GREMLIN Database
NMPC - Putative outer membrane porin protein NmpC
UniProt: P21420 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10659
Length: 365 (324)
Sequences: 5585 (4027)
Seq/√Len: 223.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
37_Y62_G4.1271.00
65_G77_G3.6651.00
297_Y315_K3.3971.00
74_T106_K3.3571.00
76_F104_G3.2661.00
78_Q102_F3.1601.00
66_E74_T3.1301.00
291_L321_A3.0641.00
252_I285_Y2.8771.00
159_N171_F2.7971.00
335_Y355_D2.7331.00
210_A241_W2.5671.00
157_Y160_N2.5061.00
124_D156_T2.4941.00
40_V85_G2.4821.00
258_Y277_Q2.4351.00
42_A85_G2.4271.00
260_E277_Q2.3071.00
121_V174_Q2.3041.00
76_F112_S2.2981.00
64_K78_Q2.2871.00
299_Q315_K2.2811.00
292_R324_Y2.2581.00
76_F114_D2.2531.00
322_T330_S2.2381.00
173_A197_F2.2331.00
208_I245_L2.1811.00
214_K239_E2.1771.00
330_S362_V2.1761.00
171_F199_A2.1531.00
291_L323_Y2.1331.00
325_F331_T2.1171.00
287_F293_P2.0761.00
18_A22_Q2.0601.00
36_L63_F2.0221.00
121_V172_A1.9961.00
154_V174_Q1.9721.00
100_L119_Y1.9691.00
37_Y80_E1.9581.00
106_K112_S1.9331.00
117_R152_T1.9161.00
73_L105_L1.8891.00
165_L170_N1.8861.00
73_L109_D1.8781.00
170_N200_T1.8581.00
86_N179_N1.8561.00
210_A243_A1.8141.00
159_N166_V1.7991.00
249_A254_L1.7821.00
37_Y78_Q1.7761.00
39_K60_R1.7631.00
82_E99_R1.7521.00
41_N332_F1.7291.00
329_M363_Y1.7251.00
115_Y155_A1.7101.00
81_Y96_D1.6581.00
339_L353_T1.6581.00
160_N166_V1.6421.00
331_T361_L1.6361.00
212_Y241_W1.6231.00
206_F247_Y1.6111.00
255_A282_V1.5931.00
37_Y64_K1.5811.00
113_I155_A1.5811.00
251_N285_Y1.5771.00
293_P321_A1.5731.00
158_R172_A1.5701.00
60_R99_R1.5621.00
214_K237_N1.5621.00
284_Q292_R1.5511.00
76_F106_K1.5481.00
95_K152_T1.5301.00
330_S364_Q1.5171.00
69_I75_G1.5021.00
92_G98_T1.4861.00
328_N363_Y1.4561.00
60_R80_E1.4431.00
80_E99_R1.4361.00
245_L256_T1.4341.00
68_Q72_Q1.4111.00
61_L81_Y1.3951.00
36_L61_L1.3781.00
337_I353_T1.3741.00
114_D158_R1.3561.00
114_D156_T1.3461.00
254_L283_A1.3291.00
110_Y157_Y1.3251.00
114_D118_N1.3181.00
111_G157_Y1.3161.00
246_K255_A1.3151.00
67_T326_N1.3141.00
57_T362_V1.3101.00
283_A295_V1.3071.00
74_T108_G1.3031.00
159_N168_G1.3031.00
129_T207_G1.2961.00
118_N154_V1.2901.00
125_I209_G1.2871.00
100_L118_N1.2851.00
76_F102_F1.2831.00
176_Q194_G1.2801.00
208_I243_A1.2711.00
241_W260_E1.2661.00
257_T280_E1.2621.00
252_I256_T1.2581.00
299_Q313_L1.2481.00
288_D291_L1.2461.00
287_F291_L1.2461.00
252_I283_A1.2441.00
73_L110_Y1.2411.00
337_I355_D1.2401.00
151_A194_G1.2341.00
205_G247_Y1.2301.00
202_E207_G1.2301.00
297_Y317_V1.2201.00
301_K313_L1.2111.00
78_Q100_L1.2071.00
155_A177_G1.2071.00
290_G324_Y1.1941.00
95_K98_T1.1911.00
286_Q292_R1.1901.00
43_K55_D1.1831.00
175_Y195_F1.1771.00
333_V359_V1.1741.00
296_A318_D1.1741.00
246_K253_Y1.1641.00
294_S320_G1.1631.00
45_Y358_A1.1541.00
68_Q74_T1.1491.00
154_V176_Q1.1441.00
248_D251_N1.1421.00
206_F245_L1.1381.00
207_G246_K1.1341.00
122_A211_T1.1181.00
314_V340_L1.1171.00
332_F360_G1.1101.00
102_F114_D1.1081.00
99_R150_R1.1071.00
110_Y113_I1.1041.00
81_Y90_S1.1031.00
40_V83_F1.1011.00
256_T279_F1.1001.00
66_E76_F1.0941.00
340_L351_V1.0941.00
174_Q196_G1.0921.00
112_S156_T1.0891.00
260_E275_K1.0861.00
39_K364_Q1.0831.00
75_G103_A1.0821.00
4_L10_A1.0811.00
34_L77_G1.0701.00
256_T281_A1.0681.00
93_S98_T1.0671.00
212_Y239_E1.0581.00
75_G105_L1.0471.00
248_D253_Y1.0441.00
73_L108_G1.0431.00
242_A259_S1.0421.00
66_E106_K1.0421.00
313_L341_D1.0391.00
60_R150_R1.0381.00
156_T174_Q1.0371.00
48_S355_D1.0341.00
67_T328_N1.0331.00
295_V317_V1.0311.00
282_V296_A1.0311.00
10_A13_A1.0241.00
320_G334_D1.0231.00
169_L203_Y1.0221.00
79_W101_A1.0181.00
79_W97_K1.0161.00
43_K358_A1.0151.00
294_S322_T1.0151.00
160_N165_L1.0091.00
170_N202_E1.0091.00
333_V357_V1.0081.00
19_M22_Q1.0051.00
278_N300_S1.0041.00
33_K66_E0.9891.00
42_A86_N0.9831.00
121_V198_S0.9801.00
169_L199_A0.9791.00
14_S18_A0.9791.00
248_D285_Y0.9751.00
314_V338_N0.9711.00
151_A154_V0.9691.00
173_A195_F0.9671.00
317_V337_I0.9671.00
248_D286_Q0.9591.00
122_A240_V0.9591.00
92_G95_K0.9581.00
287_F321_A0.9561.00
59_A83_F0.9511.00
15_V19_M0.9381.00
295_V319_V0.9321.00
39_K362_V0.9311.00
132_L320_G0.9251.00
62_G80_E0.9231.00
118_N156_T0.9160.99
122_A242_A0.9150.99
57_T330_S0.9140.99
277_Q303_K0.9140.99
176_Q179_N0.9120.99
88_A97_K0.9100.99
13_A16_L0.9080.99
173_A199_A0.9030.99
172_A198_S0.9020.99
72_Q108_G0.9020.99
325_F329_M0.9000.99
120_G151_A0.8980.99
329_M361_L0.8930.99
335_Y357_V0.8880.99
209_G244_G0.8870.99
56_T330_S0.8850.99
106_K109_D0.8810.99
324_Y330_S0.8800.99
253_Y286_Q0.8790.99
251_N286_Q0.8770.99
318_D336_K0.8730.99
41_N54_G0.8710.99
67_T329_M0.8620.99
280_E298_L0.8620.99
132_L294_S0.8620.99
198_S211_T0.8590.99
16_L19_M0.8590.99
125_I198_S0.8520.99
35_D64_K0.8470.99
131_V284_Q0.8460.99
340_L344_D0.8410.99
158_R170_N0.8410.99
279_F301_K0.8400.99
16_L20_S0.8390.99
179_N182_S0.8380.99
290_G321_A0.8350.99
32_N67_T0.8290.99
43_K57_T0.8230.99
121_V211_T0.8180.99
57_T364_Q0.8150.99
125_I200_T0.8140.99
156_T172_A0.8110.99
276_A300_S0.8100.99
153_G179_N0.8090.99
17_M20_S0.8080.99
70_N326_N0.8000.99
82_E98_T0.8000.99
84_K87_R0.7990.99
121_V196_G0.7900.98
253_Y284_Q0.7900.98
182_S188_T0.7860.98
238_A261_T0.7830.98
322_T362_V0.7770.98
196_G213_A0.7760.98
61_L96_D0.7760.98
255_A284_Q0.7750.98
129_T244_G0.7720.98
131_V296_A0.7700.98
49_N354_D0.7700.98
125_I158_R0.7690.98
160_N168_G0.7660.98
135_F138_D0.7630.98
131_V282_V0.7610.98
82_E97_K0.7600.98
67_T70_N0.7580.98
102_F118_N0.7580.98
277_Q301_K0.7530.98
5_T9_S0.7530.98
313_L339_L0.7520.98
18_A21_A0.7520.98
72_Q109_D0.7490.98
119_Y123_Y0.7480.98
132_L296_A0.7450.98
4_L8_I0.7440.98
8_I15_V0.7430.98
124_D158_R0.7430.98
60_R82_E0.7410.98
278_N298_L0.7380.98
359_V363_Y0.7340.98
258_Y279_F0.7340.98
67_T363_Y0.7300.97
159_N167_D0.7300.97
319_V335_Y0.7220.97
151_A174_Q0.7210.97
289_F323_Y0.7200.97
62_G99_R0.7190.97
86_N153_G0.7170.97
108_G113_I0.7160.97
249_A252_I0.7150.97
126_G242_A0.7140.97
11_V15_V0.7130.97
8_I13_A0.7090.97
131_V280_E0.7040.97
241_W277_Q0.7040.97
334_D358_A0.7000.97
120_G196_G0.6980.97
159_N173_A0.6950.97
128_W200_T0.6950.97
205_G249_A0.6940.97
112_S158_R0.6940.97
171_F197_F0.6910.96
292_R322_T0.6860.96
132_L138_D0.6820.96
262_Q275_K0.6760.96
68_Q71_D0.6760.96
31_S35_D0.6750.96
204_E247_Y0.6740.96
4_L9_S0.6720.96
261_T276_A0.6700.96
17_M22_Q0.6690.96
119_Y150_R0.6680.96
117_R150_R0.6650.96
47_S356_I0.6630.96
194_G215_S0.6590.95
159_N165_L0.6590.95
165_L202_E0.6550.95
15_V18_A0.6520.95
321_A333_V0.6520.95
284_Q294_S0.6470.95
48_S351_V0.6460.95
13_A20_S0.6430.95
251_N287_F0.6420.95
10_A15_V0.6420.95
190_G216_D0.6400.95
241_W258_Y0.6390.95
82_E150_R0.6390.95
339_L352_S0.6360.94
122_A196_G0.6350.94
61_L83_F0.6340.94
67_T75_G0.6340.94
280_E296_A0.6340.94
130_D135_F0.6310.94
160_N170_N0.6300.94
32_N68_Q0.6270.94
115_Y118_N0.6270.94
108_G157_Y0.6260.94
203_Y208_I0.6250.94
13_A17_M0.6240.94
81_Y97_K0.6220.94
87_R97_K0.6220.94
130_D136_G0.6210.94
14_S22_Q0.6200.94
15_V20_S0.6190.94
141_T144_D0.6170.93
200_T209_G0.6150.93
135_F139_T0.6140.93
37_Y99_R0.6140.93
55_D358_A0.6130.93
175_Y193_D0.6130.93
110_Y160_N0.6120.93
243_A258_Y0.6090.93
317_V339_L0.6070.93
287_F290_G0.6060.93
302_G312_D0.6050.93
43_K360_G0.6030.93
318_D334_D0.6020.93
69_I72_Q0.6010.93
14_S20_S0.5980.92
244_G257_T0.5970.92
326_N329_M0.5970.92
181_R188_T0.5960.92
45_Y356_I0.5950.92
238_A263_N0.5950.92
195_F199_A0.5950.92
279_F299_Q0.5940.92
93_S96_D0.5930.92
130_D133_P0.5890.92
90_S96_D0.5890.92
189_E193_D0.5870.92
151_A176_Q0.5870.92
221_Q233_A0.5860.92
46_F357_V0.5840.91
298_L316_Y0.5840.91
11_V17_M0.5820.91
344_D351_V0.5810.91
109_D113_I0.5790.91
90_S94_S0.5790.91
111_G160_N0.5780.91
55_D58_Y0.5780.91
157_Y171_F0.5770.91
316_Y338_N0.5750.91
166_V170_N0.5750.91
104_G114_D0.5740.91
34_L65_G0.5710.91
9_S16_L0.5680.90
322_T364_Q0.5670.90
59_A85_G0.5650.90
46_F337_I0.5650.90
300_S314_V0.5640.90
317_V353_T0.5630.90
46_F355_D0.5630.90
121_V124_D0.5620.90
139_T149_Q0.5610.90
148_T213_A0.5600.90
275_K301_K0.5600.90
286_Q324_Y0.5600.90
4_L16_L0.5590.90
360_G365_F0.5590.90
58_Y82_E0.5570.89
129_T255_A0.5560.89
310_D342_K0.5550.89
181_R190_G0.5540.89
168_G201_Y0.5540.89
11_V20_S0.5540.89
216_D237_N0.5530.89
120_G213_A0.5520.89
103_A326_N0.5510.89
34_L67_T0.5490.89
2_K5_T0.5490.89
279_F283_A0.5480.89
94_S98_T0.5480.89
254_L281_A0.5470.89
125_I172_A0.5460.89
60_R100_L0.5460.89
5_T14_S0.5440.88
76_F156_T0.5440.88
105_L108_G0.5440.88
178_K182_S0.5430.88
74_T112_S0.5430.88
3_K9_S0.5430.88
43_K332_F0.5420.88
67_T77_G0.5410.88
5_T8_I0.5410.88
31_S68_Q0.5400.88
96_D101_A0.5370.88
304_D312_D0.5370.88
314_V344_D0.5350.88
84_K91_Q0.5330.87
191_N217_R0.5320.87
105_L110_Y0.5320.87
159_N169_L0.5310.87
337_I357_V0.5300.87
275_K303_K0.5300.87
45_Y336_K0.5290.87
136_G358_A0.5280.87
42_A46_F0.5270.87
263_N266_V0.5270.87
159_N170_N0.5260.87
203_Y206_F0.5260.87
42_A59_A0.5250.87
9_S13_A0.5240.86
205_G248_D0.5240.86
180_D191_N0.5220.86
81_Y101_A0.5220.86
174_Q194_G0.5220.86
42_A45_Y0.5220.86
54_G59_A0.5220.86
145_V148_T0.5210.86
157_Y166_V0.5210.86
165_L168_G0.5200.86
264_M273_A0.5190.86
315_K339_L0.5180.86
124_D172_A0.5180.86
259_S276_A0.5180.86
77_G97_K0.5170.86
88_A328_N0.5170.86
315_K341_D0.5170.86
202_E205_G0.5170.86
207_G248_D0.5150.86
203_Y210_A0.5150.86
87_R95_K0.5150.86
77_G329_M0.5150.86
33_K65_G0.5140.85
257_T282_V0.5140.85
98_T101_A0.5130.85
266_V274_N0.5130.85
132_L135_F0.5130.85
316_Y336_K0.5120.85
191_N220_T0.5110.85
39_K99_R0.5100.85
126_G257_T0.5090.85
319_V333_V0.5090.85
5_T16_L0.5090.85
58_Y119_Y0.5080.85
167_D203_Y0.5070.85
193_D216_D0.5070.85
17_M21_A0.5060.85
44_H54_G0.5060.85
136_G139_T0.5050.84
123_Y147_M0.5040.84
69_I329_M0.5040.84
56_T320_G0.5030.84
326_N363_Y0.5020.84
194_G213_A0.5010.84
250_N256_T0.5010.84
169_L201_Y0.5010.84
182_S189_E0.5000.84
353_T356_I0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3nsgA 3 0.8986 100 0.26 Contact Map
2j1nA 3 0.9041 100 0.26 Contact Map
1phoA 3 0.8877 100 0.261 Contact Map
2zfgA 3 0.8877 100 0.276 Contact Map
2fgqX 3 0.8329 100 0.3 Contact Map
3vy8X 3 0.8685 100 0.316 Contact Map
3wi5A 3 0.8164 100 0.356 Contact Map
2porA 3 0.7726 100 0.39 Contact Map
3prnA 3 0.7425 100 0.402 Contact Map
2o4vA 3 0.9205 99.4 0.773 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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