GREMLIN Database
PTFBC - PTS system fructose-specific EIIBC component
UniProt: P20966 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10336
Length: 563 (460)
Sequences: 1591 (852)
Seq/√Len: 39.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
107_V162_V5.4691.00
443_A544_A5.2801.00
447_A455_F4.3311.00
305_G322_A4.0381.00
133_R197_D3.9931.00
435_A537_I3.9041.00
147_A150_A3.9011.00
154_E158_A3.8261.00
448_T463_G3.7831.00
191_K194_Q3.7291.00
294_A298_G3.7221.00
161_L199_A3.7011.00
133_R193_A3.6731.00
282_V319_G3.6421.00
286_A322_A3.5531.00
449_M467_L3.5121.00
404_T410_V3.5041.00
108_A139_V3.4941.00
329_I359_V3.4871.00
105_R158_A3.4771.00
130_A137_V3.3301.00
193_A197_D3.2591.00
132_K193_A3.1231.00
138_K155_E3.1151.00
404_T494_I3.0561.00
400_G494_I2.9701.00
229_H292_S2.9681.00
495_V547_A2.9351.00
153_P157_A2.8811.00
510_K528_T2.8671.00
197_D201_A2.7261.00
280_L307_M2.7031.00
240_M303_L2.6611.00
187_L191_K2.6351.00
129_E132_K2.5511.00
532_G535_V2.4861.00
176_A208_P2.4841.00
127_E131_K2.3981.00
485_D488_R2.3571.00
126_I137_V2.2881.00
105_R160_D2.2831.00
503_I507_I2.2130.99
451_A549_A2.2010.99
251_S270_M2.1920.99
416_A419_V2.1820.99
403_C497_G2.0970.99
135_W196_L2.0110.99
499_L543_V2.0110.99
444_M548_Y1.9850.99
418_G433_I1.9370.99
236_Y299_L1.9240.99
277_A304_I1.9090.98
455_F549_A1.9080.98
138_K149_N1.9000.98
330_A356_S1.8970.98
535_V539_A1.8760.98
270_M275_G1.8360.98
129_E133_R1.8180.98
236_Y288_Y1.8150.98
435_A500_T1.8050.98
124_E127_E1.8020.98
453_R554_P1.7960.98
105_R136_W1.7920.98
539_A543_V1.7670.97
442_L541_T1.7510.97
288_Y291_F1.7430.97
355_I359_V1.7200.97
151_I156_V1.7090.97
267_A271_Q1.7020.97
375_I378_G1.6980.97
279_A307_M1.6950.97
398_L433_I1.6900.97
107_V151_I1.6860.97
103_P136_W1.6840.97
400_G404_T1.6790.96
256_I259_F1.6570.96
300_T357_S1.6490.96
337_L351_I1.6440.96
507_I532_G1.6280.96
257_E260_K1.5990.95
179_P202_E1.5990.95
104_K160_D1.5930.95
403_C440_P1.5700.95
284_V303_L1.5700.95
248_I278_F1.5670.95
427_Y512_M1.5550.95
337_L355_I1.5510.94
406_M475_S1.5410.94
461_E464_K1.5380.94
232_T291_F1.5210.94
377_E381_H1.5170.94
133_R196_L1.5050.93
445_G449_M1.4980.93
499_L539_A1.4910.93
287_G303_L1.4890.93
495_V539_A1.4830.93
198_K203_A1.4770.93
509_A532_G1.4740.93
129_E193_A1.4650.93
490_L494_I1.4560.92
290_A326_A1.4520.92
161_L181_Y1.4480.92
317_I321_I1.4230.91
492_C547_A1.4170.91
400_G436_A1.3990.91
489_V548_Y1.3950.91
446_L541_T1.3870.90
321_I325_L1.3820.90
396_A502_A1.3780.90
454_K554_P1.3780.90
332_L336_Q1.3740.90
373_A377_E1.3720.90
445_G467_L1.3630.90
243_A357_S1.3560.89
141_T149_N1.3490.89
403_C475_S1.3360.89
378_G382_W1.3090.88
330_A352_I1.2920.87
457_K460_Q1.2880.87
176_A209_A1.2800.86
305_G360_V1.2800.86
400_G498_A1.2780.86
108_A137_V1.2760.86
116_V345_A1.2730.86
268_A366_Y1.2720.86
415_Y430_M1.2650.86
529_P532_G1.2640.86
129_E192_T1.2590.85
447_A549_A1.2580.85
109_V142_R1.2500.85
106_V130_A1.2330.84
472_C519_F1.2280.84
302_G326_A1.2240.84
108_A166_A1.2230.84
374_G378_G1.2100.83
194_Q198_K1.2090.83
111_A168_I1.2030.83
454_K549_A1.1950.82
258_A261_E1.1930.82
123_A127_E1.1840.82
333_I337_L1.1840.82
503_I506_A1.1780.81
301_P357_S1.1680.81
179_P203_A1.1670.81
509_A529_P1.1670.81
183_T187_L1.1660.81
437_G473_F1.1620.80
492_C551_L1.1580.80
152_T155_E1.1570.80
106_V200_V1.1570.80
104_K200_V1.1560.80
303_L307_M1.1550.80
485_D552_K1.1540.80
185_T188_A1.1530.80
380_T384_Q1.1460.79
144_S296_R1.1450.79
128_T458_A1.1400.79
222_E225_G1.1390.79
161_L200_V1.1370.79
128_T131_K1.1270.78
504_S509_A1.1240.78
198_K201_A1.1220.78
192_T196_L1.1190.78
106_V135_W1.1150.78
140_E174_K1.1110.77
415_Y422_L1.1050.77
325_L329_I1.1050.77
188_A191_K1.1030.77
389_A392_V1.1020.77
434_M473_F1.1000.77
546_L550_F1.0950.76
434_M437_G1.0910.76
272_I361_G1.0900.76
503_I536_A1.0850.76
172_L182_R1.0810.75
161_L202_E1.0780.75
352_I356_S1.0780.75
457_K461_E1.0780.75
491_P551_L1.0720.75
144_S349_I1.0660.74
183_T195_E1.0650.74
354_L358_L1.0640.74
251_S256_I1.0640.74
254_F265_L1.0570.74
536_A539_A1.0550.74
256_I260_K1.0520.73
188_A194_Q1.0520.73
509_A528_T1.0460.73
547_A551_L1.0380.72
372_V413_A1.0360.72
386_M390_N1.0350.72
451_A454_K1.0340.72
439_V497_G1.0330.72
268_A362_L1.0320.72
276_S308_L1.0320.72
510_K527_I1.0300.72
222_E328_Y1.0290.72
154_E157_A1.0280.72
333_I352_I1.0280.72
503_I539_A1.0250.71
503_I532_G1.0240.71
187_L198_K1.0230.71
542_L545_G1.0230.71
402_M434_M1.0140.70
220_K224_A1.0140.70
398_L429_P1.0140.70
438_M473_F1.0130.70
372_V375_I1.0080.70
125_A189_L1.0070.70
392_V506_A1.0050.70
293_I328_Y1.0030.70
378_G381_H1.0030.70
545_G549_A1.0020.70
440_P497_G1.0020.70
225_G229_H0.9990.69
290_A302_G0.9920.69
450_V541_T0.9890.69
502_A506_A0.9870.68
125_A129_E0.9760.68
541_T545_G0.9750.67
521_L530_V0.9750.67
106_V199_A0.9690.67
259_F270_M0.9680.67
402_M473_F0.9660.67
329_I360_V0.9620.66
376_L413_A0.9590.66
166_A182_R0.9580.66
339_L347_K0.9560.66
265_L358_L0.9530.66
379_L382_W0.9480.65
191_K198_K0.9480.65
92_V95_T0.9390.64
238_L347_K0.9370.64
410_V494_I0.9330.64
344_E347_K0.9320.64
288_Y299_L0.9280.64
302_G306_G0.9280.64
402_M437_G0.9280.64
161_L203_A0.9280.64
426_T429_P0.9240.63
386_M397_I0.9220.63
314_S318_G0.9220.63
109_V172_L0.9200.63
333_I356_S0.9180.63
491_P494_I0.9180.63
232_T236_Y0.9180.63
106_V161_L0.9070.62
439_V500_T0.9030.61
246_L354_L0.9030.61
256_I261_E0.8950.61
161_L192_T0.8930.61
334_S475_S0.8880.60
186_G190_K0.8870.60
308_L365_I0.8860.60
250_L253_A0.8830.60
157_A160_D0.8790.59
109_V166_A0.8790.59
421_L426_T0.8790.59
444_M466_A0.8770.59
142_R164_V0.8750.59
444_M475_S0.8740.59
419_V430_M0.8740.59
382_W397_I0.8730.59
164_V180_M0.8670.58
332_L337_L0.8660.58
415_Y438_M0.8640.58
493_C544_A0.8610.58
128_T132_K0.8610.58
133_R192_T0.8560.57
363_A367_L0.8550.57
434_M438_M0.8530.57
258_A266_A0.8520.57
257_E261_E0.8510.57
181_Y195_E0.8500.57
94_A97_P0.8470.56
286_A319_G0.8460.56
456_D484_R0.8420.56
406_M493_C0.8410.56
458_A461_E0.8410.56
106_V137_V0.8400.56
259_F262_P0.8390.56
430_M433_I0.8380.56
396_A498_A0.8370.56
222_E226_A0.8360.55
164_V172_L0.8340.55
218_E221_K0.8330.55
256_I266_A0.8300.55
498_A502_A0.8290.55
144_S348_P0.8270.55
456_D459_Q0.8250.54
290_A298_G0.8230.54
173_A209_A0.8220.54
280_L303_L0.8210.54
150_A171_D0.8210.54
184_S190_K0.8190.54
242_V462_G0.8090.53
454_K555_E0.8080.53
260_K266_A0.8080.53
294_A331_K0.8080.53
395_G399_G0.8060.53
321_I355_I0.8050.53
382_W385_T0.8050.53
203_A206_Y0.8030.52
375_I410_V0.8030.52
102_G158_A0.8020.52
402_M438_M0.8010.52
142_R171_D0.8000.52
396_A399_G0.7980.52
254_F269_L0.7970.52
428_G505_M0.7960.52
473_F501_G0.7960.52
438_M519_F0.7950.52
431_A434_M0.7950.52
420_G423_S0.7930.52
533_Y537_I0.7920.51
196_L200_V0.7910.51
221_K224_A0.7910.51
391_A508_G0.7900.51
534_L538_I0.7870.51
183_T191_K0.7850.51
92_V96_A0.7840.51
330_A333_I0.7840.51
423_S499_L0.7830.51
161_L179_P0.7830.51
201_A213_Q0.7820.51
496_G544_A0.7810.50
295_D334_S0.7780.50
511_L533_Y0.7760.50
162_V180_M0.7750.50
313_G373_A0.7750.50
120_F484_R0.7730.50
95_T98_V0.7720.50
109_V164_V0.7720.50
399_G533_Y0.7710.50
542_L546_L0.7690.49
418_G469_L0.7640.49
347_K351_I0.7630.49
432_A505_M0.7630.49
199_A203_A0.7600.49
436_A494_I0.7600.49
428_G508_G0.7590.48
144_S301_P0.7550.48
419_V423_S0.7540.48
192_T200_V0.7510.48
358_L362_L0.7510.48
97_P101_S0.7500.48
227_Y231_L0.7490.48
254_F258_A0.7490.48
111_A166_A0.7470.47
454_K553_R0.7470.47
142_R174_K0.7420.47
95_T100_A0.7410.47
255_G266_A0.7390.47
345_A445_G0.7380.47
156_V178_K0.7380.47
422_L425_Q0.7370.46
428_G504_S0.7360.46
343_M472_C0.7330.46
488_R492_C0.7320.46
452_R460_Q0.7310.46
339_L351_I0.7310.46
181_Y187_L0.7300.46
371_P481_F0.7290.46
160_D200_V0.7270.46
451_A553_R0.7250.45
107_V155_E0.7240.45
308_L369_G0.7230.45
229_H293_I0.7230.45
108_A135_W0.7220.45
104_K136_W0.7210.45
495_V499_L0.7200.45
286_A305_G0.7200.45
333_I351_I0.7180.45
531_L535_V0.7160.45
538_I542_L0.7150.44
307_M311_S0.7150.44
301_P356_S0.7140.44
226_A324_F0.7120.44
104_K158_A0.7120.44
356_S360_V0.7120.44
185_T195_E0.7110.44
493_C497_G0.7100.44
130_A133_R0.7090.44
105_R155_E0.7060.44
202_E205_P0.7060.44
232_T299_L0.7050.44
129_E197_D0.7050.44
372_V378_G0.7040.43
522_L528_T0.7020.43
161_L196_L0.7010.43
310_V319_G0.6990.43
181_Y303_L0.6990.43
422_L430_M0.6970.43
142_R467_L0.6950.43
281_M319_G0.6930.42
433_I504_S0.6930.42
446_L449_M0.6920.42
189_L195_E0.6900.42
337_L359_V0.6890.42
185_T192_T0.6880.42
340_P343_M0.6870.42
268_A272_I0.6850.42
473_F519_F0.6850.42
396_A400_G0.6840.42
500_T504_S0.6830.42
229_H328_Y0.6830.42
98_V101_S0.6820.42
142_R449_M0.6820.42
94_A98_V0.6820.42
509_A523_I0.6800.41
308_L452_R0.6790.41
437_G472_C0.6780.41
399_G436_A0.6780.41
300_T356_S0.6760.41
142_R172_L0.6750.41
381_H385_T0.6740.41
320_I420_G0.6740.41
415_Y419_V0.6730.41
166_A324_F0.6720.41
208_P211_K0.6720.41
153_P546_L0.6710.41
136_W158_A0.6700.40
127_E192_T0.6700.40
106_V212_A0.6690.40
106_V196_L0.6690.40
276_S279_A0.6670.40
446_L545_G0.6660.40
155_E158_A0.6660.40
179_P206_Y0.6660.40
325_L360_V0.6660.40
162_V178_K0.6650.40
297_P334_S0.6650.40
148_G341_Q0.6640.40
304_I357_S0.6630.40
331_K336_Q0.6630.40
183_T198_K0.6630.40
434_M519_F0.6620.40
446_L542_L0.6610.40
376_L466_A0.6600.40
96_A99_A0.6590.39
527_I539_A0.6580.39
267_A270_M0.6580.39
242_V349_I0.6560.39
415_Y473_F0.6550.39
487_M491_P0.6530.39
420_G426_T0.6510.39
258_A265_L0.6510.39
236_Y296_R0.6510.39
375_I382_W0.6490.39
286_A290_A0.6490.39
319_G360_V0.6480.39
399_G435_A0.6470.38
107_V138_K0.6460.38
288_Y334_S0.6460.38
438_M501_G0.6450.38
390_N393_L0.6450.38
368_I372_V0.6440.38
319_G390_N0.6430.38
404_T436_A0.6400.38
115_G118_H0.6390.38
417_F421_L0.6390.38
115_G119_T0.6380.38
373_A381_H0.6370.38
265_L269_L0.6370.38
225_G328_Y0.6350.37
93_A98_V0.6300.37
389_A393_L0.6290.37
97_P100_A0.6270.37
134_G539_A0.6260.37
127_E130_A0.6250.37
438_M518_L0.6250.37
371_P429_P0.6250.37
216_T219_S0.6230.36
298_G329_I0.6230.36
105_R154_E0.6180.36
431_A438_M0.6180.36
246_L304_I0.6170.36
212_A217_T0.6150.36
112_C115_G0.6150.36
430_M515_H0.6130.36
106_V188_A0.6130.36
151_I178_K0.6130.36
221_K225_G0.6120.35
384_Q426_T0.6120.35
263_G267_A0.6110.35
185_T334_S0.6100.35
346_L351_I0.6100.35
285_L289_I0.6090.35
188_A206_Y0.6080.35
181_Y203_A0.6080.35
109_V171_D0.6080.35
359_V368_I0.6070.35
370_K373_A0.6070.35
280_L429_P0.6070.35
493_C547_A0.6060.35
160_D178_K0.6060.35
254_F268_A0.6050.35
181_Y204_T0.6050.35
488_R552_K0.6050.35
314_S369_G0.6040.35
406_M441_P0.6040.35
259_F266_A0.6030.35
203_A207_E0.6020.35
345_A472_C0.6010.35
362_L366_Y0.6010.35
179_P205_P0.6010.35
112_C118_H0.6000.34
469_L521_L0.6000.34
195_E198_K0.5990.34
545_G555_E0.5990.34
112_C119_T0.5990.34
267_A422_L0.5970.34
296_R348_P0.5970.34
443_A493_C0.5960.34
350_L472_C0.5960.34
504_S533_Y0.5960.34
242_V296_R0.5950.34
334_S368_I0.5950.34
404_T493_C0.5940.34
431_A437_G0.5940.34
97_P102_G0.5920.34
187_L192_T0.5920.34
298_G330_A0.5920.34
311_S494_I0.5920.34
93_A96_A0.5910.34
287_G536_A0.5900.34
496_G540_G0.5890.34
202_E206_Y0.5890.34
442_L471_L0.5890.34
250_L269_L0.5880.33
344_E456_D0.5860.33
371_P375_I0.5860.33
161_L185_T0.5860.33
515_H520_V0.5860.33
255_G319_G0.5850.33
142_R151_I0.5840.33
319_G416_A0.5840.33
108_A331_K0.5820.33
511_L519_F0.5810.33
133_R157_A0.5810.33
251_S258_A0.5810.33
184_S187_L0.5770.33
550_F554_P0.5770.33
293_I324_F0.5770.33
138_K152_T0.5760.33
252_F437_G0.5760.33
231_L236_Y0.5760.33
421_L427_Y0.5750.32
386_M541_T0.5750.32
354_L513_A0.5750.32
234_V241_V0.5730.32
502_A505_M0.5720.32
346_L429_P0.5720.32
363_A399_G0.5720.32
379_L397_I0.5710.32
105_R137_V0.5710.32
509_A536_A0.5710.32
101_S217_T0.5700.32
138_K162_V0.5690.32
489_V493_C0.5680.32
385_T388_T0.5680.32
432_A437_G0.5670.32
450_V545_G0.5660.32
319_G426_T0.5650.32
266_A533_Y0.5640.32
336_Q352_I0.5640.32
453_R555_E0.5620.31
92_V100_A0.5610.31
490_L493_C0.5600.31
107_V426_T0.5600.31
534_L537_I0.5590.31
181_Y198_K0.5590.31
120_F485_D0.5570.31
284_V532_G0.5570.31
166_A195_E0.5570.31
132_K209_A0.5570.31
494_I497_G0.5570.31
184_S251_S0.5570.31
319_G429_P0.5560.31
263_G509_A0.5550.31
299_L303_L0.5540.31
193_A196_L0.5540.31
292_S343_M0.5520.31
281_M299_L0.5510.31
325_L359_V0.5510.31
93_A100_A0.5510.31
282_V303_L0.5500.30
220_K225_G0.5500.30
415_Y437_G0.5490.30
418_G424_T0.5490.30
300_T421_L0.5490.30
446_L450_V0.5480.30
238_L242_V0.5480.30
113_P166_A0.5470.30
434_M518_L0.5470.30
383_L417_F0.5460.30
252_F434_M0.5450.30
238_L413_A0.5450.30
199_A204_T0.5440.30
230_L324_F0.5430.30
301_P348_P0.5430.30
317_I497_G0.5420.30
431_A504_S0.5410.30
250_L254_F0.5400.30
439_V541_T0.5380.30
364_M431_A0.5380.30
98_V550_F0.5370.29
199_A395_G0.5370.29
142_R168_I0.5360.29
272_I325_L0.5350.29
125_A376_L0.5340.29
147_A295_D0.5330.29
167_D185_T0.5320.29
395_G502_A0.5320.29
320_I502_A0.5320.29
271_Q275_G0.5310.29
252_F473_F0.5310.29
226_A487_M0.5300.29
495_V543_V0.5300.29
92_V97_P0.5300.29
536_A543_V0.5300.29
435_A504_S0.5290.29
120_F148_G0.5280.29
398_L544_A0.5280.29
471_L530_V0.5280.29
303_L356_S0.5270.29
167_D436_A0.5260.29
248_I270_M0.5260.29
247_C269_L0.5260.29
96_A100_A0.5260.29
511_L528_T0.5250.29
99_A213_Q0.5250.29
521_L534_L0.5250.29
161_L195_E0.5240.28
434_M511_L0.5230.28
109_V286_A0.5220.28
281_M504_S0.5220.28
448_T452_R0.5210.28
311_S406_M0.5190.28
256_I263_G0.5190.28
161_L201_A0.5190.28
291_F299_L0.5190.28
473_F518_L0.5180.28
111_A296_R0.5170.28
137_V196_L0.5160.28
513_A520_V0.5160.28
96_A214_T0.5160.28
422_L503_I0.5150.28
450_V549_A0.5150.28
99_A214_T0.5150.28
419_V422_L0.5140.28
444_M493_C0.5130.28
166_A170_V0.5130.28
201_A204_T0.5130.28
153_P535_V0.5130.28
253_A513_A0.5130.28
459_Q548_Y0.5130.28
337_L420_G0.5130.28
437_G519_F0.5120.28
455_F481_F0.5120.28
471_L534_L0.5110.28
511_L520_V0.5110.28
145_V148_G0.5110.28
371_P374_G0.5110.28
223_S226_A0.5100.27
330_A337_L0.5100.27
404_T490_L0.5100.27
438_M514_P0.5090.27
161_L205_P0.5080.27
276_S307_M0.5080.27
416_A430_M0.5070.27
149_N452_R0.5070.27
532_G539_A0.5070.27
173_A176_A0.5070.27
441_P466_A0.5050.27
301_P546_L0.5050.27
167_D520_V0.5050.27
173_A208_P0.5050.27
113_P411_N0.5050.27
187_L194_Q0.5040.27
95_T99_A0.5040.27
163_I481_F0.5030.27
251_S342_S0.5020.27
170_V185_T0.5020.27
450_V467_L0.5020.27
407_G411_N0.5020.27
209_A214_T0.5010.27
170_V333_I0.5000.27
254_F261_E0.5000.27
187_L288_Y0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r48A 1 0.1865 100 0.815 Contact Map
3qnqA 2 0.6252 100 0.835 Contact Map
2r4qA 1 0.1812 100 0.851 Contact Map
2kyrA 1 0.1901 100 0.863 Contact Map
2m1zA 1 0.1865 100 0.871 Contact Map
4tn5A 2 0.1989 100 0.873 Contact Map
1a6jA 4 0.1652 99.8 0.907 Contact Map
3urrA 2 0.167 99.8 0.908 Contact Map
2a0jA 1 0.1599 99.8 0.909 Contact Map
4m62S 1 0.1634 99.8 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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