GREMLIN Database
PARE - DNA topoisomerase 4 subunit B
UniProt: P20083 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10687
Length: 630 (615)
Sequences: 4796 (2020)
Seq/√Len: 81.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_K70_D6.5091.00
135_Q152_V4.3861.00
39_V116_I4.3051.00
203_K210_E4.0351.00
124_K168_W3.9661.00
60_H66_E3.7411.00
127_E140_A3.7091.00
169_P179_F3.5681.00
538_A547_V3.5021.00
142_E147_V3.4021.00
125_R168_W3.2941.00
131_R160_N3.1701.00
199_E212_R3.1361.00
68_I164_S3.1221.00
406_A411_R3.0741.00
580_D583_T2.9941.00
483_G518_H2.9551.00
87_V128_V2.9191.00
7_A77_D2.9051.00
127_E138_N2.8471.00
54_R199_E2.8281.00
91_L165_V2.7891.00
87_V150_L2.7771.00
138_N151_Q2.7001.00
82_E89_L2.6761.00
36_G184_L2.6501.00
192_A215_Y2.6491.00
135_Q155_T2.6471.00
125_R140_A2.6411.00
60_H205_E2.6221.00
480_L518_H2.6181.00
296_E306_K2.6151.00
408_D411_R2.5881.00
66_E166_H2.5491.00
129_N164_S2.5451.00
196_P241_N2.5401.00
128_V165_V2.5001.00
101_S104_N2.5001.00
54_R70_D2.4791.00
60_H166_H2.4741.00
148_Q151_Q2.4111.00
87_V130_V2.3781.00
76_V137_Y2.3631.00
414_L468_I2.3521.00
56_D201_T2.3511.00
622_K625_M2.3471.00
56_D68_I2.3351.00
129_N138_N2.3331.00
61_A205_E2.2811.00
137_Y152_V2.2751.00
36_G65_L2.2661.00
59_L65_L2.2581.00
124_K171_E2.2401.00
527_Y541_E2.2131.00
409_L483_G2.2101.00
181_V211_Q2.1981.00
84_V88_E2.1871.00
199_E214_C2.1791.00
129_N136_V2.1701.00
44_V198_V2.1491.00
57_V188_L2.1251.00
7_A86_A2.1231.00
464_I468_I2.1191.00
523_L587_V2.1161.00
52_A70_D2.0881.00
127_E166_H2.0801.00
251_W320_L2.0731.00
617_N621_E2.0721.00
14_T81_E2.0721.00
143_N172_T2.0691.00
290_A351_K2.0681.00
511_R515_K2.0611.00
512_A515_K2.0591.00
293_E297_Y2.0551.00
275_Q335_E2.0471.00
530_D535_V2.0401.00
66_E164_S2.0291.00
152_V155_T2.0231.00
181_V202_F2.0151.00
131_R136_V1.9911.00
486_C586_L1.9791.00
221_D224_A1.9601.00
129_N166_H1.9501.00
239_I250_D1.9471.00
405_T432_R1.9451.00
60_H64_S1.9361.00
140_A147_V1.9121.00
307_L372_A1.9091.00
74_M90_I1.9081.00
156_C160_N1.9011.00
402_A427_K1.8961.00
139_I146_K1.8691.00
425_S571_P1.8671.00
513_L519_V1.8651.00
598_R601_A1.8611.00
266_S280_V1.8561.00
468_I485_I1.8531.00
268_V324_M1.8441.00
416_L440_L1.8361.00
416_L464_I1.8071.00
18_P95_H1.7991.00
243_A248_A1.7941.00
531_L557_K1.7571.00
189_K225_E1.7541.00
540_T543_E1.7501.00
291_M358_L1.7481.00
84_V93_R1.7421.00
343_A347_S1.7401.00
8_D80_P1.7381.00
242_F349_V1.7351.00
58_I68_I1.7331.00
266_S273_T1.7301.00
56_D203_K1.7281.00
136_V156_C1.7201.00
54_R201_T1.7091.00
58_I205_E1.6971.00
91_L116_I1.6951.00
37_Q184_L1.6551.00
77_D133_D1.6521.00
131_R164_S1.6411.00
357_W361_N1.6401.00
503_C519_V1.6341.00
140_A148_Q1.6311.00
136_V154_G1.6251.00
220_N224_A1.6231.00
14_T82_E1.6111.00
468_I480_L1.5801.00
65_L179_F1.5721.00
201_T212_R1.5621.00
185_T211_Q1.5551.00
58_I203_K1.5531.00
476_D479_Q1.5521.00
138_N153_V1.5380.99
283_L318_Y1.5380.99
6_N9_A1.5320.99
529_I547_V1.5250.99
247_E345_F1.5210.99
521_V589_L1.5180.99
227_V254_L1.5160.99
193_V225_E1.5110.99
294_F365_A1.5060.99
361_N364_A1.4730.99
77_D86_A1.4640.99
611_R614_D1.4630.99
40_I67_V1.4590.99
91_L126_V1.4590.99
309_A313_W1.4500.99
116_I126_V1.4480.99
181_V213_W1.4350.99
231_P257_P1.4330.99
406_A412_T1.4330.99
283_L320_L1.4240.99
253_L316_C1.4200.99
354_F358_L1.4140.99
125_R142_E1.4070.99
512_A516_H1.4050.99
295_C301_L1.4050.99
410_N483_G1.4040.99
141_F146_K1.4040.99
64_S168_W1.4020.99
536_Y550_Q1.4010.99
89_L93_R1.3920.99
543_E546_G1.3880.99
11_E101_S1.3880.99
342_C345_F1.3820.99
544_K548_L1.3790.99
441_K460_E1.3780.99
77_D132_R1.3740.99
412_T483_G1.3610.99
241_N250_D1.3420.99
243_A246_T1.3380.99
453_D457_A1.3350.99
68_I160_N1.3320.99
146_K149_D1.3210.98
227_V317_A1.3020.98
268_V273_T1.2970.98
44_V191_K1.2890.98
314_D375_S1.2870.98
157_G160_N1.2840.98
459_Q463_D1.2800.98
414_L464_I1.2770.98
536_Y547_V1.2770.98
561_Q573_Q1.2750.98
126_V165_V1.2720.98
58_I66_E1.2700.98
236_K364_A1.2670.98
97_G100_F1.2620.98
296_E304_G1.2580.98
444_I461_V1.2540.98
78_I83_G1.2520.98
11_E21_R1.2460.98
63_Q178_R1.2410.98
502_L506_F1.2410.98
131_R161_T1.2360.98
528_R535_V1.2320.98
460_E463_D1.2200.97
485_I506_F1.2150.97
409_L412_T1.2120.97
91_L128_V1.2110.97
220_N239_I1.2030.97
546_G550_Q1.2000.97
477_L516_H1.1990.97
109_G271_I1.1980.97
594_E599_T1.1970.97
470_I475_D1.1950.97
274_M335_E1.1930.97
47_A198_V1.1890.97
219_L239_I1.1870.97
168_W171_E1.1850.97
411_R433_E1.1840.97
324_M342_C1.1820.97
295_C369_A1.1810.97
180_S183_R1.1810.97
441_K444_I1.1800.97
331_G338_S1.1800.97
59_L63_Q1.1740.97
529_I544_K1.1730.97
64_S169_P1.1710.97
238_F253_L1.1710.97
52_A55_V1.1680.97
529_I538_A1.1650.97
616_R620_Q1.1640.97
275_Q331_G1.1600.96
291_M312_I1.1570.96
43_S165_V1.1570.96
263_L284_R1.1550.96
36_G40_I1.1500.96
201_T210_E1.1470.96
64_S166_H1.1450.96
21_R326_D1.1430.96
140_A151_Q1.1420.96
353_A356_L1.1420.96
428_Q571_P1.1400.96
575_R581_P1.1330.96
51_H72_R1.1320.96
185_T213_W1.1310.96
139_I148_Q1.1310.96
411_R434_Y1.1300.96
240_G251_W1.1290.96
247_E342_C1.1260.96
141_F148_Q1.1240.96
535_V538_A1.1180.96
536_Y543_E1.1170.96
4_T9_A1.1160.96
444_I489_A1.1140.96
389_K403_D1.1130.95
63_Q168_W1.1080.95
545_E549_E1.1080.95
544_K558_P1.1010.95
452_S456_L1.1000.95
416_L460_E1.1000.95
60_H63_Q1.0990.95
331_G335_E1.0940.95
141_F150_L1.0940.95
136_V153_V1.0930.95
413_E486_C1.0930.95
40_I188_L1.0900.95
506_F519_V1.0880.95
538_A544_K1.0850.95
64_S125_R1.0850.95
181_V185_T1.0810.95
548_L560_V1.0810.95
470_I477_L1.0790.95
288_L309_A1.0780.95
10_I86_A1.0760.95
249_V349_V1.0750.95
350_V354_F1.0740.95
358_L365_A1.0730.94
248_A323_K1.0720.94
499_A521_V1.0700.94
322_V342_C1.0680.94
196_P250_D1.0670.94
285_Q347_S1.0660.94
470_I480_L1.0650.94
135_Q154_G1.0640.94
330_A338_S1.0640.94
367_L370_E1.0620.94
356_L360_Q1.0610.94
538_A543_E1.0590.94
405_T433_E1.0530.94
133_D137_Y1.0520.94
531_L552_K1.0520.94
171_E177_P1.0510.94
330_A335_E1.0410.94
19_V94_L1.0410.94
293_E296_E1.0400.94
576_E580_D1.0380.93
130_V150_L1.0280.93
78_I81_E1.0270.93
434_Y581_P1.0210.93
604_D611_R1.0150.93
286_G290_A1.0140.93
480_L516_H1.0120.93
132_R161_T1.0100.92
268_V322_V1.0060.92
189_K215_Y1.0010.92
328_Q338_S1.0010.92
487_I506_F1.0010.92
79_H86_A1.0010.92
441_K459_Q1.0000.92
43_S91_L0.9990.92
601_A605_M0.9980.92
131_R156_C0.9950.92
259_G388_R0.9930.92
228_N601_A0.9920.92
431_D434_Y0.9910.92
273_T338_S0.9870.92
225_E601_A0.9860.92
68_I131_R0.9820.91
143_N170_D0.9800.91
255_W312_I0.9790.91
371_M388_R0.9760.91
217_D220_N0.9730.91
311_D379_R0.9730.91
193_V215_Y0.9710.91
217_D221_D0.9700.91
78_I82_E0.9700.91
402_A432_R0.9690.91
444_I463_D0.9680.91
613_E617_N0.9680.91
281_N285_Q0.9640.91
444_I460_E0.9620.91
273_T331_G0.9600.90
136_V160_N0.9590.90
249_V345_F0.9550.90
130_V163_T0.9530.90
47_A52_A0.9530.90
545_E548_L0.9500.90
35_L119_V0.9500.90
347_S351_K0.9480.90
296_E301_L0.9450.90
74_M165_V0.9440.90
74_M91_L0.9440.90
344_A348_G0.9390.89
398_P403_D0.9320.89
462_H466_V0.9270.89
80_P83_G0.9250.89
85_P89_L0.9240.89
444_I458_S0.9180.88
412_T518_H0.9170.88
124_K172_T0.9150.88
79_H84_V0.9150.88
76_V132_R0.9130.88
39_V91_L0.9110.88
116_I128_V0.9100.88
575_R580_D0.9080.88
563_F573_Q0.9050.88
84_V89_L0.9050.88
188_L202_F0.9040.88
448_W508_K0.9030.88
136_V152_V0.9020.88
236_K361_N0.9010.87
220_N236_K0.9010.87
185_T202_F0.9000.87
85_P150_L0.8970.87
593_D598_R0.8950.87
247_E324_M0.8940.87
263_L318_Y0.8930.87
217_D224_A0.8860.87
281_N347_S0.8850.87
295_C307_L0.8840.86
234_P364_A0.8820.86
48_L52_A0.8810.86
268_V338_S0.8800.86
465_S505_L0.8770.86
102_N326_D0.8770.86
4_T7_A0.8770.86
460_E489_A0.8760.86
352_D356_L0.8750.86
464_I489_A0.8710.86
78_I84_V0.8710.86
299_N303_R0.8700.86
301_L306_K0.8690.85
191_K195_C0.8670.85
6_N77_D0.8640.85
11_E81_E0.8590.85
531_L556_G0.8590.85
301_L304_G0.8570.85
156_C161_T0.8490.84
458_S463_D0.8490.84
54_R212_R0.8480.84
139_I150_L0.8480.84
366_E370_E0.8470.84
389_K393_S0.8470.84
116_I165_V0.8450.84
203_K208_N0.8450.84
572_M580_D0.8430.84
86_A89_L0.8430.84
9_A104_N0.8420.84
13_L21_R0.8390.83
48_L202_F0.8370.83
289_D347_S0.8340.83
415_F434_Y0.8330.83
312_I372_A0.8310.83
456_L461_V0.8310.83
266_S331_G0.8300.83
18_P24_G0.8280.83
552_K557_K0.8280.83
528_R573_Q0.8270.83
403_D481_R0.8230.82
617_N620_Q0.8230.82
602_M605_M0.8230.82
339_S342_C0.8210.82
428_Q570_N0.8200.82
57_V202_F0.8170.82
184_L188_L0.8170.82
478_S516_H0.8160.82
292_R296_E0.8140.82
143_N173_F0.8130.81
70_D160_N0.8120.81
263_L280_V0.8110.81
53_K199_E0.8110.81
275_Q336_R0.8110.81
241_N248_A0.8110.81
12_V82_E0.8100.81
268_V329_F0.8100.81
273_T330_A0.8100.81
15_G19_V0.8070.81
79_H89_L0.8040.81
138_N148_Q0.8030.81
499_A523_L0.8030.81
51_H145_E0.8000.80
427_K573_Q0.8000.80
600_D604_D0.7990.80
189_K193_V0.7960.80
553_R557_K0.7900.80
16_L94_L0.7900.80
315_R371_M0.7900.80
249_V346_V0.7870.79
541_E545_E0.7870.79
237_P252_A0.7860.79
351_K355_I0.7860.79
170_D173_F0.7860.79
365_A369_A0.7860.79
447_T455_V0.7860.79
266_S338_S0.7860.79
614_D617_N0.7850.79
531_L551_L0.7840.79
249_V252_A0.7840.79
124_K170_D0.7760.78
59_L206_I0.7750.78
84_V146_K0.7730.78
88_E139_I0.7720.78
464_I505_L0.7700.78
488_L522_A0.7700.78
11_E14_T0.7690.78
290_A355_I0.7670.78
53_K57_V0.7670.78
224_A237_P0.7670.78
18_P94_L0.7660.77
234_P254_L0.7640.77
18_P21_R0.7630.77
357_W364_A0.7630.77
76_V87_V0.7620.77
224_A236_K0.7620.77
134_G157_G0.7580.77
378_R383_A0.7570.77
63_Q179_F0.7560.77
133_D152_V0.7540.76
374_S377_Q0.7520.76
167_F179_F0.7520.76
281_N343_A0.7510.76
426_A437_I0.7510.76
488_L579_L0.7490.76
77_D137_Y0.7480.76
399_G467_A0.7470.76
62_D166_H0.7470.76
509_H539_L0.7470.76
185_T209_T0.7470.76
590_T594_E0.7460.76
12_V89_L0.7460.76
242_F353_A0.7460.76
14_T18_P0.7460.76
126_V139_I0.7450.75
124_K143_N0.7440.75
535_V576_E0.7430.75
514_V519_V0.7400.75
573_Q576_E0.7390.75
251_W283_L0.7390.75
153_V156_C0.7380.75
409_L518_H0.7350.75
378_R387_V0.7350.75
470_I510_F0.7340.74
80_P86_A0.7330.74
234_P237_P0.7320.74
547_V550_Q0.7310.74
406_A433_E0.7310.74
181_V209_T0.7300.74
363_Q367_L0.7280.74
415_F575_R0.7280.74
223_L319_V0.7270.74
37_Q183_R0.7270.74
374_S388_R0.7260.74
285_Q343_A0.7260.74
273_T328_Q0.7250.73
266_S328_Q0.7250.73
328_Q339_S0.7240.73
16_L95_H0.7230.73
459_Q462_H0.7230.73
249_V258_E0.7220.73
259_G371_M0.7210.73
7_A133_D0.7200.73
404_C481_R0.7200.73
44_V200_I0.7190.73
135_Q153_V0.7190.73
370_E374_S0.7180.73
14_T145_E0.7180.73
398_P481_R0.7160.73
463_D466_V0.7150.72
387_V390_K0.7130.72
283_L350_V0.7120.72
468_I483_G0.7120.72
266_S320_L0.7110.72
275_Q340_R0.7100.72
90_I165_V0.7080.72
136_V155_T0.7050.71
530_D559_N0.7040.71
82_E93_R0.7000.71
542_E545_E0.6990.71
171_E178_R0.6990.71
618_W623_G0.6980.71
5_Y10_I0.6970.71
397_L432_R0.6970.71
431_D581_P0.6960.70
363_Q366_E0.6920.70
190_A222_Y0.6920.70
415_F484_K0.6920.70
618_W622_K0.6910.70
16_L19_V0.6910.70
412_T480_L0.6900.70
587_V626_A0.6900.70
447_T461_V0.6900.70
290_A354_F0.6900.70
441_K461_V0.6880.70
275_Q330_A0.6870.69
289_D351_K0.6860.69
500_T603_M0.6850.69
272_P280_V0.6850.69
125_R147_V0.6830.69
280_V290_A0.6830.69
170_D273_T0.6810.69
96_A117_S0.6810.69
81_E145_E0.6810.69
496_L573_Q0.6810.69
386_V389_K0.6800.69
57_V207_N0.6780.68
485_I519_V0.6770.68
137_Y161_T0.6760.68
27_T30_T0.6760.68
477_L480_L0.6750.68
415_F586_L0.6740.68
335_E339_S0.6740.68
410_N518_H0.6730.68
93_R141_F0.6730.68
96_A100_F0.6730.68
373_I377_Q0.6720.68
314_D371_M0.6710.68
191_K270_L0.6680.67
82_E85_P0.6660.67
284_R313_W0.6640.67
259_G387_V0.6640.67
89_L222_Y0.6630.67
593_D597_Q0.6630.67
9_A103_K0.6620.67
125_R166_H0.6620.67
62_D168_W0.6610.66
85_P146_K0.6600.66
127_E142_E0.6600.66
512_A591_I0.6600.66
197_G214_C0.6590.66
598_R602_M0.6590.66
265_E597_Q0.6590.66
244_G345_F0.6570.66
437_I579_L0.6560.66
389_K412_T0.6560.66
468_I519_V0.6550.66
515_K594_E0.6550.66
251_W257_P0.6550.66
380_M383_A0.6550.66
136_V141_F0.6550.66
100_F112_H0.6540.66
56_D66_E0.6540.66
507_V599_T0.6520.65
537_Y573_Q0.6510.65
414_L485_I0.6510.65
404_C618_W0.6500.65
395_P454_E0.6500.65
19_V117_S0.6490.65
27_T31_R0.6490.65
234_P255_W0.6480.65
22_R111_L0.6480.65
543_E585_R0.6480.65
465_S472_P0.6470.65
577_T584_R0.6460.65
57_V200_I0.6460.65
124_K140_A0.6450.65
248_A251_W0.6450.65
394_G466_V0.6450.65
58_I64_S0.6440.64
399_G432_R0.6440.64
529_I548_L0.6430.64
250_D257_P0.6430.64
196_P239_I0.6430.64
76_V135_Q0.6430.64
54_R68_I0.6410.64
405_T412_T0.6410.64
542_E546_G0.6400.64
35_L273_T0.6400.64
268_V331_G0.6390.64
86_A104_N0.6390.64
91_L139_I0.6380.64
21_R135_Q0.6380.64
327_P447_T0.6380.64
160_N164_S0.6380.64
312_I457_A0.6370.64
278_T340_R0.6360.64
452_S455_V0.6350.63
539_L547_V0.6350.63
187_V191_K0.6350.63
563_F576_E0.6330.63
229_G604_D0.6330.63
251_W350_V0.6310.63
9_A101_S0.6310.63
78_I85_P0.6300.63
140_A168_W0.6300.63
406_A409_L0.6300.63
138_N154_G0.6300.63
561_Q575_R0.6300.63
552_K558_P0.6280.63
240_G464_I0.6270.62
505_L510_F0.6270.62
11_E102_N0.6260.62
227_V256_L0.6250.62
83_G145_E0.6250.62
91_L163_T0.6250.62
39_V118_V0.6240.62
441_K489_A0.6240.62
251_W259_G0.6220.62
441_K464_I0.6220.62
221_D463_D0.6210.62
295_C299_N0.6210.62
381_R385_K0.6200.62
549_E553_R0.6190.61
232_T254_L0.6180.61
9_A102_N0.6170.61
256_L259_G0.6160.61
523_L585_R0.6160.61
63_Q177_P0.6160.61
609_K614_D0.6150.61
90_I272_P0.6140.61
137_Y141_F0.6140.61
551_L558_P0.6130.61
220_N237_P0.6130.61
293_E351_K0.6120.61
43_S55_V0.6120.61
445_L455_V0.6120.61
414_L480_L0.6120.61
54_R203_K0.6110.60
168_W179_F0.6110.60
91_L146_K0.6110.60
12_V18_P0.6100.60
85_P149_D0.6100.60
597_Q601_A0.6090.60
594_E597_Q0.6090.60
373_I381_R0.6070.60
544_K560_V0.6070.60
608_A612_S0.6070.60
445_L450_V0.6070.60
4_T8_D0.6060.60
465_S471_D0.6040.60
65_L202_F0.6030.59
87_V126_V0.6030.59
68_I129_N0.6020.59
471_D475_D0.6020.59
105_Y325_Q0.6010.59
87_V139_I0.6000.59
455_V461_V0.6000.59
46_E50_G0.6000.59
216_Q236_K0.5990.59
403_D408_D0.5990.59
412_T433_E0.5990.59
480_L513_L0.5990.59
504_A607_L0.5980.59
237_P240_G0.5980.59
250_D258_E0.5980.59
253_L287_L0.5970.59
548_L551_L0.5970.59
40_I57_V0.5960.59
74_M87_V0.5950.58
514_V591_I0.5950.58
613_E616_R0.5940.58
411_R483_G0.5940.58
275_Q339_S0.5940.58
523_L626_A0.5930.58
300_I373_I0.5920.58
427_K432_R0.5920.58
252_A258_E0.5910.58
79_H82_E0.5910.58
61_A208_N0.5900.58
426_A488_L0.5900.58
78_I87_V0.5900.58
84_V149_D0.5890.58
139_I149_D0.5890.58
445_L458_S0.5880.58
429_A575_R0.5880.58
413_E484_K0.5870.57
29_T338_S0.5850.57
66_E125_R0.5850.57
407_Q546_G0.5840.57
391_L396_A0.5840.57
550_Q556_G0.5830.57
496_L499_A0.5830.57
129_N153_V0.5810.57
209_T621_E0.5810.57
129_N202_F0.5810.57
508_K600_D0.5800.56
247_E325_Q0.5800.56
240_G350_V0.5800.56
389_K392_T0.5780.56
142_E145_E0.5770.56
322_V346_V0.5770.56
237_P364_A0.5760.56
286_G354_F0.5760.56
60_H203_K0.5750.56
67_V165_V0.5750.56
284_R309_A0.5740.56
327_P481_R0.5740.56
569_M574_L0.5740.56
268_V325_Q0.5730.56
272_P335_E0.5730.56
461_V505_L0.5730.56
489_A499_A0.5720.55
296_E539_L0.5720.55
529_I551_L0.5710.55
42_N45_D0.5710.55
398_P467_A0.5700.55
441_K456_L0.5690.55
240_G244_G0.5690.55
15_G95_H0.5680.55
503_C603_M0.5680.55
231_P611_R0.5670.55
441_K463_D0.5670.55
246_T325_Q0.5670.55
402_A437_I0.5670.55
440_L502_L0.5670.55
590_T602_M0.5650.55
24_G102_N0.5650.55
249_V256_L0.5650.55
191_K327_P0.5650.55
539_L585_R0.5650.55
550_Q553_R0.5650.55
406_A410_N0.5640.54
299_N369_A0.5620.54
594_E602_M0.5610.54
291_M369_A0.5610.54
142_E148_Q0.5610.54
195_C270_L0.5610.54
149_D152_V0.5610.54
280_V394_G0.5610.54
43_S163_T0.5590.54
552_K556_G0.5590.54
608_A619_L0.5570.54
244_G247_E0.5570.54
132_R249_V0.5560.53
98_G108_S0.5540.53
145_E236_K0.5540.53
548_L552_K0.5530.53
199_E216_Q0.5530.53
280_V284_R0.5530.53
244_G348_G0.5520.53
59_L202_F0.5520.53
562_R568_E0.5510.53
412_T481_R0.5510.53
87_V273_T0.5500.53
38_E42_N0.5500.53
478_S483_G0.5500.53
92_C146_K0.5500.53
127_E147_V0.5490.52
548_L558_P0.5490.52
536_Y551_L0.5480.52
12_V189_K0.5480.52
448_W604_D0.5470.52
515_K591_I0.5470.52
511_R616_R0.5460.52
63_Q169_P0.5460.52
598_R621_E0.5450.52
373_I376_A0.5450.52
489_A496_L0.5450.52
395_P459_Q0.5440.52
44_V195_C0.5440.52
377_Q451_S0.5440.52
157_G236_K0.5440.52
185_T267_Y0.5430.52
44_V344_A0.5410.51
261_E313_W0.5410.51
585_R602_M0.5410.51
76_V79_H0.5410.51
398_P463_D0.5400.51
591_I609_K0.5400.51
546_G549_E0.5400.51
394_G462_H0.5390.51
330_A336_R0.5390.51
148_Q152_V0.5390.51
455_V489_A0.5390.51
251_W260_G0.5390.51
428_Q432_R0.5390.51
66_E205_E0.5380.51
178_R202_F0.5380.51
240_G353_A0.5380.51
300_I369_A0.5370.51
370_E617_N0.5370.51
414_L470_I0.5370.51
101_S296_E0.5370.51
106_Q270_L0.5360.51
47_A50_G0.5360.51
24_G487_I0.5340.51
384_K465_S0.5340.51
363_Q381_R0.5340.51
157_G560_V0.5340.51
309_A315_R0.5330.50
430_R435_Q0.5330.50
444_I459_Q0.5330.50
403_D434_Y0.5330.50
63_Q125_R0.5330.50
103_K106_Q0.5320.50
335_E338_S0.5320.50
291_M354_F0.5320.50
90_I335_E0.5310.50
77_D80_P0.5310.50
330_A339_S0.5300.50
8_D79_H0.5300.50
288_L292_R0.5300.50
415_F499_A0.5290.50
259_G381_R0.5290.50
171_E175_D0.5290.50
16_L121_A0.5280.50
362_V365_A0.5280.50
408_D412_T0.5280.50
452_S472_P0.5280.50
328_Q331_G0.5270.50
36_G59_L0.5270.50
579_L620_Q0.5270.50
12_V93_R0.5270.50
454_E618_W0.5270.50
484_K586_L0.5270.50
184_L200_I0.5260.49
307_L373_I0.5260.49
407_Q483_G0.5260.49
3_Q6_N0.5260.49
293_E355_I0.5250.49
79_H428_Q0.5250.49
572_M576_E0.5250.49
88_E141_F0.5250.49
275_Q338_S0.5240.49
424_G430_R0.5240.49
391_L412_T0.5240.49
300_I304_G0.5240.49
230_L604_D0.5240.49
570_N573_Q0.5240.49
364_A367_L0.5230.49
527_Y561_Q0.5210.49
52_A71_G0.5210.49
252_A257_P0.5210.49
403_D493_S0.5200.49
575_R582_N0.5200.49
233_L364_A0.5200.49
426_A574_L0.5200.49
15_G21_R0.5190.49
605_M611_R0.5180.48
242_F256_L0.5180.48
229_G232_T0.5180.48
369_A372_A0.5180.48
13_L19_V0.5180.48
226_A317_A0.5170.48
574_L577_T0.5150.48
327_P412_T0.5150.48
12_V15_G0.5140.48
539_L543_E0.5140.48
136_V157_G0.5140.48
145_E151_Q0.5140.48
130_V165_V0.5140.48
396_A466_V0.5140.48
414_L519_V0.5130.48
15_G18_P0.5130.48
185_T222_Y0.5130.48
544_K557_K0.5120.48
191_K335_E0.5120.48
77_D89_L0.5110.47
191_K499_A0.5110.47
295_C306_K0.5110.47
227_V234_P0.5110.47
484_K520_Y0.5110.47
8_D77_D0.5110.47
288_L313_W0.5110.47
416_L420_D0.5100.47
415_F581_P0.5090.47
102_N268_V0.5090.47
549_E552_K0.5080.47
267_Y302_P0.5070.47
13_L24_G0.5070.47
3_Q210_E0.5060.47
463_D489_A0.5060.47
392_T499_A0.5060.47
181_V206_I0.5060.47
3_Q207_N0.5050.47
291_M368_L0.5050.47
145_E170_D0.5050.47
326_D339_S0.5050.47
175_D340_R0.5050.47
539_L544_K0.5050.47
325_Q345_F0.5040.47
268_V328_Q0.5030.46
38_E45_D0.5030.46
55_V312_I0.5030.46
19_V23_P0.5030.46
190_A272_P0.5030.46
450_V455_V0.5020.46
221_D303_R0.5020.46
16_L21_R0.5010.46
14_T93_R0.5000.46
144_G173_F0.5000.46
222_Y441_K0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i3hA 2 0.8857 100 0.092 Contact Map
4gfhA 2 0.919 100 0.152 Contact Map
3zkbA 5 0.6016 100 0.543 Contact Map
3lnuA 1 0.5444 100 0.548 Contact Map
1s16A 2 0.6032 100 0.557 Contact Map
1zxmA 2 0.5508 100 0.559 Contact Map
4wubA 2 0.5984 100 0.564 Contact Map
1pvgA 2 0.5492 100 0.568 Contact Map
4urlA 1 0.5635 100 0.569 Contact Map
2xkjE 2 0.3762 100 0.571 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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