BISC - ECOLI - GREMLIN Contacts

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BISC - Biotin sulfoxide reductase

UniProt:	P20099	Sequences: MANSSSRYSVLTAAHWGPMLVETDGETVFSSRGALATGMENSLQSAVRDQVHSNTRVRFPMVRKGFLASPENPQGIRGQDEFVRVSWDEALDLIHQQHKRIREAYGPASIFAGSYGWRSNGVLHKASTLLQRYMALAGGYTGHLGDYSTGAAQAIMPYVVGGSEVYQQQTSWPLVLEHSDVVVLWSANPLNTLKIAWNASDEQGLSYFSALRDSGKKLICIDPMRSETVDFFGDKMEWVAPHMGTDVALMLGIAHTLVENGWHDEAFLARCTTGYAVFASYLLGESDGIAKTAEWAAEICGVGAAKIRELAAIFHQNTTMLMAGWGMQRQQFGEQKHWMIVTLAAMLGQIGTPGGGFGLSYHFANGGNPTRRSAVLSSMQGSLPGGCDAVDKIPVARIVEALENPGGAYQHNGMNRHFPDIRFIWWAGGANFTHHQDTNRLIRAWQKPELVVISECFWTAAAKHADIVLPATTSFERNDLTMTGDYSNQHLVPMKQVVPPRYEARNDFDVFAELSERWEKGGYARFTEGKSELQWLETFYNVARQRGASQQVELPPFAEFWQANQLIEMPENPDSERFIRFADFCRDPLAHPLKTASGKIEIFSQRIADYGYPDCPGHPMWLEPDEWQGNAEPEQLQVLSAHPAHRLHSQLNYSSLRELYAVANREPVTIHPDDAQERGIQDGDTVRLWNARGQILAGAVISEGIKPGVICIHEGAWPDLDLTADGICKNGAVNVLTKDLPSSRLGNGCAGNTALAWLEKYNGPELTLTAFEPPASS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10124
Length:	777 (658)
Sequences:	9479 (5828)
Seq/√Len:	227.2

ECOLI - BISC TORZ TORA YNFF DMSA YNFE FDHF NAPA YDEP FDNG FDOG NUOG
BACSU - NASC YOAE YYAE YJGC FDHL
HALSA - DMSA
SULSO - Q97ZA1 Q97XX8 Q97V13

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_F	84_R	5.659	1.00
680_I	699_A	4.407	1.00
92_D	517_R	4.388	1.00
687_R	759_E	4.117	1.00
684_D	760_K	3.819	1.00
505_R	513_E	3.701	1.00
260_N	312_A	3.324	1.00
687_R	694_Q	3.252	1.00
674_D	708_G	3.203	1.00
252_G	296_A	3.188	1.00
97_Q	100_R	3.178	1.00
636_L	678_R	3.141	1.00
509_D	513_E	3.132	1.00
294_E	304_A	3.115	1.00
673_D	707_P	2.944	1.00
265_E	269_A	2.903	1.00
93_L	467_I	2.888	1.00
496_Q	499_P	2.875	1.00
689_W	759_E	2.862	1.00
256_T	260_N	2.845	1.00
273_T	597_S	2.808	1.00
254_A	278_F	2.771	1.00
453_I	465_A	2.764	1.00
86_S	89_E	2.720	1.00
94_I	467_I	2.720	1.00
185_W	250_M	2.700	1.00
91_L	517_R	2.692	1.00
255_H	259_E	2.679	1.00
531_S	534_Q	2.649	1.00
689_W	757_W	2.628	1.00
100_R	104_A	2.600	1.00
597_S	601_E	2.551	1.00
237_E	309_E	2.540	1.00
297_A	304_A	2.536	1.00
101_I	109_S	2.525	1.00
85_V	467_I	2.511	1.00
254_A	346_M	2.507	1.00
690_N	756_A	2.481	1.00
670_I	758_L	2.473	1.00
304_A	308_R	2.463	1.00
677_E	707_P	2.456	1.00
220_C	233_G	2.445	1.00
59_F	503_E	2.441	1.00
303_G	306_K	2.441	1.00
217_K	313_I	2.438	1.00
249_L	300_C	2.429	1.00
686_V	699_A	2.422	1.00
91_L	513_E	2.415	1.00
306_K	309_E	2.406	1.00
670_I	699_A	2.400	1.00
665_R	698_G	2.390	1.00
62_V	93_L	2.379	1.00
62_V	467_I	2.361	1.00
675_A	701_I	2.343	1.00
263_H	268_L	2.336	1.00
62_V	85_V	2.277	1.00
292_T	295_W	2.276	1.00
689_W	694_Q	2.274	1.00
180_D	318_T	2.256	1.00
261_G	265_E	2.234	1.00
98_H	423_F	2.169	1.00
178_H	353_P	2.143	1.00
266_A	270_R	2.115	1.00
678_R	757_W	2.098	1.00
94_I	452_V	2.078	1.00
668_V	710_I	2.045	1.00
437_D	739_D	2.037	1.00
513_E	517_R	2.037	1.00
422_R	449_E	2.031	1.00
179_S	182_V	2.029	1.00
682_D	701_I	2.012	1.00
181_V	313_I	2.005	1.00
84_R	503_E	1.981	1.00
239_V	310_L	1.974	1.00
556_P	559_E	1.973	1.00
309_E	313_I	1.963	1.00
93_L	97_Q	1.935	1.00
680_I	686_V	1.932	1.00
237_E	306_K	1.926	1.00
249_L	307_I	1.918	1.00
239_V	302_V	1.888	1.00
668_V	686_V	1.888	1.00
101_I	423_F	1.885	1.00
85_V	93_L	1.885	1.00
501_R	504_A	1.883	1.00
697_A	712_I	1.866	1.00
636_L	710_I	1.851	1.00
670_I	710_I	1.849	1.00
685_T	696_L	1.830	1.00
181_V	219_I	1.825	1.00
20_L	35_L	1.823	1.00
425_W	454_S	1.822	1.00
668_V	688_L	1.821	1.00
211_L	216_K	1.804	1.00
255_H	293_A	1.804	1.00
13_A	17_G	1.797	1.00
668_V	712_I	1.794	1.00
673_D	676_Q	1.780	1.00
92_D	96_Q	1.779	1.00
258_V	279_A	1.771	1.00
687_R	696_L	1.765	1.00
76_I	79_Q	1.757	1.00
62_V	83_V	1.749	1.00
458_W	462_A	1.746	1.00
296_A	307_I	1.743	1.00
559_E	563_A	1.738	1.00
533_L	537_E	1.731	1.00
682_D	700_V	1.720	1.00
245_T	299_I	1.710	1.00
259_E	283_L	1.694	1.00
268_L	275_Y	1.688	1.00
280_S	283_L	1.686	1.00
710_I	756_A	1.686	1.00
237_E	313_I	1.681	1.00
258_V	275_Y	1.676	1.00
681_Q	684_D	1.669	1.00
260_N	308_R	1.658	1.00
352_T	355_G	1.656	1.00
478_N	496_Q	1.643	1.00
221_I	249_L	1.642	1.00
256_T	312_A	1.636	1.00
58_R	502_Y	1.630	1.00
256_T	308_R	1.626	1.00
262_W	315_H	1.621	1.00
513_E	516_E	1.614	1.00
61_M	468_V	1.608	1.00
212_R	234_D	1.607	1.00
314_F	347_L	1.586	1.00
448_P	451_V	1.570	1.00
85_V	89_E	1.553	1.00
257_L	263_H	1.550	1.00
641_A	711_C	1.544	1.00
109_S	422_R	1.536	1.00
685_T	698_G	1.533	1.00
10_V	13_A	1.532	1.00
312_A	316_Q	1.527	1.00
258_V	282_L	1.523	1.00
256_T	293_A	1.518	1.00
297_A	303_G	1.517	1.00
534_Q	537_E	1.509	1.00
99_K	103_E	1.508	1.00
249_L	310_L	1.501	1.00
472_T	506_N	1.500	1.00
272_T	602_I	1.497	1.00
257_L	315_H	1.497	1.00
536_L	540_Y	1.497	1.00
297_A	307_I	1.492	1.00
262_W	312_A	1.490	1.00
450_L	467_I	1.486	1.00
314_F	319_T	1.475	1.00
263_H	275_Y	1.473	1.00
294_E	308_R	1.471	1.00
669_T	702_S	1.461	1.00
277_V	280_S	1.456	1.00
183_V	310_L	1.451	1.00
237_E	310_L	1.445	1.00
94_I	469_L	1.444	1.00
14_A	17_G	1.443	1.00
89_E	93_L	1.437	1.00
21_V	28_V	1.433	1.00
183_V	221_I	1.431	1.00
346_M	602_I	1.423	1.00
273_T	601_E	1.423	1.00
22_E	32_R	1.422	1.00
96_Q	100_R	1.421	1.00
111_F	421_I	1.412	1.00
279_A	283_L	1.407	1.00
636_L	674_D	1.407	1.00
695_I	712_I	1.406	1.00
259_E	308_R	1.397	1.00
60_P	87_W	1.392	1.00
49_D	658_E	1.390	1.00
14_A	18_P	1.389	1.00
181_V	310_L	1.386	1.00
13_A	18_P	1.384	1.00
537_E	540_Y	1.379	1.00
248_A	299_I	1.378	1.00
133_Y	518_W	1.367	1.00
443_R	446_Q	1.363	1.00
98_H	452_V	1.356	1.00
442_I	446_Q	1.353	1.00
76_I	83_V	1.348	1.00
61_M	84_R	1.346	1.00
253_I	310_L	1.346	1.00
255_H	283_L	1.340	1.00
256_T	259_E	1.338	1.00
426_W	451_V	1.337	1.00
245_T	300_C	1.337	1.00
631_A	691_A	1.335	1.00
530_K	534_Q	1.333	1.00
105_Y	422_R	1.329	1.00
558_A	562_Q	1.325	1.00
266_A	269_A	1.321	1.00
626_E	692_R	1.317	1.00
225_R	230_D	1.317	1.00
327_M	340_I	1.310	1.00
112_A	134_M	1.304	1.00
256_T	262_W	1.295	1.00
274_G	277_V	1.293	1.00
223_P	238_W	1.280	1.00
458_W	468_V	1.280	1.00
678_R	758_L	1.279	1.00
605_Q	609_D	1.271	1.00
417_H	440_R	1.269	1.00
239_V	306_K	1.267	1.00
456_C	473_T	1.263	1.00
506_N	509_D	1.259	1.00
241_P	302_V	1.259	1.00
453_I	462_A	1.254	1.00
505_R	509_D	1.246	1.00
516_E	521_G	1.245	1.00
495_K	561_W	1.245	1.00
595_T	601_E	1.234	1.00
63_R	82_F	1.233	1.00
291_K	296_A	1.232	1.00
672_P	703_E	1.232	1.00
391_D	394_P	1.228	1.00
253_I	314_F	1.227	1.00
28_V	51_V	1.222	1.00
295_W	298_E	1.222	1.00
636_L	757_W	1.220	1.00
93_L	450_L	1.218	1.00
671_H	707_P	1.217	1.00
21_V	31_S	1.216	1.00
91_L	505_R	1.215	1.00
175_V	178_H	1.212	1.00
220_C	229_V	1.211	1.00
219_I	310_L	1.208	1.00
11_L	14_A	1.206	1.00
89_E	467_I	1.200	1.00
301_G	706_K	1.197	1.00
291_K	299_I	1.194	1.00
10_V	17_G	1.194	1.00
712_I	733_V	1.194	1.00
668_V	697_A	1.191	1.00
291_K	295_W	1.189	1.00
454_S	510_V	1.188	1.00
99_K	102_R	1.184	1.00
533_L	540_Y	1.174	1.00
283_L	290_A	1.171	1.00
258_V	263_H	1.170	1.00
667_P	700_V	1.169	1.00
440_R	443_R	1.166	1.00
349_Q	355_G	1.165	1.00
454_S	471_A	1.162	1.00
396_A	400_E	1.154	1.00
254_A	282_L	1.149	1.00
275_Y	279_A	1.148	1.00
95_H	517_R	1.142	1.00
509_D	516_E	1.141	1.00
265_E	279_A	1.140	1.00
102_R	110_I	1.136	1.00
541_N	544_R	1.134	1.00
268_L	602_I	1.128	1.00
253_I	257_L	1.126	1.00
241_P	245_T	1.123	1.00
110_I	423_F	1.120	1.00
253_I	311_A	1.114	1.00
210_A	213_D	1.113	1.00
183_V	253_I	1.109	1.00
20_L	32_R	1.108	1.00
437_D	440_R	1.105	1.00
688_L	712_I	1.098	1.00
41_N	44_Q	1.094	1.00
408_A	411_H	1.094	1.00
262_W	316_Q	1.094	1.00
702_S	705_I	1.087	1.00
537_E	541_N	1.083	1.00
423_F	450_L	1.081	1.00
710_I	758_L	1.081	1.00
633_P	691_A	1.076	1.00
633_P	757_W	1.075	1.00
111_F	412_N	1.075	1.00
427_A	511_F	1.075	1.00
250_M	340_I	1.072	1.00
256_T	307_I	1.070	1.00
257_L	347_L	1.069	1.00
297_A	305_A	1.069	1.00
225_R	704_G	1.066	1.00
472_T	504_A	1.064	1.00
78_G	83_V	1.063	1.00
102_R	107_P	1.062	1.00
8_Y	13_A	1.059	1.00
275_Y	346_M	1.058	1.00
20_L	34_A	1.055	1.00
297_A	300_C	1.054	1.00
669_T	700_V	1.053	1.00
253_I	343_L	1.053	1.00
493_P	561_W	1.052	1.00
687_R	761_Y	1.049	1.00
108_A	404_N	1.048	1.00
27_T	52_H	1.038	1.00
443_R	447_K	1.037	1.00
638_V	756_A	1.036	1.00
55_T	655_S	1.036	1.00
184_L	187_A	1.036	1.00
185_W	221_I	1.032	1.00
305_A	308_R	1.032	1.00
180_D	317_N	1.031	1.00
230_D	704_G	1.030	1.00
469_L	510_V	1.026	1.00
182_V	216_K	1.025	1.00
276_A	279_A	1.024	1.00
51_V	498_V	1.019	1.00
101_I	449_E	1.019	1.00
423_F	452_V	1.018	1.00
12_T	17_G	1.018	1.00
278_F	346_M	1.011	1.00
98_H	518_W	1.010	1.00
97_Q	449_E	1.009	1.00
176_L	320_M	1.009	1.00
252_G	307_I	1.006	1.00
101_I	450_L	1.005	1.00
221_I	239_V	1.004	1.00
10_V	16_W	1.001	1.00
31_S	48_R	0.999	1.00
296_A	300_C	0.997	1.00
290_A	295_W	0.997	1.00
635_Q	757_W	0.995	1.00
273_T	599_K	0.994	1.00
250_M	339_M	0.992	1.00
272_T	345_A	0.992	1.00
321_L	344_A	0.989	1.00
158_Y	745_L	0.989	1.00
182_V	211_L	0.989	1.00
634_E	757_W	0.987	1.00
417_H	443_R	0.984	1.00
668_V	758_L	0.979	1.00
181_V	319_T	0.977	1.00
247_V	336_K	0.977	1.00
538_T	542_V	0.976	1.00
219_I	313_I	0.975	1.00
87_W	469_L	0.973	1.00
426_W	461_A	0.970	1.00
22_E	30_S	0.969	1.00
415_N	420_D	0.969	1.00
13_A	16_W	0.965	1.00
7_R	10_V	0.965	1.00
217_K	234_D	0.965	1.00
10_V	14_A	0.960	1.00
425_W	514_L	0.960	1.00
416_R	419_P	0.959	1.00
636_L	758_L	0.958	1.00
670_I	675_A	0.957	1.00
10_V	18_P	0.956	1.00
540_Y	544_R	0.955	1.00
255_H	282_L	0.955	1.00
688_L	756_A	0.955	1.00
394_P	401_A	0.954	1.00
251_L	291_K	0.952	1.00
221_I	310_L	0.950	1.00
521_G	524_A	0.949	1.00
58_R	501_R	0.948	1.00
478_N	533_L	0.946	1.00
345_A	600_I	0.945	1.00
670_I	680_I	0.941	1.00
94_I	514_L	0.941	1.00
671_H	705_I	0.940	1.00
314_F	321_L	0.940	1.00
106_G	109_S	0.937	1.00
414_M	440_R	0.936	1.00
342_T	602_I	0.936	1.00
88_D	517_R	0.936	1.00
639_L	709_V	0.936	1.00
302_V	307_I	0.934	1.00
432_F	442_I	0.932	1.00
278_F	282_L	0.931	1.00
223_P	240_A	0.929	1.00
256_T	311_A	0.929	1.00
142_G	146_D	0.927	1.00
180_D	214_S	0.926	1.00
242_H	706_K	0.923	1.00
672_P	676_Q	0.923	1.00
631_A	755_L	0.922	1.00
243_M	709_V	0.922	1.00
94_I	450_L	0.920	1.00
97_Q	101_I	0.919	1.00
319_T	349_Q	0.917	1.00
293_A	308_R	0.917	1.00
475_F	497_V	0.916	1.00
412_N	421_I	0.916	1.00
478_N	493_P	0.915	1.00
308_R	312_A	0.914	1.00
83_V	89_E	0.911	0.99
82_F	468_V	0.910	0.99
309_E	312_A	0.906	0.99
252_G	256_T	0.905	0.99
669_T	704_G	0.905	0.99
394_P	397_R	0.904	0.99
251_L	281_Y	0.904	0.99
95_H	518_W	0.903	0.99
95_H	99_K	0.903	0.99
91_L	509_D	0.902	0.99
432_F	438_T	0.900	0.99
255_H	292_T	0.899	0.99
471_A	510_V	0.898	0.99
530_K	538_T	0.897	0.99
263_H	346_M	0.897	0.99
58_R	84_R	0.895	0.99
292_T	296_A	0.894	0.99
537_E	558_A	0.894	0.99
102_R	137_A	0.894	0.99
182_V	208_F	0.893	0.99
536_L	539_F	0.892	0.99
57_V	468_V	0.890	0.99
430_A	649_S	0.889	0.99
24_D	29_F	0.889	0.99
217_K	237_E	0.888	0.99
634_E	690_N	0.887	0.99
295_W	299_I	0.887	0.99
526_F	529_G	0.886	0.99
221_I	241_P	0.881	0.99
532_E	536_L	0.881	0.99
674_D	707_P	0.881	0.99
278_F	602_I	0.880	0.99
533_L	536_L	0.878	0.99
98_H	137_A	0.877	0.99
87_W	510_V	0.877	0.99
695_I	736_L	0.877	0.99
394_P	400_E	0.877	0.99
478_N	532_E	0.874	0.99
424_I	448_P	0.872	0.99
184_L	218_L	0.870	0.99
78_G	81_E	0.870	0.99
8_Y	17_G	0.869	0.99
411_H	414_M	0.867	0.99
10_V	15_H	0.862	0.99
12_T	18_P	0.860	0.99
146_D	150_G	0.859	0.99
21_V	475_F	0.858	0.99
37_T	40_E	0.853	0.99
254_A	343_L	0.852	0.99
462_A	468_V	0.851	0.99
62_V	89_E	0.849	0.99
650_Q	654_S	0.848	0.99
18_P	37_T	0.848	0.99
276_A	280_S	0.846	0.99
407_G	415_N	0.845	0.99
293_A	296_A	0.842	0.99
472_T	500_P	0.839	0.99
439_N	443_R	0.839	0.99
148_S	152_A	0.837	0.99
312_A	315_H	0.836	0.99
673_D	703_E	0.835	0.99
94_I	97_Q	0.834	0.99
181_V	217_K	0.833	0.99
241_P	249_L	0.832	0.99
98_H	425_W	0.832	0.99
11_L	18_P	0.832	0.99
394_P	399_V	0.828	0.99
99_K	518_W	0.827	0.99
15_H	18_P	0.826	0.99
557_F	561_W	0.826	0.99
146_D	149_T	0.825	0.99
210_A	214_S	0.825	0.99
184_L	228_T	0.823	0.99
533_L	561_W	0.822	0.99
318_T	352_T	0.822	0.99
327_M	336_K	0.820	0.99
91_L	514_L	0.819	0.99
225_R	703_E	0.815	0.99
264_D	352_T	0.815	0.99
77_R	80_D	0.815	0.99
297_A	302_V	0.814	0.99
533_L	557_F	0.811	0.99
212_R	231_F	0.811	0.99
318_T	355_G	0.810	0.99
675_A	680_I	0.810	0.99
61_M	458_W	0.808	0.99
671_H	701_I	0.807	0.99
60_P	86_S	0.807	0.99
155_I	161_G	0.806	0.99
59_F	86_S	0.806	0.99
416_R	448_P	0.804	0.99
183_V	321_L	0.803	0.99
209_S	212_R	0.803	0.99
392_K	396_A	0.801	0.99
260_N	315_H	0.800	0.99
304_A	307_I	0.798	0.99
249_L	253_I	0.796	0.99
302_V	306_K	0.794	0.99
516_E	527_T	0.793	0.99
11_L	17_G	0.790	0.99
12_T	16_W	0.790	0.99
250_M	343_L	0.789	0.99
133_Y	511_F	0.789	0.99
26_E	499_P	0.788	0.99
567_I	571_E	0.788	0.99
446_Q	464_H	0.788	0.99
498_V	501_R	0.788	0.99
490_H	568_E	0.785	0.98
432_F	445_W	0.784	0.98
409_Y	413_G	0.784	0.98
256_T	304_A	0.782	0.98
692_R	754_A	0.782	0.98
459_T	462_A	0.778	0.98
387_C	397_R	0.776	0.98
12_T	15_H	0.775	0.98
557_F	560_F	0.775	0.98
533_L	539_F	0.774	0.98
225_R	240_A	0.772	0.98
293_A	297_A	0.771	0.98
675_A	702_S	0.771	0.98
219_I	237_E	0.770	0.98
593_L	600_I	0.769	0.98
51_V	473_T	0.769	0.98
491_L	555_P	0.768	0.98
259_E	293_A	0.768	0.98
222_D	226_S	0.767	0.98
697_A	733_V	0.766	0.98
691_A	755_L	0.763	0.98
325_W	329_R	0.762	0.98
207_Y	211_L	0.761	0.98
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87_W	505_R	0.760	0.98
536_L	543_A	0.760	0.98
153_Q	156_M	0.760	0.98
414_M	418_F	0.759	0.98
155_I	337_H	0.759	0.98
560_F	563_A	0.759	0.98
21_V	497_V	0.758	0.98
281_Y	290_A	0.757	0.98
141_T	144_L	0.754	0.98
177_E	210_A	0.753	0.98
666_E	716_A	0.753	0.98
692_R	737_T	0.752	0.98
212_R	218_L	0.751	0.98
241_P	300_C	0.751	0.98
133_Y	514_L	0.750	0.98
149_T	153_Q	0.750	0.98
8_Y	16_W	0.749	0.98
455_E	468_V	0.748	0.98
177_E	207_Y	0.747	0.98
98_H	102_R	0.746	0.98
750_A	753_T	0.746	0.98
242_H	301_G	0.745	0.98
505_R	510_V	0.745	0.98
305_A	309_E	0.745	0.98
306_K	313_I	0.744	0.98
62_V	76_I	0.743	0.98
536_L	542_V	0.743	0.98
79_Q	83_V	0.742	0.98
631_A	634_E	0.741	0.98
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257_L	343_L	0.740	0.98
631_A	635_Q	0.739	0.98
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159_V	338_W	0.738	0.98
392_K	395_V	0.737	0.98
398_I	402_L	0.736	0.98
240_A	706_K	0.735	0.98
96_Q	99_K	0.735	0.98
529_G	535_W	0.732	0.98
24_D	27_T	0.731	0.98
408_A	747_N	0.730	0.98
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439_N	735_V	0.728	0.98
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251_L	282_L	0.725	0.97
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393_I	396_A	0.724	0.97
189_P	208_F	0.724	0.97
596_A	601_E	0.724	0.97
252_G	295_W	0.723	0.97
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130_L	511_F	0.721	0.97
217_K	316_Q	0.719	0.97
460_A	717_W	0.717	0.97
670_I	686_V	0.717	0.97
311_A	315_H	0.716	0.97
417_H	447_K	0.716	0.97
239_V	249_L	0.715	0.97
252_G	298_E	0.715	0.97
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512_A	516_E	0.713	0.97
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63_R	80_D	0.710	0.97
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151_A	155_I	0.706	0.97
539_F	542_V	0.706	0.97
151_A	161_G	0.704	0.97
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248_A	252_G	0.703	0.97
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688_L	758_L	0.701	0.97
279_A	282_L	0.700	0.97
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508_F	535_W	0.699	0.97
101_I	422_R	0.698	0.97
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381_G	384_P	0.698	0.97
247_V	339_M	0.698	0.97
558_A	561_W	0.697	0.97
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670_I	701_I	0.696	0.97
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91_L	95_H	0.692	0.97
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566_L	569_M	0.610	0.93
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310_L	313_I	0.604	0.93
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366_G	369_P	0.597	0.93
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319_T	324_G	0.594	0.92
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365_N	372_R	0.570	0.91
11_L	15_H	0.570	0.91
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374_A	377_S	0.567	0.91
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742_S	746_G	0.543	0.89
535_W	538_T	0.542	0.89
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156_M	341_V	0.540	0.88
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424_I	431_N	0.539	0.88
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303_G	308_R	0.535	0.88
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23_T	29_F	0.535	0.88
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252_G	297_A	0.533	0.88
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532_E	535_W	0.533	0.88
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538_T	541_N	0.530	0.87
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701_I	704_G	0.530	0.87
438_T	442_I	0.529	0.87
234_D	237_E	0.528	0.87
159_V	341_V	0.527	0.87
605_Q	608_A	0.527	0.87
395_V	400_E	0.527	0.87
425_W	452_V	0.527	0.87
334_E	746_G	0.526	0.87
351_G	356_G	0.525	0.87
374_A	379_M	0.525	0.87
255_H	290_A	0.524	0.87
535_W	544_R	0.524	0.87
460_A	463_K	0.523	0.87
49_D	656_L	0.523	0.87
9_S	16_W	0.522	0.87
642_H	714_E	0.522	0.87
254_A	339_M	0.522	0.87
101_I	110_I	0.522	0.87
220_C	228_T	0.522	0.87
306_K	310_L	0.521	0.87
191_N	644_A	0.521	0.87
43_L	46_A	0.520	0.86
104_A	449_E	0.518	0.86
222_D	229_V	0.518	0.86
667_P	713_H	0.518	0.86
453_I	461_A	0.518	0.86
671_H	674_D	0.518	0.86
281_Y	604_S	0.517	0.86
184_L	220_C	0.517	0.86
393_I	397_R	0.517	0.86
529_G	533_L	0.516	0.86
534_Q	541_N	0.514	0.86
563_A	566_L	0.514	0.86
377_S	381_G	0.514	0.86
153_Q	157_P	0.513	0.86
382_S	387_C	0.513	0.86
90_A	94_I	0.513	0.86
533_L	538_T	0.513	0.86
527_T	530_K	0.513	0.86
172_W	175_V	0.512	0.86
533_L	543_A	0.511	0.86
412_N	424_I	0.511	0.86
255_H	295_W	0.511	0.86
452_V	469_L	0.511	0.86
694_Q	759_E	0.510	0.85
451_V	465_A	0.510	0.85
526_F	537_E	0.510	0.85
684_D	699_A	0.510	0.85
678_R	710_I	0.508	0.85
185_W	343_L	0.508	0.85
46_A	659_L	0.508	0.85
211_L	218_L	0.507	0.85
603_F	608_A	0.507	0.85
156_M	163_S	0.506	0.85
144_L	163_S	0.506	0.85
207_Y	212_R	0.506	0.85
76_I	446_Q	0.506	0.85
63_R	78_G	0.505	0.85
223_P	639_L	0.505	0.85
456_C	471_A	0.505	0.85
43_L	47_V	0.505	0.85
597_S	600_I	0.505	0.85
314_F	349_Q	0.504	0.85
672_P	701_I	0.504	0.85
685_T	699_A	0.503	0.85
442_I	464_H	0.503	0.85
382_S	388_D	0.503	0.85
224_M	641_A	0.503	0.85
424_I	445_W	0.502	0.85
626_E	691_A	0.502	0.85
561_W	564_N	0.502	0.85
690_N	755_L	0.502	0.85
187_A	324_G	0.502	0.85
245_T	248_A	0.502	0.85
257_L	316_Q	0.502	0.85
555_P	561_W	0.501	0.84
98_H	514_L	0.501	0.84
264_D	267_F	0.501	0.84
257_L	262_W	0.501	0.84
451_V	461_A	0.501	0.84
476_E	504_A	0.501	0.84
597_S	604_S	0.501	0.84
83_V	93_L	0.501	0.84
471_A	507_D	0.500	0.84

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1h0hA	1	0.9048	100	0.238	Contact Map
1kqfA	3	0.8983	100	0.241	Contact Map
2vpzA	1	0.906	100	0.246	Contact Map
2e7zA	1	0.8687	100	0.247	Contact Map
1eu1A	1	0.9485	100	0.248	Contact Map
2iv2X	1	0.8546	100	0.25	Contact Map
2napA	1	0.879	100	0.257	Contact Map
2ivfA	1	0.8996	100	0.257	Contact Map
1tmoA	1	0.9704	100	0.259	Contact Map
3ml1A	1	0.8829	100	0.261	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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