GREMLIN Database
ENTD - 4'-phosphopantetheinyl transferase EntD
UniProt: P19925 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10262
Length: 206 (181)
Sequences: 1062 (779)
Seq/√Len: 57.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
53_G88_I7.4561.00
149_S201_T4.8741.00
89_S96_L3.7141.00
73_G77_Q3.6371.00
155_F163_D3.2031.00
149_S153_S3.0261.00
150_A201_T2.7001.00
89_S108_I2.6811.00
128_A170_Q2.6811.00
39_L42_A2.5581.00
56_A97_A2.5401.00
132_R170_Q2.5131.00
61_L84_V2.4231.00
179_V183_R2.2751.00
154_A169_Y2.2271.00
125_I130_H2.2241.00
125_I147_A2.2091.00
132_R136_C2.0171.00
23_A27_E2.0081.00
113_S142_L1.9391.00
157_A203_C1.9001.00
52_A95_A1.8280.99
38_Q72_I1.8150.99
126_T170_Q1.8100.99
190_V203_C1.7930.99
60_A99_V1.7470.99
75_L159_E1.7360.99
113_S194_I1.6890.99
44_R48_T1.6870.99
158_S169_Y1.6590.99
61_L99_V1.6580.99
154_A158_S1.6500.99
155_F159_E1.6450.99
74_E77_Q1.6110.99
66_Y84_V1.5700.98
120_L124_I1.5460.98
175_N179_V1.5390.98
85_Y100_S1.4960.98
153_S201_T1.4960.98
38_Q50_H1.4920.98
160_I164_A1.4820.98
158_S164_A1.4610.97
146_L192_W1.4380.97
71_A99_V1.4360.97
178_Q183_R1.4310.97
83_E102_Q1.4260.97
49_E76_R1.4050.97
44_R47_K1.4010.97
164_A185_N1.3810.96
25_F29_D1.3680.96
176_K181_I1.3610.96
55_I59_Y1.3160.95
98_V202_L1.3130.95
27_E47_K1.2570.94
181_I190_V1.2540.94
176_K179_V1.2230.93
121_T125_I1.2220.93
173_S176_K1.2100.93
174_W181_I1.1910.92
61_L71_A1.1750.92
45_K92_G1.1720.91
33_L36_Y1.1710.91
32_W35_H1.1680.91
176_K192_W1.1630.91
87_S98_V1.1550.91
42_A49_E1.1530.91
61_L100_S1.1460.90
57_A80_W1.1360.90
36_Y47_K1.1340.90
171_I184_E1.1300.90
76_R192_W1.1260.90
22_P25_F1.1250.90
120_L147_A1.1140.89
24_N31_L1.1130.89
150_A190_V1.1120.89
149_S154_A1.1070.89
36_Y51_L1.1020.89
146_L199_V1.0820.88
136_C143_A1.0800.88
39_L47_K1.0790.88
56_A60_A1.0700.87
59_Y63_E1.0660.87
82_A161_Q1.0650.87
160_I199_V1.0570.87
153_S203_C1.0350.85
163_D168_D1.0350.85
175_N178_Q1.0230.85
91_C110_E1.0220.85
61_L66_Y1.0150.84
96_L106_I1.0030.84
71_A79_V0.9920.83
31_L76_R0.9900.83
87_S106_I0.9790.82
45_K167_L0.9760.82
74_E163_D0.9300.79
177_Q183_R0.9280.78
25_F31_L0.9230.78
26_C29_D0.9070.77
57_A86_G0.8910.76
191_H202_L0.8890.75
89_S94_T0.8870.75
64_Y84_V0.8810.75
46_R49_E0.8780.74
56_A100_S0.8720.74
44_R96_L0.8690.74
155_F169_Y0.8670.74
89_S110_E0.8630.73
32_W37_A0.8540.72
117_A145_T0.8500.72
53_G79_V0.8490.72
71_A165_G0.8380.71
175_N181_I0.8370.71
176_K183_R0.8360.71
34_P70_P0.8290.70
159_E164_A0.8170.69
149_S165_G0.8140.69
150_A181_I0.8100.68
174_W179_V0.8070.68
77_Q159_E0.8050.68
179_V192_W0.8010.68
177_Q181_I0.8010.68
133_L137_G0.7990.67
104_I203_C0.7990.67
91_C198_I0.7980.67
32_W36_Y0.7960.67
193_Q200_I0.7950.67
39_L51_L0.7870.66
51_L55_I0.7840.66
32_W52_A0.7810.66
35_H50_H0.7730.65
56_A96_L0.7660.64
83_E101_R0.7610.64
121_T147_A0.7590.63
30_L50_H0.7510.62
60_A97_A0.7460.62
40_Q114_V0.7430.62
30_L51_L0.7380.61
136_C199_V0.7350.61
188_F203_C0.7320.61
177_Q182_H0.7320.61
179_V182_H0.7280.60
73_G79_V0.7260.60
87_S187_M0.7230.60
110_E145_T0.7230.60
182_H187_M0.7200.59
120_L145_T0.7130.58
139_A199_V0.7110.58
47_K147_A0.7110.58
157_A188_F0.7080.58
178_Q192_W0.7080.58
175_N180_I0.7060.58
82_A103_P0.7030.57
103_P189_A0.6960.57
178_Q181_I0.6940.56
50_H60_A0.6860.56
73_G109_E0.6850.55
85_Y102_Q0.6840.55
166_F169_Y0.6830.55
94_T108_I0.6830.55
91_C94_T0.6810.55
74_E104_I0.6780.55
86_G99_V0.6770.55
159_E163_D0.6770.55
149_S171_I0.6750.54
91_C108_I0.6740.54
194_I199_V0.6720.54
99_V110_E0.6700.54
123_N171_I0.6690.54
117_A120_L0.6680.54
101_R127_P0.6640.53
77_Q80_W0.6640.53
25_F44_R0.6600.53
35_H190_V0.6600.53
135_D195_K0.6540.52
46_R50_H0.6530.52
155_F164_A0.6510.52
155_F160_I0.6470.51
51_L88_I0.6470.51
158_S163_D0.6430.51
61_L81_P0.6390.50
136_C139_A0.6330.50
64_Y99_V0.6320.50
50_H64_Y0.6260.49
125_I164_A0.6240.49
41_H59_Y0.6190.48
37_A85_Y0.6180.48
164_A168_D0.6160.48
30_L33_L0.6160.48
169_Y203_C0.6090.47
49_E166_F0.6090.47
45_K74_E0.6090.47
114_V145_T0.6050.47
165_G168_D0.5990.46
41_H132_R0.5980.46
45_K62_R0.5970.46
104_I134_A0.5950.46
124_I171_I0.5940.45
56_A145_T0.5930.45
43_G166_F0.5930.45
30_L55_I0.5910.45
132_R168_D0.5880.45
25_F52_A0.5880.45
61_L170_Q0.5860.45
30_L36_Y0.5850.44
149_S199_V0.5830.44
66_Y101_R0.5810.44
61_L68_C0.5770.44
95_A192_W0.5760.43
170_Q182_H0.5750.43
39_L49_E0.5740.43
66_Y85_Y0.5700.43
106_I198_I0.5690.43
43_G49_E0.5690.43
98_V181_I0.5660.42
66_Y187_M0.5640.42
32_W69_V0.5640.42
113_S141_S0.5580.42
164_A169_Y0.5580.42
182_H194_I0.5580.42
58_V116_T0.5570.41
192_W195_K0.5560.41
193_Q196_E0.5550.41
90_H152_E0.5540.41
107_D152_E0.5540.41
90_H156_K0.5540.41
107_D156_K0.5540.41
90_H107_D0.5540.41
152_E156_K0.5540.41
126_T171_I0.5530.41
51_L154_A0.5530.41
72_I79_V0.5530.41
39_L196_E0.5490.41
175_N183_R0.5460.40
83_E103_P0.5460.40
116_T120_L0.5440.40
46_R166_F0.5420.40
87_S153_S0.5400.40
58_V65_G0.5400.40
124_I172_I0.5370.39
180_I183_R0.5360.39
130_H137_G0.5330.39
63_E66_Y0.5330.39
57_A73_G0.5290.38
95_A158_S0.5280.38
43_G169_Y0.5270.38
53_G145_T0.5260.38
106_I189_A0.5260.38
41_H65_G0.5250.38
89_S106_I0.5240.38
173_S180_I0.5230.38
47_K77_Q0.5190.37
48_T52_A0.5190.37
23_A37_A0.5170.37
170_Q185_N0.5170.37
49_E99_V0.5160.37
75_L123_N0.5160.37
52_A188_F0.5130.37
195_K198_I0.5120.37
139_A153_S0.5110.37
122_D130_H0.5080.36
23_A28_Q0.5070.36
131_E199_V0.5050.36
102_Q120_L0.5040.36
51_L145_T0.5030.36
54_R90_H0.5020.36
54_R156_K0.5020.36
54_R152_E0.5020.36
54_R107_D0.5020.36
59_Y122_D0.5020.36
131_E135_D0.5010.36
124_I199_V0.5010.36
78_P81_P0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4qjkA 1 0.9709 100 0.49 Contact Map
4qvhA 2 0.9757 100 0.521 Contact Map
1qr0A 2 0.9417 99.9 0.629 Contact Map
2c43A 1 0.9612 99.9 0.636 Contact Map
4jm7A 3 0.5825 99.5 0.769 Contact Map
2wasA 3 0.5049 99.2 0.798 Contact Map
3qmnA 4 0.5194 99.2 0.803 Contact Map
5cxdA 3 0.534 99.2 0.804 Contact Map
2wdsA 3 0.5194 99.1 0.809 Contact Map
3gwmA 3 0.5146 99 0.815 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0079 seconds.