CYSD - ECOLI - GREMLIN Contacts

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CYSD - Sulfate adenylyltransferase subunit 2

UniProt:	P21156	Sequences: MDQIRLTHLRQLEAESIHIIREVAAEFSNPVMLYSIGKDSSVMLHLARKAFYPGTLPFPLLHVDTGWKFREMYEFRDRTAKAYGCELLVHKNPEGVAMGINPFVHGSAKHTDIMKTEGLKQALNKYGFDAAFGGARRDEEKSRAKERIYSFRDRFHRWDPKNQRPELWHNYNGQINKGESIRVFPLSNWTEQDIWQYIWLENIDIVPLYLAAERPVLERDGMLMMIDDNRIDLQPGEVIKKRMVRFRTLGCWPLTGAVESNAQTLPEIIEEMLVSTTSERQGRVIDRDQAGSMELKKRQGYF	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10186
Length:	302 (295)
Sequences:	1476 (576)
Seq/√Len:	33.5

ECOLI - CYSD CYSH
BACSU - CYSH2 CYSH1
HALSA - Q9HS08
SULSO - Q97UT3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
10_R	200_L	6.753	1.00
93_P	97_A	5.065	1.00
263_Q	267_E	4.797	1.00
199_W	266_P	4.343	1.00
61_L	122_A	4.209	1.00
45_H	48_R	3.866	1.00
78_R	82_A	3.807	1.00
31_V	61_L	3.776	1.00
213_E	241_K	3.598	1.00
242_R	259_E	3.484	1.00
20_I	132_F	3.481	1.00
74_E	78_R	3.300	1.00
32_M	43_M	3.285	1.00
56_L	85_C	3.189	1.00
243_M	261_N	2.718	1.00
43_M	132_F	2.707	1.00
151_F	181_I	2.573	1.00
79_T	82_A	2.513	1.00
101_N	104_V	2.508	1.00
215_P	241_K	2.482	1.00
18_H	171_Y	2.459	1.00
90_H	126_Y	2.448	1.00
47_A	58_F	2.410	0.99
218_E	223_L	2.230	0.99
219_R	237_E	2.199	0.99
31_V	131_A	2.156	0.99
157_R	298_R	2.149	0.99
90_H	122_A	2.109	0.99
24_A	27_F	2.100	0.99
256_G	284_V	2.071	0.98
78_R	204_D	2.057	0.98
261_N	267_E	2.039	0.98
218_E	221_G	2.014	0.98
70_R	74_E	1.979	0.98
23_V	130_A	1.967	0.98
264_T	267_E	1.967	0.98
199_W	269_I	1.960	0.98
7_T	10_R	1.945	0.98
79_T	83_Y	1.875	0.97
270_E	274_V	1.858	0.97
42_V	194_I	1.834	0.96
49_K	201_E	1.813	0.96
218_E	240_K	1.811	0.96
27_F	130_A	1.807	0.96
68_K	115_K	1.796	0.96
48_R	83_Y	1.776	0.96
27_F	173_G	1.725	0.95
44_L	79_T	1.719	0.95
159_D	162_N	1.656	0.94
233_L	239_I	1.629	0.93
222_M	284_V	1.627	0.93
29_N	127_G	1.605	0.93
65_T	115_K	1.598	0.93
123_L	131_A	1.576	0.92
288_D	292_S	1.572	0.92
289_Q	298_R	1.562	0.92
31_V	122_A	1.557	0.92
26_E	173_G	1.546	0.91
63_V	90_H	1.527	0.91
104_V	232_D	1.525	0.91
44_L	60_L	1.523	0.91
175_I	181_I	1.508	0.90
100_I	121_Q	1.502	0.90
41_S	68_K	1.498	0.90
61_L	126_Y	1.486	0.89
95_G	114_M	1.480	0.89
243_M	263_Q	1.459	0.89
8_H	196_Q	1.450	0.88
19_I	148_I	1.432	0.88
222_M	256_G	1.424	0.87
95_G	118_G	1.424	0.87
82_A	204_D	1.415	0.87
203_I	208_L	1.412	0.87
213_E	243_M	1.409	0.87
205_I	210_L	1.406	0.87
77_D	89_V	1.398	0.86
208_L	249_L	1.386	0.86
43_M	141_K	1.375	0.85
61_L	88_L	1.341	0.84
196_Q	273_L	1.339	0.84
15_E	188_N	1.335	0.84
210_L	265_L	1.326	0.83
23_V	27_F	1.308	0.82
277_T	291_G	1.268	0.80
148_I	171_Y	1.264	0.80
284_V	287_R	1.254	0.80
149_Y	183_V	1.253	0.80
27_F	181_I	1.250	0.79
51_F	58_F	1.234	0.79
130_A	183_V	1.226	0.78
227_D	252_W	1.208	0.77
112_D	289_Q	1.183	0.75
110_H	118_G	1.181	0.75
112_D	117_E	1.173	0.75
103_F	110_H	1.170	0.75
88_L	126_Y	1.166	0.74
78_R	81_K	1.137	0.72
266_P	269_I	1.132	0.72
91_K	94_E	1.129	0.72
20_I	43_M	1.125	0.72
217_L	226_I	1.123	0.72
232_D	239_I	1.118	0.71
267_E	270_E	1.115	0.71
291_G	295_L	1.115	0.71
233_L	237_E	1.107	0.70
7_T	200_L	1.104	0.70
206_V	212_A	1.091	0.69
48_R	56_L	1.089	0.69
72_M	288_D	1.076	0.68
284_V	295_L	1.073	0.68
45_H	203_I	1.061	0.67
38_K	139_E	1.050	0.66
73_Y	118_G	1.032	0.65
20_I	23_V	1.032	0.65
93_P	99_G	1.031	0.65
273_L	278_S	1.028	0.65
52_Y	56_L	1.014	0.64
149_Y	173_G	1.013	0.63
222_M	282_G	1.011	0.63
290_A	295_L	1.007	0.63
224_M	284_V	1.003	0.63
295_L	298_R	1.000	0.62
273_L	295_L	0.991	0.62
266_P	274_V	0.988	0.62
55_T	86_E	0.985	0.61
270_E	273_L	0.983	0.61
64_D	68_K	0.982	0.61
103_F	106_G	0.981	0.61
39_D	139_E	0.978	0.61
37_G	40_S	0.975	0.60
74_E	82_A	0.975	0.60
277_T	282_G	0.972	0.60
265_L	269_I	0.968	0.60
233_L	236_G	0.951	0.59
226_I	239_I	0.948	0.58
186_L	276_T	0.946	0.58
94_E	98_M	0.944	0.58
151_F	179_E	0.943	0.58
73_Y	91_K	0.942	0.58
281_Q	298_R	0.933	0.57
285_I	296_K	0.931	0.57
218_E	242_R	0.922	0.56
277_T	290_A	0.920	0.56
110_H	114_M	0.920	0.56
27_F	298_R	0.915	0.56
43_M	186_L	0.915	0.56
151_F	175_I	0.914	0.55
209_Y	212_A	0.907	0.55
289_Q	295_L	0.904	0.55
205_I	209_Y	0.898	0.54
287_R	295_L	0.897	0.54
111_T	115_K	0.897	0.54
154_R	298_R	0.891	0.54
42_V	198_I	0.889	0.53
73_Y	101_N	0.886	0.53
49_K	197_Y	0.884	0.53
26_E	132_F	0.884	0.53
288_D	296_K	0.881	0.53
114_M	118_G	0.880	0.53
265_L	268_I	0.880	0.53
7_T	43_M	0.880	0.53
29_N	74_E	0.877	0.52
272_M	277_T	0.875	0.52
123_L	126_Y	0.869	0.52
94_E	125_K	0.865	0.51
101_N	105_H	0.864	0.51
36_I	206_V	0.864	0.51
246_F	257_A	0.863	0.51
61_L	242_R	0.863	0.51
103_F	109_K	0.859	0.51
55_T	84_G	0.858	0.51
127_G	287_R	0.858	0.51
160_P	168_W	0.856	0.51
287_R	291_G	0.850	0.50
273_L	277_T	0.850	0.50
168_W	171_Y	0.848	0.50
240_K	259_E	0.848	0.50
10_R	298_R	0.846	0.50
21_R	57_P	0.846	0.50
95_G	113_I	0.841	0.49
27_F	175_I	0.840	0.49
72_M	206_V	0.838	0.49
68_K	73_Y	0.837	0.49
57_P	152_R	0.836	0.49
266_P	270_E	0.831	0.49
64_D	89_V	0.830	0.48
88_L	128_F	0.827	0.48
124_N	156_H	0.827	0.48
40_S	139_E	0.819	0.48
196_Q	205_I	0.817	0.47
112_D	298_R	0.816	0.47
105_H	109_K	0.810	0.47
215_P	226_I	0.809	0.47
38_K	209_Y	0.809	0.47
247_R	250_G	0.809	0.47
196_Q	200_L	0.801	0.46
192_Q	196_Q	0.795	0.46
232_D	235_P	0.791	0.45
8_H	24_A	0.789	0.45
63_V	221_G	0.784	0.45
206_V	209_Y	0.783	0.45
110_H	115_K	0.783	0.45
25_A	54_G	0.781	0.44
119_L	142_S	0.779	0.44
278_S	281_Q	0.777	0.44
157_R	289_Q	0.773	0.44
44_L	85_C	0.771	0.44
217_L	231_I	0.766	0.43
275_S	282_G	0.766	0.43
32_M	81_K	0.765	0.43
68_K	111_T	0.762	0.43
211_A	264_T	0.758	0.42
12_L	15_E	0.756	0.42
173_G	295_L	0.755	0.42
36_I	72_M	0.754	0.42
35_S	40_S	0.752	0.42
55_T	161_K	0.751	0.42
170_N	175_I	0.751	0.42
235_P	239_I	0.745	0.41
108_A	292_S	0.742	0.41
153_D	157_R	0.741	0.41
157_R	161_K	0.741	0.41
216_V	223_L	0.741	0.41
47_A	51_F	0.739	0.41
112_D	115_K	0.738	0.41
227_D	230_R	0.738	0.41
118_G	131_A	0.737	0.41
295_L	299_Q	0.734	0.41
222_M	295_L	0.733	0.40
120_K	157_R	0.728	0.40
7_T	274_V	0.723	0.40
131_A	180_S	0.722	0.40
220_D	284_V	0.717	0.39
101_N	109_K	0.713	0.39
113_I	299_Q	0.711	0.39
281_Q	287_R	0.711	0.39
98_M	103_F	0.711	0.39
151_F	171_Y	0.710	0.39
208_L	212_A	0.707	0.38
35_S	39_D	0.707	0.38
287_R	292_S	0.706	0.38
112_D	157_R	0.705	0.38
20_I	56_L	0.703	0.38
252_W	257_A	0.698	0.38
39_D	209_Y	0.696	0.37
15_E	22_E	0.696	0.37
167_L	171_Y	0.693	0.37
219_R	236_G	0.693	0.37
48_R	79_T	0.691	0.37
161_K	176_N	0.690	0.37
282_G	291_G	0.690	0.37
7_T	11_Q	0.688	0.37
139_E	209_Y	0.686	0.37
270_E	277_T	0.686	0.37
108_A	289_Q	0.684	0.37
54_G	169_H	0.683	0.36
231_I	235_P	0.681	0.36
200_L	263_Q	0.680	0.36
101_N	110_H	0.680	0.36
65_T	68_K	0.678	0.36
237_E	247_R	0.677	0.36
281_Q	290_A	0.677	0.36
157_R	269_I	0.672	0.36
60_L	85_C	0.672	0.36
68_K	215_P	0.671	0.36
109_K	291_G	0.669	0.35
123_L	180_S	0.667	0.35
162_N	272_M	0.667	0.35
59_P	63_V	0.666	0.35
246_F	282_G	0.666	0.35
281_Q	296_K	0.665	0.35
268_I	292_S	0.660	0.35
277_T	287_R	0.658	0.35
111_T	227_D	0.658	0.35
40_S	209_Y	0.657	0.34
194_I	290_A	0.656	0.34
70_R	127_G	0.653	0.34
103_F	215_P	0.651	0.34
217_L	252_W	0.650	0.34
48_R	82_A	0.650	0.34
227_D	253_P	0.647	0.34
48_R	85_C	0.643	0.33
80_A	85_C	0.642	0.33
84_G	174_Q	0.642	0.33
272_M	288_D	0.641	0.33
274_V	277_T	0.641	0.33
255_T	260_S	0.641	0.33
89_V	178_G	0.640	0.33
266_P	276_T	0.639	0.33
10_R	27_F	0.639	0.33
68_K	72_M	0.639	0.33
189_W	197_Y	0.637	0.33
41_S	75_F	0.637	0.33
11_Q	299_Q	0.636	0.33
93_P	96_V	0.635	0.33
59_P	88_L	0.633	0.33
168_W	172_N	0.632	0.33
34_Y	41_S	0.630	0.32
24_A	132_F	0.627	0.32
52_Y	85_C	0.626	0.32
66_G	91_K	0.625	0.32
52_Y	55_T	0.621	0.32
246_F	288_D	0.621	0.32
175_I	210_L	0.618	0.32
261_N	264_T	0.614	0.31
11_Q	200_L	0.613	0.31
238_V	241_K	0.612	0.31
171_Y	181_I	0.610	0.31
263_Q	272_M	0.609	0.31
36_I	285_I	0.607	0.31
90_H	125_K	0.607	0.31
102_P	113_I	0.607	0.31
262_A	268_I	0.606	0.31
103_F	108_A	0.606	0.31
223_L	259_E	0.606	0.31
224_M	256_G	0.604	0.31
206_V	211_A	0.604	0.31
36_I	296_K	0.604	0.31
61_L	123_L	0.603	0.30
244_V	248_T	0.602	0.30
232_D	238_V	0.602	0.30
228_D	235_P	0.602	0.30
199_W	270_E	0.602	0.30
35_S	38_K	0.601	0.30
61_L	131_A	0.600	0.30
177_K	287_R	0.599	0.30
248_T	251_C	0.599	0.30
272_M	275_S	0.597	0.30
7_T	295_L	0.597	0.30
121_Q	125_K	0.597	0.30
86_E	94_E	0.596	0.30
230_R	252_W	0.596	0.30
270_E	275_S	0.596	0.30
281_Q	291_G	0.594	0.30
272_M	295_L	0.594	0.30
261_N	265_L	0.594	0.30
265_L	272_M	0.593	0.30
205_I	212_A	0.592	0.30
114_M	256_G	0.591	0.30
43_M	181_I	0.589	0.29
257_A	268_I	0.589	0.29
29_N	86_E	0.588	0.29
268_I	284_V	0.586	0.29
17_I	87_L	0.586	0.29
153_D	298_R	0.586	0.29
220_D	287_R	0.585	0.29
277_T	288_D	0.584	0.29
109_K	113_I	0.584	0.29
72_M	115_K	0.584	0.29
199_W	273_L	0.582	0.29
121_Q	156_H	0.581	0.29
215_P	218_E	0.580	0.29
31_V	126_Y	0.580	0.29
8_H	11_Q	0.578	0.29
282_G	296_K	0.578	0.29
292_S	295_L	0.576	0.29
175_I	298_R	0.574	0.28
119_L	145_K	0.574	0.28
124_N	208_L	0.573	0.28
169_H	174_Q	0.573	0.28
60_L	113_I	0.572	0.28
57_P	77_D	0.572	0.28
288_D	295_L	0.571	0.28
69_F	183_V	0.570	0.28
92_N	115_K	0.567	0.28
96_V	114_M	0.567	0.28
222_M	287_R	0.567	0.28
204_D	240_K	0.566	0.28
8_H	60_L	0.565	0.28
12_L	22_E	0.564	0.28
81_K	86_E	0.563	0.28
282_G	288_D	0.563	0.28
161_K	284_V	0.561	0.28
56_L	83_Y	0.560	0.28
119_L	152_R	0.559	0.27
45_H	208_L	0.559	0.27
10_R	295_L	0.558	0.27
289_Q	296_K	0.558	0.27
118_G	125_K	0.557	0.27
28_S	127_G	0.555	0.27
208_L	277_T	0.555	0.27
297_K	301_Y	0.555	0.27
42_V	132_F	0.554	0.27
215_P	239_I	0.554	0.27
46_L	50_A	0.550	0.27
10_R	16_S	0.549	0.27
269_I	287_R	0.547	0.27
249_L	254_L	0.544	0.26
7_T	14_A	0.543	0.26
18_H	25_A	0.543	0.26
56_L	272_M	0.543	0.26
21_R	25_A	0.542	0.26
10_R	289_Q	0.541	0.26
186_L	194_I	0.539	0.26
44_L	72_M	0.539	0.26
146_E	187_S	0.539	0.26
262_A	271_E	0.536	0.26
146_E	152_R	0.535	0.26
60_L	194_I	0.534	0.26
20_I	162_N	0.534	0.26
28_S	108_A	0.533	0.26
83_Y	298_R	0.532	0.26
217_L	264_T	0.531	0.26
7_T	273_L	0.530	0.26
218_E	299_Q	0.529	0.25
213_E	289_Q	0.529	0.25
110_H	221_G	0.526	0.25
87_L	93_P	0.525	0.25
95_G	117_E	0.524	0.25
100_I	104_V	0.524	0.25
16_S	23_V	0.523	0.25
26_E	149_Y	0.523	0.25
119_L	138_D	0.520	0.25
162_N	170_N	0.519	0.25
253_P	257_A	0.519	0.25
265_L	282_G	0.518	0.25
133_G	184_F	0.518	0.25
187_S	190_T	0.516	0.25
231_I	299_Q	0.515	0.25
104_V	194_I	0.515	0.25
261_N	277_T	0.515	0.25
261_N	287_R	0.514	0.25
272_M	292_S	0.514	0.25
11_Q	267_E	0.513	0.24
95_G	100_I	0.513	0.24
32_M	249_L	0.513	0.24
148_I	175_I	0.513	0.24
67_W	111_T	0.512	0.24
109_K	112_D	0.511	0.24
11_Q	42_V	0.506	0.24
263_Q	270_E	0.506	0.24
12_L	145_K	0.505	0.24
278_S	298_R	0.505	0.24
19_I	24_A	0.505	0.24
169_H	290_A	0.503	0.24
176_N	213_E	0.503	0.24
16_S	173_G	0.503	0.24
256_G	260_S	0.502	0.24
75_F	114_M	0.501	0.24
269_I	274_V	0.500	0.24
66_G	73_Y	0.500	0.24
263_Q	291_G	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zunA	1	0.6523	100	0.336	Contact Map
2oq2A	2	0.7748	100	0.514	Contact Map
4bwvA	2	0.6921	100	0.518	Contact Map
2goyA	3	0.6921	100	0.572	Contact Map
2o8vA	2	0.6755	100	0.577	Contact Map
3fwkA	1	0.8079	100	0.608	Contact Map
2wsiA	1	0.7815	100	0.614	Contact Map
1surA	2	0.6325	100	0.658	Contact Map
2pg3A	2	0.6755	99.8	0.775	Contact Map
3bl5A	3	0.596	99.8	0.782	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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