GREMLIN Database
INSJ - Insertion element IS150 uncharacterized 19.7 kDa protein
UniProt: P19768 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40010
Length: 173 (158)
Sequences: 896 (702)
Seq/√Len: 55.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
150_Q155_E5.9861.00
143_R148_E3.1971.00
143_R146_D2.9461.00
71_V89_F2.9451.00
25_Y43_V2.7741.00
14_V39_V2.5781.00
107_R111_G2.5471.00
17_H32_F2.4021.00
75_V85_A2.3491.00
72_V101_L2.3301.00
14_V28_I2.3091.00
6_Y42_W2.2951.00
71_V97_V2.2871.00
17_H28_I2.1801.00
74_A78_Q2.1211.00
10_K14_V2.0991.00
14_V32_F2.0821.00
153_F156_T2.0231.00
144_I148_E2.0181.00
67_L71_V1.9471.00
6_Y10_K1.9151.00
152_R155_E1.8160.99
158_L161_L1.8080.99
76_I101_L1.7810.99
157_R162_K1.7800.99
163_K166_A1.7650.99
17_H31_R1.7560.99
165_K168_A1.6760.99
108_G112_L1.6680.99
151_V154_L1.6530.99
17_H23_D1.6440.99
151_V158_L1.6330.99
72_V76_I1.6250.99
28_I32_F1.6210.99
114_A117_I1.6090.98
74_A89_F1.6050.98
99_R103_V1.5330.98
139_S142_R1.5210.98
144_I151_V1.4690.97
102_K106_E1.3940.96
28_I39_V1.3770.96
154_L158_L1.3620.96
157_R161_L1.3600.96
15_V54_L1.3590.96
165_K169_H1.3590.96
12_L16_N1.3540.96
156_T163_K1.3360.95
35_P83_N1.3040.95
75_V101_L1.3010.94
108_G111_G1.2990.94
72_V97_V1.2970.94
152_R159_M1.2890.94
18_Y43_V1.2890.94
152_R156_T1.2710.94
24_G27_I1.2440.93
92_A96_S1.2410.93
117_I121_R1.2030.92
142_R145_E1.1940.91
103_V107_R1.1900.91
38_Q41_T1.1810.91
156_T159_M1.1790.91
160_Y164_L1.1660.90
39_V43_V1.1540.90
101_L105_E1.1480.90
151_V155_E1.1460.90
64_D68_R1.1270.89
14_V17_H1.1200.89
85_A89_F1.0930.87
82_L101_L1.0870.87
118_G121_R1.0860.87
25_Y40_R1.0700.86
10_K34_V1.0650.86
23_D27_I1.0520.85
26_R40_R1.0290.84
72_V75_V1.0260.84
64_D67_L1.0250.84
63_A92_A1.0170.83
4_P56_P1.0150.83
49_H87_A1.0110.83
44_A47_E1.0070.83
82_L98_A1.0010.82
44_A87_A0.9950.82
95_G98_A0.9930.82
18_Y28_I0.9840.81
11_R18_Y0.9730.80
46_Y53_G0.9670.80
147_L151_V0.9490.79
74_A88_H0.9320.77
40_R43_V0.9160.76
18_Y25_Y0.9080.76
80_M84_Q0.8930.74
13_E17_H0.8930.74
166_A169_H0.8870.74
15_V18_Y0.8810.73
26_R36_R0.8780.73
57_K92_A0.8700.72
149_R152_R0.8640.72
72_V85_A0.8620.72
34_V39_V0.8570.71
85_A88_H0.8530.71
79_H85_A0.8430.70
48_K87_A0.8410.70
116_K119_T0.8390.70
50_G167_L0.8260.68
141_D151_V0.8230.68
64_D129_P0.8200.68
7_P11_R0.8180.68
63_A68_R0.8180.68
8_F12_L0.8170.68
14_V34_V0.8160.67
168_A171_T0.8130.67
80_M88_H0.8110.67
7_P10_K0.8050.66
103_V111_G0.8030.66
140_K143_R0.8030.66
150_Q153_F0.7890.65
74_A80_M0.7850.64
10_K42_W0.7820.64
145_E149_R0.7750.63
49_H52_K0.7730.63
112_L118_G0.7660.63
158_L162_K0.7620.62
63_A67_L0.7560.62
8_F55_I0.7530.61
8_F54_L0.7530.61
75_V78_Q0.7530.61
145_E148_E0.7490.61
142_R146_D0.7460.61
96_S99_R0.7440.60
80_M85_A0.7430.60
40_R83_N0.7300.59
19_F43_V0.7270.59
24_G29_S0.7270.59
61_V92_A0.7240.58
15_V19_F0.7140.57
37_T40_R0.7090.57
74_A85_A0.7060.56
156_T166_A0.7050.56
65_P113_R0.7040.56
30_A129_P0.6980.55
42_W46_Y0.6950.55
12_L51_E0.6910.55
35_P40_R0.6770.53
10_K17_H0.6750.53
82_L85_A0.6740.53
153_F158_L0.6690.52
73_K77_E0.6690.52
122_N125_I0.6670.52
8_F51_E0.6630.52
41_T97_V0.6600.51
114_A119_T0.6590.51
104_Y108_G0.6580.51
23_D32_F0.6560.51
141_D146_D0.6500.50
164_L169_H0.6490.50
18_Y42_W0.6470.50
95_G101_L0.6370.49
115_L119_T0.6340.49
156_T165_K0.6200.47
82_L93_G0.6140.46
164_L170_P0.6140.46
33_G64_D0.6120.46
40_R62_S0.6120.46
12_L90_M0.6050.45
35_P38_Q0.6030.45
66_E70_K0.5990.45
140_K144_I0.5990.45
130_E171_T0.5990.45
41_T91_L0.5960.44
5_K162_K0.5940.44
114_A118_G0.5940.44
31_R34_V0.5920.44
153_F160_Y0.5910.44
44_A54_L0.5910.44
102_K110_A0.5830.43
68_R72_V0.5810.43
34_V40_R0.5810.43
149_R156_T0.5800.43
107_R120_K0.5800.43
19_F47_E0.5790.43
12_L46_Y0.5790.43
68_R100_W0.5780.43
115_L118_G0.5730.42
160_Y167_L0.5700.42
83_N87_A0.5690.42
70_K73_K0.5690.42
67_L89_F0.5690.42
65_P72_V0.5650.41
19_F42_W0.5650.41
48_K97_V0.5640.41
10_K13_E0.5640.41
84_Q88_H0.5630.41
73_K104_Y0.5620.41
84_Q159_M0.5620.41
44_A83_N0.5610.41
157_R166_A0.5580.40
37_T94_S0.5560.40
23_D31_R0.5550.40
110_A113_R0.5540.40
127_V130_E0.5530.40
29_S108_G0.5490.39
68_R115_L0.5480.39
116_K143_R0.5470.39
38_Q95_G0.5450.39
46_Y51_E0.5440.39
28_I68_R0.5390.38
20_T23_D0.5370.38
86_A90_M0.5370.38
149_R153_F0.5370.38
63_A154_L0.5340.38
163_K167_L0.5330.38
82_L97_V0.5310.38
10_K28_I0.5300.38
111_G160_Y0.5300.38
65_P110_A0.5300.38
159_M168_A0.5290.37
69_I72_V0.5260.37
7_P151_V0.5200.37
72_V77_E0.5180.36
113_R117_I0.5180.36
41_T45_L0.5180.36
15_V43_V0.5160.36
87_A91_L0.5140.36
78_Q88_H0.5130.36
45_L68_R0.5120.36
28_I31_R0.5110.36
9_E106_E0.5110.36
159_M164_L0.5110.36
29_S39_V0.5090.35
109_E120_K0.5060.35
42_W71_V0.5060.35
155_E166_A0.5050.35
144_I150_Q0.5040.35
39_V84_Q0.5010.35
76_I105_E0.5010.35
110_A116_K0.5000.35
45_L97_V0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rn7A 1 0.5491 99.6 0.664 Contact Map
2jn6A 1 0.5549 99.4 0.706 Contact Map
1u78A 1 0.5838 99.3 0.721 Contact Map
1pdnC 1 0.578 99.2 0.723 Contact Map
2k27A 1 0.7341 99.2 0.724 Contact Map
1k78A 1 0.5954 99.1 0.736 Contact Map
1hlvA 1 0.6301 99.1 0.743 Contact Map
2oa4A 1 0.422 98.9 0.759 Contact Map
2elhA 1 0.4046 98.6 0.786 Contact Map
2jrtA 1 0.3931 98.4 0.797 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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