GREMLIN Database
FADA - 3-ketoacyl-CoA thiolase
UniProt: P21151 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10278
Length: 387 (368)
Sequences: 15251 (8307)
Seq/√Len: 433.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
171_R175_R3.3471.00
3_Q253_E3.3381.00
255_R259_L3.2331.00
164_M320_K3.2321.00
110_A113_C2.9081.00
178_A182_S2.7361.00
98_L353_S2.7091.00
37_S40_A2.7091.00
170_A216_V2.6841.00
253_E257_H2.6421.00
181_Q212_P2.6351.00
165_Q232_M2.6091.00
171_R174_A2.5811.00
255_R258_E2.5621.00
156_R227_D2.5551.00
356_L368_G2.4241.00
9_A354_T2.3741.00
291_A383_V2.3031.00
5_V256_A2.2941.00
105_I250_V2.2931.00
35_M114_L2.2881.00
291_A295_A2.2591.00
10_I41_R2.2401.00
186_K205_N2.1191.00
38_L249_L2.1181.00
112_A251_M2.0701.00
265_A357_L2.0681.00
101_A113_C2.0301.00
325_I330_E2.0141.00
161_S164_M1.9961.00
360_M365_V1.9841.00
269_S295_A1.9721.00
266_R385_E1.9611.00
31_S55_W1.9451.00
180_T210_I1.9431.00
46_E49_A1.9421.00
304_V334_L1.9381.00
105_I252_S1.9141.00
325_I329_D1.8911.00
177_W181_Q1.8901.00
297_L367_F1.8861.00
7_V251_M1.8841.00
209_V240_A1.8811.00
227_D230_N1.8721.00
33_H192_T1.8611.00
3_Q266_R1.8571.00
264_R361_E1.8551.00
177_W210_I1.7711.00
163_E167_A1.7701.00
49_A259_L1.7501.00
246_A350_A1.7471.00
319_I329_D1.7451.00
193_G203_Q1.7261.00
303_G365_V1.7191.00
111_Q252_S1.6941.00
269_S291_A1.6581.00
171_R329_D1.6551.00
186_K206_Y1.6451.00
219_L236_G1.6441.00
251_M255_R1.6421.00
251_M256_A1.6401.00
180_T189_I1.6341.00
157_M279_I1.6221.00
297_L302_I1.6191.00
288_S371_T1.6121.00
299_A305_F1.6121.00
335_N359_L1.6091.00
111_Q255_R1.6091.00
289_K293_K1.6021.00
319_I332_I1.6011.00
302_I383_V1.5831.00
184_A335_N1.5731.00
103_R109_D1.5711.00
170_A174_A1.5641.00
218_A221_T1.5601.00
154_L160_I1.5581.00
359_L363_K1.5541.00
252_S255_R1.5531.00
104_M110_A1.5481.00
55_W116_G1.5461.00
85_V100_D1.5421.00
286_P289_K1.5381.00
187_N361_E1.5351.00
180_T206_Y1.5341.00
21_A204_F1.5311.00
148_G226_F1.5271.00
38_L42_N1.5251.00
33_H190_I1.5171.00
29_D75_L1.5121.00
8_D42_N1.5091.00
37_S190_I1.5031.00
248_M350_A1.4991.00
302_I305_F1.4981.00
31_S72_A1.4851.00
268_R385_E1.4761.00
35_M72_A1.4671.00
36_R40_A1.4531.00
304_V359_L1.4501.00
101_A250_V1.4351.00
120_H123_H1.4131.00
167_A216_V1.4031.00
297_L383_V1.4031.00
167_A171_R1.4031.00
359_L362_R1.4011.00
184_A359_L1.4001.00
5_V266_R1.3971.00
353_S384_F1.3931.00
34_L245_A1.3761.00
34_L247_A1.3751.00
174_A178_A1.3611.00
112_A255_R1.3601.00
366_Q385_E1.3401.00
271_A290_L1.3331.00
292_L299_A1.3271.00
99_H382_T1.3141.00
174_A213_E1.2921.00
37_S41_R1.2901.00
80_H276_D1.2831.00
290_L293_K1.2811.00
177_W213_E1.2781.00
68_I118_V1.2751.00
305_F369_L1.2741.00
365_V368_G1.2691.00
302_I367_F1.2541.00
271_A291_A1.2541.00
325_I331_K1.2481.00
22_F204_F1.2441.00
25_V33_H1.2411.00
57_C60_Q1.2391.00
184_A362_R1.2391.00
8_D38_L1.2371.00
14_M347_C1.2341.00
164_M167_A1.2271.00
4_V250_V1.2271.00
99_H270_M1.2251.00
187_N362_R1.2231.00
51_D110_A1.2141.00
254_S258_E1.2101.00
357_L361_E1.2031.00
289_K321_D1.1971.00
32_A75_L1.1941.00
10_I190_I1.1931.00
334_L359_L1.1891.00
92_G380_I1.1761.00
354_T358_N1.1751.00
369_L383_V1.1741.00
114_L249_L1.1741.00
285_V289_K1.1701.00
98_L248_M1.1591.00
50_L112_A1.1581.00
55_W247_A1.1501.00
130_V135_G1.1481.00
273_V286_P1.1431.00
298_S301_D1.1381.00
162_R234_T1.1371.00
287_A381_A1.1261.00
149_L227_D1.1241.00
92_G374_I1.1231.00
295_A383_V1.1211.00
152_E227_D1.1181.00
275_C282_Y1.1151.00
5_V253_E1.1091.00
14_M341_L1.1091.00
42_N45_L1.1011.00
51_D111_Q1.0981.00
288_S369_L1.0941.00
160_I165_Q1.0891.00
188_E355_T1.0881.00
49_A255_R1.0751.00
268_R367_F1.0671.00
9_A358_N1.0651.00
168_F315_I1.0631.00
153_M157_M1.0601.00
109_D294_K1.0551.00
33_H37_S1.0501.00
160_I316_L1.0501.00
95_M353_S1.0461.00
282_Y285_V1.0441.00
19_G128_H1.0441.00
187_N358_N1.0421.00
106_M109_D1.0391.00
364_D368_G1.0381.00
158_H282_Y1.0371.00
54_Y113_C1.0371.00
367_F385_E1.0351.00
177_W212_P1.0341.00
5_V251_M1.0291.00
101_A115_V1.0291.00
96_Q100_D1.0171.00
356_L370_A1.0141.00
216_V220_A1.0141.00
6_I384_F1.0021.00
267_V382_T0.9991.00
279_I282_Y0.9981.00
35_M78_V0.9921.00
214_T219_L0.9921.00
269_S294_K0.9891.00
148_G225_A0.9861.00
103_R107_T0.9851.00
10_I37_S0.9841.00
56_G93_S0.9831.00
157_M278_S0.9721.00
98_L250_V0.9721.00
299_A302_I0.9611.00
8_D41_R0.9611.00
53_I73_A0.9601.00
136_L141_A0.9571.00
335_N362_R0.9571.00
222_L236_G0.9561.00
273_V290_L0.9551.00
32_A36_R0.9511.00
334_L363_K0.9461.00
9_A357_L0.9451.00
127_S132_F0.9451.00
269_S383_V0.9441.00
305_F324_L0.9381.00
215_T218_A0.9371.00
351_R355_T0.9341.00
26_R29_D0.9331.00
304_V363_K0.9331.00
39_L78_V0.9321.00
264_R357_L0.9261.00
152_E156_R0.9241.00
139_N142_K0.9231.00
303_G360_M0.9221.00
178_A184_A0.9191.00
168_F316_L0.9171.00
49_A258_E0.9141.00
253_E266_R0.9111.00
34_L37_S0.9051.00
246_A347_C0.9011.00
304_V356_L0.9001.00
324_L332_I0.8941.00
127_S130_V0.8941.00
180_T186_K0.8921.00
178_A181_Q0.8921.00
352_I370_A0.8881.00
371_T374_I0.8871.00
170_A219_L0.8871.00
158_H321_D0.8851.00
78_V82_V0.8821.00
170_A213_E0.8821.00
367_F383_V0.8751.00
288_S322_L0.8731.00
282_Y317_P0.8711.00
282_Y321_D0.8711.00
290_L294_K0.8711.00
302_I369_L0.8681.00
57_C64_Q0.8681.00
3_Q106_M0.8671.00
12_T34_L0.8671.00
222_L234_T0.8601.00
14_M242_S0.8591.00
39_L45_L0.8581.00
353_S382_T0.8581.00
374_I380_I0.8561.00
155_A313_A0.8561.00
171_R330_E0.8541.00
174_A177_W0.8531.00
102_A267_V0.8531.00
4_V252_S0.8511.00
194_G204_F0.8511.00
246_A354_T0.8491.00
4_V102_A0.8481.00
176_A210_I0.8441.00
54_Y97_A0.8411.00
153_M156_R0.8411.00
154_L317_P0.8401.00
7_V261_L0.8391.00
89_R96_Q0.8331.00
54_Y85_V0.8321.00
129_G132_F0.8321.00
138_R142_K0.8321.00
13_P204_F0.8251.00
251_M261_L0.8251.00
319_I324_L0.8231.00
54_Y101_A0.8211.00
102_A106_M0.8191.00
357_L384_F0.8181.00
15_G208_E0.8171.00
267_V270_M0.8151.00
223_R235_A0.8141.00
227_D231_G0.8111.00
285_V321_D0.8101.00
127_S133_H0.8081.00
224_P227_D0.8081.00
74_L80_H0.8071.00
9_A248_M0.8061.00
12_T30_L0.8041.00
315_I319_I0.8021.00
115_V248_M0.8011.00
154_L282_Y0.8001.00
137_S141_A0.8001.00
374_I378_Q0.8001.00
338_A348_S0.7981.00
13_P33_H0.7951.00
38_L114_L0.7951.00
49_A112_A0.7941.00
16_R209_V0.7921.00
131_D134_P0.7911.00
163_E220_A0.7841.00
12_T33_H0.7801.00
180_T212_P0.7801.00
14_M351_R0.7801.00
181_Q206_Y0.7801.00
176_A180_T0.7761.00
253_E256_A0.7721.00
122_G243_D0.7711.00
166_D237_T0.7671.00
27_A118_V0.7651.00
312_A339_I0.7651.00
50_L114_L0.7621.00
303_G331_K0.7621.00
97_A350_A0.7611.00
254_S257_H0.7601.00
364_D367_F0.7601.00
132_F135_G0.7591.00
335_N363_K0.7581.00
53_I82_V0.7571.00
136_L140_V0.7571.00
262_K361_E0.7571.00
99_H380_I0.7561.00
182_S362_R0.7511.00
25_V29_D0.7481.00
137_S142_K0.7471.00
4_V106_M0.7431.00
34_L38_L0.7431.00
237_T312_A0.7431.00
275_C286_P0.7381.00
109_D270_M0.7381.00
51_D290_L0.7351.00
55_W69_A0.7321.00
52_D104_M0.7281.00
63_E123_H0.7271.00
169_A173_H0.7271.00
307_M371_T0.7271.00
39_L50_L0.7261.00
114_L247_A0.7261.00
100_D103_R0.7261.00
100_D104_M0.7241.00
289_K322_L0.7211.00
31_S116_G0.7171.00
217_E221_T0.7111.00
38_L247_A0.7101.00
33_H36_R0.7091.00
214_T218_A0.7071.00
103_R106_M0.7071.00
163_E216_V0.7061.00
151_A313_A0.7051.00
137_S140_V0.7051.00
104_M109_D0.7001.00
95_M382_T0.6971.00
280_M284_P0.6971.00
307_M318_C0.6951.00
297_L301_D0.6951.00
299_A324_L0.6951.00
57_C68_I0.6931.00
183_A186_K0.6921.00
288_S381_A0.6901.00
275_C283_G0.6901.00
130_V134_P0.6871.00
54_Y100_D0.6871.00
300_S323_G0.6831.00
51_D113_C0.6811.00
4_V105_I0.6801.00
89_R272_V0.6781.00
288_S307_M0.6781.00
129_G133_H0.6761.00
264_R358_N0.6761.00
39_L47_A0.6761.00
214_T236_G0.6731.00
21_A208_E0.6691.00
10_I34_L0.6691.00
111_Q294_K0.6671.00
42_N249_L0.6671.00
52_D272_V0.6651.00
12_T192_T0.6631.00
39_L44_A0.6631.00
170_A218_A0.6621.00
175_R178_A0.6591.00
36_R47_A0.6581.00
268_R295_A0.6581.00
104_M113_C0.6570.99
164_M316_L0.6540.99
149_L153_M0.6540.99
87_V100_D0.6520.99
276_D279_I0.6520.99
317_P321_D0.6520.99
272_V380_I0.6510.99
6_I250_V0.6470.99
175_R329_D0.6460.99
225_A235_A0.6460.99
35_M76_A0.6430.99
26_R123_H0.6430.99
146_M149_L0.6380.99
10_I38_L0.6360.99
128_H133_H0.6360.99
112_A259_L0.6360.99
170_A215_T0.6340.99
233_V238_S0.6340.99
131_D135_G0.6330.99
36_R77_E0.6320.99
360_M368_G0.6310.99
111_Q258_E0.6300.99
128_H131_D0.6300.99
288_S299_A0.6280.99
129_G134_P0.6270.99
374_I379_G0.6260.99
72_A76_A0.6250.99
78_V114_L0.6250.99
184_A363_K0.6240.99
28_E75_L0.6240.99
303_G367_F0.6220.99
29_D32_A0.6220.99
32_A76_A0.6210.99
250_V267_V0.6200.99
48_A81_S0.6190.99
101_A110_A0.6180.99
291_A369_L0.6180.99
98_L115_V0.6160.99
154_L158_H0.6150.99
28_E64_Q0.6140.99
170_A214_T0.6130.99
292_L297_L0.6130.99
158_H279_I0.6120.99
145_G149_L0.6120.99
138_R141_A0.6110.99
173_H177_W0.6100.99
6_I357_L0.6100.99
315_I332_I0.6100.99
173_H209_V0.6070.99
85_V96_Q0.6070.99
248_M354_T0.6060.99
173_H210_I0.6050.99
73_A84_A0.6050.99
348_S352_I0.6040.99
141_A144_A0.6030.99
209_V242_S0.6020.99
303_G366_Q0.6020.99
268_R297_L0.5980.99
50_L78_V0.5980.99
8_D264_R0.5970.99
31_S118_V0.5950.99
25_V123_H0.5940.99
5_V252_S0.5940.99
145_G278_S0.5930.99
95_M370_A0.5930.99
52_D89_R0.5930.99
47_A79_P0.5910.99
83_P272_V0.5910.99
160_I320_K0.5900.99
167_A329_D0.5850.99
35_M39_L0.5850.99
55_W72_A0.5850.99
58_V345_L0.5840.99
341_L351_R0.5840.99
19_G122_G0.5830.99
353_S370_A0.5800.99
151_A233_V0.5790.99
7_V256_A0.5780.99
73_A78_V0.5760.99
127_S131_D0.5760.99
136_L146_M0.5760.99
35_M247_A0.5740.99
96_Q99_H0.5740.99
24_N123_H0.5730.99
271_A294_K0.5710.99
293_K298_S0.5710.99
251_M259_L0.5680.99
59_Q124_V0.5680.99
30_L192_T0.5680.99
7_V255_R0.5680.99
67_N378_Q0.5680.99
292_L295_A0.5670.99
177_W180_T0.5660.99
305_F371_T0.5650.98
96_Q272_V0.5640.98
116_G247_A0.5630.98
60_Q86_T0.5630.98
176_A341_L0.5620.98
72_A118_V0.5610.98
289_K323_G0.5610.98
39_L42_N0.5600.98
191_P205_N0.5590.98
361_E364_D0.5590.98
260_G263_P0.5580.98
121_M345_L0.5580.98
288_S318_C0.5570.98
106_M270_M0.5540.98
286_P290_L0.5540.98
25_V120_H0.5530.98
319_I325_I0.5530.98
150_T280_M0.5520.98
316_L320_K0.5510.98
128_H134_P0.5500.98
158_H317_P0.5490.98
97_A115_V0.5480.98
267_V384_F0.5470.98
5_V255_R0.5470.98
160_I164_M0.5460.98
98_L350_A0.5440.98
263_P266_R0.5440.98
166_D216_V0.5440.98
310_A343_H0.5430.98
347_C350_A0.5420.98
372_M375_G0.5410.98
10_I42_N0.5390.98
176_A340_A0.5390.98
188_E358_N0.5370.98
36_R76_A0.5360.98
130_V133_H0.5360.98
370_A373_C0.5340.98
52_D110_A0.5330.98
145_G153_M0.5330.98
45_L249_L0.5300.98
314_Q318_C0.5290.98
169_A219_L0.5290.98
136_L142_K0.5270.98
179_A183_A0.5260.98
307_M315_I0.5250.98
33_H193_G0.5240.98
35_M53_I0.5220.97
291_A302_I0.5220.97
5_V259_L0.5210.97
313_A317_P0.5210.97
155_A160_I0.5200.97
301_D367_F0.5200.97
173_H339_I0.5200.97
152_E233_V0.5200.97
104_M107_T0.5180.97
320_K323_G0.5180.97
185_F341_L0.5160.97
368_G384_F0.5150.97
151_A155_A0.5150.97
25_V195_H0.5150.97
51_D82_V0.5140.97
15_G204_F0.5140.97
370_A374_I0.5140.97
288_S292_L0.5140.97
152_E231_G0.5120.97
168_F337_G0.5120.97
54_Y104_M0.5100.97
371_T375_G0.5100.97
164_M331_K0.5100.97
173_H213_E0.5070.97
337_G340_A0.5060.97
95_M380_I0.5060.97
373_C376_L0.5030.97
65_G71_N0.5030.97
58_V90_L0.5020.97
373_C379_G0.5010.97
310_A314_Q0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1wdkC 2 1 100 0.243 Contact Map
1ulqA 4 0.9845 100 0.247 Contact Map
3goaA 2 0.9845 100 0.25 Contact Map
2wu9A 2 0.9871 100 0.255 Contact Map
3ss6A 4 0.9793 100 0.258 Contact Map
2vu1A 4 0.9742 100 0.259 Contact Map
4n46A 4 0.9793 100 0.263 Contact Map
4e1lA 4 0.9767 100 0.264 Contact Map
3svkA 2 0.8915 100 0.268 Contact Map
4c2jA 4 0.9716 100 0.271 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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