GREMLIN Database
INSK - Putative transposase InsK for insertion sequence element IS150
UniProt: P19769 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40011
Length: 283 (242)
Sequences: 10863 (7965)
Seq/√Len: 512.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
143_P227_F2.8561.00
156_S172_Q2.5741.00
122_N125_W2.4021.00
127_T187_S2.3971.00
171_D201_I2.3061.00
151_E272_I2.3051.00
120_R123_E2.3001.00
44_K86_L2.2871.00
259_S272_I2.2321.00
228_G232_S2.2241.00
123_E183_P2.2151.00
48_S52_H2.1541.00
126_V223_V2.1471.00
269_L274_Y2.1351.00
213_R219_D2.1191.00
119_T123_E2.0891.00
255_E259_S2.0831.00
64_T68_H2.0641.00
202_L207_I2.0571.00
126_V147_L2.0071.00
143_P223_V1.9811.00
44_K85_T1.8961.00
147_L222_V1.8691.00
225_C228_G1.8531.00
130_T231_K1.8401.00
46_R49_E1.8331.00
242_N245_E1.8211.00
187_S209_Q1.7751.00
125_W173_A1.7701.00
151_E275_R1.7621.00
189_Q211_M1.7321.00
270_T273_E1.7301.00
212_S220_N1.7201.00
69_R273_E1.7121.00
241_S245_E1.7031.00
161_P192_Q1.6791.00
124_K184_V1.6691.00
23_P26_T1.6651.00
202_L209_Q1.6461.00
240_F249_A1.6461.00
127_T185_L1.6421.00
75_N78_A1.6411.00
65_L268_G1.6311.00
120_R183_P1.6011.00
152_V258_N1.5791.00
160_R165_M1.5671.00
156_S168_N1.5581.00
199_Q209_Q1.5581.00
131_E138_K1.5581.00
46_R70_E1.5551.00
40_Y78_A1.5311.00
225_C229_T1.5071.00
127_T193_Y1.5051.00
189_Q214_K1.4961.00
129_V192_Q1.4931.00
230_L250_V1.4671.00
150_N263_S1.4471.00
162_V165_M1.4451.00
152_V226_F1.4331.00
49_E53_E1.4311.00
163_M167_E1.3941.00
60_Y80_Q1.3791.00
142_S193_Y1.3721.00
66_S70_E1.3641.00
144_V173_A1.3631.00
234_C249_A1.3601.00
201_I205_H1.3571.00
64_T79_V1.3561.00
155_Y254_I1.3541.00
149_N274_Y1.3501.00
66_S262_I1.3481.00
223_V227_F1.3451.00
233_E261_R1.3421.00
58_Y62_R1.3391.00
167_E201_I1.2931.00
53_E260_R1.2931.00
69_R262_I1.2771.00
141_L230_L1.2591.00
133_A138_K1.2551.00
154_S169_M1.2501.00
149_N275_R1.2451.00
126_V222_V1.2291.00
131_E140_Y1.2251.00
44_K82_L1.2251.00
125_W144_V1.2181.00
47_I63_V1.2161.00
121_P149_N1.2101.00
269_L273_E1.2071.00
150_N222_V1.2071.00
126_V220_N1.2041.00
118_A124_K1.1991.00
127_T144_V1.1981.00
194_R211_M1.1981.00
213_R216_N1.1931.00
150_N265_K1.1861.00
254_I258_N1.1801.00
144_V169_M1.1791.00
218_L221_A1.1771.00
62_R233_E1.1761.00
142_S169_M1.1741.00
78_A81_R1.1711.00
66_S69_R1.1611.00
152_V254_I1.1601.00
80_Q84_G1.1541.00
64_T76_H1.1531.00
141_L155_Y1.1491.00
212_S219_D1.1461.00
139_L243_I1.1461.00
247_K251_T1.1431.00
124_K147_L1.1391.00
200_N204_E1.1341.00
186_H219_D1.1341.00
266_L274_Y1.1221.00
234_C240_F1.1201.00
167_E197_R1.1181.00
186_H210_S1.1111.00
192_Q195_M1.1091.00
60_Y76_H1.1041.00
46_R72_K1.1011.00
44_K48_S1.0921.00
246_L250_V1.0851.00
233_E253_Y1.0671.00
174_F207_I1.0591.00
139_L246_L1.0591.00
184_V210_S1.0561.00
25_S28_Y1.0481.00
163_M197_R1.0451.00
216_N219_D1.0371.00
118_A123_E1.0371.00
183_P207_I1.0281.00
129_V161_P1.0271.00
25_S29_Y1.0261.00
159_E243_I1.0251.00
255_E260_R1.0251.00
45_K49_E1.0171.00
145_I223_V1.0131.00
120_R148_F1.0091.00
145_I222_V1.0061.00
158_S165_M1.0021.00
154_S172_Q0.9971.00
130_T227_F0.9881.00
77_K80_Q0.9871.00
124_K186_H0.9801.00
46_R50_I0.9791.00
245_E249_A0.9781.00
163_M195_M0.9641.00
29_Y33_A0.9561.00
121_P148_F0.9501.00
270_T274_Y0.9491.00
257_Y263_S0.9461.00
220_N223_V0.9381.00
266_L270_T0.9381.00
191_W195_M0.9331.00
226_F230_L0.9321.00
164_N168_N0.9301.00
43_V46_R0.9291.00
164_N197_R0.9271.00
198_Y202_L0.9271.00
41_A45_K0.9271.00
249_A252_E0.9211.00
134_V137_R0.9201.00
174_F205_H0.9171.00
264_L268_G0.9121.00
77_K81_R0.9071.00
129_V142_S0.9041.00
76_H80_Q0.9011.00
262_I266_L0.9001.00
191_W194_R0.8991.00
170_L185_L0.8951.00
185_L198_Y0.8951.00
126_V221_A0.8941.00
24_R28_Y0.8921.00
185_L207_I0.8921.00
82_L86_L0.8861.00
238_D249_A0.8851.00
263_S266_L0.8831.00
26_T30_H0.8831.00
153_I176_K0.8821.00
157_L247_K0.8751.00
122_N177_L0.8731.00
143_P226_F0.8701.00
47_I82_L0.8691.00
22_I26_T0.8661.00
22_I27_F0.8621.00
229_T263_S0.8591.00
50_I66_S0.8591.00
161_P191_W0.8561.00
129_V140_Y0.8561.00
48_S86_L0.8501.00
118_A147_L0.8501.00
129_V166_V0.8471.00
243_I247_K0.8461.00
167_E171_D0.8441.00
266_L269_L0.8421.00
145_I152_V0.8411.00
42_D46_R0.8361.00
186_H212_S0.8311.00
161_P165_M0.8291.00
43_V74_I0.8291.00
158_S162_V0.8241.00
48_S51_Y0.8241.00
86_L89_K0.8241.00
196_R200_N0.8201.00
50_I63_V0.8181.00
26_T29_Y0.8161.00
51_Y56_G0.8161.00
187_S211_M0.8161.00
229_T257_Y0.8141.00
63_V83_M0.8091.00
200_N203_K0.8081.00
122_N275_R0.8061.00
177_L275_R0.8051.00
145_I226_F0.7941.00
112_L124_K0.7841.00
251_T255_E0.7841.00
153_I254_I0.7841.00
166_V198_Y0.7781.00
140_Y161_P0.7771.00
67_L79_V0.7721.00
31_L35_S0.7711.00
134_V139_L0.7681.00
142_S165_M0.7661.00
127_T142_S0.7591.00
125_W183_P0.7561.00
234_C250_V0.7521.00
126_V186_H0.7521.00
184_V208_K0.7471.00
195_M198_Y0.7461.00
62_R66_S0.7451.00
145_I150_N0.7441.00
115_D124_K0.7381.00
199_Q203_K0.7351.00
153_I173_A0.7331.00
132_F246_L0.7311.00
60_Y63_V0.7301.00
245_E248_D0.7291.00
52_H56_G0.7281.00
58_Y66_S0.7261.00
78_A82_L0.7251.00
62_R264_L0.7251.00
141_L250_V0.7231.00
169_M173_A0.7231.00
65_L262_I0.7231.00
161_P166_V0.7221.00
132_F235_F0.7201.00
25_S32_K0.7181.00
177_L180_H0.7171.00
171_D175_K0.7171.00
155_Y251_T0.7141.00
174_F179_P0.7091.00
125_W153_I0.7041.00
142_S166_V0.7031.00
63_V79_V0.7011.00
118_A148_F0.6931.00
154_S173_A0.6921.00
43_V47_I0.6821.00
227_F230_L0.6791.00
156_S169_M0.6761.00
198_Y209_Q0.6751.00
27_F31_L0.6751.00
82_L85_T0.6721.00
122_N173_A0.6711.00
197_R201_I0.6691.00
250_V254_I0.6671.00
189_Q194_R0.6621.00
197_R200_N0.6571.00
97_Y100_Y0.6551.00
74_I79_V0.6511.00
47_I79_V0.6511.00
51_Y88_L0.6491.00
58_Y256_Y0.6471.00
43_V51_Y0.6451.00
157_L250_V0.6441.00
74_I78_A0.6411.00
46_R52_H0.6401.00
63_V67_L0.6361.00
226_F257_Y0.6351.00
141_L157_L0.6351.00
210_S219_D0.6341.00
29_Y32_K0.6321.00
130_T230_L0.6321.00
179_P205_H0.6261.00
40_Y81_R0.6261.00
185_L202_L0.6241.00
68_H73_Q0.6231.00
41_A44_K0.6221.00
32_K35_S0.6171.00
151_E259_S0.6161.00
55_R58_Y0.6161.00
139_L157_L0.6151.00
130_T141_L0.6151.00
172_Q176_K0.6151.00
31_L34_L0.6111.00
169_M172_Q0.6091.00
75_N81_R0.6041.00
232_S236_Y0.5990.99
186_H220_N0.5950.99
168_N171_D0.5940.99
22_I30_H0.5940.99
226_F254_I0.5940.99
229_T232_S0.5900.99
64_T75_N0.5880.99
28_Y31_L0.5870.99
262_I268_G0.5850.99
158_S168_N0.5810.99
185_L209_Q0.5800.99
225_C232_S0.5800.99
28_Y32_K0.5770.99
132_F141_L0.5770.99
87_S91_A0.5770.99
45_K52_H0.5760.99
256_Y260_R0.5710.99
212_S215_G0.5690.99
57_R256_Y0.5660.99
64_T67_L0.5660.99
50_I70_E0.5610.99
175_K178_N0.5600.99
48_S88_L0.5590.99
60_Y64_T0.5590.99
198_Y201_I0.5570.99
58_Y262_I0.5560.99
156_S165_M0.5560.99
140_Y192_Q0.5540.99
111_V208_K0.5540.99
167_E198_Y0.5490.99
141_L227_F0.5470.99
42_D45_K0.5460.99
212_S216_N0.5460.99
49_E70_E0.5450.99
36_K40_Y0.5420.99
51_Y89_K0.5390.99
190_G193_Y0.5340.99
158_S161_P0.5340.99
234_C253_Y0.5330.99
152_V257_Y0.5330.99
201_I204_E0.5310.99
96_R99_S0.5290.99
187_S198_Y0.5290.99
55_R252_E0.5280.99
151_E177_L0.5280.99
49_E52_H0.5270.99
53_E70_E0.5260.99
131_E161_P0.5200.99
198_Y211_M0.5190.99
51_Y63_V0.5180.98
244_S248_D0.5170.98
84_G89_K0.5170.98
170_L202_L0.5150.98
75_N79_V0.5150.98
262_I269_L0.5150.98
126_V145_I0.5140.98
61_R264_L0.5140.98
180_H183_P0.5140.98
153_I177_L0.5140.98
156_S247_K0.5110.98
91_A95_K0.5090.98
199_Q211_M0.5080.98
158_S169_M0.5060.98
168_N172_Q0.5040.98
42_D72_K0.5020.98
58_Y63_V0.5020.98
151_E176_K0.5010.98
155_Y250_V0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4fcyA 4 0.9329 100 0.362 Contact Map
3oymA 3 0.9258 100 0.435 Contact Map
3f9kA 5 0.7314 100 0.488 Contact Map
1bcoA 1 0.576 100 0.488 Contact Map
4fw2A 2 0.5512 100 0.497 Contact Map
4u7bA 2 0.9505 100 0.498 Contact Map
1k6yA 4 0.6714 100 0.501 Contact Map
4cf8A 2 0.523 100 0.504 Contact Map
3hphA 3 0.6961 100 0.509 Contact Map
3l3uA 2 0.5371 100 0.513 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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