GREMLIN Database
YCAC - Uncharacterized protein YcaC
UniProt: P21367 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11241
Length: 208 (162)
Sequences: 7961 (5406)
Seq/√Len: 424.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_V101_K3.2351.00
89_N125_S2.9171.00
107_Q132_D2.6571.00
12_D106_K2.6221.00
110_I123_A2.5401.00
20_H40_V2.5391.00
155_L160_A2.5031.00
47_A52_L2.4621.00
145_E149_H2.3751.00
136_V168_V2.3411.00
97_V131_F2.3241.00
46_L169_A2.2971.00
39_N165_W2.2171.00
43_L136_V2.1871.00
40_V111_A2.0761.00
97_V129_E2.0461.00
164_T167_G2.0401.00
108_L126_A1.9201.00
14_A105_K1.9141.00
58_T83_A1.8941.00
137_T162_L1.8501.00
107_Q134_F1.8351.00
126_A133_V1.7601.00
39_N42_A1.7381.00
46_L50_F1.7131.00
95_D99_A1.6731.00
90_A122_P1.6541.00
48_K79_T1.6511.00
138_D165_W1.6431.00
42_A166_F1.6381.00
22_A70_P1.6081.00
23_G65_N1.5941.00
15_V47_A1.5671.00
139_A165_W1.5591.00
116_E142_T1.5381.00
137_T164_T1.5231.00
115_T148_R1.5081.00
17_L111_A1.5041.00
13_A107_Q1.5011.00
120_A124_L1.4901.00
13_A109_I1.4571.00
80_P99_A1.4481.00
153_D156_S1.4311.00
41_L45_D1.4281.00
82_I99_A1.4121.00
98_K102_A1.3791.00
109_I168_V1.3661.00
99_A103_T1.3511.00
119_V135_V1.3491.00
17_L44_G1.3351.00
55_I99_A1.3291.00
25_L69_V1.3231.00
9_D12_D1.3211.00
115_T140_S1.3041.00
22_A64_P1.2911.00
47_A109_I1.2891.00
41_L71_E1.2751.00
18_V118_C1.2531.00
149_H153_D1.2491.00
53_P103_T1.2471.00
146_I149_H1.2361.00
91_W126_A1.2141.00
58_T68_L1.2021.00
36_F40_V1.1851.00
22_A67_P1.1791.00
123_A155_L1.1781.00
136_V163_M1.1561.00
57_T90_A1.1551.00
127_I160_A1.1531.00
166_F170_C1.1171.00
120_A151_A1.1101.00
43_L111_A1.0901.00
44_G48_K1.0831.00
61_E83_A1.0741.00
17_L20_H1.0621.00
67_P73_K1.0541.00
134_F163_M1.0441.00
60_F83_A1.0441.00
135_V140_S1.0431.00
17_L40_V1.0411.00
46_L49_Y1.0391.00
110_I122_P1.0181.00
16_L110_I1.0131.00
60_F66_G1.0051.00
123_A135_V0.9981.00
101_K131_F0.9901.00
137_T152_W0.9791.00
121_F124_L0.9691.00
39_N139_A0.9651.00
163_M168_V0.9631.00
39_N138_D0.9501.00
110_I119_V0.9471.00
73_K76_F0.9461.00
123_A160_A0.9441.00
14_A55_I0.9381.00
144_N147_T0.9211.00
92_D129_E0.9161.00
125_S129_E0.9151.00
56_L79_T0.9131.00
45_D76_F0.9031.00
64_P67_P0.8951.00
19_D84_R0.8951.00
163_M167_G0.8871.00
15_V111_A0.8701.00
125_S128_E0.8701.00
152_W162_L0.8651.00
42_A165_W0.8631.00
20_H113_V0.8591.00
99_A102_A0.8481.00
43_L168_V0.8471.00
12_D107_Q0.8451.00
115_T152_W0.8441.00
140_S152_W0.8421.00
95_D98_K0.8411.00
45_D49_Y0.8361.00
91_W97_V0.8331.00
140_S148_R0.8301.00
48_K78_D0.8291.00
15_V43_L0.8261.00
109_I136_V0.8241.00
58_T81_Y0.8161.00
38_N71_E0.8131.00
16_L96_F0.8051.00
120_A154_R0.7971.00
146_I150_S0.7971.00
22_A26_S0.7971.00
68_L81_Y0.7971.00
116_E143_F0.7971.00
43_L165_W0.7961.00
70_P73_K0.7891.00
41_L74_A0.7881.00
76_F79_T0.7881.00
56_L74_A0.7841.00
87_N130_G0.7741.00
135_V155_L0.7741.00
148_R152_W0.7671.00
13_A52_L0.7611.00
63_G66_G0.7581.00
37_K69_V0.7581.00
47_A172_L0.7541.00
119_V140_S0.7501.00
98_K101_K0.7501.00
90_A96_F0.7471.00
36_F141_G0.7411.00
116_E154_R0.7371.00
82_I95_D0.7371.00
48_K76_F0.7291.00
56_L68_L0.7261.00
38_N41_L0.7241.00
74_A79_T0.7221.00
156_S162_L0.7221.00
35_K38_N0.7191.00
55_I103_T0.7151.00
44_G56_L0.7061.00
87_N93_N0.7051.00
142_T148_R0.7011.00
60_F63_G0.7001.00
111_A139_A0.6981.00
92_D125_S0.6961.00
137_T148_R0.6921.00
116_E147_T0.6791.00
132_D161_Q0.6781.00
161_Q171_E0.6771.00
123_A133_V0.6761.00
101_K129_E0.6751.00
37_K41_L0.6751.00
36_F113_V0.6610.99
135_V160_A0.6610.99
70_P74_A0.6590.99
136_V139_A0.6550.99
165_W169_A0.6450.99
108_L133_V0.6420.99
43_L139_A0.6410.99
87_N92_D0.6400.99
24_L118_C0.6390.99
135_V152_W0.6310.99
121_F159_G0.6290.99
91_W129_E0.6230.99
24_L114_V0.6210.99
167_G170_C0.6190.99
44_G54_T0.6170.99
25_L37_K0.6150.99
42_A45_D0.6120.99
40_V139_A0.6120.99
147_T153_D0.6110.99
94_E98_K0.6060.99
42_A46_L0.6060.99
14_A108_L0.6060.99
37_K71_E0.6020.99
150_S153_D0.5990.99
93_N98_K0.5990.99
38_N42_A0.5980.99
20_H72_L0.5940.99
114_V143_F0.5910.99
124_L158_A0.5840.99
41_L73_K0.5830.99
13_A172_L0.5830.99
53_P105_K0.5820.99
124_L159_G0.5810.99
22_A25_L0.5790.99
113_V141_G0.5780.99
114_V142_T0.5750.99
82_I96_F0.5720.99
42_A169_A0.5700.98
14_A103_T0.5660.98
88_I122_P0.5660.98
15_V54_T0.5590.98
110_I133_V0.5550.98
134_F161_Q0.5500.98
89_N128_E0.5460.98
152_W156_S0.5450.98
62_T67_P0.5430.98
59_S114_V0.5400.98
64_P70_P0.5390.98
146_I153_D0.5380.98
69_V72_L0.5360.98
52_L172_L0.5350.98
28_V31_I0.5350.98
14_A100_V0.5280.98
106_K132_D0.5240.97
26_S64_P0.5220.97
9_D107_Q0.5210.97
20_H36_F0.5200.97
100_V131_F0.5170.97
22_A69_V0.5130.97
58_T67_P0.5130.97
88_I127_I0.5120.97
150_S164_T0.5120.97
24_L113_V0.5110.97
114_V117_V0.5080.97
25_L113_V0.5080.97
127_I133_V0.5070.97
88_I117_V0.5060.97
18_V90_A0.5060.97
34_D38_N0.5060.97
62_T65_N0.5050.97
147_T150_S0.5040.97
80_P103_T0.5030.97
137_T156_S0.5030.97
43_L169_A0.5020.97
133_V136_V0.5010.97
124_L128_E0.5000.97
44_G79_T0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1yacA 5 0.976 100 0.187 Contact Map
2b34A 8 0.9087 100 0.234 Contact Map
2fq1A 2 0.9904 100 0.255 Contact Map
3tg2A 2 0.8221 100 0.26 Contact Map
3mcwA 2 0.8462 100 0.262 Contact Map
1x9gA 3 0.8942 100 0.263 Contact Map
3kl2A 4 0.8269 100 0.263 Contact Map
3irvA 2 0.8365 100 0.263 Contact Map
1nf9A 2 0.8077 100 0.264 Contact Map
4l07A 4 0.8413 100 0.266 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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