DPO2 - ECOLI - GREMLIN Contacts

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DPO2 - DNA polymerase II

UniProt:	P21189	Sequences: MAQAGFILTRHWRDTPQGTEVSFWLATDNGPLQVTLAPQESVAFIPADQVPRAQHILQGEQGFRLTPLALKDFHRQPVYGLYCRAHRQLMNYEKRLREGGVTVYEADVRPPERYLMERFITSPVWVEGDMHNGTIVNARLKPHPDYRPPLKWVSIDIETTRHGELYCIGLEGCGQRIVYMLGPENGDASSLDFELEYVASRPQLLEKLNAWFANYDPDVIIGWNVVQFDLRMLQKHAERYRLPLRLGRDNSELEWREHGFKNGVFFAQAKGRLIIDGIEALKSAFWNFSSFSLETVAQELLGEGKSIDNPWDRMDEIDRRFAEDKPALATYNLKDCELVTQIFHKTEIMPFLLERATVNGLPVDRHGGSVAAFGHLYFPRMHRAGYVAPNLGEVPPHASPGGYVMDSRPGLYDSVLVLDYKSLYPSIIRTFLIDPVGLVEGMAQPDPEHSTEGFLDAWFSREKHCLPEIVTNIWHGRDEAKRQGNKPLSQALKIIMNAFYGVLGTTACRFFDPRLASSITMRGHQIMRQTKALIEAQGYDVIYGDTDSTFVWLKGAHSEEEAAKIGRALVQHVNAWWAETLQKQRLTSALELEYETHFCRFLMPTIRGADTGSKKRYAGLIQEGDKQRMVFKGLETVRTDWTPLAQQFQQELYLRIFRNEPYQEYVRETIDKLMAGELDARLVYRKRLRRPLSEYQRNVPPHVRAARLADEENQKRGRPLQYQNRGTIKYVWTTNGPEPLDYQRSPLDYEHYLTRQLQPVAEGILPFIEDNFATLMTGQLGLF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10747
Length:	783 (734)
Sequences:	2005 (1229)
Seq/√Len:	45.3

ECOLI - DPO2
HALSA - Q9HRV9 Q9HHJ8
SULSO - DPOL1 DPOL3 DPOL2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
408_R	540_D	6.032	1.00
647_Q	681_R	5.701	1.00
672_K	677_E	5.258	1.00
303_E	341_Q	5.241	1.00
83_C	92_Y	4.619	1.00
558_S	561_E	4.525	1.00
668_E	672_K	3.986	1.00
313_R	316_E	3.923	1.00
463_K	471_T	3.698	1.00
648_F	669_T	3.695	1.00
42_V	117_E	3.689	1.00
673_L	682_L	3.508	1.00
196_E	207_K	3.455	1.00
133_G	138_A	3.441	1.00
155_I	208_L	3.371	1.00
174_G	233_L	3.358	1.00
561_E	564_K	3.338	1.00
200_S	203_Q	3.275	1.00
212_F	220_I	3.089	1.00
651_E	655_R	2.948	1.00
198_V	207_K	2.820	1.00
207_K	210_A	2.800	1.00
532_A	536_A	2.798	1.00
314_M	318_D	2.757	1.00
303_E	334_K	2.663	1.00
201_R	236_H	2.604	1.00
133_G	136_V	2.602	1.00
177_I	208_L	2.594	1.00
531_K	535_E	2.565	1.00
664_E	668_E	2.556	1.00
229_D	335_D	2.548	1.00
384_A	468_E	2.548	1.00
298_Q	304_G	2.535	1.00
360_G	379_P	2.534	1.00
598_F	630_V	2.473	1.00
174_G	178_V	2.461	1.00
68_L	71_K	2.428	1.00
202_P	206_E	2.406	1.00
224_N	229_D	2.401	1.00
750_E	754_T	2.384	1.00
380_R	472_N	2.376	1.00
380_R	383_R	2.372	1.00
83_C	89_L	2.352	1.00
19_T	41_S	2.344	1.00
81_L	92_Y	2.333	1.00
70_L	73_F	2.263	1.00
56_I	59_G	2.255	1.00
537_Q	572_H	2.247	1.00
708_L	739_P	2.240	1.00
374_G	509_R	2.217	1.00
150_L	219_V	2.204	1.00
572_H	575_A	2.172	1.00
720_L	723_Q	2.164	1.00
564_K	568_A	2.132	1.00
216_D	248_R	2.120	1.00
53_A	57_L	2.107	1.00
216_D	272_R	2.101	1.00
165_L	168_I	2.093	1.00
313_R	317_I	2.088	1.00
650_Q	654_L	2.087	1.00
156_D	331_Y	2.052	0.99
174_G	177_I	2.050	0.99
158_E	335_D	2.029	0.99
471_T	475_H	2.004	0.99
45_I	81_L	1.999	0.99
714_Q	719_P	1.994	0.99
571_Q	575_A	1.986	0.99
103_V	106_A	1.981	0.99
297_A	338_L	1.976	0.99
63_F	67_P	1.971	0.99
222_G	225_V	1.959	0.99
618_A	634_L	1.949	0.99
248_R	272_R	1.940	0.99
53_A	56_I	1.931	0.99
733_T	748_D	1.931	0.99
314_M	317_I	1.929	0.99
36_L	114_Y	1.921	0.99
714_Q	718_R	1.908	0.99
674_M	750_E	1.903	0.99
334_K	337_E	1.892	0.99
621_I	628_R	1.888	0.99
568_A	572_H	1.880	0.99
376_L	495_I	1.872	0.99
654_L	658_R	1.869	0.99
110_P	117_E	1.865	0.99
704_R	708_L	1.856	0.99
417_V	550_F	1.855	0.99
235_K	238_E	1.845	0.99
729_K	732_W	1.828	0.99
175_Q	178_V	1.828	0.99
172_G	177_I	1.827	0.99
714_Q	720_L	1.819	0.99
83_C	86_H	1.817	0.99
93_E	98_E	1.807	0.99
164_E	167_C	1.798	0.99
500_Y	516_A	1.797	0.99
317_I	324_D	1.795	0.99
401_G	404_V	1.794	0.98
158_E	229_D	1.794	0.98
185_N	188_A	1.793	0.98
167_C	177_I	1.781	0.98
68_L	73_F	1.777	0.98
92_Y	95_R	1.757	0.98
152_W	219_V	1.745	0.98
224_N	228_F	1.739	0.98
219_V	349_M	1.730	0.98
177_I	184_E	1.726	0.98
86_H	110_P	1.725	0.98
736_G	739_P	1.720	0.98
452_E	456_D	1.717	0.98
290_S	295_T	1.710	0.98
47_A	79_Y	1.704	0.98
479_E	482_R	1.699	0.98
651_E	654_L	1.696	0.98
172_G	178_V	1.691	0.98
335_D	520_T	1.688	0.98
540_D	552_W	1.680	0.98
53_A	58_Q	1.668	0.98
570_V	574_N	1.656	0.97
313_R	318_D	1.655	0.97
198_V	204_L	1.652	0.97
637_V	702_H	1.644	0.97
464_H	467_P	1.643	0.97
672_K	678_L	1.640	0.97
95_R	98_E	1.639	0.97
723_Q	747_L	1.637	0.97
173_C	178_V	1.628	0.97
529_Q	532_A	1.624	0.97
178_V	182_G	1.619	0.97
119_F	383_R	1.617	0.97
456_D	518_S	1.616	0.97
671_D	675_A	1.616	0.97
154_S	339_V	1.614	0.97
156_D	335_D	1.613	0.97
533_L	576_W	1.608	0.97
432_L	437_G	1.604	0.97
68_L	72_D	1.602	0.97
109_R	112_E	1.585	0.97
178_V	187_D	1.585	0.97
69_A	72_D	1.579	0.97
310_P	313_R	1.576	0.97
728_I	732_W	1.567	0.96
224_N	278_I	1.567	0.96
596_T	630_V	1.567	0.96
635_E	763_G	1.559	0.96
708_L	735_N	1.555	0.96
62_G	66_T	1.542	0.96
82_Y	85_A	1.541	0.96
421_K	593_E	1.538	0.96
347_E	350_P	1.536	0.96
178_V	336_C	1.533	0.96
178_V	181_L	1.532	0.96
735_N	739_P	1.530	0.96
181_L	184_E	1.521	0.96
41_S	105_E	1.520	0.96
229_D	305_K	1.514	0.96
665_Y	669_T	1.512	0.96
46_P	104_Y	1.510	0.96
516_A	523_G	1.507	0.96
305_K	335_D	1.501	0.95
156_D	229_D	1.498	0.95
76_Q	82_Y	1.489	0.95
544_G	548_S	1.486	0.95
72_D	76_Q	1.484	0.95
648_F	665_Y	1.468	0.95
431_F	526_I	1.458	0.95
202_P	240_Y	1.457	0.95
174_G	187_D	1.456	0.95
432_L	464_H	1.451	0.94
78_V	82_Y	1.451	0.94
708_L	734_T	1.450	0.94
707_R	710_D	1.447	0.94
21_V	114_Y	1.446	0.94
92_Y	98_E	1.445	0.94
482_R	486_K	1.445	0.94
466_L	503_L	1.445	0.94
117_E	385_G	1.441	0.94
167_C	174_G	1.434	0.94
545_D	615_K	1.433	0.94
289_S	646_Q	1.418	0.94
131_H	134_T	1.417	0.94
401_G	520_T	1.414	0.94
474_W	496_M	1.406	0.94
535_E	540_D	1.397	0.93
688_L	703_V	1.395	0.93
355_R	491_A	1.393	0.93
482_R	485_N	1.379	0.93
686_K	722_Y	1.377	0.93
60_E	64_R	1.375	0.93
153_V	212_F	1.368	0.93
294_E	304_G	1.363	0.92
93_E	96_L	1.362	0.92
81_L	84_R	1.355	0.92
108_V	378_F	1.352	0.92
75_R	81_L	1.351	0.92
171_E	178_V	1.350	0.92
352_L	363_V	1.347	0.92
169_G	172_G	1.344	0.92
596_T	619_G	1.343	0.92
209_N	213_A	1.339	0.92
158_E	224_N	1.338	0.92
417_V	619_G	1.338	0.92
771_N	774_T	1.337	0.92
719_P	723_Q	1.335	0.92
167_C	170_L	1.332	0.92
64_R	67_P	1.331	0.91
724_N	728_I	1.318	0.91
73_F	82_Y	1.312	0.91
80_G	84_R	1.311	0.91
224_N	335_D	1.309	0.91
84_R	88_Q	1.308	0.91
381_M	465_C	1.305	0.91
172_G	176_R	1.304	0.91
180_M	183_P	1.302	0.91
533_L	573_V	1.301	0.91
306_S	330_T	1.300	0.90
189_S	192_D	1.298	0.90
362_P	365_R	1.295	0.90
51_P	59_G	1.295	0.90
218_D	272_R	1.293	0.90
308_D	335_D	1.292	0.90
82_Y	89_L	1.291	0.90
80_G	97_R	1.288	0.90
534_I	549_T	1.286	0.90
72_D	92_Y	1.285	0.90
337_E	341_Q	1.285	0.90
70_L	80_G	1.284	0.90
420_Y	426_S	1.284	0.90
378_F	388_A	1.282	0.90
158_E	305_K	1.280	0.90
69_A	73_F	1.277	0.90
381_M	436_V	1.277	0.90
431_F	590_L	1.272	0.90
158_E	228_F	1.271	0.89
691_P	694_E	1.269	0.89
228_F	335_D	1.263	0.89
733_T	736_G	1.259	0.89
158_E	331_Y	1.254	0.89
206_E	210_A	1.253	0.89
78_V	81_L	1.248	0.89
528_R	532_A	1.242	0.88
282_K	291_F	1.242	0.88
449_H	452_E	1.242	0.88
51_P	55_H	1.241	0.88
75_R	83_C	1.237	0.88
55_H	220_I	1.236	0.88
43_A	89_L	1.229	0.88
55_H	59_G	1.219	0.87
173_C	179_Y	1.218	0.87
182_G	187_D	1.216	0.87
172_G	175_Q	1.212	0.87
172_G	179_Y	1.207	0.87
83_C	90_M	1.202	0.87
473_I	492_L	1.200	0.87
316_E	319_R	1.194	0.86
553_L	565_I	1.189	0.86
724_N	727_T	1.186	0.86
81_L	85_A	1.183	0.86
53_A	59_G	1.179	0.86
335_D	401_G	1.179	0.86
85_A	92_Y	1.178	0.86
52_R	55_H	1.177	0.85
86_H	92_Y	1.176	0.85
422_S	494_I	1.175	0.85
105_E	108_V	1.173	0.85
81_L	86_H	1.169	0.85
526_I	530_T	1.169	0.85
618_A	657_F	1.168	0.85
723_Q	730_Y	1.168	0.85
758_Q	773_A	1.165	0.85
697_R	700_P	1.164	0.85
151_K	215_Y	1.158	0.85
453_G	456_D	1.151	0.84
502_V	508_C	1.149	0.84
70_L	78_V	1.147	0.84
157_I	224_N	1.144	0.84
616_R	635_E	1.142	0.84
73_F	78_V	1.142	0.84
447_P	451_T	1.139	0.84
168_I	177_I	1.133	0.83
555_G	562_A	1.130	0.83
173_C	181_L	1.130	0.83
761_A	765_L	1.128	0.83
185_N	189_S	1.127	0.83
563_A	594_Y	1.123	0.83
123_P	353_L	1.123	0.83
663_Q	771_N	1.120	0.82
71_K	75_R	1.119	0.82
84_R	92_Y	1.118	0.82
179_Y	185_N	1.113	0.82
640_D	686_K	1.113	0.82
504_G	702_H	1.111	0.82
404_V	614_K	1.109	0.82
648_F	652_L	1.108	0.82
78_V	83_C	1.104	0.82
167_C	172_G	1.098	0.81
81_L	95_R	1.095	0.81
40_E	64_R	1.091	0.81
86_H	117_E	1.088	0.81
79_Y	82_Y	1.083	0.80
42_V	80_G	1.082	0.80
78_V	84_R	1.079	0.80
477_R	489_S	1.077	0.80
331_Y	335_D	1.075	0.80
177_I	181_L	1.074	0.80
481_K	485_N	1.074	0.80
427_I	526_I	1.073	0.80
690_R	694_E	1.071	0.80
89_L	93_E	1.067	0.79
75_R	84_R	1.067	0.79
170_L	235_K	1.066	0.79
480_A	492_L	1.065	0.79
305_K	331_Y	1.063	0.79
572_H	576_W	1.063	0.79
635_E	638_R	1.059	0.79
277_G	339_V	1.057	0.79
454_F	518_S	1.055	0.79
273_L	378_F	1.052	0.78
182_G	185_N	1.052	0.78
574_N	586_L	1.050	0.78
700_P	703_V	1.050	0.78
251_S	270_K	1.046	0.78
301_L	338_L	1.044	0.78
178_V	189_S	1.044	0.78
533_L	536_A	1.042	0.78
93_E	106_A	1.042	0.78
168_I	174_G	1.037	0.77
186_G	190_S	1.036	0.77
79_Y	83_C	1.034	0.77
26_A	246_L	1.033	0.77
642_T	756_Q	1.031	0.77
232_M	236_H	1.028	0.77
623_E	628_R	1.027	0.77
228_F	278_I	1.026	0.77
651_E	665_Y	1.026	0.77
172_G	185_N	1.026	0.77
631_F	634_L	1.025	0.76
45_I	103_V	1.024	0.76
68_L	78_V	1.024	0.76
154_S	336_C	1.021	0.76
173_C	182_G	1.021	0.76
276_D	401_G	1.021	0.76
417_V	596_T	1.021	0.76
527_M	549_T	1.017	0.76
273_L	363_V	1.016	0.76
167_C	171_E	1.016	0.76
178_V	184_E	1.016	0.76
479_E	483_Q	1.014	0.76
60_E	65_L	1.012	0.76
86_H	90_M	1.009	0.75
76_Q	85_A	1.009	0.75
409_P	613_S	1.008	0.75
170_L	177_I	1.007	0.75
437_G	464_H	1.007	0.75
602_L	618_A	1.005	0.75
310_P	314_M	1.005	0.75
637_V	640_D	1.003	0.75
751_H	763_G	0.999	0.75
85_A	91_N	0.998	0.75
70_L	76_Q	0.998	0.75
68_L	85_A	0.991	0.74
305_K	338_L	0.990	0.74
464_H	468_E	0.990	0.74
225_V	274_I	0.988	0.74
173_C	177_I	0.987	0.74
312_D	317_I	0.986	0.74
354_E	357_T	0.984	0.73
415_V	542_I	0.984	0.73
86_H	95_R	0.981	0.73
216_D	360_G	0.980	0.73
242_L	560_E	0.977	0.73
22_S	35_T	0.977	0.73
398_A	506_T	0.976	0.73
488_L	496_M	0.975	0.73
86_H	98_E	0.975	0.73
601_F	619_G	0.974	0.73
82_Y	88_Q	0.974	0.73
84_R	89_L	0.972	0.73
170_L	185_N	0.972	0.73
157_I	177_I	0.972	0.73
526_I	590_L	0.971	0.72
641_W	645_A	0.971	0.72
186_G	191_L	0.970	0.72
536_A	564_K	0.968	0.72
664_E	667_R	0.966	0.72
180_M	185_N	0.966	0.72
50_V	195_L	0.965	0.72
60_E	63_F	0.960	0.72
349_M	634_L	0.957	0.71
293_L	335_D	0.955	0.71
328_L	358_V	0.955	0.71
409_P	521_M	0.954	0.71
96_L	101_V	0.954	0.71
56_I	63_F	0.952	0.71
721_Q	737_P	0.947	0.71
46_P	76_Q	0.945	0.70
131_H	138_A	0.945	0.70
354_E	488_L	0.944	0.70
645_A	760_V	0.943	0.70
156_D	228_F	0.942	0.70
311_W	314_M	0.942	0.70
451_T	456_D	0.942	0.70
530_T	549_T	0.942	0.70
81_L	89_L	0.941	0.70
324_D	327_A	0.939	0.70
498_A	520_T	0.938	0.70
122_S	360_G	0.935	0.70
83_C	88_Q	0.933	0.69
292_S	297_A	0.930	0.69
85_A	89_L	0.930	0.69
183_P	186_G	0.929	0.69
19_T	22_S	0.926	0.69
718_R	721_Q	0.926	0.69
175_Q	185_N	0.924	0.69
718_R	723_Q	0.924	0.69
167_C	178_V	0.923	0.69
209_N	237_A	0.923	0.69
382_H	385_G	0.921	0.68
706_A	748_D	0.921	0.68
374_G	502_V	0.920	0.68
19_T	86_H	0.919	0.68
84_R	95_R	0.917	0.68
550_F	619_G	0.916	0.68
76_Q	84_R	0.916	0.68
34_V	128_G	0.915	0.68
52_R	66_T	0.914	0.68
380_R	469_I	0.912	0.68
92_Y	97_R	0.910	0.67
389_P	410_G	0.909	0.67
213_A	246_L	0.907	0.67
174_G	192_D	0.907	0.67
293_L	401_G	0.903	0.67
476_G	479_E	0.902	0.67
161_R	318_D	0.900	0.67
135_I	138_A	0.900	0.67
269_A	348_I	0.899	0.67
229_D	331_Y	0.898	0.66
162_H	171_E	0.898	0.66
43_A	92_Y	0.898	0.66
75_R	95_R	0.897	0.66
81_L	98_E	0.895	0.66
254_E	260_F	0.894	0.66
51_P	57_L	0.893	0.66
88_Q	92_Y	0.893	0.66
557_H	561_E	0.892	0.66
155_I	220_I	0.890	0.66
83_C	96_L	0.887	0.65
370_V	511_F	0.887	0.65
406_D	429_R	0.885	0.65
277_G	343_F	0.885	0.65
113_R	117_E	0.883	0.65
59_G	63_F	0.882	0.65
280_A	349_M	0.881	0.65
94_K	98_E	0.879	0.65
277_G	773_A	0.877	0.65
130_M	133_G	0.877	0.65
421_K	591_E	0.877	0.65
132_N	135_I	0.875	0.64
570_V	573_V	0.875	0.64
85_A	88_Q	0.875	0.64
81_L	88_Q	0.875	0.64
500_Y	523_G	0.874	0.64
421_K	467_P	0.874	0.64
88_Q	91_N	0.874	0.64
257_E	260_F	0.871	0.64
45_I	77_P	0.871	0.64
685_R	719_P	0.871	0.64
384_A	465_C	0.870	0.64
703_V	706_A	0.868	0.64
332_N	336_C	0.868	0.64
509_R	635_E	0.867	0.64
673_L	753_L	0.866	0.64
635_E	649_Q	0.866	0.64
174_G	189_S	0.865	0.64
416_L	551_V	0.865	0.64
333_L	592_L	0.864	0.63
638_R	695_Y	0.862	0.63
700_P	704_R	0.861	0.63
53_A	60_E	0.859	0.63
82_Y	95_R	0.858	0.63
335_D	338_L	0.857	0.63
573_V	592_L	0.856	0.63
158_E	332_N	0.855	0.63
712_E	735_N	0.854	0.63
493_K	501_G	0.853	0.62
79_Y	88_Q	0.853	0.62
289_S	295_T	0.853	0.62
573_V	576_W	0.853	0.62
309_N	317_I	0.852	0.62
120_I	647_Q	0.852	0.62
42_V	113_R	0.852	0.62
526_I	586_L	0.851	0.62
529_Q	533_L	0.849	0.62
180_M	246_L	0.848	0.62
502_V	510_F	0.847	0.62
55_H	63_F	0.846	0.62
279_E	282_K	0.844	0.62
72_D	78_V	0.841	0.61
78_V	98_E	0.840	0.61
559_E	599_C	0.839	0.61
89_L	94_K	0.838	0.61
220_I	303_E	0.835	0.61
186_G	192_D	0.834	0.61
68_L	80_G	0.833	0.61
751_H	755_R	0.832	0.60
631_F	653_Y	0.832	0.60
69_A	78_V	0.830	0.60
643_P	647_Q	0.829	0.60
105_E	117_E	0.826	0.60
50_V	54_Q	0.826	0.60
28_D	146_Y	0.826	0.60
56_I	60_E	0.823	0.60
172_G	181_L	0.822	0.60
737_P	740_L	0.819	0.59
51_P	56_I	0.819	0.59
131_H	135_I	0.819	0.59
134_T	138_A	0.819	0.59
316_E	323_E	0.818	0.59
753_L	758_Q	0.816	0.59
234_Q	238_E	0.815	0.59
655_R	658_R	0.814	0.59
641_W	759_P	0.814	0.59
430_T	589_A	0.814	0.59
167_C	181_L	0.812	0.59
38_P	88_Q	0.812	0.59
86_H	89_L	0.811	0.58
173_C	187_D	0.809	0.58
730_Y	751_H	0.809	0.58
420_Y	473_I	0.809	0.58
176_R	329_A	0.807	0.58
83_C	87_R	0.807	0.58
380_R	384_A	0.806	0.58
156_D	224_N	0.806	0.58
167_C	176_R	0.806	0.58
603_M	632_K	0.806	0.58
293_L	331_Y	0.805	0.58
229_D	520_T	0.805	0.58
496_M	639_T	0.805	0.58
179_Y	182_G	0.804	0.58
177_I	187_D	0.803	0.58
181_L	185_N	0.803	0.58
93_E	97_R	0.801	0.58
448_E	451_T	0.799	0.57
705_A	734_T	0.799	0.57
21_V	573_V	0.798	0.57
85_A	90_M	0.797	0.57
157_I	338_L	0.797	0.57
169_G	180_M	0.795	0.57
433_I	450_S	0.794	0.57
205_L	233_L	0.791	0.57
748_D	760_V	0.791	0.57
669_T	672_K	0.790	0.56
178_V	183_P	0.789	0.56
634_L	649_Q	0.789	0.56
228_F	331_Y	0.789	0.56
28_D	49_Q	0.788	0.56
156_D	520_T	0.786	0.56
182_G	188_A	0.784	0.56
288_F	296_V	0.783	0.56
130_M	242_L	0.782	0.56
34_V	126_V	0.782	0.56
75_R	80_G	0.781	0.56
271_G	422_S	0.781	0.56
181_L	192_D	0.780	0.56
97_R	120_I	0.779	0.55
354_E	485_N	0.779	0.55
172_G	180_M	0.779	0.55
69_A	79_Y	0.778	0.55
79_Y	92_Y	0.778	0.55
281_L	284_A	0.777	0.55
55_H	58_Q	0.777	0.55
209_N	245_R	0.776	0.55
75_R	78_V	0.776	0.55
84_R	90_M	0.776	0.55
175_Q	192_D	0.776	0.55
414_S	552_W	0.774	0.55
377_Y	491_A	0.774	0.55
233_L	456_D	0.773	0.55
80_G	117_E	0.773	0.55
636_T	649_Q	0.773	0.55
631_F	637_V	0.773	0.55
558_S	562_A	0.772	0.55
505_T	596_T	0.772	0.55
77_P	82_Y	0.771	0.55
743_Q	746_P	0.767	0.54
156_D	305_K	0.767	0.54
443_A	446_D	0.766	0.54
224_N	305_K	0.766	0.54
153_V	208_L	0.765	0.54
84_R	98_E	0.764	0.54
158_E	520_T	0.763	0.54
415_V	552_W	0.763	0.54
41_S	86_H	0.763	0.54
586_L	590_L	0.763	0.54
311_W	315_D	0.762	0.54
504_G	548_S	0.762	0.54
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68_L	82_Y	0.762	0.54
91_N	95_R	0.760	0.54
709_A	712_E	0.759	0.53
525_Q	529_Q	0.757	0.53
53_A	128_G	0.757	0.53
172_G	232_M	0.756	0.53
427_I	590_L	0.756	0.53
399_S	404_V	0.755	0.53
54_Q	58_Q	0.753	0.53
82_Y	97_R	0.753	0.53
240_Y	387_V	0.753	0.53
762_E	766_P	0.751	0.53
68_L	83_C	0.749	0.53
226_V	274_I	0.747	0.52
445_P	664_E	0.747	0.52
359_N	601_F	0.746	0.52
688_L	692_L	0.746	0.52
276_D	498_A	0.746	0.52
736_G	740_L	0.745	0.52
730_Y	733_T	0.744	0.52
560_E	564_K	0.743	0.52
599_C	627_Q	0.743	0.52
276_D	520_T	0.740	0.52
736_G	741_D	0.740	0.52
78_V	387_V	0.739	0.52
18_G	22_S	0.739	0.52
34_V	66_T	0.738	0.51
154_S	221_I	0.738	0.51
69_A	80_G	0.737	0.51
85_A	94_K	0.735	0.51
501_G	546_T	0.734	0.51
69_A	85_A	0.733	0.51
272_R	541_V	0.733	0.51
446_D	460_S	0.732	0.51
199_A	203_Q	0.732	0.51
358_V	492_L	0.732	0.51
56_I	64_R	0.730	0.51
723_Q	728_I	0.730	0.51
720_L	724_N	0.730	0.51
381_M	503_L	0.729	0.51
374_G	391_L	0.728	0.50
716_R	720_L	0.727	0.50
714_Q	723_Q	0.725	0.50
218_D	271_G	0.723	0.50
169_G	177_I	0.723	0.50
187_D	190_S	0.722	0.50
280_A	348_I	0.721	0.50
676_G	679_D	0.721	0.50
165_L	178_V	0.720	0.50
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158_E	401_G	0.718	0.49
171_E	177_I	0.717	0.49
107_D	113_R	0.716	0.49
446_D	449_H	0.716	0.49
132_N	219_V	0.716	0.49
172_G	184_E	0.716	0.49
534_I	569_L	0.716	0.49
205_L	237_A	0.716	0.49
229_D	278_I	0.715	0.49
176_R	179_Y	0.714	0.49
434_D	437_G	0.714	0.49
684_Y	756_Q	0.714	0.49
309_N	313_R	0.711	0.49
643_P	646_Q	0.711	0.49
604_P	689_R	0.710	0.49
272_R	360_G	0.710	0.49
238_E	693_S	0.709	0.49
75_R	98_E	0.709	0.49
184_E	189_S	0.708	0.49
318_D	322_A	0.707	0.48
180_M	184_E	0.706	0.48
131_H	136_V	0.706	0.48
179_Y	198_V	0.705	0.48
534_I	603_M	0.704	0.48
662_Y	768_I	0.703	0.48
221_I	343_F	0.703	0.48
293_L	491_A	0.701	0.48
75_R	79_Y	0.700	0.48
435_P	503_L	0.700	0.48
420_Y	543_Y	0.699	0.48
82_Y	93_E	0.698	0.48
448_E	522_R	0.698	0.48
20_E	23_F	0.697	0.47
181_L	191_L	0.696	0.47
175_Q	180_M	0.696	0.47
210_A	443_A	0.696	0.47
201_R	204_L	0.695	0.47
228_F	305_K	0.694	0.47
209_N	242_L	0.693	0.47
60_E	67_P	0.691	0.47
401_G	615_K	0.691	0.47
415_V	709_A	0.690	0.47
72_D	75_R	0.690	0.47
69_A	84_R	0.689	0.47
418_L	569_L	0.686	0.46
237_A	682_L	0.686	0.46
68_L	81_L	0.685	0.46
123_P	642_T	0.684	0.46
501_G	547_D	0.683	0.46
89_L	98_E	0.683	0.46
193_F	333_L	0.683	0.46
277_G	519_I	0.683	0.46
159_T	232_M	0.682	0.46
206_E	242_L	0.682	0.46
182_G	186_G	0.681	0.46
735_N	745_S	0.681	0.46
51_P	63_F	0.681	0.46
254_E	257_E	0.680	0.46
69_A	77_P	0.680	0.46
162_H	168_I	0.680	0.46
355_R	369_S	0.680	0.46
69_A	95_R	0.679	0.46
459_F	463_K	0.678	0.46
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224_N	338_L	0.676	0.45
421_K	494_I	0.676	0.45
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621_I	682_L	0.668	0.45
401_G	504_G	0.666	0.44
426_S	480_A	0.665	0.44
177_I	182_G	0.665	0.44
168_I	173_C	0.664	0.44
315_D	319_R	0.664	0.44
282_K	687_R	0.664	0.44
224_N	520_T	0.661	0.44
620_L	658_R	0.661	0.44
368_G	616_R	0.661	0.44
223_W	296_V	0.661	0.44
422_S	548_S	0.660	0.44
422_S	508_C	0.660	0.44
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684_Y	763_G	0.660	0.44
647_Q	651_E	0.659	0.44
183_P	190_S	0.659	0.44
69_A	81_L	0.659	0.44
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667_R	673_L	0.655	0.43
83_C	98_E	0.655	0.43
233_L	237_A	0.654	0.43
154_S	340_T	0.654	0.43
281_L	296_V	0.654	0.43
738_E	741_D	0.654	0.43
732_W	738_E	0.654	0.43
74_H	82_Y	0.653	0.43
235_K	239_R	0.653	0.43
720_L	730_Y	0.652	0.43
90_M	95_R	0.651	0.43
509_R	763_G	0.651	0.43
86_H	96_L	0.651	0.43
629_M	654_L	0.651	0.43
401_G	410_G	0.651	0.43
214_N	711_E	0.649	0.43
493_K	546_T	0.649	0.43
133_G	137_N	0.648	0.43
184_E	187_D	0.648	0.43
543_Y	548_S	0.646	0.43
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23_F	26_A	0.646	0.43
293_L	520_T	0.645	0.42
176_R	181_L	0.645	0.42
223_W	692_L	0.644	0.42
355_R	359_N	0.644	0.42
211_W	215_Y	0.642	0.42
174_G	624_G	0.641	0.42
62_G	65_L	0.640	0.42
367_G	515_L	0.639	0.42
641_W	756_Q	0.639	0.42
207_K	211_W	0.638	0.42
64_R	567_R	0.638	0.42
572_H	668_E	0.638	0.42
293_L	305_K	0.638	0.42
170_L	173_C	0.637	0.42
80_G	98_E	0.637	0.42
194_E	246_L	0.637	0.42
279_E	366_H	0.636	0.42
549_T	554_K	0.635	0.41
70_L	82_Y	0.634	0.41
666_V	753_L	0.634	0.41
218_D	640_D	0.634	0.41
89_L	92_Y	0.634	0.41
314_M	328_L	0.633	0.41
423_L	523_G	0.633	0.41
90_M	93_E	0.632	0.41
646_Q	650_Q	0.632	0.41
199_A	202_P	0.632	0.41
171_E	175_Q	0.632	0.41
43_A	394_V	0.631	0.41
199_A	561_E	0.630	0.41
224_N	401_G	0.630	0.41
503_L	645_A	0.630	0.41
670_I	674_M	0.630	0.41
426_S	543_Y	0.630	0.41
54_Q	79_Y	0.629	0.41
355_R	372_A	0.629	0.41
548_S	551_V	0.626	0.41
63_F	127_E	0.626	0.41
317_I	327_A	0.626	0.41
79_Y	84_R	0.625	0.41
59_G	65_L	0.625	0.41
119_F	382_H	0.625	0.41
130_M	138_A	0.625	0.41
70_L	83_C	0.625	0.41
544_G	551_V	0.625	0.41
692_L	707_R	0.624	0.40
127_E	195_L	0.624	0.40
276_D	293_L	0.623	0.40
415_V	601_F	0.622	0.40
691_P	716_R	0.622	0.40
447_P	455_L	0.622	0.40
301_L	470_V	0.621	0.40
565_I	568_A	0.621	0.40
139_R	143_H	0.621	0.40
52_R	65_L	0.620	0.40
229_D	401_G	0.619	0.40
409_P	412_Y	0.619	0.40
288_F	291_F	0.619	0.40
168_I	178_V	0.618	0.40
63_F	66_T	0.617	0.40
158_E	293_L	0.617	0.40
85_A	98_E	0.615	0.40
47_A	571_Q	0.615	0.40
159_T	197_Y	0.615	0.40
82_Y	92_Y	0.614	0.40
156_D	293_L	0.614	0.40
619_G	635_E	0.613	0.39
179_Y	186_G	0.613	0.39
728_I	733_T	0.613	0.39
62_G	91_N	0.613	0.39
123_P	221_I	0.612	0.39
752_Y	756_Q	0.609	0.39
435_P	649_Q	0.609	0.39
354_E	598_F	0.608	0.39
213_A	388_A	0.608	0.39
241_R	665_Y	0.607	0.39
438_L	512_D	0.606	0.39
445_P	450_S	0.606	0.39
174_G	181_L	0.605	0.39
701_P	705_A	0.605	0.39
675_A	680_A	0.604	0.39
19_T	110_P	0.604	0.39
532_A	535_E	0.604	0.39
42_V	110_P	0.604	0.39
503_L	518_S	0.603	0.38
722_Y	752_Y	0.603	0.38
493_K	547_D	0.603	0.38
731_V	736_G	0.602	0.38
68_L	98_E	0.601	0.38
470_V	519_I	0.600	0.38
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179_Y	211_W	0.599	0.38
619_G	630_V	0.599	0.38
399_S	504_G	0.599	0.38
95_R	445_P	0.597	0.38
22_S	33_Q	0.597	0.38
174_G	179_Y	0.596	0.38
496_M	502_V	0.596	0.38
78_V	85_A	0.596	0.38
638_R	642_T	0.595	0.38
77_P	89_L	0.595	0.38
40_E	84_R	0.595	0.38
305_K	332_N	0.595	0.38
543_Y	550_F	0.595	0.38
639_T	719_P	0.595	0.38
68_L	79_Y	0.594	0.38
365_R	371_A	0.593	0.38
69_A	82_Y	0.593	0.38
702_H	705_A	0.593	0.38
643_P	681_R	0.592	0.37
644_L	757_L	0.592	0.37
65_L	84_R	0.592	0.37
51_P	129_D	0.591	0.37
80_G	83_C	0.591	0.37
419_D	424_Y	0.591	0.37
176_R	192_D	0.590	0.37
176_R	185_N	0.589	0.37
456_D	459_F	0.588	0.37
72_D	83_C	0.588	0.37
434_D	642_T	0.586	0.37
104_Y	107_D	0.586	0.37
185_N	191_L	0.585	0.37
157_I	205_L	0.585	0.37
188_A	191_L	0.585	0.37
170_L	184_E	0.585	0.37
327_A	330_T	0.585	0.37
79_Y	98_E	0.583	0.37
54_Q	67_P	0.583	0.37
114_Y	118_R	0.583	0.37
55_H	67_P	0.583	0.37
308_D	593_E	0.582	0.37
555_G	561_E	0.581	0.36
402_G	421_K	0.579	0.36
54_Q	57_L	0.578	0.36
294_E	298_Q	0.578	0.36
473_I	706_A	0.576	0.36
187_D	192_D	0.576	0.36
178_V	191_L	0.576	0.36
483_Q	486_K	0.575	0.36
398_A	415_V	0.575	0.36
49_Q	63_F	0.575	0.36
54_Q	97_R	0.575	0.36
573_V	710_D	0.575	0.36
52_R	67_P	0.575	0.36
562_A	566_G	0.574	0.36
332_N	765_L	0.573	0.36
615_K	638_R	0.573	0.36
168_I	181_L	0.573	0.36
512_D	630_V	0.573	0.36
25_L	432_L	0.572	0.36
645_A	756_Q	0.572	0.36
415_V	718_R	0.572	0.36
64_R	385_G	0.571	0.36
186_G	189_S	0.570	0.35
420_Y	512_D	0.570	0.35
331_Y	338_L	0.569	0.35
163_G	173_C	0.568	0.35
420_Y	470_V	0.568	0.35
208_L	327_A	0.568	0.35
373_F	502_V	0.568	0.35
202_P	243_P	0.567	0.35
220_I	269_A	0.566	0.35
172_G	183_P	0.566	0.35
701_P	759_P	0.566	0.35
173_C	176_R	0.565	0.35
22_S	36_L	0.565	0.35
106_A	390_N	0.565	0.35
493_K	548_S	0.564	0.35
246_L	415_V	0.564	0.35
398_A	720_L	0.564	0.35
157_I	228_F	0.563	0.35
545_D	614_K	0.563	0.35
180_M	187_D	0.563	0.35
224_N	331_Y	0.563	0.35
21_V	269_A	0.563	0.35
402_G	520_T	0.563	0.35
538_G	557_H	0.562	0.35
182_G	340_T	0.562	0.35
80_G	89_L	0.561	0.35
748_D	752_Y	0.561	0.35
208_L	330_T	0.560	0.35
652_L	720_L	0.560	0.35
342_I	346_T	0.559	0.34
222_G	229_D	0.559	0.34
38_P	181_L	0.559	0.34
233_L	567_R	0.558	0.34
733_T	739_P	0.558	0.34
86_H	106_A	0.558	0.34
88_Q	98_E	0.557	0.34
540_D	554_K	0.556	0.34
134_T	137_N	0.556	0.34
382_H	388_A	0.556	0.34
351_F	634_L	0.555	0.34
411_L	767_F	0.555	0.34
80_G	85_A	0.555	0.34
636_T	760_V	0.554	0.34
372_A	435_P	0.553	0.34
180_M	192_D	0.553	0.34
533_L	572_H	0.553	0.34
241_R	302_G	0.552	0.34
713_N	718_R	0.551	0.34
546_T	615_K	0.550	0.34
505_T	600_R	0.550	0.34
221_I	428_I	0.549	0.34
115_L	122_S	0.549	0.34
224_N	297_A	0.549	0.34
404_V	520_T	0.549	0.34
662_Y	666_V	0.548	0.34
501_G	548_S	0.547	0.33
21_V	111_P	0.546	0.33
596_T	621_I	0.546	0.33
616_R	682_L	0.544	0.33
250_N	253_L	0.544	0.33
54_Q	66_T	0.543	0.33
168_I	172_G	0.543	0.33
723_Q	743_Q	0.543	0.33
52_R	56_I	0.543	0.33
80_G	86_H	0.543	0.33
709_A	736_G	0.543	0.33
182_G	191_L	0.542	0.33
480_A	483_Q	0.542	0.33
704_R	707_R	0.542	0.33
316_E	322_A	0.542	0.33
130_M	571_Q	0.541	0.33
83_C	95_R	0.541	0.33
618_A	653_Y	0.541	0.33
41_S	85_A	0.540	0.33
401_G	498_A	0.539	0.33
147_R	353_L	0.539	0.33
44_F	250_N	0.539	0.33
55_H	203_Q	0.539	0.33
48_D	63_F	0.539	0.33
241_R	542_I	0.538	0.33
642_T	645_A	0.536	0.32
568_A	571_Q	0.536	0.32
57_L	532_A	0.536	0.32
86_H	93_E	0.536	0.32
519_I	669_T	0.536	0.32
421_K	509_R	0.536	0.32
477_R	524_H	0.535	0.32
410_G	491_A	0.535	0.32
272_R	618_A	0.534	0.32
198_V	203_Q	0.534	0.32
603_M	630_V	0.534	0.32
329_A	334_K	0.534	0.32
223_W	381_M	0.533	0.32
62_G	67_P	0.533	0.32
152_W	221_I	0.533	0.32
511_F	719_P	0.533	0.32
616_R	638_R	0.533	0.32
569_L	592_L	0.533	0.32
356_A	570_V	0.532	0.32
233_L	676_G	0.531	0.32
204_L	678_L	0.531	0.32
351_F	376_L	0.531	0.32
646_Q	770_D	0.531	0.32
486_K	764_I	0.531	0.32
120_I	342_I	0.531	0.32
27_T	30_G	0.530	0.32
324_D	330_T	0.530	0.32
527_M	598_F	0.529	0.32
293_L	404_V	0.529	0.32
332_N	335_D	0.529	0.32
368_G	511_F	0.529	0.32
170_L	179_Y	0.528	0.32
90_M	94_K	0.528	0.32
505_T	619_G	0.527	0.32
504_G	543_Y	0.527	0.32
757_L	770_D	0.526	0.32
21_V	726_G	0.526	0.32
217_P	635_E	0.526	0.32
669_T	678_L	0.525	0.32
120_I	588_S	0.525	0.32
44_F	204_L	0.524	0.31
407_S	524_H	0.524	0.31
306_S	327_A	0.523	0.31
371_A	402_G	0.523	0.31
173_C	189_S	0.523	0.31
297_A	364_D	0.523	0.31
69_A	94_K	0.521	0.31
448_E	456_D	0.521	0.31
150_L	446_D	0.520	0.31
422_S	474_W	0.520	0.31
54_Q	625_D	0.519	0.31
200_S	533_L	0.519	0.31
431_F	527_M	0.519	0.31
132_N	136_V	0.518	0.31
223_W	277_G	0.518	0.31
425_P	633_G	0.517	0.31
76_Q	89_L	0.517	0.31
539_Y	622_Q	0.517	0.31
444_Q	449_H	0.517	0.31
278_I	292_S	0.517	0.31
655_R	665_Y	0.517	0.31
498_A	593_E	0.516	0.31
598_F	645_A	0.515	0.31
399_S	489_S	0.515	0.31
272_R	640_D	0.515	0.31
547_D	615_K	0.515	0.31
53_A	64_R	0.514	0.31
509_R	638_R	0.514	0.31
491_A	523_G	0.514	0.31
710_D	720_L	0.514	0.31
735_N	738_E	0.514	0.31
699_V	707_R	0.513	0.31
497_N	523_G	0.513	0.31
602_L	767_F	0.513	0.31
467_P	496_M	0.512	0.30
571_Q	754_T	0.512	0.30
450_S	456_D	0.512	0.30
476_G	485_N	0.512	0.30
69_A	83_C	0.511	0.30
254_E	258_H	0.510	0.30
489_S	639_T	0.510	0.30
49_Q	55_H	0.510	0.30
618_A	656_I	0.509	0.30
157_I	166_Y	0.509	0.30
215_Y	345_K	0.509	0.30
18_G	39_Q	0.509	0.30
156_D	276_D	0.508	0.30
112_E	371_A	0.508	0.30
420_Y	541_V	0.507	0.30
280_A	284_A	0.507	0.30
222_G	271_G	0.507	0.30
276_D	399_S	0.506	0.30
342_I	404_V	0.505	0.30
435_P	604_P	0.505	0.30
155_I	348_I	0.505	0.30
453_G	525_Q	0.505	0.30
431_F	512_D	0.504	0.30
152_W	668_E	0.504	0.30
645_A	759_P	0.504	0.30
655_R	661_P	0.504	0.30
52_R	59_G	0.503	0.30
158_E	338_L	0.503	0.30
177_I	192_D	0.503	0.30
390_N	509_R	0.503	0.30
135_I	664_E	0.502	0.30
176_R	180_M	0.501	0.30
78_V	92_Y	0.501	0.30
205_L	416_L	0.500	0.29
168_I	183_P	0.500	0.29

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3k59A	1	0.9757	100	0.176	Contact Map
3iayA	1	0.954	100	0.184	Contact Map
4qclA	1	0.9502	100	0.213	Contact Map
1qhtA	1	0.8544	100	0.222	Contact Map
2gv9A	1	0.9553	100	0.223	Contact Map
4fvmA	1	0.9119	100	0.239	Contact Map
4m8oA	1	0.9579	100	0.27	Contact Map
1s5jA	1	0.8008	100	0.293	Contact Map
3qexA	1	0.917	100	0.302	Contact Map
2py5A	2	0.5722	100	0.672	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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