FIC - ECOLI - GREMLIN Contacts

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FIC - Probable adenosine monophosphate-protein transferase fic

UniProt:	P20605	Sequences: MSDKFGEGRDPYLYPGLDIMRNRLNIRQQQRLEQAAYEMTALRAATIELGPLVRGLPHLRTIHRQLYQDIFDWAGQLREVDIYQGDTPFCHFAYIEKEGNALMQDLEEEGYLVGLEKAKFVERLAHYYCEINVLHPFRVGSGLAQRIFFEQLAIHAGYQLSWQGIEKEAWNQANQSGAMGDLTALQMIFSKVVSEAGESE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10307
Length:	200 (177)
Sequences:	1066 (822)
Seq/√Len:	61.8

ECOLI - FIC

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
43_R	68_Q	4.517	1.00
109_E	123_R	3.518	1.00
81_D	92_F	3.074	1.00
56_L	77_L	2.955	1.00
56_L	99_G	2.675	1.00
24_L	35_A	2.670	1.00
89_F	142_G	2.634	1.00
23_R	72_D	2.534	1.00
129_C	177_G	2.368	1.00
44_A	66_L	2.358	1.00
84_Q	139_V	2.320	1.00
109_E	127_Y	2.244	1.00
36_A	71_F	2.221	1.00
43_R	46_T	2.220	1.00
62_I	147_I	2.214	1.00
147_I	150_E	2.077	1.00
132_N	142_G	2.068	1.00
43_R	69_D	2.067	1.00
128_Y	189_F	2.025	1.00
29_Q	33_E	2.012	1.00
57_P	60_R	1.994	1.00
142_G	146_R	1.932	1.00
98_E	101_A	1.918	1.00
122_E	186_Q	1.894	1.00
52_L	58_H	1.894	1.00
58_H	151_Q	1.780	1.00
189_F	192_V	1.760	0.99
116_E	119_K	1.758	0.99
128_Y	149_F	1.750	0.99
89_F	132_N	1.712	0.99
60_R	77_L	1.699	0.99
99_G	134_L	1.694	0.99
64_R	68_Q	1.679	0.99
139_V	143_L	1.677	0.99
120_F	153_A	1.639	0.99
55_G	58_H	1.630	0.99
87_T	178_A	1.591	0.99
169_A	191_K	1.570	0.99
120_F	156_A	1.520	0.98
64_R	76_Q	1.512	0.98
40_T	66_L	1.489	0.98
123_R	127_Y	1.454	0.98
35_A	39_M	1.437	0.98
90_C	98_E	1.381	0.97
87_T	90_C	1.379	0.97
36_A	84_Q	1.370	0.97
28_Q	31_R	1.365	0.97
135_H	143_L	1.357	0.97
170_W	174_N	1.355	0.97
60_R	76_Q	1.351	0.97
80_V	138_R	1.338	0.96
174_N	177_G	1.328	0.96
46_T	68_Q	1.312	0.96
181_D	184_A	1.271	0.95
39_M	70_I	1.259	0.95
36_A	143_L	1.247	0.95
153_A	160_L	1.244	0.95
161_S	164_G	1.237	0.94
133_V	178_A	1.214	0.94
61_T	64_R	1.205	0.94
104_Q	108_E	1.201	0.94
171_N	175_Q	1.192	0.93
153_A	156_A	1.190	0.93
132_N	174_N	1.164	0.92
65_Q	68_Q	1.161	0.92
142_G	174_N	1.151	0.92
94_Y	98_E	1.150	0.92
60_R	96_E	1.127	0.91
67_Y	143_L	1.124	0.91
128_Y	170_W	1.114	0.91
176_S	181_D	1.113	0.91
71_F	74_A	1.103	0.90
105_D	126_H	1.101	0.90
26_I	35_A	1.092	0.90
132_N	145_Q	1.088	0.90
103_M	127_Y	1.086	0.90
100_N	104_Q	1.071	0.89
176_S	184_A	1.064	0.89
23_R	193_V	1.058	0.88
54_R	58_H	1.044	0.88
106_L	127_Y	1.034	0.87
126_H	130_E	1.030	0.87
90_C	99_G	1.026	0.87
183_T	187_M	1.021	0.86
128_Y	174_N	1.016	0.86
32_L	71_F	1.015	0.86
118_A	190_S	1.011	0.86
81_D	91_H	1.008	0.86
46_T	65_Q	1.000	0.85
120_F	158_Y	0.983	0.84
39_M	43_R	0.969	0.83
22_N	32_L	0.969	0.83
131_I	145_Q	0.964	0.83
102_L	134_L	0.959	0.83
172_Q	176_S	0.958	0.83
162_W	165_I	0.955	0.83
56_L	103_M	0.948	0.82
96_E	100_N	0.944	0.82
174_N	178_A	0.944	0.82
90_C	95_I	0.943	0.82
39_M	68_Q	0.942	0.82
146_R	162_W	0.940	0.82
20_M	138_R	0.939	0.81
19_I	138_R	0.932	0.81
47_I	62_I	0.915	0.80
125_A	186_Q	0.914	0.80
35_A	70_I	0.898	0.79
97_K	100_N	0.891	0.78
107_E	111_Y	0.888	0.78
21_R	72_D	0.877	0.77
55_G	148_F	0.875	0.77
43_R	65_Q	0.873	0.77
130_E	134_L	0.869	0.76
184_A	187_M	0.868	0.76
117_K	190_S	0.861	0.76
132_N	139_V	0.853	0.75
126_H	182_L	0.843	0.74
89_F	171_N	0.840	0.74
77_L	99_G	0.839	0.74
61_T	65_Q	0.836	0.73
32_L	138_R	0.835	0.73
36_A	139_V	0.830	0.73
129_C	185_L	0.829	0.73
171_N	174_N	0.827	0.73
55_G	99_G	0.826	0.72
90_C	133_V	0.825	0.72
103_M	131_I	0.822	0.72
150_E	154_I	0.818	0.72
56_L	60_R	0.817	0.72
22_N	73_W	0.817	0.72
52_L	65_Q	0.803	0.70
59_L	144_A	0.797	0.70
19_I	29_Q	0.795	0.70
89_F	146_R	0.794	0.69
84_Q	143_L	0.794	0.69
97_K	144_A	0.793	0.69
124_L	153_A	0.790	0.69
110_G	114_G	0.781	0.68
162_W	185_L	0.780	0.68
110_G	113_V	0.778	0.68
76_Q	79_E	0.773	0.67
84_Q	132_N	0.771	0.67
94_Y	97_K	0.770	0.67
172_Q	175_Q	0.767	0.67
175_Q	178_A	0.767	0.67
120_F	124_L	0.762	0.66
24_L	39_M	0.762	0.66
55_G	60_R	0.761	0.66
32_L	132_N	0.759	0.66
121_V	190_S	0.757	0.66
166_E	169_A	0.756	0.66
121_V	125_A	0.752	0.65
148_F	152_L	0.743	0.64
89_F	135_H	0.743	0.64
46_T	69_D	0.740	0.64
51_P	54_R	0.735	0.63
123_R	126_H	0.729	0.63
99_G	103_M	0.727	0.63
119_K	122_E	0.721	0.62
79_E	96_E	0.720	0.62
90_C	103_M	0.720	0.62
129_C	182_L	0.712	0.61
87_T	133_V	0.710	0.61
89_F	174_N	0.710	0.61
79_E	152_L	0.705	0.60
82_I	92_F	0.703	0.60
115_L	120_F	0.699	0.60
130_E	133_V	0.698	0.59
147_I	154_I	0.690	0.59
88_P	133_V	0.686	0.58
85_G	142_G	0.686	0.58
128_Y	162_W	0.685	0.58
44_A	147_I	0.685	0.58
184_A	189_F	0.682	0.58
26_I	31_R	0.682	0.58
59_L	148_F	0.681	0.58
30_Q	34_Q	0.679	0.57
22_N	71_F	0.671	0.56
124_L	193_V	0.664	0.56
16_G	23_R	0.663	0.56
101_A	105_D	0.661	0.55
35_A	38_E	0.657	0.55
124_L	158_Y	0.648	0.54
23_R	73_W	0.647	0.54
142_G	171_N	0.647	0.54
48_E	147_I	0.642	0.53
94_Y	130_E	0.636	0.53
64_R	119_K	0.636	0.53
138_R	143_L	0.635	0.52
89_F	139_V	0.633	0.52
109_E	126_H	0.632	0.52
59_L	103_M	0.631	0.52
168_E	172_Q	0.630	0.52
132_N	177_G	0.626	0.51
80_V	84_Q	0.625	0.51
25_N	28_Q	0.625	0.51
115_L	119_K	0.624	0.51
179_M	182_L	0.621	0.51
67_Y	139_V	0.619	0.51
102_L	130_E	0.618	0.50
98_E	133_V	0.610	0.50
84_Q	171_N	0.605	0.49
142_G	175_Q	0.603	0.49
103_M	134_L	0.602	0.49
66_L	182_L	0.599	0.48
31_R	34_Q	0.594	0.48
22_N	25_N	0.593	0.48
136_P	149_F	0.592	0.48
79_E	122_E	0.590	0.47
51_P	115_L	0.590	0.47
30_Q	68_Q	0.590	0.47
183_T	186_Q	0.590	0.47
100_N	187_M	0.590	0.47
132_N	138_R	0.589	0.47
176_S	179_M	0.588	0.47
59_L	131_I	0.585	0.47
121_V	186_Q	0.584	0.47
58_H	61_T	0.584	0.47
50_G	151_Q	0.582	0.46
106_L	156_A	0.581	0.46
53_V	58_H	0.577	0.46
58_H	103_M	0.574	0.45
43_R	58_H	0.572	0.45
135_H	142_G	0.571	0.45
59_L	162_W	0.571	0.45
163_Q	185_L	0.569	0.45
107_E	123_R	0.569	0.45
94_Y	171_N	0.569	0.45
84_Q	89_F	0.568	0.45
33_E	125_A	0.564	0.44
36_A	67_Y	0.564	0.44
57_P	76_Q	0.561	0.44
166_E	170_W	0.559	0.44
90_C	94_Y	0.556	0.43
56_L	162_W	0.555	0.43
134_L	145_Q	0.555	0.43
132_N	171_N	0.553	0.43
150_E	162_W	0.550	0.43
51_P	66_L	0.549	0.43
187_M	191_K	0.549	0.43
39_M	131_I	0.548	0.43
142_G	165_I	0.548	0.43
23_R	26_I	0.540	0.42
106_L	153_A	0.538	0.41
116_E	190_S	0.534	0.41
128_Y	145_Q	0.533	0.41
83_Y	88_P	0.528	0.40
147_I	170_W	0.527	0.40
88_P	91_H	0.525	0.40
73_W	87_T	0.521	0.40
80_V	170_W	0.518	0.39
106_L	109_E	0.516	0.39
40_T	132_N	0.515	0.39
120_F	193_V	0.514	0.39
67_Y	140_G	0.512	0.39
89_F	133_V	0.512	0.39
50_G	65_Q	0.512	0.39
43_R	70_I	0.512	0.39
107_E	114_G	0.509	0.38
25_N	74_A	0.509	0.38
139_V	144_A	0.507	0.38
42_L	46_T	0.505	0.38
88_P	178_A	0.504	0.38
142_G	162_W	0.501	0.37
41_A	45_A	0.501	0.37
30_Q	53_V	0.500	0.37

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3zc7A	1	0.96	100	0.339	Contact Map
3shgA	1	0.98	100	0.354	Contact Map
4npsA	1	0.96	100	0.374	Contact Map
4n67A	1	0.97	100	0.384	Contact Map
2jk8A	1	0.975	100	0.385	Contact Map
4py3A	1	0.985	100	0.402	Contact Map
4m16A	1	0.995	100	0.411	Contact Map
3se5A	4	0.77	100	0.584	Contact Map
2f6sA	2	0.81	99.9	0.596	Contact Map
3zlmA	2	0.79	99.9	0.603	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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