AGP - ECOLI - GREMLIN Contacts

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AGP - Glucose-1-phosphatase

UniProt:	P19926	Sequences: MNKTLIAAAVAGIVLLASNAQAQTVPEGYQLQQVLMMSRHNLRAPLANNGSVLEQSTPNKWPEWDVPGGQLTTKGGVLEVYMGHYMREWLAEQGMVKSGECPPPYTVYAYANSLQRTVATAQFFITGAFPGCDIPVHHQEKMGTMDPTFNPVITDDSAAFSEQAVAAMEKELSKLQLTDSYQLLEKIVNYKDSPACKEKQQCSLVDGKNTFSAKYQQEPGVSGPLKVGNSLVDAFTLQYYEGFPMDQVAWGEIKSDQQWKVLSKLKNGYQDSLFTSPEVARNVAKPLVSYIDKALVTDRTSAPKITVLVGHDSNIASLLTALDFKPYQLHDQNERTPIGGKIVFQRWHDSKANRDLMKIEYVYQSAEQLRNADALTLQAPAQRVTLELSGCPIDADGFCPMDKFDSVLNEAVK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10033
Length:	413 (334)
Sequences:	2937 (2350)
Seq/√Len:	128.6

ECOLI - AGP PPA

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
79_E	120_T	5.170	1.00
391_C	399_C	5.159	1.00
109_A	125_I	4.643	1.00
32_Q	348_H	3.720	1.00
296_V	405_D	3.517	1.00
184_L	187_I	3.396	1.00
400_P	403_K	2.844	1.00
31_L	347_W	2.681	1.00
34_V	305_I	2.675	1.00
319_L	342_I	2.665	1.00
344_F	359_I	2.589	1.00
37_M	318_L	2.536	1.00
86_M	124_F	2.506	1.00
290_Y	294_A	2.494	1.00
42_L	78_L	2.419	1.00
187_I	190_Y	2.409	1.00
79_E	339_G	2.402	1.00
76_G	123_F	2.314	1.00
149_F	152_V	2.284	1.00
146_D	150_N	2.206	1.00
295_L	346_R	2.187	1.00
116_R	311_H	2.122	1.00
346_R	355_D	2.121	1.00
42_L	241_E	2.101	1.00
32_Q	355_D	2.086	1.00
109_A	121_A	2.086	1.00
29_Y	349_D	2.079	1.00
184_L	188_V	2.062	1.00
203_S	207_G	2.055	1.00
39_R	43_R	2.035	1.00
207_G	210_T	2.019	1.00
42_L	338_I	2.011	1.00
207_G	212_S	2.007	1.00
112_N	117_T	2.001	1.00
79_E	124_F	1.940	1.00
310_G	314_N	1.940	1.00
77_V	81_Y	1.844	1.00
39_R	116_R	1.814	1.00
248_V	251_G	1.796	1.00
43_R	116_R	1.776	1.00
80_V	126_T	1.725	1.00
86_M	343_V	1.689	1.00
38_S	82_M	1.677	1.00
117_T	311_H	1.669	1.00
106_T	304_K	1.662	1.00
32_Q	346_R	1.650	1.00
291_I	344_F	1.645	1.00
235_F	251_G	1.634	1.00
110_Y	290_Y	1.613	1.00
181_Y	184_L	1.613	1.00
255_S	258_Q	1.591	1.00
154_T	157_S	1.581	1.00
82_M	341_K	1.578	1.00
145_M	151_P	1.576	1.00
157_S	162_E	1.573	1.00
168_M	172_L	1.561	1.00
44_A	72_T	1.538	1.00
61_W	64_W	1.533	1.00
208_K	212_S	1.532	1.00
40_H	43_R	1.531	1.00
315_I	342_I	1.526	1.00
36_M	343_V	1.525	1.00
205_V	209_N	1.525	1.00
287_L	291_I	1.525	1.00
299_R	401_M	1.525	1.00
29_Y	347_W	1.524	1.00
207_G	211_F	1.507	1.00
208_K	214_K	1.499	1.00
148_T	152_V	1.494	1.00
148_T	151_P	1.489	1.00
90_L	345_Q	1.455	1.00
245_M	248_V	1.443	1.00
300_T	303_P	1.439	1.00
203_S	206_D	1.421	1.00
147_P	150_N	1.417	1.00
33_Q	295_L	1.414	1.00
89_W	360_E	1.412	1.00
347_W	358_K	1.387	1.00
183_L	186_K	1.380	1.00
354_R	400_P	1.375	1.00
145_M	150_N	1.370	1.00
40_H	116_R	1.369	1.00
83_G	127_G	1.354	1.00
257_Q	261_V	1.351	1.00
147_P	151_P	1.348	1.00
73_T	76_G	1.342	1.00
152_V	157_S	1.337	1.00
177_L	184_L	1.327	1.00
208_K	211_F	1.325	1.00
294_A	306_T	1.321	1.00
70_Q	115_Q	1.318	1.00
78_L	339_G	1.300	1.00
39_R	311_H	1.293	1.00
124_F	128_A	1.288	1.00
403_K	406_S	1.283	1.00
212_S	215_Y	1.281	1.00
204_L	215_Y	1.277	1.00
157_S	165_V	1.277	1.00
64_W	68_G	1.273	1.00
318_L	321_A	1.268	1.00
97_K	106_T	1.264	1.00
356_L	398_F	1.258	1.00
210_T	214_K	1.254	1.00
204_L	207_G	1.253	1.00
43_R	311_H	1.243	1.00
64_W	67_P	1.242	1.00
115_Q	119_A	1.237	1.00
149_F	153_I	1.236	1.00
203_S	210_T	1.230	1.00
348_H	355_D	1.230	1.00
392_P	403_K	1.226	1.00
30_Q	348_H	1.224	1.00
354_R	402_D	1.219	0.99
145_M	148_T	1.219	0.99
288_V	321_A	1.212	0.99
345_Q	358_K	1.212	0.99
204_L	208_K	1.211	0.99
61_W	66_V	1.210	0.99
165_V	171_E	1.208	0.99
312_D	336_T	1.203	0.99
203_S	212_S	1.202	0.99
180_S	183_L	1.197	0.99
41_N	78_L	1.192	0.99
177_L	188_V	1.192	0.99
118_V	122_Q	1.191	0.99
38_S	124_F	1.186	0.99
43_R	312_D	1.185	0.99
146_D	151_P	1.185	0.99
292_D	405_D	1.184	0.99
143_G	146_D	1.184	0.99
87_R	130_P	1.181	0.99
36_M	86_M	1.168	0.99
256_D	260_K	1.166	0.99
112_N	311_H	1.164	0.99
295_L	357_M	1.160	0.99
356_L	400_P	1.152	0.99
270_Q	273_L	1.147	0.99
357_M	401_M	1.136	0.99
145_M	149_F	1.134	0.99
208_K	213_A	1.132	0.99
40_H	311_H	1.125	0.99
204_L	210_T	1.122	0.99
29_Y	356_L	1.121	0.99
336_T	361_Y	1.120	0.99
177_L	187_I	1.119	0.99
46_L	312_D	1.111	0.99
347_W	398_F	1.106	0.99
184_L	189_N	1.097	0.99
120_T	339_G	1.096	0.99
177_L	180_S	1.094	0.99
41_N	79_E	1.093	0.99
85_Y	363_Y	1.089	0.99
234_A	238_Q	1.084	0.99
39_R	338_I	1.083	0.99
263_S	267_N	1.081	0.99
185_E	188_V	1.077	0.99
232_V	259_W	1.073	0.99
205_V	212_S	1.073	0.99
69_G	114_L	1.069	0.99
209_N	213_A	1.068	0.99
318_L	344_F	1.065	0.99
147_P	152_V	1.065	0.99
137_H	140_E	1.064	0.99
264_K	267_N	1.060	0.99
263_S	333_N	1.053	0.99
46_L	69_G	1.049	0.98
38_S	307_V	1.040	0.98
87_R	128_A	1.031	0.98
240_Y	338_I	1.030	0.98
31_L	345_Q	1.021	0.98
401_M	405_D	1.020	0.98
38_S	79_E	1.020	0.98
60_K	63_E	1.015	0.98
146_D	152_V	1.013	0.98
144_T	147_P	1.010	0.98
181_Y	188_V	1.009	0.98
159_A	163_Q	1.008	0.98
181_Y	185_E	1.004	0.98
182_Q	185_E	1.001	0.98
74_K	78_L	0.988	0.98
43_R	233_D	0.987	0.98
76_G	119_A	0.987	0.98
144_T	149_F	0.981	0.98
143_G	148_T	0.975	0.98
183_L	190_Y	0.969	0.97
34_V	345_Q	0.963	0.97
201_Q	205_V	0.958	0.97
69_G	116_R	0.954	0.97
203_S	208_K	0.953	0.97
119_A	122_Q	0.949	0.97
83_G	87_R	0.946	0.97
60_K	64_W	0.944	0.97
311_H	314_N	0.941	0.97
224_P	227_V	0.939	0.97
358_K	365_S	0.939	0.97
203_S	209_N	0.939	0.97
116_R	312_D	0.938	0.97
37_M	310_G	0.936	0.97
35_L	294_A	0.935	0.97
403_K	407_V	0.932	0.97
33_Q	298_D	0.926	0.97
180_S	188_V	0.926	0.97
143_G	151_P	0.926	0.97
405_D	409_N	0.925	0.97
42_L	240_Y	0.921	0.97
288_V	292_D	0.919	0.96
291_I	318_L	0.917	0.96
144_T	152_V	0.916	0.96
289_S	293_K	0.915	0.96
168_M	173_S	0.915	0.96
318_L	342_I	0.912	0.96
128_A	305_I	0.900	0.96
180_S	187_I	0.894	0.96
168_M	171_E	0.890	0.96
362_V	366_A	0.889	0.96
123_F	127_G	0.889	0.96
204_L	209_N	0.886	0.96
210_T	215_Y	0.883	0.96
182_Q	187_I	0.883	0.96
35_L	295_L	0.882	0.96
87_R	91_A	0.881	0.96
150_N	153_I	0.878	0.95
178_T	182_Q	0.876	0.95
180_S	190_Y	0.876	0.95
38_S	309_V	0.875	0.95
318_L	322_L	0.875	0.95
257_Q	260_K	0.864	0.95
113_S	155_D	0.861	0.95
328_Q	331_D	0.859	0.95
31_L	95_M	0.854	0.95
402_D	406_S	0.853	0.95
284_A	317_S	0.853	0.95
29_Y	398_F	0.851	0.95
176_Q	187_I	0.850	0.95
33_Q	306_T	0.848	0.94
158_A	162_E	0.847	0.94
109_A	307_V	0.841	0.94
270_Q	312_D	0.841	0.94
153_I	156_D	0.839	0.94
145_M	152_V	0.839	0.94
103_P	106_T	0.836	0.94
319_L	324_F	0.836	0.94
80_V	83_G	0.832	0.94
34_V	89_W	0.831	0.94
61_W	67_P	0.830	0.94
340_G	361_Y	0.830	0.94
36_M	305_I	0.829	0.94
83_G	128_A	0.829	0.94
207_G	213_A	0.826	0.94
208_K	215_Y	0.821	0.93
178_T	184_L	0.818	0.93
157_S	160_F	0.817	0.93
185_E	189_N	0.815	0.93
157_S	172_L	0.811	0.93
319_L	361_Y	0.806	0.93
35_L	308_L	0.805	0.93
71_L	75_G	0.801	0.93
228_G	235_F	0.800	0.93
337_P	362_V	0.800	0.93
206_D	210_T	0.798	0.92
96_V	99_G	0.796	0.92
144_T	150_N	0.794	0.92
219_P	222_S	0.794	0.92
46_L	49_N	0.794	0.92
80_V	127_G	0.794	0.92
282_N	285_K	0.792	0.92
362_V	365_S	0.788	0.92
156_D	162_E	0.787	0.92
31_L	96_V	0.787	0.92
112_N	340_G	0.787	0.92
46_L	114_L	0.786	0.92
22_A	25_V	0.785	0.92
41_N	339_G	0.784	0.92
176_Q	180_S	0.782	0.92
209_N	212_S	0.778	0.92
127_G	130_P	0.771	0.91
299_R	346_R	0.764	0.91
177_L	185_E	0.764	0.91
254_K	258_Q	0.761	0.91
41_N	71_L	0.760	0.91
211_F	214_K	0.759	0.91
292_D	296_V	0.759	0.91
202_C	205_V	0.758	0.90
81_Y	84_H	0.754	0.90
294_A	308_L	0.754	0.90
111_A	117_T	0.751	0.90
95_M	98_S	0.749	0.90
125_I	130_P	0.742	0.90
313_S	316_A	0.742	0.90
44_A	66_V	0.741	0.89
62_P	66_V	0.740	0.89
269_Y	273_L	0.738	0.89
37_M	287_L	0.737	0.89
21_Q	24_T	0.733	0.89
406_S	409_N	0.733	0.89
177_L	181_Y	0.733	0.89
341_K	362_V	0.728	0.89
393_I	403_K	0.727	0.89
126_T	149_F	0.727	0.89
204_L	211_F	0.723	0.88
89_W	345_Q	0.722	0.88
96_V	128_A	0.721	0.88
204_L	214_K	0.719	0.88
146_D	149_F	0.716	0.88
268_G	272_S	0.716	0.88
184_L	190_Y	0.716	0.88
202_C	206_D	0.714	0.88
147_P	153_I	0.714	0.88
158_A	161_S	0.712	0.87
114_L	117_T	0.708	0.87
80_V	84_H	0.706	0.87
205_V	210_T	0.705	0.87
108_Y	293_K	0.705	0.87
237_L	338_I	0.701	0.87
343_V	360_E	0.698	0.86
157_S	161_S	0.695	0.86
358_K	398_F	0.690	0.86
267_N	272_S	0.689	0.86
245_M	259_W	0.688	0.86
186_K	189_N	0.688	0.86
46_L	112_N	0.686	0.86
124_F	309_V	0.685	0.85
207_G	214_K	0.685	0.85
148_T	160_F	0.681	0.85
299_R	355_D	0.681	0.85
213_A	219_P	0.680	0.85
169_E	173_S	0.675	0.85
118_V	156_D	0.675	0.85
33_Q	343_V	0.670	0.84
205_V	211_F	0.669	0.84
235_F	239_Y	0.669	0.84
295_L	298_D	0.668	0.84
72_T	241_E	0.666	0.84
88_E	353_N	0.666	0.84
208_K	225_L	0.666	0.84
346_R	357_M	0.665	0.84
296_V	401_M	0.664	0.84
295_L	401_M	0.662	0.83
393_I	401_M	0.660	0.83
162_E	165_V	0.660	0.83
144_T	151_P	0.658	0.83
250_W	407_V	0.658	0.83
180_S	184_L	0.656	0.83
274_F	320_T	0.655	0.83
233_D	236_T	0.655	0.83
177_L	190_Y	0.654	0.83
42_L	74_K	0.654	0.83
203_S	214_K	0.653	0.83
167_A	170_K	0.653	0.83
157_S	171_E	0.653	0.83
390_G	393_I	0.653	0.83
179_D	183_L	0.652	0.83
227_V	230_S	0.652	0.83
201_Q	211_F	0.651	0.82
135_P	138_H	0.649	0.82
178_T	181_Y	0.648	0.82
341_K	345_Q	0.647	0.82
206_D	212_S	0.646	0.82
177_L	183_L	0.646	0.82
182_Q	186_K	0.644	0.82
31_L	34_V	0.643	0.82
211_F	215_Y	0.643	0.82
135_P	139_Q	0.643	0.82
125_I	154_T	0.642	0.82
291_I	322_L	0.640	0.81
125_I	307_V	0.639	0.81
179_D	185_E	0.637	0.81
233_D	312_D	0.636	0.81
124_F	307_V	0.636	0.81
41_N	75_G	0.635	0.81
204_L	213_A	0.635	0.81
176_Q	186_K	0.634	0.81
160_F	165_V	0.632	0.81
165_V	169_E	0.632	0.81
268_G	271_D	0.628	0.80
136_V	139_Q	0.627	0.80
61_W	65_D	0.627	0.80
77_V	80_V	0.627	0.80
152_V	155_D	0.626	0.80
91_A	129_F	0.626	0.80
185_E	190_Y	0.625	0.80
125_I	129_F	0.625	0.80
143_G	150_N	0.624	0.80
276_S	279_V	0.624	0.80
60_K	67_P	0.623	0.80
250_W	253_I	0.623	0.80
30_Q	256_D	0.619	0.79
229_N	265_L	0.616	0.79
181_Y	187_I	0.616	0.79
85_Y	362_V	0.615	0.79
402_D	405_D	0.612	0.78
203_S	215_Y	0.611	0.78
204_L	219_P	0.610	0.78
206_D	213_A	0.605	0.78
69_G	312_D	0.604	0.77
235_F	238_Q	0.603	0.77
69_G	313_S	0.603	0.77
287_L	318_L	0.600	0.77
63_E	67_P	0.597	0.77
33_Q	346_R	0.597	0.77
284_A	288_V	0.595	0.76
311_H	322_L	0.595	0.76
201_Q	208_K	0.594	0.76
287_L	337_P	0.592	0.76
186_K	190_Y	0.591	0.76
206_D	209_N	0.590	0.76
287_L	308_L	0.590	0.76
330_H	336_T	0.589	0.76
209_N	215_Y	0.589	0.76
295_L	405_D	0.588	0.76
121_A	309_V	0.584	0.75
170_K	173_S	0.584	0.75
202_C	209_N	0.583	0.75
183_L	187_I	0.581	0.75
143_G	149_F	0.580	0.75
201_Q	204_L	0.577	0.74
293_K	297_T	0.577	0.74
288_V	322_L	0.576	0.74
177_L	182_Q	0.575	0.74
183_L	188_V	0.574	0.74
26_P	29_Y	0.573	0.74
80_V	123_F	0.572	0.74
257_Q	294_A	0.572	0.74
284_A	287_L	0.570	0.73
119_A	123_F	0.569	0.73
340_G	364_Q	0.568	0.73
39_R	312_D	0.567	0.73
78_L	363_Y	0.567	0.73
258_Q	272_S	0.566	0.73
156_D	161_S	0.564	0.73
274_F	277_P	0.564	0.73
288_V	291_I	0.563	0.72
143_G	152_V	0.563	0.72
152_V	165_V	0.563	0.72
207_G	215_Y	0.562	0.72
148_T	153_I	0.561	0.72
34_V	90_L	0.561	0.72
263_S	266_K	0.559	0.72
21_Q	25_V	0.557	0.72
248_V	253_I	0.556	0.71
312_D	315_I	0.554	0.71
159_A	169_E	0.554	0.71
229_N	233_D	0.553	0.71
102_P	129_F	0.553	0.71
87_R	131_G	0.552	0.71
204_L	212_S	0.549	0.71
251_G	254_K	0.548	0.70
309_V	338_I	0.548	0.70
167_A	171_E	0.548	0.70
71_L	76_G	0.547	0.70
112_N	310_G	0.547	0.70
342_I	359_I	0.547	0.70
124_F	343_V	0.546	0.70
204_L	228_G	0.546	0.70
201_Q	207_G	0.544	0.70
231_L	235_F	0.543	0.70
35_L	291_I	0.543	0.70
404_F	408_L	0.543	0.70
40_H	312_D	0.542	0.70
162_E	169_E	0.542	0.70
311_H	337_P	0.540	0.69
312_D	335_R	0.540	0.69
113_S	117_T	0.539	0.69
44_A	241_E	0.536	0.69
98_S	206_D	0.535	0.69
265_L	269_Y	0.533	0.68
120_T	309_V	0.531	0.68
117_T	312_D	0.531	0.68
118_V	155_D	0.531	0.68
348_H	353_N	0.530	0.68
43_R	338_I	0.530	0.68
390_G	407_V	0.530	0.68
39_R	117_T	0.528	0.68
236_T	239_Y	0.527	0.67
78_L	241_E	0.526	0.67
83_G	345_Q	0.525	0.67
233_D	238_Q	0.525	0.67
30_Q	304_K	0.524	0.67
203_S	232_V	0.523	0.67
261_V	265_L	0.523	0.67
233_D	338_I	0.522	0.67
45_P	237_L	0.522	0.67
179_D	184_L	0.521	0.67
79_E	314_N	0.520	0.66
292_D	408_L	0.519	0.66
205_V	208_K	0.518	0.66
83_G	124_F	0.517	0.66
132_C	135_P	0.514	0.66
157_S	163_Q	0.514	0.66
348_H	402_D	0.514	0.66
157_S	168_M	0.513	0.65
166_A	172_L	0.512	0.65
38_S	343_V	0.509	0.65
205_V	213_A	0.509	0.65
331_D	334_E	0.508	0.65
200_Q	207_G	0.508	0.65
159_A	164_A	0.506	0.64
77_V	354_R	0.505	0.64
41_N	120_T	0.505	0.64
86_M	211_F	0.504	0.64
315_I	319_L	0.500	0.63

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4arvA	1	0.9201	100	0.275	Contact Map
3zhcA	2	0.9274	100	0.277	Contact Map
3ntlA	2	0.9419	100	0.3	Contact Map
1dkqA	1	0.9298	100	0.304	Contact Map
4aruA	1	0.9177	100	0.309	Contact Map
2wnhA	3	0.9298	100	0.319	Contact Map
1nd6A	4	0.7845	100	0.331	Contact Map
3it3A	2	0.7772	100	0.332	Contact Map
4jobA	1	0.7772	100	0.364	Contact Map
1qwoA	1	0.8668	100	0.392	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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