GREMLIN Database
HYAD - Hydrogenase 1 maturation protease
UniProt: P19930 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10471
Length: 195 (152)
Sequences: 1063 (807)
Seq/√Len: 65.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
125_A137_L5.7221.00
26_A41_I3.7951.00
24_R27_E3.0231.00
78_T152_Q2.9921.00
64_L149_A2.9371.00
25_V64_L2.5511.00
68_D123_Q2.4381.00
21_F122_L2.3481.00
5_R59_S2.1381.00
120_V145_A2.1061.00
40_E58_A2.0221.00
122_L138_A2.0161.00
78_T120_V2.0151.00
17_A126_M2.0141.00
148_A151_A1.9981.00
124_P127_L1.9461.00
60_H156_W1.9401.00
59_S115_A1.9011.00
70_G123_Q1.8801.00
60_H116_H1.8771.00
62_L156_W1.7951.00
62_L149_A1.7931.00
67_I121_G1.7531.00
32_H150_L1.7521.00
28_R146_E1.7511.00
25_V142_L1.7491.00
72_E75_T1.7200.99
152_Q155_A1.6960.99
14_L23_V1.6770.99
71_L77_R1.6680.99
28_R32_H1.6520.99
136_E140_E1.6190.99
26_A64_L1.6020.99
120_V149_A1.5780.99
14_L19_E1.5440.99
143_P147_Q1.5410.99
136_E139_R1.5400.99
78_T118_A1.5130.99
56_E112_H1.5040.99
71_L75_T1.4720.98
7_V42_V1.4550.98
138_A141_Q1.4480.98
8_V153_L1.4280.98
6_V158_I1.4110.98
76_L144_A1.3840.98
21_F145_A1.3730.97
71_L123_Q1.3610.97
16_W19_E1.3580.97
64_L145_A1.3490.97
122_L145_A1.3070.97
69_Y77_R1.2980.96
141_Q145_A1.2790.96
141_Q144_A1.2730.96
36_P39_V1.2610.96
28_R143_P1.2520.96
122_L141_Q1.2460.95
32_H143_P1.2460.95
7_V58_A1.2290.95
35_W150_L1.2270.95
24_R133_S1.1990.94
77_R123_Q1.1960.94
69_Y123_Q1.1500.93
23_V43_D1.1470.93
80_A116_H1.1220.92
6_V153_L1.1140.92
6_V60_H1.0720.90
23_V26_A1.0690.90
25_V146_E1.0610.90
56_E110_R1.0430.89
99_S102_E1.0420.89
118_A152_Q1.0390.89
61_L117_I1.0310.89
33_Y157_G1.0290.88
63_I117_I1.0210.88
10_G22_G1.0110.88
23_V124_P1.0060.87
116_H156_W1.0050.87
76_L145_A1.0020.87
35_W41_I0.9870.86
153_L158_I0.9860.86
17_A131_G0.9770.86
62_L152_Q0.9750.86
28_R31_A0.9720.85
143_P146_E0.9690.85
10_G26_A0.9650.85
21_F138_A0.9440.84
76_L122_L0.9390.83
153_L157_G0.9390.83
151_A154_A0.9010.81
78_T148_A0.9010.81
80_A118_A0.8940.80
20_G134_L0.8790.79
42_V54_Y0.8700.78
13_N20_G0.8680.78
34_H38_Y0.8590.77
126_M135_S0.8420.76
28_R139_R0.8360.76
62_L120_V0.8320.75
150_L157_G0.8300.75
144_A147_Q0.8290.75
49_L106_L0.8160.74
152_Q156_W0.8060.73
73_P123_Q0.7940.72
29_L35_W0.7910.71
43_D46_T0.7870.71
73_P140_E0.7770.70
108_D113_L0.7750.70
19_E44_G0.7740.70
44_G51_L0.7670.69
27_E30_Y0.7620.69
16_W50_N0.7610.68
80_A83_R0.7600.68
144_A148_A0.7590.68
19_E23_V0.7550.68
52_L107_A0.7500.67
20_G24_R0.7480.67
105_A108_D0.7470.67
75_T123_Q0.7460.67
120_V152_Q0.7450.67
95_L130_Y0.7450.67
29_L64_L0.7440.67
48_G99_S0.7410.66
126_M137_L0.7400.66
9_M44_G0.7390.66
142_L145_A0.7380.66
133_S139_R0.7340.66
11_L51_L0.7330.66
20_G43_D0.7320.65
60_H118_A0.7320.65
147_Q151_A0.7300.65
137_L140_E0.7250.65
100_F103_V0.7230.65
33_Y150_L0.7080.63
67_I77_R0.7050.63
7_V61_L0.7000.62
69_Y75_T0.6970.62
49_L53_G0.6890.61
21_F66_A0.6840.60
103_V110_R0.6770.59
19_E124_P0.6730.59
12_G18_D0.6670.58
65_D96_H0.6670.58
139_R142_L0.6610.58
95_L98_N0.6590.57
49_L94_S0.6560.57
111_G151_A0.6510.56
53_G97_Q0.6460.56
19_E96_H0.6430.56
118_A123_Q0.6430.56
20_G23_V0.6390.55
63_I100_F0.6370.55
34_H146_E0.6360.55
50_N94_S0.6340.55
42_V71_L0.6340.55
5_R117_I0.6260.54
43_D48_G0.6260.54
13_N45_G0.6240.53
148_A152_Q0.6210.53
58_A114_P0.6200.53
17_A61_L0.6150.52
94_S102_E0.6130.52
29_L124_P0.6120.52
19_E24_R0.6060.51
25_V145_A0.6060.51
33_Y158_I0.6050.51
29_L41_I0.6050.51
44_G94_S0.6030.51
12_G22_G0.6000.51
79_Y130_Y0.5970.50
145_A152_Q0.5920.50
15_L44_G0.5910.49
8_V38_Y0.5870.49
86_A115_A0.5860.49
29_L150_L0.5830.49
52_L106_L0.5810.48
89_S101_S0.5780.48
64_L138_A0.5760.48
44_G53_G0.5730.47
47_Q103_V0.5720.47
94_S122_L0.5720.47
16_W100_F0.5700.47
20_G45_G0.5700.47
59_S111_G0.5690.47
122_L148_A0.5670.47
27_E43_D0.5620.46
74_G141_Q0.5600.46
103_V123_Q0.5600.46
101_S111_G0.5510.45
26_A43_D0.5510.45
53_G56_E0.5510.45
50_N98_N0.5500.45
20_G94_S0.5490.45
37_E139_R0.5490.45
72_E125_A0.5470.44
5_R60_H0.5470.44
32_H147_Q0.5420.44
60_H115_A0.5410.44
7_V30_Y0.5400.44
7_V27_E0.5400.44
17_A132_G0.5380.43
91_K95_L0.5380.43
21_F114_P0.5360.43
110_R119_L0.5350.43
72_E155_A0.5340.43
58_A61_L0.5300.42
36_P158_I0.5280.42
67_I101_S0.5270.42
67_I157_G0.5240.42
69_Y79_Y0.5240.42
49_L99_S0.5240.42
11_L44_G0.5230.42
5_R151_A0.5220.41
19_E46_T0.5210.41
19_E109_I0.5190.41
56_E98_N0.5180.41
16_W98_N0.5150.41
47_Q79_Y0.5120.40
37_E72_E0.5120.40
34_H151_A0.5100.40
9_M42_V0.5070.40
116_H152_Q0.5060.40
82_E151_A0.5040.39
18_D135_S0.5040.39
5_R8_V0.5040.39
104_L108_D0.5030.39
77_R121_G0.5030.39
121_G124_P0.5020.39
6_V156_W0.5000.39
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1cfzA 1 0.8256 100 0.289 Contact Map
2e85A 2 0.7949 100 0.373 Contact Map
3pu6A 1 0.6821 100 0.395 Contact Map
1c8bA 3 0.7128 95.8 0.884 Contact Map
2hk9A 1 0.6974 79.7 0.919 Contact Map
3b1fA 2 0.8769 75.1 0.923 Contact Map
2rcyA 5 0.8872 74.7 0.923 Contact Map
3triA 2 0.8872 74.1 0.923 Contact Map
2dbqA 2 0.8256 72.6 0.924 Contact Map
2d0iA 2 0.8462 71 0.925 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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