GREMLIN Database
FIC - Probable adenosine monophosphate-protein transferase fic
UniProt: P20605 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10307
Length: 200 (177)
Sequences: 1066 (822)
Seq/√Len: 61.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
43_R68_Q4.5171.00
109_E123_R3.5181.00
81_D92_F3.0741.00
56_L77_L2.9551.00
56_L99_G2.6751.00
24_L35_A2.6701.00
89_F142_G2.6341.00
23_R72_D2.5341.00
129_C177_G2.3681.00
44_A66_L2.3581.00
84_Q139_V2.3201.00
109_E127_Y2.2441.00
36_A71_F2.2211.00
43_R46_T2.2201.00
62_I147_I2.2141.00
147_I150_E2.0771.00
132_N142_G2.0681.00
43_R69_D2.0671.00
128_Y189_F2.0251.00
29_Q33_E2.0121.00
57_P60_R1.9941.00
142_G146_R1.9321.00
98_E101_A1.9181.00
122_E186_Q1.8941.00
52_L58_H1.8941.00
58_H151_Q1.7801.00
189_F192_V1.7600.99
116_E119_K1.7580.99
128_Y149_F1.7500.99
89_F132_N1.7120.99
60_R77_L1.6990.99
99_G134_L1.6940.99
64_R68_Q1.6790.99
139_V143_L1.6770.99
120_F153_A1.6390.99
55_G58_H1.6300.99
87_T178_A1.5910.99
169_A191_K1.5700.99
120_F156_A1.5200.98
64_R76_Q1.5120.98
40_T66_L1.4890.98
123_R127_Y1.4540.98
35_A39_M1.4370.98
90_C98_E1.3810.97
87_T90_C1.3790.97
36_A84_Q1.3700.97
28_Q31_R1.3650.97
135_H143_L1.3570.97
170_W174_N1.3550.97
60_R76_Q1.3510.97
80_V138_R1.3380.96
174_N177_G1.3280.96
46_T68_Q1.3120.96
181_D184_A1.2710.95
39_M70_I1.2590.95
36_A143_L1.2470.95
153_A160_L1.2440.95
161_S164_G1.2370.94
133_V178_A1.2140.94
61_T64_R1.2050.94
104_Q108_E1.2010.94
171_N175_Q1.1920.93
153_A156_A1.1900.93
132_N174_N1.1640.92
65_Q68_Q1.1610.92
142_G174_N1.1510.92
94_Y98_E1.1500.92
60_R96_E1.1270.91
67_Y143_L1.1240.91
128_Y170_W1.1140.91
176_S181_D1.1130.91
71_F74_A1.1030.90
105_D126_H1.1010.90
26_I35_A1.0920.90
132_N145_Q1.0880.90
103_M127_Y1.0860.90
100_N104_Q1.0710.89
176_S184_A1.0640.89
23_R193_V1.0580.88
54_R58_H1.0440.88
106_L127_Y1.0340.87
126_H130_E1.0300.87
90_C99_G1.0260.87
183_T187_M1.0210.86
128_Y174_N1.0160.86
32_L71_F1.0150.86
118_A190_S1.0110.86
81_D91_H1.0080.86
46_T65_Q1.0000.85
120_F158_Y0.9830.84
39_M43_R0.9690.83
22_N32_L0.9690.83
131_I145_Q0.9640.83
102_L134_L0.9590.83
172_Q176_S0.9580.83
162_W165_I0.9550.83
56_L103_M0.9480.82
96_E100_N0.9440.82
174_N178_A0.9440.82
90_C95_I0.9430.82
39_M68_Q0.9420.82
146_R162_W0.9400.82
20_M138_R0.9390.81
19_I138_R0.9320.81
47_I62_I0.9150.80
125_A186_Q0.9140.80
35_A70_I0.8980.79
97_K100_N0.8910.78
107_E111_Y0.8880.78
21_R72_D0.8770.77
55_G148_F0.8750.77
43_R65_Q0.8730.77
130_E134_L0.8690.76
184_A187_M0.8680.76
117_K190_S0.8610.76
132_N139_V0.8530.75
126_H182_L0.8430.74
89_F171_N0.8400.74
77_L99_G0.8390.74
61_T65_Q0.8360.73
32_L138_R0.8350.73
36_A139_V0.8300.73
129_C185_L0.8290.73
171_N174_N0.8270.73
55_G99_G0.8260.72
90_C133_V0.8250.72
103_M131_I0.8220.72
150_E154_I0.8180.72
56_L60_R0.8170.72
22_N73_W0.8170.72
52_L65_Q0.8030.70
59_L144_A0.7970.70
19_I29_Q0.7950.70
89_F146_R0.7940.69
84_Q143_L0.7940.69
97_K144_A0.7930.69
124_L153_A0.7900.69
110_G114_G0.7810.68
162_W185_L0.7800.68
110_G113_V0.7780.68
76_Q79_E0.7730.67
84_Q132_N0.7710.67
94_Y97_K0.7700.67
172_Q175_Q0.7670.67
175_Q178_A0.7670.67
120_F124_L0.7620.66
24_L39_M0.7620.66
55_G60_R0.7610.66
32_L132_N0.7590.66
121_V190_S0.7570.66
166_E169_A0.7560.66
121_V125_A0.7520.65
148_F152_L0.7430.64
89_F135_H0.7430.64
46_T69_D0.7400.64
51_P54_R0.7350.63
123_R126_H0.7290.63
99_G103_M0.7270.63
119_K122_E0.7210.62
79_E96_E0.7200.62
90_C103_M0.7200.62
129_C182_L0.7120.61
87_T133_V0.7100.61
89_F174_N0.7100.61
79_E152_L0.7050.60
82_I92_F0.7030.60
115_L120_F0.6990.60
130_E133_V0.6980.59
147_I154_I0.6900.59
88_P133_V0.6860.58
85_G142_G0.6860.58
128_Y162_W0.6850.58
44_A147_I0.6850.58
184_A189_F0.6820.58
26_I31_R0.6820.58
59_L148_F0.6810.58
30_Q34_Q0.6790.57
22_N71_F0.6710.56
124_L193_V0.6640.56
16_G23_R0.6630.56
101_A105_D0.6610.55
35_A38_E0.6570.55
124_L158_Y0.6480.54
23_R73_W0.6470.54
142_G171_N0.6470.54
48_E147_I0.6420.53
94_Y130_E0.6360.53
64_R119_K0.6360.53
138_R143_L0.6350.52
89_F139_V0.6330.52
109_E126_H0.6320.52
59_L103_M0.6310.52
168_E172_Q0.6300.52
132_N177_G0.6260.51
80_V84_Q0.6250.51
25_N28_Q0.6250.51
115_L119_K0.6240.51
179_M182_L0.6210.51
67_Y139_V0.6190.51
102_L130_E0.6180.50
98_E133_V0.6100.50
84_Q171_N0.6050.49
142_G175_Q0.6030.49
103_M134_L0.6020.49
66_L182_L0.5990.48
31_R34_Q0.5940.48
22_N25_N0.5930.48
136_P149_F0.5920.48
79_E122_E0.5900.47
51_P115_L0.5900.47
30_Q68_Q0.5900.47
183_T186_Q0.5900.47
100_N187_M0.5900.47
132_N138_R0.5890.47
176_S179_M0.5880.47
59_L131_I0.5850.47
121_V186_Q0.5840.47
58_H61_T0.5840.47
50_G151_Q0.5820.46
106_L156_A0.5810.46
53_V58_H0.5770.46
58_H103_M0.5740.45
43_R58_H0.5720.45
135_H142_G0.5710.45
59_L162_W0.5710.45
163_Q185_L0.5690.45
107_E123_R0.5690.45
94_Y171_N0.5690.45
84_Q89_F0.5680.45
33_E125_A0.5640.44
36_A67_Y0.5640.44
57_P76_Q0.5610.44
166_E170_W0.5590.44
90_C94_Y0.5560.43
56_L162_W0.5550.43
134_L145_Q0.5550.43
132_N171_N0.5530.43
150_E162_W0.5500.43
51_P66_L0.5490.43
187_M191_K0.5490.43
39_M131_I0.5480.43
142_G165_I0.5480.43
23_R26_I0.5400.42
106_L153_A0.5380.41
116_E190_S0.5340.41
128_Y145_Q0.5330.41
83_Y88_P0.5280.40
147_I170_W0.5270.40
88_P91_H0.5250.40
73_W87_T0.5210.40
80_V170_W0.5180.39
106_L109_E0.5160.39
40_T132_N0.5150.39
120_F193_V0.5140.39
67_Y140_G0.5120.39
89_F133_V0.5120.39
50_G65_Q0.5120.39
43_R70_I0.5120.39
107_E114_G0.5090.38
25_N74_A0.5090.38
139_V144_A0.5070.38
42_L46_T0.5050.38
88_P178_A0.5040.38
142_G162_W0.5010.37
41_A45_A0.5010.37
30_Q53_V0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zc7A 1 0.96 100 0.339 Contact Map
3shgA 1 0.98 100 0.354 Contact Map
4npsA 1 0.96 100 0.374 Contact Map
4n67A 1 0.97 100 0.384 Contact Map
2jk8A 1 0.975 100 0.385 Contact Map
4py3A 1 0.985 100 0.402 Contact Map
4m16A 1 0.995 100 0.411 Contact Map
3se5A 4 0.77 100 0.584 Contact Map
2f6sA 2 0.81 99.9 0.596 Contact Map
3zlmA 2 0.79 99.9 0.603 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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