GREMLIN Database
AGP - Glucose-1-phosphatase
UniProt: P19926 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10033
Length: 413 (334)
Sequences: 2937 (2350)
Seq/√Len: 128.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
79_E120_T5.1701.00
391_C399_C5.1591.00
109_A125_I4.6431.00
32_Q348_H3.7201.00
296_V405_D3.5171.00
184_L187_I3.3961.00
400_P403_K2.8441.00
31_L347_W2.6811.00
34_V305_I2.6751.00
319_L342_I2.6651.00
344_F359_I2.5891.00
37_M318_L2.5361.00
86_M124_F2.5061.00
290_Y294_A2.4941.00
42_L78_L2.4191.00
187_I190_Y2.4091.00
79_E339_G2.4021.00
76_G123_F2.3141.00
149_F152_V2.2841.00
146_D150_N2.2061.00
295_L346_R2.1871.00
116_R311_H2.1221.00
346_R355_D2.1211.00
42_L241_E2.1011.00
32_Q355_D2.0861.00
109_A121_A2.0861.00
29_Y349_D2.0791.00
184_L188_V2.0621.00
203_S207_G2.0551.00
39_R43_R2.0351.00
207_G210_T2.0191.00
42_L338_I2.0111.00
207_G212_S2.0071.00
112_N117_T2.0011.00
79_E124_F1.9401.00
310_G314_N1.9401.00
77_V81_Y1.8441.00
39_R116_R1.8141.00
248_V251_G1.7961.00
43_R116_R1.7761.00
80_V126_T1.7251.00
86_M343_V1.6891.00
38_S82_M1.6771.00
117_T311_H1.6691.00
106_T304_K1.6621.00
32_Q346_R1.6501.00
291_I344_F1.6451.00
235_F251_G1.6341.00
110_Y290_Y1.6131.00
181_Y184_L1.6131.00
255_S258_Q1.5911.00
154_T157_S1.5811.00
82_M341_K1.5781.00
145_M151_P1.5761.00
157_S162_E1.5731.00
168_M172_L1.5611.00
44_A72_T1.5381.00
61_W64_W1.5331.00
208_K212_S1.5321.00
40_H43_R1.5311.00
315_I342_I1.5261.00
36_M343_V1.5251.00
205_V209_N1.5251.00
287_L291_I1.5251.00
299_R401_M1.5251.00
29_Y347_W1.5241.00
207_G211_F1.5071.00
208_K214_K1.4991.00
148_T152_V1.4941.00
148_T151_P1.4891.00
90_L345_Q1.4551.00
245_M248_V1.4431.00
300_T303_P1.4391.00
203_S206_D1.4211.00
147_P150_N1.4171.00
33_Q295_L1.4141.00
89_W360_E1.4121.00
347_W358_K1.3871.00
183_L186_K1.3801.00
354_R400_P1.3751.00
145_M150_N1.3701.00
40_H116_R1.3691.00
83_G127_G1.3541.00
257_Q261_V1.3511.00
147_P151_P1.3481.00
73_T76_G1.3421.00
152_V157_S1.3371.00
177_L184_L1.3271.00
208_K211_F1.3251.00
294_A306_T1.3211.00
70_Q115_Q1.3181.00
78_L339_G1.3001.00
39_R311_H1.2931.00
124_F128_A1.2881.00
403_K406_S1.2831.00
212_S215_Y1.2811.00
204_L215_Y1.2771.00
157_S165_V1.2771.00
64_W68_G1.2731.00
318_L321_A1.2681.00
97_K106_T1.2641.00
356_L398_F1.2581.00
210_T214_K1.2541.00
204_L207_G1.2531.00
43_R311_H1.2431.00
64_W67_P1.2421.00
115_Q119_A1.2371.00
149_F153_I1.2361.00
203_S210_T1.2301.00
348_H355_D1.2301.00
392_P403_K1.2261.00
30_Q348_H1.2241.00
354_R402_D1.2190.99
145_M148_T1.2190.99
288_V321_A1.2120.99
345_Q358_K1.2120.99
204_L208_K1.2110.99
61_W66_V1.2100.99
165_V171_E1.2080.99
312_D336_T1.2030.99
203_S212_S1.2020.99
180_S183_L1.1970.99
41_N78_L1.1920.99
177_L188_V1.1920.99
118_V122_Q1.1910.99
38_S124_F1.1860.99
43_R312_D1.1850.99
146_D151_P1.1850.99
292_D405_D1.1840.99
143_G146_D1.1840.99
87_R130_P1.1810.99
36_M86_M1.1680.99
256_D260_K1.1660.99
112_N311_H1.1640.99
295_L357_M1.1600.99
356_L400_P1.1520.99
270_Q273_L1.1470.99
357_M401_M1.1360.99
145_M149_F1.1340.99
208_K213_A1.1320.99
40_H311_H1.1250.99
204_L210_T1.1220.99
29_Y356_L1.1210.99
336_T361_Y1.1200.99
177_L187_I1.1190.99
46_L312_D1.1110.99
347_W398_F1.1060.99
184_L189_N1.0970.99
120_T339_G1.0960.99
177_L180_S1.0940.99
41_N79_E1.0930.99
85_Y363_Y1.0890.99
234_A238_Q1.0840.99
39_R338_I1.0830.99
263_S267_N1.0810.99
185_E188_V1.0770.99
232_V259_W1.0730.99
205_V212_S1.0730.99
69_G114_L1.0690.99
209_N213_A1.0680.99
318_L344_F1.0650.99
147_P152_V1.0650.99
137_H140_E1.0640.99
264_K267_N1.0600.99
263_S333_N1.0530.99
46_L69_G1.0490.98
38_S307_V1.0400.98
87_R128_A1.0310.98
240_Y338_I1.0300.98
31_L345_Q1.0210.98
401_M405_D1.0200.98
38_S79_E1.0200.98
60_K63_E1.0150.98
146_D152_V1.0130.98
144_T147_P1.0100.98
181_Y188_V1.0090.98
159_A163_Q1.0080.98
181_Y185_E1.0040.98
182_Q185_E1.0010.98
74_K78_L0.9880.98
43_R233_D0.9870.98
76_G119_A0.9870.98
144_T149_F0.9810.98
143_G148_T0.9750.98
183_L190_Y0.9690.97
34_V345_Q0.9630.97
201_Q205_V0.9580.97
69_G116_R0.9540.97
203_S208_K0.9530.97
119_A122_Q0.9490.97
83_G87_R0.9460.97
60_K64_W0.9440.97
311_H314_N0.9410.97
224_P227_V0.9390.97
358_K365_S0.9390.97
203_S209_N0.9390.97
116_R312_D0.9380.97
37_M310_G0.9360.97
35_L294_A0.9350.97
403_K407_V0.9320.97
33_Q298_D0.9260.97
180_S188_V0.9260.97
143_G151_P0.9260.97
405_D409_N0.9250.97
42_L240_Y0.9210.97
288_V292_D0.9190.96
291_I318_L0.9170.96
144_T152_V0.9160.96
289_S293_K0.9150.96
168_M173_S0.9150.96
318_L342_I0.9120.96
128_A305_I0.9000.96
180_S187_I0.8940.96
168_M171_E0.8900.96
362_V366_A0.8890.96
123_F127_G0.8890.96
204_L209_N0.8860.96
210_T215_Y0.8830.96
182_Q187_I0.8830.96
35_L295_L0.8820.96
87_R91_A0.8810.96
150_N153_I0.8780.95
178_T182_Q0.8760.95
180_S190_Y0.8760.95
38_S309_V0.8750.95
318_L322_L0.8750.95
257_Q260_K0.8640.95
113_S155_D0.8610.95
328_Q331_D0.8590.95
31_L95_M0.8540.95
402_D406_S0.8530.95
284_A317_S0.8530.95
29_Y398_F0.8510.95
176_Q187_I0.8500.95
33_Q306_T0.8480.94
158_A162_E0.8470.94
109_A307_V0.8410.94
270_Q312_D0.8410.94
153_I156_D0.8390.94
145_M152_V0.8390.94
103_P106_T0.8360.94
319_L324_F0.8360.94
80_V83_G0.8320.94
34_V89_W0.8310.94
61_W67_P0.8300.94
340_G361_Y0.8300.94
36_M305_I0.8290.94
83_G128_A0.8290.94
207_G213_A0.8260.94
208_K215_Y0.8210.93
178_T184_L0.8180.93
157_S160_F0.8170.93
185_E189_N0.8150.93
157_S172_L0.8110.93
319_L361_Y0.8060.93
35_L308_L0.8050.93
71_L75_G0.8010.93
228_G235_F0.8000.93
337_P362_V0.8000.93
206_D210_T0.7980.92
96_V99_G0.7960.92
144_T150_N0.7940.92
219_P222_S0.7940.92
46_L49_N0.7940.92
80_V127_G0.7940.92
282_N285_K0.7920.92
362_V365_S0.7880.92
156_D162_E0.7870.92
31_L96_V0.7870.92
112_N340_G0.7870.92
46_L114_L0.7860.92
22_A25_V0.7850.92
41_N339_G0.7840.92
176_Q180_S0.7820.92
209_N212_S0.7780.92
127_G130_P0.7710.91
299_R346_R0.7640.91
177_L185_E0.7640.91
254_K258_Q0.7610.91
41_N71_L0.7600.91
211_F214_K0.7590.91
292_D296_V0.7590.91
202_C205_V0.7580.90
81_Y84_H0.7540.90
294_A308_L0.7540.90
111_A117_T0.7510.90
95_M98_S0.7490.90
125_I130_P0.7420.90
313_S316_A0.7420.90
44_A66_V0.7410.89
62_P66_V0.7400.89
269_Y273_L0.7380.89
37_M287_L0.7370.89
21_Q24_T0.7330.89
406_S409_N0.7330.89
177_L181_Y0.7330.89
341_K362_V0.7280.89
393_I403_K0.7270.89
126_T149_F0.7270.89
204_L211_F0.7230.88
89_W345_Q0.7220.88
96_V128_A0.7210.88
204_L214_K0.7190.88
146_D149_F0.7160.88
268_G272_S0.7160.88
184_L190_Y0.7160.88
202_C206_D0.7140.88
147_P153_I0.7140.88
158_A161_S0.7120.87
114_L117_T0.7080.87
80_V84_H0.7060.87
205_V210_T0.7050.87
108_Y293_K0.7050.87
237_L338_I0.7010.87
343_V360_E0.6980.86
157_S161_S0.6950.86
358_K398_F0.6900.86
267_N272_S0.6890.86
245_M259_W0.6880.86
186_K189_N0.6880.86
46_L112_N0.6860.86
124_F309_V0.6850.85
207_G214_K0.6850.85
148_T160_F0.6810.85
299_R355_D0.6810.85
213_A219_P0.6800.85
169_E173_S0.6750.85
118_V156_D0.6750.85
33_Q343_V0.6700.84
205_V211_F0.6690.84
235_F239_Y0.6690.84
295_L298_D0.6680.84
72_T241_E0.6660.84
88_E353_N0.6660.84
208_K225_L0.6660.84
346_R357_M0.6650.84
296_V401_M0.6640.84
295_L401_M0.6620.83
393_I401_M0.6600.83
162_E165_V0.6600.83
144_T151_P0.6580.83
250_W407_V0.6580.83
180_S184_L0.6560.83
274_F320_T0.6550.83
233_D236_T0.6550.83
177_L190_Y0.6540.83
42_L74_K0.6540.83
203_S214_K0.6530.83
167_A170_K0.6530.83
157_S171_E0.6530.83
390_G393_I0.6530.83
179_D183_L0.6520.83
227_V230_S0.6520.83
201_Q211_F0.6510.82
135_P138_H0.6490.82
178_T181_Y0.6480.82
341_K345_Q0.6470.82
206_D212_S0.6460.82
177_L183_L0.6460.82
182_Q186_K0.6440.82
31_L34_V0.6430.82
211_F215_Y0.6430.82
135_P139_Q0.6430.82
125_I154_T0.6420.82
291_I322_L0.6400.81
125_I307_V0.6390.81
179_D185_E0.6370.81
233_D312_D0.6360.81
124_F307_V0.6360.81
41_N75_G0.6350.81
204_L213_A0.6350.81
176_Q186_K0.6340.81
160_F165_V0.6320.81
165_V169_E0.6320.81
268_G271_D0.6280.80
136_V139_Q0.6270.80
61_W65_D0.6270.80
77_V80_V0.6270.80
152_V155_D0.6260.80
91_A129_F0.6260.80
185_E190_Y0.6250.80
125_I129_F0.6250.80
143_G150_N0.6240.80
276_S279_V0.6240.80
60_K67_P0.6230.80
250_W253_I0.6230.80
30_Q256_D0.6190.79
229_N265_L0.6160.79
181_Y187_I0.6160.79
85_Y362_V0.6150.79
402_D405_D0.6120.78
203_S215_Y0.6110.78
204_L219_P0.6100.78
206_D213_A0.6050.78
69_G312_D0.6040.77
235_F238_Q0.6030.77
69_G313_S0.6030.77
287_L318_L0.6000.77
63_E67_P0.5970.77
33_Q346_R0.5970.77
284_A288_V0.5950.76
311_H322_L0.5950.76
201_Q208_K0.5940.76
287_L337_P0.5920.76
186_K190_Y0.5910.76
206_D209_N0.5900.76
287_L308_L0.5900.76
330_H336_T0.5890.76
209_N215_Y0.5890.76
295_L405_D0.5880.76
121_A309_V0.5840.75
170_K173_S0.5840.75
202_C209_N0.5830.75
183_L187_I0.5810.75
143_G149_F0.5800.75
201_Q204_L0.5770.74
293_K297_T0.5770.74
288_V322_L0.5760.74
177_L182_Q0.5750.74
183_L188_V0.5740.74
26_P29_Y0.5730.74
80_V123_F0.5720.74
257_Q294_A0.5720.74
284_A287_L0.5700.73
119_A123_F0.5690.73
340_G364_Q0.5680.73
39_R312_D0.5670.73
78_L363_Y0.5670.73
258_Q272_S0.5660.73
156_D161_S0.5640.73
274_F277_P0.5640.73
288_V291_I0.5630.72
143_G152_V0.5630.72
152_V165_V0.5630.72
207_G215_Y0.5620.72
148_T153_I0.5610.72
34_V90_L0.5610.72
263_S266_K0.5590.72
21_Q25_V0.5570.72
248_V253_I0.5560.71
312_D315_I0.5540.71
159_A169_E0.5540.71
229_N233_D0.5530.71
102_P129_F0.5530.71
87_R131_G0.5520.71
204_L212_S0.5490.71
251_G254_K0.5480.70
309_V338_I0.5480.70
167_A171_E0.5480.70
71_L76_G0.5470.70
112_N310_G0.5470.70
342_I359_I0.5470.70
124_F343_V0.5460.70
204_L228_G0.5460.70
201_Q207_G0.5440.70
231_L235_F0.5430.70
35_L291_I0.5430.70
404_F408_L0.5430.70
40_H312_D0.5420.70
162_E169_E0.5420.70
311_H337_P0.5400.69
312_D335_R0.5400.69
113_S117_T0.5390.69
44_A241_E0.5360.69
98_S206_D0.5350.69
265_L269_Y0.5330.68
120_T309_V0.5310.68
117_T312_D0.5310.68
118_V155_D0.5310.68
348_H353_N0.5300.68
43_R338_I0.5300.68
390_G407_V0.5300.68
39_R117_T0.5280.68
236_T239_Y0.5270.67
78_L241_E0.5260.67
83_G345_Q0.5250.67
233_D238_Q0.5250.67
30_Q304_K0.5240.67
203_S232_V0.5230.67
261_V265_L0.5230.67
233_D338_I0.5220.67
45_P237_L0.5220.67
179_D184_L0.5210.67
79_E314_N0.5200.66
292_D408_L0.5190.66
205_V208_K0.5180.66
83_G124_F0.5170.66
132_C135_P0.5140.66
157_S163_Q0.5140.66
348_H402_D0.5140.66
157_S168_M0.5130.65
166_A172_L0.5120.65
38_S343_V0.5090.65
205_V213_A0.5090.65
331_D334_E0.5080.65
200_Q207_G0.5080.65
159_A164_A0.5060.64
77_V354_R0.5050.64
41_N120_T0.5050.64
86_M211_F0.5040.64
315_I319_L0.5000.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4arvA 1 0.9201 100 0.275 Contact Map
3zhcA 2 0.9274 100 0.277 Contact Map
3ntlA 2 0.9419 100 0.3 Contact Map
1dkqA 1 0.9298 100 0.304 Contact Map
4aruA 1 0.9177 100 0.309 Contact Map
2wnhA 3 0.9298 100 0.319 Contact Map
1nd6A 4 0.7845 100 0.331 Contact Map
3it3A 2 0.7772 100 0.332 Contact Map
4jobA 1 0.7772 100 0.364 Contact Map
1qwoA 1 0.8668 100 0.392 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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