GREMLIN Database
PNCA - Pyrazinamidase/nicotinamidase
UniProt: P21369 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11135
Length: 213 (176)
Sequences: 9521 (6582)
Seq/√Len: 496.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_D139_R3.2131.00
51_Q110_H2.8781.00
135_D169_Y2.7611.00
145_E170_K2.7471.00
121_S163_D2.7471.00
40_C45_E2.5161.00
4_R145_E2.4401.00
33_A149_M2.4191.00
135_D167_L2.2641.00
11_L33_A2.2351.00
148_V161_V2.2011.00
36_L174_I2.1931.00
145_E172_N2.1601.00
195_M200_A2.0231.00
13_N92_E1.9921.00
14_D93_G1.9601.00
133_S137_W1.9221.00
164_A171_V1.8501.00
5_A143_I1.8451.00
3_P144_D1.8401.00
122_A160_T1.8331.00
158_K162_L1.8191.00
204_T207_D1.8181.00
39_W43_R1.8071.00
109_F137_W1.7951.00
175_T202_L1.7921.00
175_T204_T1.7841.00
183_I189_A1.7821.00
32_V177_G1.7761.00
32_V205_L1.7541.00
32_V35_R1.7391.00
153_T188_S1.7261.00
13_N98_P1.6391.00
4_R147_I1.5851.00
16_C97_H1.5671.00
48_I137_W1.5651.00
180_G188_S1.5301.00
41_Q106_A1.4891.00
176_D205_L1.4811.00
147_I174_I1.4781.00
158_K194_E1.4751.00
50_S122_A1.4691.00
107_A137_W1.4581.00
40_C147_I1.4521.00
8_L149_M1.4461.00
8_L37_I1.4381.00
153_T192_F1.4201.00
34_N38_D1.4121.00
146_L164_A1.3841.00
153_T178_C1.3801.00
154_D180_G1.3731.00
157_V173_V1.3681.00
46_A141_H1.3571.00
35_R206_A1.3531.00
92_E95_Q1.3481.00
25_E28_S1.3361.00
7_L148_V1.3271.00
53_W94_A1.3101.00
189_A193_M1.2991.00
148_V160_T1.2941.00
63_S85_D1.2721.00
186_Q189_A1.2701.00
8_L11_L1.2441.00
175_T192_F1.2411.00
158_K191_A1.2311.00
89_Q110_H1.2271.00
136_D140_D1.2151.00
38_D42_S1.2151.00
139_R169_Y1.2011.00
137_W141_H1.1971.00
177_G205_L1.1891.00
6_L40_C1.1851.00
29_T33_A1.1791.00
31_D99_L1.1751.00
34_N99_L1.1661.00
9_V156_C1.1601.00
8_L33_A1.1421.00
51_Q96_L1.1241.00
37_I41_Q1.1141.00
182_N186_Q1.1091.00
173_V178_C1.1011.00
133_S136_D1.0951.00
51_Q108_V1.0821.00
147_I172_N1.0771.00
163_D167_L1.0561.00
13_N95_Q1.0551.00
36_L177_G1.0501.00
172_N201_T1.0411.00
178_C188_S1.0241.00
32_V176_D1.0201.00
161_V173_V1.0161.00
4_R45_E1.0151.00
170_K201_T1.0091.00
146_L171_V0.9841.00
95_Q101_H0.9771.00
153_T180_G0.9751.00
161_V195_M0.9681.00
37_I49_A0.9571.00
85_D88_V0.9501.00
96_L108_V0.9431.00
144_D170_K0.9421.00
39_W42_S0.9391.00
55_P89_Q0.9301.00
182_N187_D0.9301.00
53_W110_H0.9281.00
10_D111_K0.9241.00
5_A48_I0.9231.00
34_N102_Q0.9151.00
186_Q190_H0.9131.00
123_F164_A0.9071.00
119_S168_G0.9031.00
46_A143_I0.9021.00
172_N203_Y0.8951.00
174_I203_Y0.8891.00
192_F202_L0.8701.00
186_Q193_M0.8691.00
7_L134_L0.8671.00
35_R39_W0.8671.00
174_I177_G0.8671.00
188_S192_F0.8561.00
9_V148_V0.8521.00
159_F162_L0.8501.00
57_N60_S0.8471.00
137_W140_D0.8451.00
53_W89_Q0.8411.00
35_R38_D0.8311.00
13_N17_A0.8261.00
49_A96_L0.8191.00
28_S31_D0.8181.00
11_L151_L0.8151.00
17_A27_D0.8111.00
31_D35_R0.8111.00
122_A134_L0.8101.00
203_Y207_D0.8081.00
163_D166_Q0.8011.00
5_A138_L0.7991.00
103_K106_A0.7931.00
3_P145_E0.7921.00
191_A195_M0.7921.00
37_I47_V0.7911.00
149_M177_G0.7901.00
102_Q106_A0.7881.00
36_L149_M0.7871.00
193_M196_S0.7861.00
154_D187_D0.7841.00
92_E98_P0.7731.00
151_L179_R0.7721.00
29_T179_R0.7711.00
30_V34_N0.7611.00
148_V157_V0.7551.00
31_D34_N0.7511.00
49_A102_Q0.7481.00
33_A177_G0.7461.00
48_I141_H0.7461.00
13_N97_H0.7411.00
49_A105_I0.7351.00
62_A65_H0.7291.00
8_L49_A0.7251.00
46_A137_W0.7191.00
91_S94_A0.7171.00
90_N95_Q0.7151.00
138_L169_Y0.7131.00
154_D194_E0.7131.00
190_H194_E0.7071.00
136_D139_R0.7021.00
98_P101_H0.6981.00
35_R205_L0.6981.00
165_L200_A0.6921.00
187_D190_H0.6921.00
16_C30_V0.6901.00
30_V97_H0.6891.00
193_M197_A0.6881.00
36_L205_L0.6841.00
65_H82_F0.6781.00
14_D87_C0.6761.00
173_V192_F0.6681.00
29_T151_L0.6651.00
38_D101_H0.6631.00
15_F156_C0.6631.00
14_D19_G0.6621.00
27_D99_L0.6601.00
34_N101_H0.6581.00
154_D181_V0.6561.00
3_P142_E0.6551.00
119_S131_K0.6531.00
51_Q95_Q0.6521.00
187_D193_M0.6501.00
190_H193_M0.6501.00
48_I107_A0.6491.00
161_V200_A0.6451.00
49_A108_V0.6451.00
18_G22_A0.6441.00
36_L40_C0.6441.00
38_D103_K0.6411.00
178_C192_F0.6401.00
11_L29_T0.6391.00
55_P60_S0.6391.00
6_L149_M0.6351.00
131_K136_D0.6351.00
148_V171_V0.6241.00
24_P28_S0.6231.00
55_P58_H0.6201.00
37_I106_A0.6201.00
37_I40_C0.6191.00
159_F199_G0.6171.00
56_A85_D0.6151.00
41_Q105_I0.6151.00
26_G151_L0.6141.00
130_Q167_L0.6100.99
16_C26_G0.6020.99
40_C44_G0.6020.99
102_Q108_V0.6020.99
175_T196_S0.5980.99
107_A141_H0.5980.99
88_V91_S0.5960.99
19_G22_A0.5940.99
6_L36_L0.5930.99
162_L198_A0.5920.99
152_A155_Y0.5900.99
87_C93_G0.5900.99
49_A106_A0.5880.99
155_Y181_V0.5860.99
48_I109_F0.5830.99
57_N64_Q0.5800.99
41_Q103_K0.5800.99
15_F152_A0.5790.99
192_F196_S0.5790.99
30_V100_L0.5760.99
175_T188_S0.5740.99
11_L100_L0.5660.99
49_A100_L0.5630.99
171_V174_I0.5610.99
83_W86_H0.5600.99
11_L97_H0.5600.99
120_Y166_Q0.5560.99
6_L37_I0.5560.99
59_G64_Q0.5460.99
173_V195_M0.5440.99
6_L47_V0.5430.99
183_I186_Q0.5430.99
46_A107_A0.5420.99
97_H100_L0.5340.99
13_N93_G0.5340.99
148_V164_A0.5330.99
102_Q105_I0.5310.99
41_Q47_V0.5290.99
120_Y160_T0.5280.99
109_F133_S0.5270.98
9_V157_V0.5270.98
54_H60_S0.5270.98
121_S166_Q0.5260.98
194_E197_A0.5220.98
41_Q49_A0.5200.98
152_A180_G0.5200.98
161_V171_V0.5160.98
5_A46_A0.5130.98
157_V178_C0.5110.98
20_A23_V0.5100.98
12_Q51_Q0.5040.98
149_M174_I0.5040.98
22_A27_D0.5040.98
61_F64_Q0.5020.98
46_A106_A0.5000.98
12_Q50_S0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3v8eA 2 0.9484 100 0.242 Contact Map
3hb7A 3 0.8404 100 0.242 Contact Map
1im5A 1 0.8404 100 0.243 Contact Map
2wt9A 2 0.9577 100 0.243 Contact Map
1nbaA 4 0.8873 100 0.247 Contact Map
3irvA 2 0.8873 100 0.247 Contact Map
3ot4A 4 0.8732 100 0.249 Contact Map
3hu5A 3 0.8826 100 0.25 Contact Map
3r2jA 2 0.8967 100 0.25 Contact Map
4l07A 4 0.8732 100 0.251 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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