GREMLIN Database
GLTP - Proton glutamate symport protein
UniProt: P21345 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10405
Length: 437 (392)
Sequences: 6299 (3698)
Seq/√Len: 186.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
153_A157_K4.6601.00
292_E298_V3.4841.00
183_E187_T3.4051.00
104_N340_E3.1841.00
102_L240_A3.0541.00
83_K412_E2.9861.00
179_A183_E2.9411.00
18_L212_F2.9391.00
146_L165_F2.9091.00
61_I167_S2.8351.00
42_S46_D2.7811.00
65_V189_F2.7531.00
284_L305_V2.7031.00
47_I147_V2.5781.00
198_K201_H2.5561.00
184_P191_S2.5371.00
22_L212_F2.5361.00
297_P414_K2.5241.00
11_Q205_R2.5071.00
61_I65_V2.4341.00
410_K417_R2.4181.00
336_S339_Q2.4161.00
62_S192_I2.4091.00
44_A213_A2.3951.00
107_Q110_A2.3731.00
7_S10_W2.3171.00
297_P409_A2.2931.00
271_L399_V2.2731.00
170_F195_T2.2611.00
238_H392_A2.1941.00
235_L239_F2.1781.00
178_P182_R2.1541.00
91_I252_V2.1371.00
141_G145_S2.1291.00
87_Y404_A2.1001.00
254_R257_G2.0831.00
270_E290_K2.0401.00
13_L17_V2.0051.00
102_L243_F1.9791.00
185_L188_V1.9621.00
83_K411_W1.9491.00
21_L25_Y1.9201.00
149_T153_A1.8841.00
327_I378_G1.8831.00
181_H194_E1.8801.00
101_T105_V1.8751.00
296_A406_L1.8731.00
241_I392_A1.8581.00
97_I101_T1.8381.00
62_S196_M1.8281.00
106_F236_L1.8241.00
70_G190_R1.8171.00
103_A325_I1.8171.00
243_F247_V1.8141.00
184_P187_T1.8061.00
291_M402_A1.7891.00
55_I203_V1.7891.00
386_D393_R1.7751.00
15_A212_F1.7751.00
159_E162_P1.7671.00
228_W232_K1.7651.00
185_L191_S1.7621.00
289_E293_A1.7541.00
108_P329_Q1.7541.00
82_A86_I1.7411.00
174_L195_T1.7151.00
152_V155_M1.6951.00
185_L195_T1.6751.00
176_S198_K1.6671.00
304_V405_V1.6341.00
266_I294_Y1.6281.00
296_A409_A1.6211.00
106_F239_F1.6051.00
103_A322_I1.6031.00
79_R412_E1.6011.00
256_C410_K1.5991.00
15_A19_G1.5951.00
267_L402_A1.5821.00
151_I166_F1.5591.00
327_I374_I1.5571.00
102_L236_L1.5561.00
262_I265_R1.5431.00
334_D338_W1.5341.00
241_I396_L1.5341.00
287_I402_A1.5331.00
390_D394_T1.5031.00
231_A235_L1.4951.00
47_I144_L1.4911.00
152_V156_A1.4821.00
292_E301_T1.4661.00
253_A403_L1.4631.00
240_A318_L1.4361.00
113_D332_G1.4211.00
69_A186_V1.4201.00
22_L26_L1.4141.00
331_Y378_G1.4141.00
271_L395_A1.4111.00
252_V407_V1.3901.00
53_K149_T1.3891.00
281_E356_G1.3871.00
266_I293_A1.3821.00
176_S202_M1.3791.00
10_W14_F1.3651.00
147_V165_F1.3561.00
288_I301_T1.3531.00
11_Q15_A1.3501.00
68_I168_V1.3441.00
46_D50_H1.3421.00
60_V160_M1.3391.00
337_I341_I1.3321.00
188_V191_S1.3321.00
190_R194_E1.3261.00
173_G199_V1.3251.00
61_I155_M1.3251.00
54_M166_F1.3051.00
145_S159_E1.2991.00
27_H220_A1.2941.00
297_P300_I1.2861.00
84_T304_V1.2841.00
409_A415_F1.2731.00
259_S262_I1.2721.00
66_V189_F1.2661.00
170_F192_I1.2591.00
300_I409_A1.2451.00
236_L322_I1.2441.00
184_P188_V1.2401.00
50_H149_T1.2401.00
174_L185_L1.2391.00
267_L399_V1.2331.00
251_I255_L1.2321.00
310_S313_L1.2301.00
173_G202_M1.2271.00
201_H289_E1.2261.00
202_M206_Y1.2171.00
100_I340_E1.2161.00
334_D339_Q1.2111.00
229_P232_K1.2071.00
261_W265_R1.2061.00
16_M215_I1.2031.00
324_A343_L1.1981.00
246_L250_G1.1971.00
234_V385_V1.1951.00
287_I305_V1.1911.00
409_A413_H1.1901.00
55_I200_T1.1841.00
253_A258_L1.1671.00
138_G141_G1.1611.00
254_R259_S1.1601.00
168_V172_L1.1591.00
101_T104_N1.1561.00
196_M200_T1.1521.00
217_V221_N1.1511.00
274_A394_T1.1501.00
362_F383_A1.1441.00
113_D116_Q1.1401.00
263_L267_L1.1371.00
169_L199_V1.1301.00
86_I90_V1.1211.00
57_V163_I1.1191.00
88_F304_V1.1161.00
42_S217_V1.1101.00
153_A156_A1.1011.00
343_L372_V1.0951.00
319_Y386_D1.0941.00
269_D293_A1.0921.00
134_S137_H1.0791.00
177_L191_S1.0741.00
284_L309_Y1.0721.00
283_V287_I1.0711.00
177_L182_R1.0711.00
232_K235_L1.0681.00
47_I51_L1.0651.00
91_I314_D1.0651.00
206_Y209_V1.0641.00
257_G410_K1.0621.00
76_Q299_S1.0601.00
314_D351_S1.0581.00
44_A206_Y1.0571.00
90_V94_V1.0541.00
245_A396_L1.0531.00
185_L189_F1.0501.00
179_A182_R1.0471.00
62_S66_V1.0451.00
287_I398_V1.0441.00
21_L24_S1.0391.00
258_L415_F1.0381.00
244_F318_L1.0371.00
409_A414_K1.0371.00
341_I345_L1.0341.00
151_I156_A1.0341.00
244_F248_V1.0321.00
296_A301_T1.0281.00
97_I341_I1.0201.00
64_L164_I1.0191.00
278_A387_R1.0191.00
187_T191_S1.0181.00
109_G329_Q1.0151.00
116_Q119_T1.0101.00
291_M305_V1.0090.99
80_I300_I1.0080.99
410_K413_H1.0050.99
319_Y393_R1.0030.99
97_I344_V1.0020.99
291_M296_A1.0000.99
177_L195_T0.9990.99
165_F169_L0.9960.99
18_L22_L0.9950.99
187_T190_R0.9860.99
225_S228_W0.9790.99
249_L252_V0.9780.99
89_E93_T0.9770.99
45_G214_L0.9740.99
258_L262_I0.9710.99
358_P390_D0.9700.99
183_E186_V0.9630.99
312_N401_N0.9590.99
25_Y29_H0.9560.99
232_K329_Q0.9540.99
137_H141_G0.9540.99
178_P183_E0.9470.99
73_D76_Q0.9460.99
142_T148_P0.9450.99
102_L106_F0.9420.99
139_I143_I0.9420.99
99_G321_S0.9390.99
266_I290_K0.9350.99
265_R268_K0.9340.99
137_H145_S0.9320.99
292_E302_S0.9310.99
172_L176_S0.9300.99
247_V250_G0.9280.99
22_L216_A0.9270.99
154_S166_F0.9250.99
144_L148_P0.9230.99
79_R83_K0.9210.99
19_G27_H0.9170.99
316_S361_S0.9160.99
93_T97_I0.9150.99
275_Y391_M0.9140.99
15_A27_H0.9100.99
325_I340_E0.9100.99
319_Y389_L0.9080.99
290_K293_A0.9070.99
182_R191_S0.9060.99
270_E283_V0.9050.99
283_V286_R0.9020.99
17_V21_L0.9010.99
337_I340_E0.8990.99
26_L29_H0.8980.99
75_K78_G0.8980.99
234_V388_I0.8970.99
239_F243_F0.8890.99
50_H53_K0.8890.99
248_V252_V0.8870.99
234_V389_L0.8850.99
100_I104_N0.8830.99
251_I254_R0.8810.99
95_A244_F0.8810.99
169_L202_M0.8790.99
350_T368_T0.8770.99
239_F242_L0.8760.99
313_L401_N0.8760.99
238_H242_L0.8740.99
237_V389_L0.8730.99
320_Q365_L0.8720.99
270_E287_I0.8710.99
247_V251_I0.8710.99
170_F199_V0.8700.99
198_K202_M0.8700.99
98_L243_F0.8700.99
151_I154_S0.8690.98
55_I199_V0.8680.98
135_S138_G0.8670.98
266_I270_E0.8670.98
141_G144_L0.8640.98
309_Y401_N0.8570.98
182_R195_T0.8570.98
250_G264_I0.8560.98
280_S397_N0.8520.98
65_V174_L0.8510.98
41_L213_A0.8510.98
216_A220_A0.8430.98
167_S171_G0.8430.98
66_V190_R0.8410.98
291_M301_T0.8380.98
147_V150_N0.8370.98
113_D117_L0.8370.98
7_S11_Q0.8360.98
409_A416_D0.8350.98
263_L402_A0.8340.98
65_V170_F0.8300.98
228_W231_A0.8300.98
237_V322_I0.8270.98
166_F170_F0.8180.98
289_E292_E0.8180.98
273_L283_V0.8170.98
212_F216_A0.8160.98
273_L286_R0.8110.98
201_H205_R0.8110.98
178_P186_V0.8110.98
62_S189_F0.8090.98
268_K272_I0.8080.98
150_N166_F0.8040.98
151_I158_G0.8030.97
65_V167_S0.8020.97
182_R186_V0.8010.97
242_L246_L0.8000.97
29_H40_L0.8000.97
174_L189_F0.8000.97
140_M144_L0.7910.97
22_L41_L0.7860.97
323_A382_I0.7840.97
366_L379_L0.7810.97
26_L41_L0.7800.97
233_L322_I0.7800.97
362_F379_L0.7790.97
46_D144_L0.7780.97
324_A368_T0.7760.97
193_S197_F0.7730.97
76_Q79_R0.7700.97
233_L389_L0.7680.97
51_L147_V0.7670.97
102_L105_V0.7670.97
41_L216_A0.7650.97
45_G210_G0.7650.97
273_L277_T0.7630.97
50_H145_S0.7610.97
80_I408_I0.7610.97
234_V238_H0.7610.97
99_G322_I0.7580.96
320_Q362_F0.7560.96
300_I304_V0.7550.96
40_L43_P0.7550.96
331_Y377_E0.7520.96
270_E286_R0.7490.96
410_K415_F0.7480.96
111_G114_M0.7450.96
249_L253_A0.7440.96
311_F352_K0.7440.96
48_F207_A0.7440.96
38_V220_A0.7400.96
233_L319_Y0.7380.96
117_L120_V0.7330.96
8_L11_Q0.7320.96
278_A390_D0.7310.96
287_I401_N0.7310.96
207_A210_G0.7290.96
63_T193_S0.7290.96
102_L239_F0.7290.96
366_L370_G0.7280.96
145_S148_P0.7240.95
196_M203_V0.7230.95
274_A398_V0.7210.95
262_I266_I0.7180.95
114_M117_L0.7180.95
48_F206_Y0.7160.95
233_L382_I0.7150.95
335_L339_Q0.7140.95
362_F389_L0.7130.95
138_G142_T0.7130.95
28_Y220_A0.7120.95
263_L406_L0.7110.95
28_Y39_N0.7050.95
107_Q329_Q0.7040.95
188_V192_I0.7040.95
179_A184_P0.7040.95
250_G254_R0.7010.95
111_G232_K0.6980.94
150_N154_S0.6970.94
237_V241_I0.6970.94
39_N220_A0.6960.94
170_F185_L0.6960.94
324_A328_A0.6940.94
316_S354_I0.6920.94
211_V358_P0.6920.94
69_A175_S0.6920.94
71_V80_I0.6920.94
144_L147_V0.6910.94
307_T311_F0.6900.94
86_I89_E0.6880.94
155_M166_F0.6860.94
338_W341_I0.6840.94
12_I207_A0.6800.94
347_L364_V0.6800.94
142_T145_S0.6740.93
340_E344_V0.6730.93
316_S320_Q0.6710.93
257_G260_V0.6700.93
84_T408_I0.6700.93
244_F314_D0.6690.93
26_L216_A0.6670.93
236_L239_F0.6660.93
19_G216_A0.6640.93
298_V302_S0.6630.93
113_D119_T0.6600.93
74_A172_L0.6600.93
131_A134_S0.6570.92
240_A322_I0.6560.92
99_G318_L0.6560.92
104_N337_I0.6550.92
165_F206_Y0.6550.92
98_L248_V0.6530.92
93_T348_M0.6530.92
309_Y313_L0.6470.92
200_T275_Y0.6460.92
207_A277_T0.6460.92
258_L266_I0.6450.92
40_L44_A0.6450.92
79_R82_A0.6440.92
108_P111_G0.6430.92
354_I364_V0.6430.92
65_V192_I0.6410.91
74_A81_G0.6410.91
342_I372_V0.6410.91
76_Q81_G0.6400.91
209_V213_A0.6390.91
191_S194_E0.6380.91
177_L194_E0.6370.91
194_E198_K0.6360.91
22_L27_H0.6360.91
254_R260_V0.6360.91
155_M162_P0.6350.91
98_L240_A0.6340.91
414_K417_R0.6340.91
233_L241_I0.6330.91
11_Q209_V0.6320.91
27_H38_V0.6310.91
73_D81_G0.6310.91
174_L186_V0.6310.91
12_I15_A0.6300.91
91_I95_A0.6300.91
88_F244_F0.6270.91
88_F401_N0.6270.91
352_K401_N0.6260.91
190_R193_S0.6260.91
253_A256_C0.6250.90
51_L169_L0.6250.90
89_E352_K0.6240.90
88_F404_A0.6240.90
115_S119_T0.6230.90
346_T371_S0.6220.90
181_H187_T0.6220.90
344_V347_L0.6190.90
246_L251_I0.6180.90
320_Q354_I0.6180.90
338_W342_I0.6150.90
76_Q414_K0.6140.90
294_Y406_L0.6120.90
320_Q324_A0.6110.89
313_L354_I0.6110.89
230_L233_L0.6090.89
356_G359_G0.6080.89
263_L294_Y0.6070.89
331_Y375_P0.6060.89
305_V405_V0.6040.89
47_I165_F0.6030.89
100_I344_V0.6010.89
258_L416_D0.6000.89
149_T157_K0.6000.89
44_A209_V0.6000.89
233_L323_A0.5990.89
405_V409_A0.5970.88
164_I331_Y0.5970.88
198_K205_R0.5960.88
328_A333_I0.5950.88
59_I164_I0.5930.88
14_F18_L0.5930.88
288_I305_V0.5930.88
191_S195_T0.5920.88
314_D400_G0.5870.87
210_G214_L0.5860.87
377_E380_A0.5820.87
297_P301_T0.5810.87
66_V186_V0.5800.87
185_L192_I0.5790.87
323_A386_D0.5790.87
267_L287_I0.5760.87
378_G381_F0.5760.87
356_G360_V0.5750.86
143_I147_V0.5750.86
183_E188_V0.5730.86
265_R269_D0.5720.86
281_E309_Y0.5710.86
321_S347_L0.5700.86
413_H417_R0.5700.86
245_A250_G0.5700.86
54_M199_V0.5690.86
342_I346_T0.5690.86
51_L206_Y0.5690.86
186_V190_R0.5670.86
131_A135_S0.5650.85
94_V248_V0.5650.85
334_D337_I0.5650.85
66_V70_G0.5630.85
344_V348_M0.5630.85
359_G363_V0.5620.85
327_I364_V0.5620.85
94_V97_I0.5620.85
373_G377_E0.5590.85
133_Q136_S0.5590.85
397_N401_N0.5590.85
245_A264_I0.5580.85
224_F228_W0.5580.85
27_H39_N0.5570.85
283_V309_Y0.5550.84
177_L198_K0.5540.84
286_R289_E0.5530.84
274_A390_D0.5530.84
16_M211_V0.5530.84
115_S118_A0.5530.84
102_L235_L0.5520.84
361_S368_T0.5510.84
19_G212_F0.5510.84
148_P152_V0.5510.84
335_L343_L0.5500.84
283_V398_V0.5500.84
80_I412_E0.5490.84
230_L241_I0.5480.84
133_Q137_H0.5460.83
205_R209_V0.5460.83
57_V155_M0.5450.83
407_V411_W0.5430.83
300_I414_K0.5430.83
263_L399_V0.5420.83
173_G177_L0.5420.83
253_A407_V0.5410.83
82_A85_I0.5410.83
278_A282_S0.5400.83
274_A395_A0.5390.83
56_V360_V0.5390.83
8_L14_F0.5380.83
19_G215_I0.5380.83
92_T317_T0.5380.83
91_I311_F0.5380.83
59_I196_M0.5360.82
250_G253_A0.5350.82
23_G27_H0.5350.82
94_V98_L0.5350.82
343_L347_L0.5350.82
88_F308_G0.5330.82
296_A405_V0.5330.82
56_V381_F0.5300.82
319_Y323_A0.5290.82
13_L16_M0.5290.82
106_F232_K0.5280.81
354_I361_S0.5280.81
24_S224_F0.5280.81
330_L381_F0.5270.81
235_L238_H0.5260.81
148_P154_S0.5250.81
232_K236_L0.5250.81
39_N221_N0.5250.81
375_P378_G0.5240.81
71_V405_V0.5240.81
387_R391_M0.5240.81
96_I348_M0.5230.81
156_A159_E0.5220.81
134_S138_G0.5220.81
22_L25_Y0.5220.81
295_G416_D0.5210.81
84_T300_I0.5210.81
291_M401_N0.5200.80
339_Q342_I0.5200.80
230_L234_V0.5190.80
316_S390_D0.5190.80
154_S157_K0.5190.80
327_I331_Y0.5190.80
406_L415_F0.5180.80
51_L203_V0.5180.80
249_L400_G0.5170.80
174_L191_S0.5170.80
16_M27_H0.5160.80
351_S363_V0.5140.80
52_I273_L0.5130.80
347_L355_A0.5130.80
385_V389_L0.5130.80
249_L264_I0.5080.79
316_S393_R0.5080.79
324_A327_I0.5070.79
308_G405_V0.5070.79
23_G26_L0.5060.79
162_P359_G0.5030.78
204_M207_A0.5030.78
26_L40_L0.5020.78
315_G396_L0.5010.78
46_D217_V0.5010.78
20_I23_G0.5010.78
267_L271_L0.5000.78
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nwlA 3 0.8924 100 0.104 Contact Map
3zuxA 1 0.6522 70.2 0.957 Contact Map
3nd0A 2 0.8398 29.8 0.967 Contact Map
4cz8A 2 0.6224 25.1 0.968 Contact Map
4czbA 2 0.611 21.4 0.969 Contact Map
4ryoA 1 0.3432 18.1 0.97 Contact Map
4n7wA 2 0.3638 14.4 0.971 Contact Map
4bgnA 3 0.4485 10 0.973 Contact Map
3klyA 3 0.524 7.2 0.975 Contact Map
4eneA 2 0.8467 6.5 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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