GREMLIN Database
BISC - Biotin sulfoxide reductase
UniProt: P20099 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10124
Length: 777 (658)
Sequences: 9479 (5828)
Seq/√Len: 227.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_F84_R5.6591.00
680_I699_A4.4071.00
92_D517_R4.3881.00
687_R759_E4.1171.00
684_D760_K3.8191.00
505_R513_E3.7011.00
260_N312_A3.3241.00
687_R694_Q3.2521.00
674_D708_G3.2031.00
252_G296_A3.1881.00
97_Q100_R3.1781.00
636_L678_R3.1411.00
509_D513_E3.1321.00
294_E304_A3.1151.00
673_D707_P2.9441.00
265_E269_A2.9031.00
93_L467_I2.8881.00
496_Q499_P2.8751.00
689_W759_E2.8621.00
256_T260_N2.8451.00
273_T597_S2.8081.00
254_A278_F2.7711.00
453_I465_A2.7641.00
86_S89_E2.7201.00
94_I467_I2.7201.00
185_W250_M2.7001.00
91_L517_R2.6921.00
255_H259_E2.6791.00
531_S534_Q2.6491.00
689_W757_W2.6281.00
100_R104_A2.6001.00
597_S601_E2.5511.00
237_E309_E2.5401.00
297_A304_A2.5361.00
101_I109_S2.5251.00
85_V467_I2.5111.00
254_A346_M2.5071.00
690_N756_A2.4811.00
670_I758_L2.4731.00
304_A308_R2.4631.00
677_E707_P2.4561.00
220_C233_G2.4451.00
59_F503_E2.4411.00
303_G306_K2.4411.00
217_K313_I2.4381.00
249_L300_C2.4291.00
686_V699_A2.4221.00
91_L513_E2.4151.00
306_K309_E2.4061.00
670_I699_A2.4001.00
665_R698_G2.3901.00
62_V93_L2.3791.00
62_V467_I2.3611.00
675_A701_I2.3431.00
263_H268_L2.3361.00
62_V85_V2.2771.00
292_T295_W2.2761.00
689_W694_Q2.2741.00
180_D318_T2.2561.00
261_G265_E2.2341.00
98_H423_F2.1691.00
178_H353_P2.1431.00
266_A270_R2.1151.00
678_R757_W2.0981.00
94_I452_V2.0781.00
668_V710_I2.0451.00
437_D739_D2.0371.00
513_E517_R2.0371.00
422_R449_E2.0311.00
179_S182_V2.0291.00
682_D701_I2.0121.00
181_V313_I2.0051.00
84_R503_E1.9811.00
239_V310_L1.9741.00
556_P559_E1.9731.00
309_E313_I1.9631.00
93_L97_Q1.9351.00
680_I686_V1.9321.00
237_E306_K1.9261.00
249_L307_I1.9181.00
239_V302_V1.8881.00
668_V686_V1.8881.00
101_I423_F1.8851.00
85_V93_L1.8851.00
501_R504_A1.8831.00
697_A712_I1.8661.00
636_L710_I1.8511.00
670_I710_I1.8491.00
685_T696_L1.8301.00
181_V219_I1.8251.00
20_L35_L1.8231.00
425_W454_S1.8221.00
668_V688_L1.8211.00
211_L216_K1.8041.00
255_H293_A1.8041.00
13_A17_G1.7971.00
668_V712_I1.7941.00
673_D676_Q1.7801.00
92_D96_Q1.7791.00
258_V279_A1.7711.00
687_R696_L1.7651.00
76_I79_Q1.7571.00
62_V83_V1.7491.00
458_W462_A1.7461.00
296_A307_I1.7431.00
559_E563_A1.7381.00
533_L537_E1.7311.00
682_D700_V1.7201.00
245_T299_I1.7101.00
259_E283_L1.6941.00
268_L275_Y1.6881.00
280_S283_L1.6861.00
710_I756_A1.6861.00
237_E313_I1.6811.00
258_V275_Y1.6761.00
681_Q684_D1.6691.00
260_N308_R1.6581.00
352_T355_G1.6561.00
478_N496_Q1.6431.00
221_I249_L1.6421.00
256_T312_A1.6361.00
58_R502_Y1.6301.00
256_T308_R1.6261.00
262_W315_H1.6211.00
513_E516_E1.6141.00
61_M468_V1.6081.00
212_R234_D1.6071.00
314_F347_L1.5861.00
448_P451_V1.5701.00
85_V89_E1.5531.00
257_L263_H1.5501.00
641_A711_C1.5441.00
109_S422_R1.5361.00
685_T698_G1.5331.00
10_V13_A1.5321.00
312_A316_Q1.5271.00
258_V282_L1.5231.00
256_T293_A1.5181.00
297_A303_G1.5171.00
534_Q537_E1.5091.00
99_K103_E1.5081.00
249_L310_L1.5011.00
472_T506_N1.5001.00
272_T602_I1.4971.00
257_L315_H1.4971.00
536_L540_Y1.4971.00
297_A307_I1.4921.00
262_W312_A1.4901.00
450_L467_I1.4861.00
314_F319_T1.4751.00
263_H275_Y1.4731.00
294_E308_R1.4711.00
669_T702_S1.4611.00
277_V280_S1.4561.00
183_V310_L1.4511.00
237_E310_L1.4451.00
94_I469_L1.4441.00
14_A17_G1.4431.00
89_E93_L1.4371.00
21_V28_V1.4331.00
183_V221_I1.4311.00
346_M602_I1.4231.00
273_T601_E1.4231.00
22_E32_R1.4221.00
96_Q100_R1.4211.00
111_F421_I1.4121.00
279_A283_L1.4071.00
636_L674_D1.4071.00
695_I712_I1.4061.00
259_E308_R1.3971.00
60_P87_W1.3921.00
49_D658_E1.3901.00
14_A18_P1.3891.00
181_V310_L1.3861.00
13_A18_P1.3841.00
537_E540_Y1.3791.00
248_A299_I1.3781.00
133_Y518_W1.3671.00
443_R446_Q1.3631.00
98_H452_V1.3561.00
442_I446_Q1.3531.00
76_I83_V1.3481.00
61_M84_R1.3461.00
253_I310_L1.3461.00
255_H283_L1.3401.00
256_T259_E1.3381.00
426_W451_V1.3371.00
245_T300_C1.3371.00
631_A691_A1.3351.00
530_K534_Q1.3331.00
105_Y422_R1.3291.00
558_A562_Q1.3251.00
266_A269_A1.3211.00
626_E692_R1.3171.00
225_R230_D1.3171.00
327_M340_I1.3101.00
112_A134_M1.3041.00
256_T262_W1.2951.00
274_G277_V1.2931.00
223_P238_W1.2801.00
458_W468_V1.2801.00
678_R758_L1.2791.00
605_Q609_D1.2711.00
417_H440_R1.2691.00
239_V306_K1.2671.00
456_C473_T1.2631.00
506_N509_D1.2591.00
241_P302_V1.2591.00
453_I462_A1.2541.00
505_R509_D1.2461.00
516_E521_G1.2451.00
495_K561_W1.2451.00
595_T601_E1.2341.00
63_R82_F1.2331.00
291_K296_A1.2321.00
672_P703_E1.2321.00
391_D394_P1.2281.00
253_I314_F1.2271.00
28_V51_V1.2221.00
295_W298_E1.2221.00
636_L757_W1.2201.00
93_L450_L1.2181.00
671_H707_P1.2171.00
21_V31_S1.2161.00
91_L505_R1.2151.00
175_V178_H1.2121.00
220_C229_V1.2111.00
219_I310_L1.2081.00
11_L14_A1.2061.00
89_E467_I1.2001.00
301_G706_K1.1971.00
291_K299_I1.1941.00
10_V17_G1.1941.00
712_I733_V1.1941.00
668_V697_A1.1911.00
291_K295_W1.1891.00
454_S510_V1.1881.00
99_K102_R1.1841.00
533_L540_Y1.1741.00
283_L290_A1.1711.00
258_V263_H1.1701.00
667_P700_V1.1691.00
440_R443_R1.1661.00
349_Q355_G1.1651.00
454_S471_A1.1621.00
396_A400_E1.1541.00
254_A282_L1.1491.00
275_Y279_A1.1481.00
95_H517_R1.1421.00
509_D516_E1.1411.00
265_E279_A1.1401.00
102_R110_I1.1361.00
541_N544_R1.1341.00
268_L602_I1.1281.00
253_I257_L1.1261.00
241_P245_T1.1231.00
110_I423_F1.1201.00
253_I311_A1.1141.00
210_A213_D1.1131.00
183_V253_I1.1091.00
20_L32_R1.1081.00
437_D440_R1.1051.00
688_L712_I1.0981.00
41_N44_Q1.0941.00
408_A411_H1.0941.00
262_W316_Q1.0941.00
702_S705_I1.0871.00
537_E541_N1.0831.00
423_F450_L1.0811.00
710_I758_L1.0811.00
633_P691_A1.0761.00
633_P757_W1.0751.00
111_F412_N1.0751.00
427_A511_F1.0751.00
250_M340_I1.0721.00
256_T307_I1.0701.00
257_L347_L1.0691.00
297_A305_A1.0691.00
225_R704_G1.0661.00
472_T504_A1.0641.00
78_G83_V1.0631.00
102_R107_P1.0621.00
8_Y13_A1.0591.00
275_Y346_M1.0581.00
20_L34_A1.0551.00
297_A300_C1.0541.00
669_T700_V1.0531.00
253_I343_L1.0531.00
493_P561_W1.0521.00
687_R761_Y1.0491.00
108_A404_N1.0481.00
27_T52_H1.0381.00
443_R447_K1.0371.00
638_V756_A1.0361.00
55_T655_S1.0361.00
184_L187_A1.0361.00
185_W221_I1.0321.00
305_A308_R1.0321.00
180_D317_N1.0311.00
230_D704_G1.0301.00
469_L510_V1.0261.00
182_V216_K1.0251.00
276_A279_A1.0241.00
51_V498_V1.0191.00
101_I449_E1.0191.00
423_F452_V1.0181.00
12_T17_G1.0181.00
278_F346_M1.0111.00
98_H518_W1.0101.00
97_Q449_E1.0091.00
176_L320_M1.0091.00
252_G307_I1.0061.00
101_I450_L1.0051.00
221_I239_V1.0041.00
10_V16_W1.0011.00
31_S48_R0.9991.00
296_A300_C0.9971.00
290_A295_W0.9971.00
635_Q757_W0.9951.00
273_T599_K0.9941.00
250_M339_M0.9921.00
272_T345_A0.9921.00
321_L344_A0.9891.00
158_Y745_L0.9891.00
182_V211_L0.9891.00
634_E757_W0.9871.00
417_H443_R0.9841.00
668_V758_L0.9791.00
181_V319_T0.9771.00
247_V336_K0.9771.00
538_T542_V0.9761.00
219_I313_I0.9751.00
87_W469_L0.9731.00
426_W461_A0.9701.00
22_E30_S0.9691.00
415_N420_D0.9691.00
13_A16_W0.9651.00
7_R10_V0.9651.00
217_K234_D0.9651.00
10_V14_A0.9601.00
425_W514_L0.9601.00
416_R419_P0.9591.00
636_L758_L0.9581.00
670_I675_A0.9571.00
10_V18_P0.9561.00
540_Y544_R0.9551.00
255_H282_L0.9551.00
688_L756_A0.9551.00
394_P401_A0.9541.00
251_L291_K0.9521.00
221_I310_L0.9501.00
521_G524_A0.9491.00
58_R501_R0.9481.00
478_N533_L0.9461.00
345_A600_I0.9451.00
670_I680_I0.9411.00
94_I514_L0.9411.00
671_H705_I0.9401.00
314_F321_L0.9401.00
106_G109_S0.9371.00
414_M440_R0.9361.00
342_T602_I0.9361.00
88_D517_R0.9361.00
639_L709_V0.9361.00
302_V307_I0.9341.00
432_F442_I0.9321.00
278_F282_L0.9311.00
223_P240_A0.9291.00
256_T311_A0.9291.00
142_G146_D0.9271.00
180_D214_S0.9261.00
242_H706_K0.9231.00
672_P676_Q0.9231.00
631_A755_L0.9221.00
243_M709_V0.9221.00
94_I450_L0.9201.00
97_Q101_I0.9191.00
319_T349_Q0.9171.00
293_A308_R0.9171.00
475_F497_V0.9161.00
412_N421_I0.9161.00
478_N493_P0.9151.00
308_R312_A0.9141.00
83_V89_E0.9110.99
82_F468_V0.9100.99
309_E312_A0.9060.99
252_G256_T0.9050.99
669_T704_G0.9050.99
394_P397_R0.9040.99
251_L281_Y0.9040.99
95_H518_W0.9030.99
95_H99_K0.9030.99
91_L509_D0.9020.99
432_F438_T0.9000.99
255_H292_T0.8990.99
471_A510_V0.8980.99
530_K538_T0.8970.99
263_H346_M0.8970.99
58_R84_R0.8950.99
292_T296_A0.8940.99
537_E558_A0.8940.99
102_R137_A0.8940.99
182_V208_F0.8930.99
536_L539_F0.8920.99
57_V468_V0.8900.99
430_A649_S0.8890.99
24_D29_F0.8890.99
217_K237_E0.8880.99
634_E690_N0.8870.99
295_W299_I0.8870.99
526_F529_G0.8860.99
221_I241_P0.8810.99
532_E536_L0.8810.99
674_D707_P0.8810.99
278_F602_I0.8800.99
533_L536_L0.8780.99
98_H137_A0.8770.99
87_W510_V0.8770.99
695_I736_L0.8770.99
394_P400_E0.8770.99
478_N532_E0.8740.99
424_I448_P0.8720.99
184_L218_L0.8700.99
78_G81_E0.8700.99
8_Y17_G0.8690.99
411_H414_M0.8670.99
10_V15_H0.8620.99
12_T18_P0.8600.99
146_D150_G0.8590.99
21_V475_F0.8580.99
37_T40_E0.8530.99
254_A343_L0.8520.99
462_A468_V0.8510.99
62_V89_E0.8490.99
650_Q654_S0.8480.99
18_P37_T0.8480.99
276_A280_S0.8460.99
407_G415_N0.8450.99
293_A296_A0.8420.99
472_T500_P0.8390.99
439_N443_R0.8390.99
148_S152_A0.8370.99
312_A315_H0.8360.99
673_D703_E0.8350.99
94_I97_Q0.8340.99
181_V217_K0.8330.99
241_P249_L0.8320.99
98_H425_W0.8320.99
11_L18_P0.8320.99
394_P399_V0.8280.99
99_K518_W0.8270.99
15_H18_P0.8260.99
557_F561_W0.8260.99
146_D149_T0.8250.99
210_A214_S0.8250.99
184_L228_T0.8230.99
533_L561_W0.8220.99
318_T352_T0.8220.99
327_M336_K0.8200.99
91_L514_L0.8190.99
225_R703_E0.8150.99
264_D352_T0.8150.99
77_R80_D0.8150.99
297_A302_V0.8140.99
533_L557_F0.8110.99
212_R231_F0.8110.99
318_T355_G0.8100.99
675_A680_I0.8100.99
61_M458_W0.8080.99
671_H701_I0.8070.99
60_P86_S0.8070.99
155_I161_G0.8060.99
59_F86_S0.8060.99
416_R448_P0.8040.99
183_V321_L0.8030.99
209_S212_R0.8030.99
392_K396_A0.8010.99
260_N315_H0.8000.99
304_A307_I0.7980.99
249_L253_I0.7960.99
302_V306_K0.7940.99
516_E527_T0.7930.99
11_L17_G0.7900.99
12_T16_W0.7900.99
250_M343_L0.7890.99
133_Y511_F0.7890.99
26_E499_P0.7880.99
567_I571_E0.7880.99
446_Q464_H0.7880.99
498_V501_R0.7880.99
490_H568_E0.7850.98
432_F445_W0.7840.98
409_Y413_G0.7840.98
256_T304_A0.7820.98
692_R754_A0.7820.98
459_T462_A0.7780.98
387_C397_R0.7760.98
12_T15_H0.7750.98
557_F560_F0.7750.98
533_L539_F0.7740.98
225_R240_A0.7720.98
293_A297_A0.7710.98
675_A702_S0.7710.98
219_I237_E0.7700.98
593_L600_I0.7690.98
51_V473_T0.7690.98
491_L555_P0.7680.98
259_E293_A0.7680.98
222_D226_S0.7670.98
697_A733_V0.7660.98
691_A755_L0.7630.98
325_W329_R0.7620.98
207_Y211_L0.7610.98
97_Q450_L0.7610.98
87_W505_R0.7600.98
536_L543_A0.7600.98
153_Q156_M0.7600.98
414_M418_F0.7590.98
155_I337_H0.7590.98
560_F563_A0.7590.98
21_V497_V0.7580.98
281_Y290_A0.7570.98
141_T144_L0.7540.98
177_E210_A0.7530.98
666_E716_A0.7530.98
692_R737_T0.7520.98
212_R218_L0.7510.98
241_P300_C0.7510.98
133_Y514_L0.7500.98
149_T153_Q0.7500.98
8_Y16_W0.7490.98
455_E468_V0.7480.98
177_E207_Y0.7470.98
98_H102_R0.7460.98
750_A753_T0.7460.98
242_H301_G0.7450.98
505_R510_V0.7450.98
305_A309_E0.7450.98
306_K313_I0.7440.98
62_V76_I0.7430.98
536_L542_V0.7430.98
79_Q83_V0.7420.98
631_A634_E0.7410.98
85_V90_A0.7400.98
257_L343_L0.7400.98
631_A635_Q0.7390.98
706_K709_V0.7390.98
159_V338_W0.7380.98
392_K395_V0.7370.98
398_I402_L0.7360.98
240_A706_K0.7350.98
96_Q99_K0.7350.98
529_G535_W0.7320.98
24_D27_T0.7310.98
408_A747_N0.7300.98
181_V314_F0.7280.98
439_N735_V0.7280.98
693_G698_G0.7270.98
93_L96_Q0.7250.97
251_L282_L0.7250.97
422_R448_P0.7250.97
393_I396_A0.7240.97
189_P208_F0.7240.97
596_A601_E0.7240.97
252_G295_W0.7230.97
281_Y291_K0.7220.97
130_L511_F0.7210.97
217_K316_Q0.7190.97
460_A717_W0.7170.97
670_I686_V0.7170.97
311_A315_H0.7160.97
417_H447_K0.7160.97
239_V249_L0.7150.97
252_G298_E0.7150.97
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229_V238_W0.6410.95
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439_N442_I0.6290.94
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399_V402_L0.6270.94
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738_K754_A0.5660.91
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243_M639_L0.5650.90
105_Y449_E0.5650.90
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412_N419_P0.5650.90
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180_D319_T0.5640.90
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141_T146_D0.5560.90
681_Q760_K0.5560.90
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568_E571_E0.5550.90
594_K597_S0.5550.90
411_H747_N0.5550.90
327_M337_H0.5540.90
112_A130_L0.5540.90
101_I105_Y0.5530.90
171_S320_M0.5520.89
142_G150_G0.5520.89
42_S45_S0.5500.89
144_L149_T0.5500.89
176_L322_M0.5490.89
121_G124_H0.5490.89
506_N532_E0.5490.89
434_H649_S0.5490.89
560_F564_N0.5490.89
147_Y152_A0.5480.89
323_A357_F0.5480.89
401_A542_V0.5470.89
441_L445_W0.5460.89
242_H637_Q0.5460.89
267_F272_T0.5460.89
189_P228_T0.5440.89
331_Q744_R0.5440.89
135_A138_G0.5440.89
415_N418_F0.5430.89
742_S746_G0.5430.89
535_W538_T0.5420.89
330_Q753_T0.5420.89
100_R449_E0.5420.89
529_G540_Y0.5410.88
119_S123_L0.5410.88
557_F563_A0.5410.88
532_E539_F0.5400.88
692_R738_K0.5400.88
160_V350_I0.5400.88
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303_G308_R0.5350.88
51_V475_F0.5350.88
23_T29_F0.5350.88
31_S47_V0.5350.88
680_I758_L0.5340.88
252_G297_A0.5330.88
23_T28_V0.5330.88
406_G410_Q0.5330.88
368_N376_L0.5330.88
532_E535_W0.5330.88
263_H279_A0.5320.88
260_N293_A0.5320.88
154_A157_P0.5310.88
155_I341_V0.5310.88
538_T541_N0.5300.87
190_L205_L0.5300.87
701_I704_G0.5300.87
438_T442_I0.5290.87
234_D237_E0.5280.87
159_V341_V0.5270.87
605_Q608_A0.5270.87
395_V400_E0.5270.87
425_W452_V0.5270.87
334_E746_G0.5260.87
351_G356_G0.5250.87
374_A379_M0.5250.87
255_H290_A0.5240.87
535_W544_R0.5240.87
460_A463_K0.5230.87
49_D656_L0.5230.87
9_S16_W0.5220.87
642_H714_E0.5220.87
254_A339_M0.5220.87
101_I110_I0.5220.87
220_C228_T0.5220.87
306_K310_L0.5210.87
191_N644_A0.5210.87
43_L46_A0.5200.86
104_A449_E0.5180.86
222_D229_V0.5180.86
667_P713_H0.5180.86
453_I461_A0.5180.86
671_H674_D0.5180.86
281_Y604_S0.5170.86
184_L220_C0.5170.86
393_I397_R0.5170.86
529_G533_L0.5160.86
534_Q541_N0.5140.86
563_A566_L0.5140.86
377_S381_G0.5140.86
153_Q157_P0.5130.86
382_S387_C0.5130.86
90_A94_I0.5130.86
533_L538_T0.5130.86
527_T530_K0.5130.86
172_W175_V0.5120.86
533_L543_A0.5110.86
412_N424_I0.5110.86
255_H295_W0.5110.86
452_V469_L0.5110.86
694_Q759_E0.5100.85
451_V465_A0.5100.85
526_F537_E0.5100.85
684_D699_A0.5100.85
678_R710_I0.5080.85
185_W343_L0.5080.85
46_A659_L0.5080.85
211_L218_L0.5070.85
603_F608_A0.5070.85
156_M163_S0.5060.85
144_L163_S0.5060.85
207_Y212_R0.5060.85
76_I446_Q0.5060.85
63_R78_G0.5050.85
223_P639_L0.5050.85
456_C471_A0.5050.85
43_L47_V0.5050.85
597_S600_I0.5050.85
314_F349_Q0.5040.85
672_P701_I0.5040.85
685_T699_A0.5030.85
442_I464_H0.5030.85
382_S388_D0.5030.85
224_M641_A0.5030.85
424_I445_W0.5020.85
626_E691_A0.5020.85
561_W564_N0.5020.85
690_N755_L0.5020.85
187_A324_G0.5020.85
245_T248_A0.5020.85
257_L316_Q0.5020.85
555_P561_W0.5010.84
98_H514_L0.5010.84
264_D267_F0.5010.84
257_L262_W0.5010.84
451_V461_A0.5010.84
476_E504_A0.5010.84
597_S604_S0.5010.84
83_V93_L0.5010.84
471_A507_D0.5000.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1h0hA 1 0.9048 100 0.238 Contact Map
1kqfA 3 0.8983 100 0.241 Contact Map
2vpzA 1 0.906 100 0.246 Contact Map
2e7zA 1 0.8687 100 0.247 Contact Map
1eu1A 1 0.9485 100 0.248 Contact Map
2iv2X 1 0.8546 100 0.25 Contact Map
2napA 1 0.879 100 0.257 Contact Map
2ivfA 1 0.8996 100 0.257 Contact Map
1tmoA 1 0.9704 100 0.259 Contact Map
3ml1A 1 0.8829 100 0.261 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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