GREMLIN Database
PDXA - 4-hydroxythreonine-4-phosphate dehydrogenase
UniProt: P19624 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10691
Length: 329 (320)
Sequences: 2873 (1961)
Seq/√Len: 109.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_A236_Q5.1971.00
220_T224_D4.9141.00
170_R174_D4.4221.00
167_L175_A3.7371.00
144_S290_F3.6121.00
8_V113_F3.3491.00
148_K183_E3.3181.00
37_C107_G3.2091.00
178_P232_E3.1931.00
189_H193_R3.1441.00
40_A77_P2.7901.00
182_H232_E2.7411.00
116_L140_F2.6621.00
108_C113_F2.6291.00
106_D143_R2.4791.00
85_T88_Q2.4721.00
133_F142_E2.3821.00
95_H99_E2.3811.00
220_T223_I2.3371.00
163_A181_L2.2691.00
7_V115_A2.2111.00
6_R33_E2.2111.00
182_H233_L2.2021.00
171_D174_D2.1621.00
102_A139_F2.0801.00
188_L260_A2.0561.00
22_V36_V2.0531.00
182_H229_V2.0451.00
231_N234_R2.0261.00
227_I231_N2.0131.00
241_N244_L1.9921.00
185_I233_L1.9821.00
168_P218_M1.9671.00
191_D195_K1.9171.00
169_L172_I1.8971.00
249_L261_V1.8871.00
178_P229_V1.8601.00
122_H301_L1.8531.00
206_C249_L1.8381.00
280_R316_T1.8341.00
108_C116_L1.8341.00
119_G314_F1.8181.00
28_R315_I1.7701.00
102_A106_D1.7681.00
227_I243_P1.7401.00
263_A269_G1.7331.00
231_N235_A1.6911.00
189_H238_M1.6851.00
99_E102_A1.6711.00
101_L121_V1.6391.00
161_A188_L1.6381.00
226_I264_M1.6201.00
162_L270_L1.6181.00
7_V117_I1.6091.00
223_I227_I1.5801.00
63_S112_E1.5741.00
252_P258_A1.5681.00
105_C143_R1.5611.00
311_V315_I1.5601.00
102_A143_R1.5571.00
115_A321_A1.5471.00
40_A44_T1.5261.00
177_T225_T1.5251.00
107_G113_F1.5131.00
200_E239_K1.5041.00
155_T277_G1.4951.00
6_R114_A1.4941.00
279_G310_D1.4931.00
170_R173_A1.4751.00
22_V119_G1.4591.00
104_A116_L1.4521.00
124_G215_G1.4361.00
154_A320_L1.4351.00
168_P172_I1.4261.00
21_L314_F1.4211.00
106_D110_N1.3981.00
23_V54_L1.3971.00
182_H186_A1.3931.00
180_L184_V1.3841.00
185_I262_L1.3741.00
25_L318_L1.3721.00
303_L308_K1.3711.00
13_E301_L1.3711.00
163_A264_M1.3701.00
20_D46_R1.3671.00
253_K256_D1.3451.00
205_V226_I1.3421.00
181_L229_V1.3321.00
229_V233_L1.3110.99
188_L262_L1.3110.99
57_R72_T1.3050.99
20_D24_Q1.3030.99
207_G212_A1.2930.99
25_L315_I1.2860.99
62_N65_A1.2750.99
109_L144_S1.2750.99
208_L226_I1.2310.99
103_R106_D1.2310.99
273_L281_G1.2250.99
222_E227_I1.2200.99
192_L260_A1.2200.99
60_S64_P1.2190.99
277_G280_R1.2150.99
37_C103_R1.2090.99
171_D175_A1.2070.99
150_V187_I1.1900.99
95_H131_I1.1860.99
89_L125_V1.1860.99
40_A58_P1.1820.99
164_T176_I1.1780.99
39_D77_P1.1770.99
163_A180_L1.1750.99
201_P259_D1.1750.99
164_T172_I1.1720.99
205_V230_L1.1710.99
204_L258_A1.1690.99
20_D306_R1.1650.99
176_I225_T1.1650.99
232_E236_Q1.1590.99
316_T319_N1.1570.99
96_Y100_T1.1570.99
222_E226_I1.1550.99
141_E149_V1.1520.99
160_V273_L1.1500.99
271_P275_Y1.1490.99
13_E97_V1.1390.98
8_V37_C1.1360.98
202_R259_D1.1330.98
181_L185_I1.1230.98
103_R107_G1.1220.98
61_P64_P1.1190.98
35_V62_N1.1190.98
181_L226_I1.1120.98
40_A75_L1.1110.98
252_P257_N1.1060.98
204_L249_L1.0940.98
105_C109_L1.0930.98
151_M283_N1.0930.98
182_H236_Q1.0900.98
49_M86_A1.0830.98
159_R198_I1.0790.98
224_D227_I1.0780.98
23_V43_L1.0710.98
107_G112_E1.0690.98
185_I205_V1.0640.98
230_L234_R1.0590.98
89_L93_N1.0570.98
186_A238_M1.0510.97
181_L264_M1.0400.97
21_L25_L1.0390.97
46_R50_L1.0390.97
189_H203_I1.0380.97
61_P112_E1.0350.97
35_V59_Y1.0320.97
90_A93_N1.0050.97
23_V47_A1.0040.97
10_T116_L1.0030.97
154_A159_R1.0010.97
293_T321_A0.9980.96
23_V50_L0.9950.96
101_L143_R0.9900.96
89_L301_L0.9820.96
168_P173_A0.9800.96
9_I314_F0.9770.96
137_T292_R0.9760.96
178_P225_T0.9750.96
5_Q32_V0.9750.96
56_L75_L0.9730.96
105_C140_F0.9700.96
57_R74_T0.9680.96
26_A73_L0.9680.96
59_Y112_E0.9630.96
89_L122_H0.9620.96
178_P182_H0.9560.96
153_L273_L0.9530.95
320_L324_M0.9510.95
28_R311_V0.9510.95
36_V43_L0.9470.95
44_T48_A0.9460.95
137_T285_T0.9460.95
37_C76_L0.9450.95
157_E276_Q0.9440.95
124_G128_D0.9430.95
182_H238_M0.9420.95
11_P38_A0.9410.95
162_L269_G0.9370.95
102_A105_C0.9270.95
222_E230_L0.9250.95
43_L75_L0.9240.95
9_I34_L0.9220.95
11_P22_V0.9220.95
82_A90_A0.9210.94
127_N217_H0.9210.94
11_P119_G0.9160.94
58_P77_P0.9160.94
8_V108_C0.9160.94
42_L80_L0.9150.94
137_T151_M0.9110.94
149_V187_I0.9030.94
314_F318_L0.8990.94
195_K324_M0.8930.94
35_V113_F0.8910.93
93_N97_V0.8900.93
170_R221_E0.8870.93
118_T136_H0.8870.93
59_Y62_N0.8860.93
156_E280_R0.8840.93
20_D50_L0.8820.93
97_V301_L0.8800.93
232_E235_A0.8800.93
118_T292_R0.8790.93
135_G138_E0.8760.93
150_V184_V0.8760.93
5_Q33_E0.8740.93
229_V238_M0.8740.93
23_V46_R0.8720.93
244_L249_L0.8690.93
40_A56_L0.8640.92
233_L240_L0.8640.92
152_M188_L0.8610.92
189_H200_E0.8480.92
291_I324_M0.8470.92
98_V139_F0.8460.92
316_T320_L0.8440.91
105_C139_F0.8380.91
148_K180_L0.8360.91
31_P319_N0.8360.91
134_T138_E0.8350.91
19_P38_A0.8350.91
285_T292_R0.8330.91
76_L107_G0.8330.91
13_E122_H0.8310.91
91_V125_V0.8280.91
47_A50_L0.8270.91
161_A260_A0.8240.90
163_A176_I0.8200.90
303_L309_A0.8180.90
59_Y76_L0.8150.90
179_A183_E0.8150.90
156_E323_K0.8150.90
204_L261_V0.8150.90
162_L165_T0.8120.90
65_A68_Q0.8090.90
118_T137_T0.8070.90
168_P171_D0.8040.89
246_A249_L0.8020.89
189_H240_L0.7970.89
55_T72_T0.7960.89
152_M260_A0.7940.89
46_R86_A0.7890.89
17_I309_A0.7890.89
151_M270_L0.7880.88
24_Q311_V0.7830.88
186_A233_L0.7760.88
77_P80_L0.7740.88
98_V126_I0.7710.87
33_E68_Q0.7610.87
229_V240_L0.7610.87
171_D220_T0.7610.87
185_I240_L0.7590.87
80_L99_E0.7580.86
33_E74_T0.7560.86
105_C144_S0.7550.86
76_L103_R0.7550.86
46_R49_M0.7540.86
5_Q114_A0.7510.86
151_M292_R0.7490.86
202_R239_K0.7470.86
161_A286_L0.7450.85
254_Y258_A0.7430.85
251_Q254_Y0.7420.85
213_G223_I0.7370.85
234_R239_K0.7330.85
59_Y65_A0.7300.84
136_H294_S0.7280.84
109_L112_E0.7270.84
7_V322_I0.7230.84
198_I201_P0.7230.84
153_L162_L0.7220.84
150_V161_A0.7210.84
117_I321_A0.7210.84
167_L171_D0.7190.83
205_V264_M0.7180.83
24_Q309_A0.7130.83
244_L258_A0.7130.83
141_E146_A0.7120.83
146_A149_V0.7100.83
114_A322_I0.7100.83
68_Q72_T0.7090.83
32_V322_I0.7090.83
27_Q52_L0.7080.82
202_R241_N0.7060.82
270_L295_V0.7050.82
80_L84_V0.7050.82
179_A182_H0.7030.82
78_V103_R0.7010.82
118_T285_T0.6980.82
233_L238_M0.6970.81
37_C104_A0.6950.81
159_R260_A0.6930.81
153_L165_T0.6900.81
128_D217_H0.6870.81
212_A245_P0.6860.80
138_E165_T0.6810.80
9_I318_L0.6790.80
45_N49_M0.6770.80
50_L307_G0.6770.80
173_A208_L0.6750.79
101_L140_F0.6750.79
84_V93_N0.6750.79
115_A291_I0.6750.79
35_V107_G0.6720.79
293_T317_A0.6700.79
11_P43_L0.6700.79
98_V131_I0.6680.79
23_V56_L0.6650.78
315_I319_N0.6630.78
45_N48_A0.6620.78
252_P255_L0.6600.78
62_N76_L0.6600.78
104_A140_F0.6570.78
11_P100_T0.6560.77
44_T58_P0.6550.77
68_Q74_T0.6550.77
277_G281_G0.6540.77
207_G246_A0.6510.77
185_I229_V0.6500.77
254_Y276_Q0.6500.77
136_H313_S0.6480.77
292_R296_D0.6470.76
159_R196_F0.6460.76
251_Q275_Y0.6440.76
173_A225_T0.6400.76
11_P96_Y0.6400.76
127_N134_T0.6390.76
31_P34_L0.6390.76
136_H292_R0.6390.76
270_L283_N0.6390.76
166_H211_H0.6350.75
144_S289_P0.6350.75
98_V133_F0.6330.75
182_H240_L0.6330.75
151_M285_T0.6320.75
9_I22_V0.6290.74
10_T104_A0.6290.74
138_E285_T0.6260.74
25_L314_F0.6250.74
186_A190_H0.6250.74
94_G125_V0.6250.74
117_I318_L0.6220.74
296_D313_S0.6220.74
123_K137_T0.6200.73
17_I300_A0.6180.73
319_N323_K0.6180.73
20_D308_K0.6160.73
167_L170_R0.6160.73
316_T323_K0.6130.73
227_I230_L0.6120.72
154_A284_I0.6110.72
322_I326_V0.6100.72
118_T294_S0.6100.72
39_D79_A0.6070.72
253_K257_N0.6070.72
8_V116_L0.6040.71
33_E114_A0.6030.71
118_T151_M0.6030.71
29_E34_L0.5980.71
10_T136_H0.5970.71
127_N132_P0.5970.71
153_L263_A0.5930.70
283_N292_R0.5930.70
103_R112_E0.5930.70
25_L311_V0.5920.70
92_E95_H0.5910.70
19_P42_L0.5900.70
32_V114_A0.5900.70
135_G292_R0.5890.70
137_T283_N0.5890.70
155_T273_L0.5880.69
27_Q53_P0.5870.69
114_A325_I0.5870.69
225_T229_V0.5840.69
153_L283_N0.5830.69
6_R35_V0.5820.69
152_M191_D0.5820.69
57_R66_Q0.5800.68
45_N86_A0.5800.68
312_G316_T0.5790.68
151_M162_L0.5780.68
283_N294_S0.5780.68
214_E217_H0.5740.68
152_M284_I0.5740.68
162_L295_V0.5740.68
167_L172_I0.5710.67
251_Q290_F0.5710.67
69_T74_T0.5700.67
47_A54_L0.5690.67
157_E280_R0.5670.67
166_H298_G0.5670.67
240_L244_L0.5660.67
34_L74_T0.5640.66
198_I259_D0.5640.66
97_V121_V0.5630.66
230_L240_L0.5630.66
11_P36_V0.5620.66
37_C100_T0.5600.66
87_G263_A0.5600.66
86_A305_G0.5590.66
115_A325_I0.5580.65
184_V245_P0.5560.65
211_H298_G0.5550.65
252_P256_D0.5530.65
190_H193_R0.5520.65
177_T180_L0.5520.65
141_E148_K0.5510.64
165_T281_G0.5510.64
284_I320_L0.5500.64
182_H185_I0.5500.64
38_A42_L0.5490.64
165_T324_M0.5480.64
135_G151_M0.5460.64
115_A293_T0.5420.63
19_P43_L0.5400.63
153_L272_V0.5390.63
165_T283_N0.5340.62
121_V126_I0.5330.62
10_T119_G0.5330.62
123_K292_R0.5330.62
69_T72_T0.5330.62
38_A96_Y0.5320.62
118_T283_N0.5320.62
229_V232_E0.5300.61
125_V128_D0.5300.61
265_Y268_Q0.5300.61
156_E276_Q0.5290.61
184_V187_I0.5280.61
152_M161_A0.5280.61
183_E187_I0.5270.61
167_L174_D0.5260.61
285_T294_S0.5260.61
205_V242_G0.5260.61
270_L294_S0.5260.61
101_L139_F0.5250.61
91_V129_A0.5250.61
55_T69_T0.5250.61
226_I230_L0.5250.61
78_V99_E0.5230.60
41_T79_A0.5230.60
168_P207_G0.5220.60
8_V35_V0.5220.60
45_N83_P0.5210.60
121_V136_H0.5210.60
251_Q278_F0.5200.60
6_R34_L0.5200.60
123_K151_M0.5190.60
253_K279_G0.5180.60
31_P322_I0.5180.60
151_M165_T0.5170.60
131_I139_F0.5160.59
91_V128_D0.5160.59
212_A244_L0.5160.59
168_P174_D0.5150.59
155_T276_Q0.5140.59
96_Y99_E0.5090.58
303_L306_R0.5090.58
162_L283_N0.5090.58
15_A93_N0.5090.58
118_T296_D0.5090.58
164_T173_A0.5080.58
188_L192_L0.5080.58
150_V188_L0.5070.58
285_T313_S0.5070.58
137_T313_S0.5050.58
66_Q69_T0.5050.58
36_V119_G0.5040.58
246_A271_P0.5040.58
146_A289_P0.5030.58
57_R71_G0.5030.58
81_R93_N0.5020.57
118_T123_K0.5000.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2hi1A 2 0.9757 100 0.061 Contact Map
4atyA 2 0.9149 100 0.082 Contact Map
3tsnA 2 0.9666 100 0.103 Contact Map
4jqpA 2 0.9878 100 0.264 Contact Map
3lxyA 2 0.997 100 0.271 Contact Map
1yxoA 2 0.9939 100 0.272 Contact Map
1r5jA 4 0.8754 100 0.572 Contact Map
1td9A 3 0.8693 100 0.573 Contact Map
1vmiA 2 0.8663 100 0.581 Contact Map
1u7nA 2 0.8328 100 0.589 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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