GREMLIN Database
CYSD - Sulfate adenylyltransferase subunit 2
UniProt: P21156 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10186
Length: 302 (295)
Sequences: 1476 (576)
Seq/√Len: 33.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_R200_L6.7531.00
93_P97_A5.0651.00
263_Q267_E4.7971.00
199_W266_P4.3431.00
61_L122_A4.2091.00
45_H48_R3.8661.00
78_R82_A3.8071.00
31_V61_L3.7761.00
213_E241_K3.5981.00
242_R259_E3.4841.00
20_I132_F3.4811.00
74_E78_R3.3001.00
32_M43_M3.2851.00
56_L85_C3.1891.00
243_M261_N2.7181.00
43_M132_F2.7071.00
151_F181_I2.5731.00
79_T82_A2.5131.00
101_N104_V2.5081.00
215_P241_K2.4821.00
18_H171_Y2.4591.00
90_H126_Y2.4481.00
47_A58_F2.4100.99
218_E223_L2.2300.99
219_R237_E2.1990.99
31_V131_A2.1560.99
157_R298_R2.1490.99
90_H122_A2.1090.99
24_A27_F2.1000.99
256_G284_V2.0710.98
78_R204_D2.0570.98
261_N267_E2.0390.98
218_E221_G2.0140.98
70_R74_E1.9790.98
23_V130_A1.9670.98
264_T267_E1.9670.98
199_W269_I1.9600.98
7_T10_R1.9450.98
79_T83_Y1.8750.97
270_E274_V1.8580.97
42_V194_I1.8340.96
49_K201_E1.8130.96
218_E240_K1.8110.96
27_F130_A1.8070.96
68_K115_K1.7960.96
48_R83_Y1.7760.96
27_F173_G1.7250.95
44_L79_T1.7190.95
159_D162_N1.6560.94
233_L239_I1.6290.93
222_M284_V1.6270.93
29_N127_G1.6050.93
65_T115_K1.5980.93
123_L131_A1.5760.92
288_D292_S1.5720.92
289_Q298_R1.5620.92
31_V122_A1.5570.92
26_E173_G1.5460.91
63_V90_H1.5270.91
104_V232_D1.5250.91
44_L60_L1.5230.91
175_I181_I1.5080.90
100_I121_Q1.5020.90
41_S68_K1.4980.90
61_L126_Y1.4860.89
95_G114_M1.4800.89
243_M263_Q1.4590.89
8_H196_Q1.4500.88
19_I148_I1.4320.88
222_M256_G1.4240.87
95_G118_G1.4240.87
82_A204_D1.4150.87
203_I208_L1.4120.87
213_E243_M1.4090.87
205_I210_L1.4060.87
77_D89_V1.3980.86
208_L249_L1.3860.86
43_M141_K1.3750.85
61_L88_L1.3410.84
196_Q273_L1.3390.84
15_E188_N1.3350.84
210_L265_L1.3260.83
23_V27_F1.3080.82
277_T291_G1.2680.80
148_I171_Y1.2640.80
284_V287_R1.2540.80
149_Y183_V1.2530.80
27_F181_I1.2500.79
51_F58_F1.2340.79
130_A183_V1.2260.78
227_D252_W1.2080.77
112_D289_Q1.1830.75
110_H118_G1.1810.75
112_D117_E1.1730.75
103_F110_H1.1700.75
88_L126_Y1.1660.74
78_R81_K1.1370.72
266_P269_I1.1320.72
91_K94_E1.1290.72
20_I43_M1.1250.72
217_L226_I1.1230.72
232_D239_I1.1180.71
267_E270_E1.1150.71
291_G295_L1.1150.71
233_L237_E1.1070.70
7_T200_L1.1040.70
206_V212_A1.0910.69
48_R56_L1.0890.69
72_M288_D1.0760.68
284_V295_L1.0730.68
45_H203_I1.0610.67
38_K139_E1.0500.66
73_Y118_G1.0320.65
20_I23_V1.0320.65
93_P99_G1.0310.65
273_L278_S1.0280.65
52_Y56_L1.0140.64
149_Y173_G1.0130.63
222_M282_G1.0110.63
290_A295_L1.0070.63
224_M284_V1.0030.63
295_L298_R1.0000.62
273_L295_L0.9910.62
266_P274_V0.9880.62
55_T86_E0.9850.61
270_E273_L0.9830.61
64_D68_K0.9820.61
103_F106_G0.9810.61
39_D139_E0.9780.61
37_G40_S0.9750.60
74_E82_A0.9750.60
277_T282_G0.9720.60
265_L269_I0.9680.60
233_L236_G0.9510.59
226_I239_I0.9480.58
186_L276_T0.9460.58
94_E98_M0.9440.58
151_F179_E0.9430.58
73_Y91_K0.9420.58
281_Q298_R0.9330.57
285_I296_K0.9310.57
218_E242_R0.9220.56
277_T290_A0.9200.56
110_H114_M0.9200.56
27_F298_R0.9150.56
43_M186_L0.9150.56
151_F175_I0.9140.55
209_Y212_A0.9070.55
289_Q295_L0.9040.55
205_I209_Y0.8980.54
287_R295_L0.8970.54
111_T115_K0.8970.54
154_R298_R0.8910.54
42_V198_I0.8890.53
73_Y101_N0.8860.53
49_K197_Y0.8840.53
26_E132_F0.8840.53
288_D296_K0.8810.53
114_M118_G0.8800.53
265_L268_I0.8800.53
7_T43_M0.8800.53
29_N74_E0.8770.52
272_M277_T0.8750.52
123_L126_Y0.8690.52
94_E125_K0.8650.51
101_N105_H0.8640.51
36_I206_V0.8640.51
246_F257_A0.8630.51
61_L242_R0.8630.51
103_F109_K0.8590.51
55_T84_G0.8580.51
127_G287_R0.8580.51
160_P168_W0.8560.51
287_R291_G0.8500.50
273_L277_T0.8500.50
168_W171_Y0.8480.50
240_K259_E0.8480.50
10_R298_R0.8460.50
21_R57_P0.8460.50
95_G113_I0.8410.49
27_F175_I0.8400.49
72_M206_V0.8380.49
68_K73_Y0.8370.49
57_P152_R0.8360.49
266_P270_E0.8310.49
64_D89_V0.8300.48
88_L128_F0.8270.48
124_N156_H0.8270.48
40_S139_E0.8190.48
196_Q205_I0.8170.47
112_D298_R0.8160.47
105_H109_K0.8100.47
215_P226_I0.8090.47
38_K209_Y0.8090.47
247_R250_G0.8090.47
196_Q200_L0.8010.46
192_Q196_Q0.7950.46
232_D235_P0.7910.45
8_H24_A0.7890.45
63_V221_G0.7840.45
206_V209_Y0.7830.45
110_H115_K0.7830.45
25_A54_G0.7810.44
119_L142_S0.7790.44
278_S281_Q0.7770.44
157_R289_Q0.7730.44
44_L85_C0.7710.44
217_L231_I0.7660.43
275_S282_G0.7660.43
32_M81_K0.7650.43
68_K111_T0.7620.43
211_A264_T0.7580.42
12_L15_E0.7560.42
173_G295_L0.7550.42
36_I72_M0.7540.42
35_S40_S0.7520.42
55_T161_K0.7510.42
170_N175_I0.7510.42
235_P239_I0.7450.41
108_A292_S0.7420.41
153_D157_R0.7410.41
157_R161_K0.7410.41
216_V223_L0.7410.41
47_A51_F0.7390.41
112_D115_K0.7380.41
227_D230_R0.7380.41
118_G131_A0.7370.41
295_L299_Q0.7340.41
222_M295_L0.7330.40
120_K157_R0.7280.40
7_T274_V0.7230.40
131_A180_S0.7220.40
220_D284_V0.7170.39
101_N109_K0.7130.39
113_I299_Q0.7110.39
281_Q287_R0.7110.39
98_M103_F0.7110.39
151_F171_Y0.7100.39
208_L212_A0.7070.38
35_S39_D0.7070.38
287_R292_S0.7060.38
112_D157_R0.7050.38
20_I56_L0.7030.38
252_W257_A0.6980.38
39_D209_Y0.6960.37
15_E22_E0.6960.37
167_L171_Y0.6930.37
219_R236_G0.6930.37
48_R79_T0.6910.37
161_K176_N0.6900.37
282_G291_G0.6900.37
7_T11_Q0.6880.37
139_E209_Y0.6860.37
270_E277_T0.6860.37
108_A289_Q0.6840.37
54_G169_H0.6830.36
231_I235_P0.6810.36
200_L263_Q0.6800.36
101_N110_H0.6800.36
65_T68_K0.6780.36
237_E247_R0.6770.36
281_Q290_A0.6770.36
157_R269_I0.6720.36
60_L85_C0.6720.36
68_K215_P0.6710.36
109_K291_G0.6690.35
123_L180_S0.6670.35
162_N272_M0.6670.35
59_P63_V0.6660.35
246_F282_G0.6660.35
281_Q296_K0.6650.35
268_I292_S0.6600.35
277_T287_R0.6580.35
111_T227_D0.6580.35
40_S209_Y0.6570.34
194_I290_A0.6560.34
70_R127_G0.6530.34
103_F215_P0.6510.34
217_L252_W0.6500.34
48_R82_A0.6500.34
227_D253_P0.6470.34
48_R85_C0.6430.33
80_A85_C0.6420.33
84_G174_Q0.6420.33
272_M288_D0.6410.33
274_V277_T0.6410.33
255_T260_S0.6410.33
89_V178_G0.6400.33
266_P276_T0.6390.33
10_R27_F0.6390.33
68_K72_M0.6390.33
189_W197_Y0.6370.33
41_S75_F0.6370.33
11_Q299_Q0.6360.33
93_P96_V0.6350.33
59_P88_L0.6330.33
168_W172_N0.6320.33
34_Y41_S0.6300.32
24_A132_F0.6270.32
52_Y85_C0.6260.32
66_G91_K0.6250.32
52_Y55_T0.6210.32
246_F288_D0.6210.32
175_I210_L0.6180.32
261_N264_T0.6140.31
11_Q200_L0.6130.31
238_V241_K0.6120.31
171_Y181_I0.6100.31
263_Q272_M0.6090.31
36_I285_I0.6070.31
90_H125_K0.6070.31
102_P113_I0.6070.31
262_A268_I0.6060.31
103_F108_A0.6060.31
223_L259_E0.6060.31
224_M256_G0.6040.31
206_V211_A0.6040.31
36_I296_K0.6040.31
61_L123_L0.6030.30
244_V248_T0.6020.30
232_D238_V0.6020.30
228_D235_P0.6020.30
199_W270_E0.6020.30
35_S38_K0.6010.30
61_L131_A0.6000.30
177_K287_R0.5990.30
248_T251_C0.5990.30
272_M275_S0.5970.30
7_T295_L0.5970.30
121_Q125_K0.5970.30
86_E94_E0.5960.30
230_R252_W0.5960.30
270_E275_S0.5960.30
281_Q291_G0.5940.30
272_M295_L0.5940.30
261_N265_L0.5940.30
265_L272_M0.5930.30
205_I212_A0.5920.30
114_M256_G0.5910.30
43_M181_I0.5890.29
257_A268_I0.5890.29
29_N86_E0.5880.29
268_I284_V0.5860.29
17_I87_L0.5860.29
153_D298_R0.5860.29
220_D287_R0.5850.29
277_T288_D0.5840.29
109_K113_I0.5840.29
72_M115_K0.5840.29
199_W273_L0.5820.29
121_Q156_H0.5810.29
215_P218_E0.5800.29
31_V126_Y0.5800.29
8_H11_Q0.5780.29
282_G296_K0.5780.29
292_S295_L0.5760.29
175_I298_R0.5740.28
119_L145_K0.5740.28
124_N208_L0.5730.28
169_H174_Q0.5730.28
60_L113_I0.5720.28
57_P77_D0.5720.28
288_D295_L0.5710.28
69_F183_V0.5700.28
92_N115_K0.5670.28
96_V114_M0.5670.28
222_M287_R0.5670.28
204_D240_K0.5660.28
8_H60_L0.5650.28
12_L22_E0.5640.28
81_K86_E0.5630.28
282_G288_D0.5630.28
161_K284_V0.5610.28
56_L83_Y0.5600.28
119_L152_R0.5590.27
45_H208_L0.5590.27
10_R295_L0.5580.27
289_Q296_K0.5580.27
118_G125_K0.5570.27
28_S127_G0.5550.27
208_L277_T0.5550.27
297_K301_Y0.5550.27
42_V132_F0.5540.27
215_P239_I0.5540.27
46_L50_A0.5500.27
10_R16_S0.5490.27
269_I287_R0.5470.27
249_L254_L0.5440.26
7_T14_A0.5430.26
18_H25_A0.5430.26
56_L272_M0.5430.26
21_R25_A0.5420.26
10_R289_Q0.5410.26
186_L194_I0.5390.26
44_L72_M0.5390.26
146_E187_S0.5390.26
262_A271_E0.5360.26
146_E152_R0.5350.26
60_L194_I0.5340.26
20_I162_N0.5340.26
28_S108_A0.5330.26
83_Y298_R0.5320.26
217_L264_T0.5310.26
7_T273_L0.5300.26
218_E299_Q0.5290.25
213_E289_Q0.5290.25
110_H221_G0.5260.25
87_L93_P0.5250.25
95_G117_E0.5240.25
100_I104_V0.5240.25
16_S23_V0.5230.25
26_E149_Y0.5230.25
119_L138_D0.5200.25
162_N170_N0.5190.25
253_P257_A0.5190.25
265_L282_G0.5180.25
133_G184_F0.5180.25
187_S190_T0.5160.25
231_I299_Q0.5150.25
104_V194_I0.5150.25
261_N277_T0.5150.25
261_N287_R0.5140.25
272_M292_S0.5140.25
11_Q267_E0.5130.24
95_G100_I0.5130.24
32_M249_L0.5130.24
148_I175_I0.5130.24
67_W111_T0.5120.24
109_K112_D0.5110.24
11_Q42_V0.5060.24
263_Q270_E0.5060.24
12_L145_K0.5050.24
278_S298_R0.5050.24
19_I24_A0.5050.24
169_H290_A0.5030.24
176_N213_E0.5030.24
16_S173_G0.5030.24
256_G260_S0.5020.24
75_F114_M0.5010.24
269_I274_V0.5000.24
66_G73_Y0.5000.24
263_Q291_G0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1zunA 1 0.6523 100 0.336 Contact Map
2oq2A 2 0.7748 100 0.514 Contact Map
4bwvA 2 0.6921 100 0.518 Contact Map
2goyA 3 0.6921 100 0.572 Contact Map
2o8vA 2 0.6755 100 0.577 Contact Map
3fwkA 1 0.8079 100 0.608 Contact Map
2wsiA 1 0.7815 100 0.614 Contact Map
1surA 2 0.6325 100 0.658 Contact Map
2pg3A 2 0.6755 99.8 0.775 Contact Map
3bl5A 3 0.596 99.8 0.782 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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