GREMLIN Database
INSA7 - Insertion element IS1 7 protein InsA
UniProt: P19767 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG40001
Length: 91 (73)
Sequences: 587 (530)
Seq/√Len: 62.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
20_N24_T3.1091.00
8_C11_C2.6601.00
7_R11_C2.5261.00
72_I75_V2.2301.00
59_M62_N2.2151.00
21_G49_Q2.1641.00
48_S52_K1.8631.00
32_C35_C1.8341.00
20_N32_C1.7530.99
57_I62_N1.7240.99
35_C48_S1.6740.99
45_Y48_S1.6690.99
62_N66_C1.6430.99
72_I76_G1.6360.99
62_N75_V1.5480.99
32_C48_S1.4760.98
22_K27_H1.4330.98
74_G78_N1.4160.98
24_T32_C1.4120.97
59_M66_C1.3630.97
25_A28_Q1.3620.97
70_A78_N1.3310.96
73_M76_G1.3260.96
20_N35_C1.3150.96
11_C20_N1.3080.96
16_G19_R1.2900.96
46_T49_Q1.2840.96
14_T42_Q1.2380.95
22_K29_R1.1970.94
11_C39_W1.1940.93
66_C75_V1.1580.92
25_A29_R1.1570.92
62_N72_I1.1360.92
22_K26_G1.1330.92
19_R22_K1.1020.90
31_L36_R1.0820.90
24_T48_S1.0650.89
40_Q47_A1.0610.89
30_Y46_T1.0080.86
43_F47_A0.9960.85
6_I43_F0.9930.85
15_E43_F0.9800.84
58_D73_M0.9530.83
30_Y51_G0.9520.82
27_H30_Y0.9320.81
18_V21_G0.9210.80
57_I66_C0.8880.78
66_C78_N0.8840.78
22_K25_A0.8650.76
17_V24_T0.8550.75
60_A70_A0.8520.75
61_M67_R0.8490.75
19_R25_A0.8470.74
16_G23_S0.8440.74
42_Q46_T0.8440.74
58_D61_M0.8430.74
33_S42_Q0.8400.74
37_K50_P0.8310.73
23_S27_H0.8310.73
64_V68_A0.8100.71
29_R48_S0.8040.71
56_I71_R0.8020.70
15_E44_T0.7890.69
8_C21_G0.7590.66
68_A76_G0.7540.66
71_R78_N0.7200.62
63_G76_G0.7190.62
20_N48_S0.7160.62
59_M75_V0.7090.61
31_L38_T0.7060.61
41_L44_T0.6920.59
73_M77_L0.6800.58
12_S18_V0.6740.57
28_Q34_P0.6650.56
59_M71_R0.6620.56
54_Q57_I0.6600.55
69_S72_I0.6560.55
18_V34_P0.6550.55
59_M72_I0.6530.55
65_G70_A0.6530.55
33_S58_D0.6420.53
26_G29_R0.6340.52
39_W48_S0.6270.52
7_R35_C0.6240.51
26_G30_Y0.6180.51
75_V78_N0.6140.50
56_I59_M0.6130.50
17_V27_H0.6020.49
21_G39_W0.6000.49
64_V76_G0.5970.48
10_S25_A0.5940.48
18_V22_K0.5850.47
69_S74_G0.5820.47
13_A16_G0.5760.46
28_Q47_A0.5700.45
11_C24_T0.5690.45
34_P54_Q0.5670.45
45_Y52_K0.5650.45
7_R20_N0.5640.44
7_R24_T0.5620.44
50_P54_Q0.5520.43
15_E36_R0.5400.42
61_M68_A0.5360.41
12_S16_G0.5360.41
6_I11_C0.5290.41
49_Q54_Q0.5230.40
41_L49_Q0.5230.40
36_R73_M0.5180.39
54_Q70_A0.5020.38
35_C52_K0.5000.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i13A 1 0.8681 99.4 0.325 Contact Map
3w5kB 1 0.9121 99.4 0.334 Contact Map
2m9aA 1 0.9121 99.4 0.34 Contact Map
2rsjA 1 0.9121 99.4 0.343 Contact Map
2dmdA 1 0.967 99.4 0.346 Contact Map
2n25A 1 0.3077 99.4 0.35 Contact Map
2kmkA 1 0.8901 99.4 0.35 Contact Map
4x9jA 1 0.8901 99.4 0.357 Contact Map
2yt9A 1 0.9341 99.4 0.358 Contact Map
2ee8A 1 0.978 99.3 0.363 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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