GREMLIN Database
PEPQ - Xaa-Pro dipeptidase
UniProt: P21165 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10698
Length: 443 (339)
Sequences: 5695 (4063)
Seq/√Len: 220.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_R434_E6.4621.00
377_P430_E5.3051.00
288_M428_I5.1001.00
167_L427_V3.4841.00
275_K279_D3.3171.00
239_E265_K2.9521.00
293_S296_D2.9511.00
276_D308_L2.7561.00
172_E175_K2.6531.00
171_R175_K2.5831.00
269_D272_Q2.5821.00
273_L420_I2.5781.00
283_A286_A2.4761.00
283_A304_R2.4691.00
287_T300_Q2.4311.00
295_V372_T2.4011.00
282_L286_A2.3791.00
268_N272_Q2.3511.00
170_M380_V2.3181.00
298_H302_H2.2981.00
179_N208_R2.2701.00
183_A204_A2.1661.00
161_F376_Q2.1661.00
54_P344_Q2.1531.00
269_D392_S2.0531.00
271_A275_K2.0501.00
238_E241_R2.0421.00
341_L425_N2.0291.00
203_T207_H2.0161.00
139_L142_E1.9921.00
213_P255_A1.9641.00
279_D308_L1.9401.00
114_G117_S1.9261.00
305_I387_I1.9251.00
267_D270_Y1.8941.00
277_V420_I1.8681.00
178_V440_L1.8651.00
284_L297_Y1.8541.00
285_I426_V1.8461.00
427_V436_M1.8391.00
196_D207_H1.7991.00
293_S374_I1.7921.00
169_C252_N1.7571.00
200_A203_T1.7511.00
279_D283_A1.7241.00
426_V435_N1.7051.00
125_N147_N1.6881.00
190_S239_E1.6711.00
41_V46_H1.6641.00
284_L301_F1.6641.00
280_E304_R1.6631.00
193_S235_Q1.6551.00
183_A186_E1.6421.00
242_S261_T1.6281.00
193_S196_D1.6231.00
289_K292_V1.6091.00
236_A264_A1.6021.00
55_Q156_H1.5901.00
288_M383_I1.5651.00
61_P70_L1.5231.00
204_A208_R1.5221.00
118_L121_A1.5191.00
177_A258_L1.5061.00
199_I203_T1.5051.00
126_I129_I1.5041.00
170_M174_Q1.4971.00
246_D257_D1.4951.00
257_D423_E1.4931.00
182_R186_E1.4811.00
204_A207_H1.4801.00
292_V296_D1.4801.00
429_H434_E1.4671.00
60_V158_Y1.4581.00
283_A300_Q1.4471.00
279_D307_K1.4411.00
197_I243_F1.4381.00
222_E234_H1.4291.00
304_R308_L1.4221.00
303_Q307_K1.4081.00
300_Q304_R1.3971.00
69_W72_V1.3961.00
376_Q379_M1.3931.00
43_L46_H1.3831.00
130_G139_L1.3791.00
202_L206_G1.3781.00
280_E305_I1.3661.00
198_N202_L1.3631.00
380_V427_V1.3621.00
284_L300_Q1.3561.00
250_E255_A1.3441.00
299_I303_Q1.3291.00
281_Q285_I1.3281.00
134_E137_L1.3191.00
301_F333_M1.3171.00
78_P108_A1.3171.00
220_L234_H1.3161.00
187_A200_A1.3131.00
378_G427_V1.3091.00
285_I435_N1.3091.00
295_V299_I1.3081.00
127_G131_P1.3051.00
301_F337_I1.2971.00
290_A377_P1.2951.00
161_F379_M1.2851.00
84_L87_D1.2841.00
268_N271_A1.2801.00
296_D299_I1.2741.00
288_M433_V1.2731.00
58_A253_G1.2731.00
177_A256_A1.2721.00
246_D423_E1.2631.00
341_L380_V1.2631.00
287_T292_V1.2591.00
133_P138_Q1.2561.00
165_Y169_C1.2521.00
300_Q303_Q1.2511.00
135_R138_Q1.2501.00
172_E251_Y1.2401.00
183_A200_A1.2351.00
306_A315_I1.2321.00
175_K439_D1.2291.00
160_S379_M1.2271.00
220_L236_A1.2251.00
41_V45_D1.2221.00
179_N182_R1.2201.00
288_M297_Y1.2191.00
375_L381_L1.2171.00
383_I426_V1.2121.00
429_H432_N1.2081.00
74_G77_K1.2061.00
41_V44_D1.1801.00
127_G130_G1.1771.00
279_D304_R1.1751.00
185_E262_W1.1721.00
281_Q424_D1.1701.00
242_S263_S1.1591.00
138_Q142_E1.1561.00
174_Q437_T1.1541.00
283_A287_T1.1501.00
188_F197_I1.1261.00
53_N56_F1.1201.00
290_A433_V1.1161.00
125_N149_K1.1121.00
79_K106_V1.1031.00
292_V300_Q1.1021.00
290_A428_I1.0981.00
45_D127_G1.0871.00
60_V155_L1.0851.00
273_L389_F1.0831.00
427_V434_E1.0831.00
290_A429_H1.0801.00
288_M426_V1.0771.00
164_E168_A1.0691.00
235_Q238_E1.0661.00
234_H241_R1.0641.00
192_M196_D1.0571.00
278_N282_L1.0571.00
188_F262_W1.0561.00
51_K250_E1.0391.00
110_P114_G1.0331.00
123_R129_I1.0291.00
276_D304_R1.0271.00
99_F103_D1.0251.00
169_C251_Y1.0241.00
272_Q275_K1.0171.00
178_V439_D1.0141.00
165_Y168_A1.0061.00
384_E423_E0.9961.00
171_R427_V0.9951.00
242_S270_Y0.9951.00
99_F102_E0.9861.00
297_Y375_L0.9701.00
249_A256_A0.9701.00
278_N422_I0.9661.00
169_C172_E0.9631.00
69_W115_I0.9551.00
285_I433_V0.9531.00
101_T105_E0.9511.00
243_F264_A0.9511.00
151_V154_Y0.9491.00
221_N241_R0.9461.00
223_H234_H0.9451.00
189_R192_M0.9441.00
292_V297_Y0.9371.00
181_H262_W0.9371.00
287_T290_A0.9341.00
298_H337_I0.9341.00
45_D50_F0.9311.00
157_Y373_R0.9291.00
297_Y300_Q0.9271.00
201_Y245_L0.9250.99
224_A419_G0.9220.99
192_M200_A0.9190.99
184_A245_L0.9180.99
41_V47_P0.9180.99
175_K179_N0.9130.99
220_L264_A0.9110.99
168_A171_R0.9090.99
257_D339_H0.9090.99
284_L287_T0.9090.99
273_L276_D0.9070.99
289_K433_V0.9040.99
127_G132_V0.9000.99
340_P347_D0.9000.99
297_Y337_I0.8990.99
133_P140_G0.8980.99
339_H423_E0.8960.99
81_W91_N0.8960.99
59_W158_Y0.8880.99
167_L380_V0.8870.99
102_E105_E0.8870.99
126_I131_P0.8870.99
355_D373_R0.8870.99
245_L262_W0.8840.99
68_C72_V0.8840.99
134_E138_Q0.8820.99
234_H238_E0.8820.99
172_E252_N0.8800.99
137_L140_G0.8780.99
275_K278_N0.8750.99
428_I433_V0.8730.99
201_Y205_T0.8710.99
222_E225_A0.8670.99
51_K56_F0.8640.99
164_E378_G0.8620.99
194_E223_H0.8620.99
195_F233_D0.8560.99
174_Q425_N0.8540.99
116_G120_P0.8520.99
40_N48_Y0.8500.99
240_M264_A0.8480.99
133_P139_L0.8460.99
223_H226_V0.8460.99
51_K54_P0.8450.99
183_A187_A0.8450.99
274_V422_I0.8450.99
177_A180_G0.8420.99
280_E284_L0.8410.99
173_A177_A0.8350.99
305_I333_M0.8340.99
170_M341_L0.8310.99
137_L141_I0.8300.99
426_V433_V0.8280.99
56_F68_C0.8280.99
388_Y421_R0.8250.99
202_L216_N0.8240.99
289_K431_N0.8240.99
290_A430_E0.8220.99
129_I132_V0.8210.99
82_F118_L0.8170.99
214_Y248_G0.8170.99
200_A207_H0.8170.99
192_M197_I0.8140.99
246_D384_E0.8140.99
128_Y131_P0.8130.99
202_L212_V0.8130.99
284_L337_I0.8120.99
58_A343_L0.8100.99
296_D300_Q0.8070.99
174_Q178_V0.8060.99
166_E254_Y0.8020.99
276_D305_I0.7930.98
374_I377_P0.7920.98
294_Y338_G0.7870.98
70_L79_K0.7870.98
157_Y376_Q0.7860.98
223_H229_Y0.7800.98
69_W73_D0.7730.98
55_Q59_W0.7720.98
240_M265_K0.7720.98
40_N46_H0.7700.98
174_Q256_A0.7700.98
272_Q276_D0.7690.98
228_H346_H0.7690.98
200_A204_A0.7660.98
212_V216_N0.7660.98
138_Q141_I0.7650.98
302_H333_M0.7620.98
123_R127_G0.7600.98
73_D80_L0.7590.98
382_T425_N0.7580.98
303_Q306_A0.7570.98
285_I383_I0.7530.98
257_D384_E0.7530.98
274_V278_N0.7500.98
98_S101_T0.7470.98
44_D47_P0.7460.98
193_S236_A0.7460.98
288_M375_L0.7460.98
335_H346_H0.7450.98
222_E391_E0.7440.98
94_P99_F0.7430.98
340_P349_A0.7410.98
133_P137_L0.7410.98
94_P104_V0.7400.98
70_L73_D0.7400.98
283_A301_F0.7400.98
135_R139_L0.7360.97
123_R131_P0.7360.97
144_S148_P0.7330.97
280_E283_A0.7330.97
246_D259_T0.7320.97
50_F60_V0.7300.97
117_S121_A0.7300.97
64_Q253_G0.7290.97
136_A139_L0.7280.97
339_H384_E0.7250.97
124_G127_G0.7240.97
215_S230_T0.7200.97
88_Y92_V0.7200.97
184_A200_A0.7190.97
290_A434_E0.7150.97
63_T68_C0.7130.97
280_E301_F0.7120.97
40_N45_D0.7100.97
47_P50_F0.7080.97
67_N84_L0.7080.97
259_T423_E0.7080.97
168_A172_E0.7060.97
388_Y419_G0.7050.97
162_K166_E0.7050.97
224_A244_L0.7040.97
123_R126_I0.7010.97
386_G419_G0.7010.97
114_G118_L0.6990.97
126_I130_G0.6980.97
117_S120_P0.6970.96
287_T296_D0.6970.96
177_A440_L0.6960.96
178_V438_R0.6930.96
246_D339_H0.6910.96
167_L171_R0.6880.96
52_V56_F0.6870.96
128_Y132_V0.6840.96
174_Q436_M0.6810.96
190_S264_A0.6810.96
103_D106_V0.6800.96
180_G205_T0.6800.96
219_A224_A0.6800.96
134_E140_G0.6790.96
133_P136_A0.6790.96
228_H419_G0.6780.96
128_Y135_R0.6760.96
135_R141_I0.6750.96
73_D77_K0.6740.96
179_N204_A0.6740.96
68_C73_D0.6710.96
290_A376_Q0.6700.96
226_V229_Y0.6700.96
59_W62_V0.6690.96
380_V436_M0.6660.95
294_Y375_L0.6650.95
290_A432_N0.6640.95
178_V182_R0.6630.95
183_A208_R0.6600.95
228_H388_Y0.6590.95
335_H421_R0.6580.95
125_N130_G0.6580.95
218_V245_L0.6560.95
124_G130_G0.6540.95
113_D117_S0.6520.95
198_N210_T0.6480.95
287_T297_Y0.6480.95
172_E176_M0.6480.95
73_D79_K0.6470.95
228_H335_H0.6460.95
125_N128_Y0.6460.95
269_D273_L0.6460.95
46_H215_S0.6440.95
40_N47_P0.6430.95
101_T106_V0.6430.95
101_T104_V0.6400.94
85_P113_D0.6400.94
241_R270_Y0.6360.94
140_G143_A0.6360.94
386_G421_R0.6340.94
220_L241_R0.6340.94
136_A140_G0.6340.94
314_I389_F0.6340.94
219_A229_Y0.6330.94
212_V215_S0.6330.94
176_M249_A0.6310.94
384_E388_Y0.6290.94
202_L211_D0.6280.94
134_E139_L0.6280.94
340_P379_M0.6270.94
277_V386_G0.6260.94
260_R424_D0.6250.94
156_H348_V0.6230.94
304_R307_K0.6220.93
181_H247_A0.6210.93
195_F199_I0.6180.93
425_N437_T0.6160.93
263_S266_S0.6140.93
124_G128_Y0.6130.93
384_E421_R0.6120.93
98_S102_E0.6110.93
182_R439_D0.6080.93
129_I134_E0.6040.92
201_Y247_A0.6040.92
224_A242_S0.6040.92
377_P429_H0.6020.92
214_Y256_A0.6010.92
187_A204_A0.5990.92
332_F390_I0.5980.92
294_Y297_Y0.5980.92
183_A201_Y0.5980.92
263_S270_Y0.5980.92
255_A345_V0.5970.92
71_L82_F0.5920.92
346_H385_P0.5910.92
197_I218_V0.5910.92
199_I206_G0.5900.92
174_Q258_L0.5890.92
429_H433_V0.5890.92
52_V55_Q0.5860.91
197_I236_A0.5860.91
180_G201_Y0.5850.91
276_D279_D0.5830.91
346_H421_R0.5830.91
301_F305_I0.5830.91
177_A247_A0.5810.91
72_V79_K0.5800.91
242_S420_I0.5800.91
382_T385_P0.5790.91
123_R128_Y0.5780.91
160_S340_P0.5780.91
54_P343_L0.5780.91
293_S372_T0.5770.91
80_L108_A0.5760.91
205_T212_V0.5760.91
385_P421_R0.5720.90
352_M355_D0.5680.90
382_T423_E0.5670.90
335_H388_Y0.5670.90
193_S233_D0.5630.90
70_L106_V0.5630.90
259_T386_G0.5630.90
160_S376_Q0.5630.90
90_H94_P0.5610.89
92_V99_F0.5610.89
175_K178_V0.5600.89
280_E300_Q0.5590.89
348_V351_F0.5590.89
298_H336_G0.5590.89
122_A131_P0.5590.89
188_F243_F0.5580.89
48_Y151_V0.5570.89
93_E96_P0.5550.89
376_Q430_E0.5540.89
299_I302_H0.5530.89
259_T421_R0.5530.89
297_Y428_I0.5510.89
170_M256_A0.5490.88
122_A126_I0.5490.88
244_L421_R0.5490.88
346_H384_E0.5480.88
273_L417_F0.5480.88
257_D382_T0.5480.88
430_E433_V0.5450.88
228_H421_R0.5450.88
176_M251_Y0.5430.88
205_T249_A0.5430.88
229_Y232_L0.5420.88
434_E438_R0.5420.88
174_Q177_A0.5410.88
295_V354_D0.5410.88
85_P111_K0.5380.87
124_G129_I0.5380.87
228_H386_G0.5350.87
257_D346_H0.5340.87
99_F104_V0.5320.87
333_M336_G0.5300.87
167_L436_M0.5290.87
431_N434_E0.5290.87
168_A175_K0.5270.86
261_T420_I0.5270.86
180_G204_A0.5220.86
100_W104_V0.5210.86
128_Y138_Q0.5200.86
80_L110_P0.5200.86
381_L428_I0.5200.86
259_T384_E0.5190.86
73_D76_N0.5180.85
298_H333_M0.5180.85
244_L259_T0.5170.85
120_P145_N0.5170.85
377_P433_V0.5170.85
273_L387_I0.5160.85
276_D280_E0.5150.85
139_L143_A0.5150.85
122_A128_Y0.5130.85
174_Q435_N0.5110.85
248_G257_D0.5090.84
131_P134_E0.5080.84
160_S373_R0.5070.84
157_Y160_S0.5070.84
198_N232_L0.5060.84
346_H382_T0.5050.84
185_E188_F0.5050.84
72_V75_V0.5050.84
183_A203_T0.5050.84
107_I114_G0.5040.84
346_H386_G0.5020.84
91_N95_L0.5010.84
385_P389_F0.5000.83
45_D48_Y0.5000.83
266_S271_A0.5000.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2iw2A 2 0.9842 100 0.258 Contact Map
3l24A 2 0.9481 100 0.277 Contact Map
2v3zA 3 0.9029 100 0.281 Contact Map
4qr8A 2 0.9842 100 0.282 Contact Map
3rvaA 2 0.9797 100 0.284 Contact Map
3ig4A 4 0.8578 100 0.309 Contact Map
3q6dA 1 0.7856 100 0.339 Contact Map
4r60A 2 0.8307 100 0.342 Contact Map
2zsgA 2 0.781 100 0.345 Contact Map
1wn1A 2 0.7765 100 0.349 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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