260_V269_D0.5870.26
198_D305_L0.5870.26
317_I320_L0.5850.26
128_A131_A0.5850.26
172_E205_Y0.5850.26
202_D301_R0.5840.26
111_L218_C0.5830.26
114_A266_Y0.5820.26
56_E62_A0.5800.26
260_V266_Y0.5790.25
144_N156_L0.5790.25
302_T321_H0.5770.25
120_K161_L0.5760.25
32_D118_Y0.5760.25
130_G258_M0.5760.25
64_M211_P0.5760.25
82_A211_P0.5750.25
280_S304_T0.5750.25
176_L304_T0.5740.25
57_G89_T0.5720.25
140_D143_R0.5720.25
133_D220_V0.5710.25
13_E302_T0.5710.25
7_P313_T0.5690.25
154_D197_Q0.5660.25
280_S308_G0.5660.25
200_P293_I0.5650.25
21_P222_A0.5650.25
59_I113_H0.5650.25
96_Q103_M0.5650.25
98_N181_F0.5630.25
174_T302_T0.5630.25
120_K232_I0.5600.24
128_A149_L0.5590.24
56_E89_T0.5580.24
27_D31_I0.5580.24
197_Q202_D0.5570.24
83_V257_A0.5560.24
115_P124_V0.5550.24
64_M83_V0.5550.24
262_V266_Y0.5540.24
87_E188_V0.5530.24
255_C262_V0.5510.24
275_N310_A0.5500.24
151_K255_C0.5500.24
122_L148_A0.5500.24
29_N59_I0.5490.24
202_D296_T0.5470.24
37_T86_I0.5460.24
193_L304_T0.5460.24
97_S297_A0.5460.24
47_A319_S0.5450.24
193_L288_E0.5450.24
22_Q31_I0.5430.23
289_L305_L0.5410.23
18_A38_A0.5410.23
31_I230_E0.5400.23
221_K277_I0.5400.23
36_V56_E0.5390.23
23_T295_Q0.5380.23
21_P155_K0.5380.23
105_F307_I0.5380.23
22_Q151_K0.5360.23
249_E252_R0.5360.23
196_W316_I0.5350.23
57_G66_W0.5350.23
117_M232_I0.5340.23
122_L145_V0.5330.23
54_I57_G0.5330.23
9_F12_T0.5310.23
252_R262_V0.5300.23
29_N61_H0.5300.23
230_E265_V0.5290.23
132_I227_M0.5290.23
36_V91_M0.5280.23
123_V194_T0.5270.23
8_L312_Q0.5260.22
36_V64_M0.5250.22
183_L255_C0.5240.22
195_C223_L0.5240.22
43_L151_K0.5240.22
137_P194_T0.5230.22
224_G259_G0.5230.22
128_A226_D0.5230.22
98_N192_V0.5230.22
133_D136_L0.5200.22
61_H101_A0.5160.22
2_M274_G0.5160.22
229_A287_G0.5150.22
160_T172_E0.5150.22
115_P216_S0.5150.22
83_V98_N0.5150.22
62_A82_A0.5140.22
162_D184_P0.5130.22
215_I220_V0.5130.22
156_L284_V0.5120.22
104_A228_Q0.5110.22
86_I231_L0.5110.22
132_I168_A0.5100.22
220_V227_M0.5100.22
20_W180_V0.5090.22
219_A271_L0.5090.22
25_C198_D0.5080.22
137_P172_E0.5070.21
119_M229_A0.5060.21
193_L218_C0.5050.21
91_M99_A0.5050.21
92_V272_V0.5050.21
204_M266_Y0.5040.21
122_L232_I0.5040.21
141_N148_A0.5030.21
26_G174_T0.5020.21
110_S274_G0.5020.21
46_V79_V0.5010.21
7_P183_L0.5010.21
184_P272_V0.5000.21
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bigA 1 0.9907 100 0.001 Contact Map
3rojA 3 0.9969 100 0.014 Contact Map
3b8bA 1 0.7196 96 0.953 Contact Map
2pcrA 3 0.6854 94.6 0.957 Contact Map
3lv0A 2 0.7227 93.8 0.959 Contact Map
4n81A 2 0.7009 93.4 0.959 Contact Map
2qflA 1 0.7259 93 0.96 Contact Map
1inpA 1 0.8754 92.7 0.96 Contact Map
4i3yA 2 0.7477 92.7 0.96 Contact Map
3t0jA 3 0.7632 91.9 0.961 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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