GREMLIN Database
EUTC - Ethanolamine ammonia-lyase light chain
UniProt: P19636 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG50007
Length: 295 (233)
Sequences: 783 (539)
Seq/√Len: 35.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
166_S205_G4.3761.00
250_T255_D4.1951.00
202_V209_I4.1931.00
177_N269_P3.5631.00
215_E248_M3.3731.00
214_G246_P3.2781.00
174_I238_L3.2101.00
160_D220_K3.0951.00
221_V280_A2.9401.00
91_A94_R2.8071.00
210_E224_L2.7641.00
128_S132_L2.7501.00
81_G88_R2.7091.00
161_V223_I2.6891.00
110_V175_T2.5131.00
164_V222_V2.4231.00
240_C276_I2.3921.00
240_C262_I2.3600.99
123_V202_V2.3360.99
124_R144_C2.2980.99
240_C259_I2.2940.99
123_V200_F2.2650.99
129_D132_L2.2260.99
210_E222_V2.1690.99
172_D176_V2.1680.99
244_Y287_K2.1120.99
234_Q263_H2.0580.99
112_E201_F1.9910.98
194_L284_L1.9650.98
244_Y284_L1.8920.98
194_L280_A1.8590.97
163_V185_L1.8060.97
202_V205_G1.7870.96
252_V255_D1.7710.96
148_V216_I1.7690.96
143_L147_A1.7690.96
130_K204_Y1.7300.96
159_P197_G1.7240.96
247_R255_D1.7170.96
165_I178_Y1.6260.94
214_G217_L1.5700.93
144_C147_A1.5620.93
110_V201_F1.5380.92
221_V289_S1.5250.92
67_L98_D1.5190.92
165_I174_I1.4910.91
67_L78_V1.4880.91
148_V212_Q1.4850.91
271_E274_A1.4640.90
162_Q219_A1.4390.89
179_E183_P1.4360.89
259_I276_I1.4320.89
181_I240_C1.4260.89
126_E148_V1.4250.89
166_S224_L1.4150.88
209_I213_I1.4020.88
283_M289_S1.3950.88
282_R285_E1.3790.87
112_E203_R1.3790.87
177_N265_G1.3510.86
127_I204_Y1.3470.86
289_S292_N1.3470.86
163_V223_I1.3450.86
205_G209_I1.3390.85
164_V224_L1.3200.85
202_V213_I1.3200.85
94_R98_D1.2860.83
93_L104_D1.2830.83
145_A153_A1.2700.82
126_E142_R1.2560.81
88_R91_A1.2550.81
221_V244_Y1.2480.81
221_V284_L1.2280.80
235_S265_G1.2150.79
142_R212_Q1.2110.79
120_L199_P1.2100.79
174_I178_Y1.2100.79
282_R286_Q1.1960.78
91_A96_L1.1940.78
112_E116_K1.1880.78
275_V278_D1.1770.77
187_A271_E1.1760.77
184_P273_A1.1580.76
94_R184_P1.1550.76
188_G274_A1.1530.76
123_V209_I1.1330.74
212_Q248_M1.1090.73
97_A101_R1.0830.71
152_K216_I1.0800.71
214_G250_T1.0780.70
160_D195_K1.0780.70
220_K245_S1.0770.70
113_E122_E1.0710.70
176_V265_G1.0710.70
281_K285_E1.0630.69
242_A280_A1.0620.69
121_L200_F1.0620.69
178_Y182_L1.0600.69
124_R203_R1.0580.69
220_K247_R1.0570.69
164_V202_V1.0520.69
109_E171_T1.0520.69
143_L212_Q1.0410.68
223_I276_I1.0380.67
212_Q216_I1.0310.67
268_P271_E1.0280.67
149_E153_A1.0060.65
142_R248_M1.0030.65
223_I280_A1.0020.65
157_A218_G0.9970.64
214_G247_R0.9900.64
147_A150_A0.9890.64
111_P114_W0.9880.64
115_V226_V0.9820.63
186_M196_V0.9790.63
288_A292_N0.9690.62
62_H65_D0.9640.62
162_Q197_G0.9620.61
148_V152_K0.9610.61
116_K122_E0.9570.61
96_L282_R0.9540.61
163_V182_L0.9420.60
208_K256_R0.9320.59
114_W118_Q0.9310.59
144_C189_L0.9300.59
225_L240_C0.9250.58
180_E277_V0.9250.58
86_R235_S0.9230.58
95_F151_L0.9070.57
98_D101_R0.9030.57
184_P277_V0.9030.57
192_A281_K0.9020.57
118_Q179_E0.8960.56
71_R130_K0.8960.56
75_V265_G0.8950.56
79_C263_H0.8880.55
85_P123_V0.8860.55
244_Y275_V0.8790.55
236_E263_H0.8760.54
215_E247_R0.8750.54
154_Q197_G0.8750.54
92_L96_L0.8670.54
184_P221_V0.8670.54
218_G259_I0.8630.53
278_D289_S0.8610.53
211_D260_S0.8560.53
108_K172_D0.8550.52
117_A152_K0.8480.52
171_T269_P0.8480.52
117_A179_E0.8470.52
174_I181_I0.8470.52
107_L134_L0.8460.52
281_K284_L0.8440.52
279_L291_I0.8420.51
79_C234_Q0.8360.51
118_Q183_P0.8360.51
113_E220_K0.8320.51
190_K193_G0.8320.51
188_G273_A0.8280.50
135_T238_L0.8270.50
131_N135_T0.8230.50
107_L133_Y0.8220.50
161_V196_V0.8190.49
210_E243_V0.8170.49
76_A100_S0.8170.49
110_V199_P0.8150.49
87_P238_L0.8130.49
158_N280_A0.8110.49
242_A289_S0.8100.49
125_S209_I0.8100.49
104_D134_L0.8100.49
150_A154_Q0.8080.48
181_I185_L0.7990.48
75_V274_A0.7970.47
98_D265_G0.7940.47
113_E117_A0.7940.47
253_E256_R0.7900.47
182_L240_C0.7880.47
237_S261_N0.7780.46
95_F232_L0.7740.46
143_L209_I0.7720.45
146_E161_V0.7700.45
85_P171_T0.7610.44
262_I276_I0.7590.44
211_D256_R0.7590.44
65_D83_A0.7540.44
189_L277_V0.7530.44
101_R235_S0.7470.43
185_L189_L0.7460.43
87_P243_V0.7440.43
89_T236_E0.7430.43
105_T253_E0.7410.43
189_L280_A0.7400.43
97_A280_A0.7400.43
253_E257_T0.7400.43
154_Q213_I0.7360.42
223_I240_C0.7270.42
278_D282_R0.7210.41
275_V282_R0.7150.41
280_A284_L0.7110.40
136_R139_M0.7090.40
242_A284_L0.7070.40
242_A291_I0.7050.40
171_T194_L0.7040.40
71_R124_R0.7020.39
164_V210_E0.7020.39
157_A195_K0.6980.39
188_G277_V0.6960.39
69_E215_E0.6950.39
257_T294_T0.6920.39
243_V250_T0.6910.39
77_R232_L0.6860.38
67_L70_L0.6850.38
135_T204_Y0.6820.38
282_R288_A0.6820.38
186_M190_K0.6820.38
134_L236_E0.6800.38
179_E215_E0.6800.38
75_V263_H0.6760.37
145_A158_N0.6730.37
146_E287_K0.6710.37
78_V106_V0.6700.37
181_I238_L0.6700.37
96_L135_T0.6690.37
126_E144_C0.6670.37
120_L288_A0.6570.36
166_S209_I0.6560.36
153_A157_A0.6520.35
82_R89_T0.6480.35
150_A153_A0.6480.35
108_K171_T0.6470.35
249_A253_E0.6450.35
89_T171_T0.6440.35
220_K284_L0.6410.35
97_A275_V0.6390.34
123_V216_I0.6360.34
165_I199_P0.6360.34
83_A88_R0.6340.34
83_A165_I0.6340.34
74_T82_R0.6330.34
233_G243_V0.6300.34
171_T277_V0.6300.34
151_L195_K0.6280.34
211_D243_V0.6250.33
89_T254_A0.6230.33
89_T265_G0.6230.33
110_V115_V0.6210.33
181_I269_P0.6200.33
126_E139_M0.6190.33
283_M286_Q0.6180.33
125_S226_V0.6130.32
95_F265_G0.6100.32
162_Q199_P0.6100.32
172_D212_Q0.6090.32
86_R234_Q0.6090.32
205_G224_L0.6080.32
164_V200_F0.6070.32
145_A149_E0.6060.32
240_C271_E0.6050.32
83_A254_A0.6040.32
187_A284_L0.6040.32
189_L271_E0.6020.32
183_P218_G0.6020.32
127_I132_L0.5990.31
277_V281_K0.5990.31
98_D277_V0.5990.31
271_E276_I0.5950.31
61_P64_A0.5950.31
208_K211_D0.5940.31
126_E145_A0.5930.31
124_R147_A0.5910.31
259_I262_I0.5870.31
239_S243_V0.5860.30
146_E149_E0.5840.30
151_L160_D0.5830.30
87_P91_A0.5820.30
141_R211_D0.5810.30
171_T226_V0.5800.30
208_K249_A0.5790.30
122_E203_R0.5770.30
177_N264_Q0.5770.30
184_P292_N0.5770.30
85_P209_I0.5760.30
123_V151_L0.5760.30
78_V92_L0.5750.30
67_L294_T0.5750.30
110_V174_I0.5720.29
159_P163_V0.5700.29
211_D263_H0.5700.29
119_G154_Q0.5700.29
157_A163_V0.5700.29
245_S287_K0.5690.29
180_E269_P0.5670.29
170_S173_A0.5660.29
188_G289_S0.5650.29
114_W213_I0.5620.29
129_D204_Y0.5610.29
165_I182_L0.5600.29
161_V194_L0.5590.28
158_N195_K0.5580.28
62_H97_A0.5570.28
181_I276_I0.5560.28
267_T275_V0.5540.28
255_D292_N0.5510.28
122_E201_F0.5510.28
146_E156_V0.5500.28
162_Q273_A0.5460.28
107_L130_K0.5460.28
153_A165_I0.5440.27
153_A226_V0.5440.27
109_E133_Y0.5410.27
75_V177_N0.5390.27
145_A186_M0.5380.27
145_A148_V0.5370.27
193_G201_F0.5350.27
159_P198_T0.5350.27
80_T233_G0.5350.27
77_R141_R0.5340.27
182_L269_P0.5320.27
281_K292_N0.5310.27
124_R128_S0.5280.26
133_Y211_D0.5260.26
79_C210_E0.5260.26
89_T93_L0.5240.26
174_I194_L0.5240.26
127_I133_Y0.5230.26
219_A293_M0.5220.26
162_Q222_V0.5220.26
85_P181_I0.5210.26
211_D261_N0.5210.26
67_L110_V0.5180.26
243_V257_T0.5170.26
160_D198_T0.5170.26
225_L265_G0.5170.26
80_T91_A0.5170.26
162_Q223_I0.5130.25
222_V246_P0.5130.25
219_A243_V0.5120.25
177_N271_E0.5110.25
125_S143_L0.5100.25
113_E270_V0.5090.25
89_T106_V0.5070.25
117_A146_E0.5050.25
74_T78_V0.5040.25
147_A233_G0.5040.25
124_R154_Q0.5030.25
85_P205_G0.5020.25
113_E116_K0.5020.25
74_T100_S0.5020.25
185_L223_I0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3abqB 1 0.8508 100 0.038 Contact Map
4narA 2 0.5322 38.5 0.969 Contact Map
4d86A 1 0.4814 16.9 0.974 Contact Map
2zktA 3 0.3831 15.6 0.974 Contact Map
2kkeA 2 0.0983 15 0.974 Contact Map
1n91A 1 0.2237 12.9 0.975 Contact Map
3ip4B 1 0.2102 12 0.976 Contact Map
1mugA 1 0.2508 11 0.976 Contact Map
3al0B 1 0.2136 10.7 0.976 Contact Map
3h0lB 1 0 10 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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