GREMLIN Database
NARZ - Respiratory nitrate reductase 2 alpha chain
UniProt: P19319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10648
Length: 1246 (1195)
Sequences: 669 (262)
Seq/√Len: 7.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
146_C150_K6.7411.00
507_G518_I6.4541.00
344_E354_G6.2581.00
984_H1031_E6.0421.00
850_Q886_V5.4341.00
1126_E1156_P5.2101.00
1029_V1035_W5.2011.00
686_A691_D5.0240.99
141_N176_W4.9040.99
337_M563_F4.8910.99
170_I784_I4.7490.99
528_T536_S4.6140.99
832_A835_Q4.4860.98
527_D531_K4.4340.98
61_K75_Q4.2520.98
146_C705_H4.2450.98
150_K705_H4.1840.98
252_A288_V4.1720.98
876_L882_A4.1250.97
316_K321_D4.0690.97
332_R414_E4.0510.97
1051_M1198_I4.0160.97
810_S1000_Q3.9930.97
936_D940_Q3.9380.96
711_V778_T3.8860.96
69_V103_L3.8810.96
125_A138_S3.7340.95
210_L895_T3.6870.95
248_S528_T3.5260.93
114_I119_I3.5210.93
858_A884_N3.4310.92
126_L168_Q3.3770.92
688_K875_D3.2530.90
320_L483_L3.2470.90
322_N530_H3.2060.89
673_D845_T3.1720.89
129_H138_S3.1560.89
326_Y569_Q3.1320.88
319_H331_C3.1170.88
770_T782_S3.0780.87
308_M502_Y3.0430.87
371_N397_G3.0410.87
975_G981_E3.0270.86
606_N609_S2.9710.85
737_G1177_T2.9680.85
833_F895_T2.9680.85
684_A885_I2.9590.85
873_E881_T2.9280.84
867_L873_E2.9210.84
669_K847_V2.9140.84
806_I962_T2.8810.83
845_T887_A2.8650.83
391_S394_F2.8620.83
85_L246_N2.8460.83
968_V986_A2.8310.82
169_L784_I2.8220.82
849_L885_I2.8220.82
271_V274_K2.7960.82
620_Y730_Y2.7930.81
198_V955_I2.7760.81
296_L517_Y2.7750.81
320_L478_L2.7630.81
103_L813_V2.7550.81
616_S700_D2.7460.80
271_V276_T2.7060.79
907_D942_R2.6960.79
252_A286_S2.6920.79
459_N469_P2.6790.79
872_G875_D2.6680.78
179_K840_H2.6590.78
843_K893_P2.6540.78
847_V885_I2.6390.77
268_F291_L2.6360.77
167_N828_G2.6250.77
698_Q757_Q2.5940.76
329_N333_R2.5390.75
795_D948_A2.5240.74
252_A268_F2.5190.74
114_I161_S2.5190.74
1129_I1148_A2.5190.74
375_K393_G2.5130.74
1154_V1160_M2.5080.74
226_P1211_Y2.5070.74
606_N655_L2.4970.73
540_L557_M2.4880.73
161_S166_L2.4800.73
688_K873_E2.4750.73
616_S761_I2.4680.72
47_R59_S2.4590.72
562_I1044_L2.4400.71
648_R652_M2.4310.71
616_S730_Y2.4050.70
546_H550_M2.3990.70
300_Q1158_M2.3970.70
324_S530_H2.3900.70
1052_R1057_S2.3810.69
123_R165_E2.3810.69
331_C337_M2.3750.69
200_Y1208_F2.3740.69
215_L607_S2.3650.69
131_D840_H2.3650.69
872_G881_T2.3590.69
379_V383_G2.3570.69
128_Q138_S2.3450.68
914_K1016_E2.3120.67
894_A897_E2.3120.67
824_E948_A2.3050.67
613_N643_I2.3000.67
424_D458_K2.2670.65
326_Y664_N2.2660.65
425_A457_V2.2600.65
121_L145_K2.2440.65
360_S864_C2.2300.64
119_I161_S2.2270.64
492_S495_D2.2220.64
251_I281_I2.2070.63
538_I557_M2.1980.63
544_V557_M2.1750.62
345_P349_G2.1650.62
311_G481_Y2.1550.61
208_S594_F2.1460.61
615_S711_V2.1440.61
280_A288_V2.1410.61
583_L586_Q2.1200.60
454_Q488_E2.1000.59
867_L872_G2.0990.59
202_A899_F2.0910.59
1122_T1156_P2.0900.59
902_L954_V2.0890.59
326_Y533_H2.0880.59
602_P848_V2.0820.59
457_V469_P2.0630.58
268_F278_T2.0590.58
833_F893_P2.0570.58
319_H337_M2.0560.58
928_G933_T2.0420.57
249_Y524_E2.0370.57
280_A286_S2.0350.57
386_V413_T2.0220.56
525_F536_S2.0180.56
975_G1031_E2.0130.56
280_A289_A1.9990.55
1093_Q1162_Y1.9980.55
175_V840_H1.9860.55
167_N829_I1.9810.55
702_S705_H1.9750.54
355_R1049_P1.9420.53
425_A459_N1.9400.53
375_K394_F1.9320.53
693_R755_E1.9320.53
1008_S1015_L1.9270.52
454_Q489_D1.9250.52
592_L951_A1.9090.52
345_P348_D1.9010.51
489_D492_S1.8880.51
527_D530_H1.8860.51
897_E939_A1.8850.51
121_L148_S1.8740.50
138_S145_K1.8730.50
670_A844_E1.8680.50
690_G870_R1.8650.50
989_K992_E1.8590.50
912_G917_S1.8550.50
845_T889_E1.8480.49
663_R695_A1.8400.49
925_D929_K1.8380.49
686_A689_S1.8370.49
683_T847_V1.8340.49
1039_S1044_L1.8320.49
663_R671_E1.8180.48
170_I829_I1.8170.48
709_L716_L1.8110.48
351_Y469_P1.8080.48
679_P847_V1.8060.48
246_N267_F1.7960.47
248_S532_T1.7840.47
961_E1009_S1.7820.47
662_G703_S1.7800.47
661_L849_L1.7800.47
820_R828_G1.7670.46
1089_L1154_V1.7660.46
934_K944_L1.7580.46
662_G693_R1.7500.45
797_M956_L1.7430.45
427_A469_P1.7420.45
138_S141_N1.7400.45
131_D175_V1.7400.45
614_H1166_E1.7380.45
174_N206_Y1.7340.45
867_L881_T1.7310.45
358_R374_W1.7230.44
730_Y761_I1.7170.44
376_T391_S1.7120.44
427_A457_V1.7030.44
492_S496_Y1.6850.43
155_R735_E1.6840.43
901_S939_A1.6840.43
418_T421_G1.6840.43
133_V175_V1.6830.43
142_D145_K1.6810.43
351_Y427_A1.6800.43
759_A762_E1.6700.42
687_L882_A1.6690.42
197_M585_P1.6530.42
486_G489_D1.6460.41
663_R692_L1.6420.41
1023_N1026_Y1.6370.41
248_S535_R1.6370.41
877_I880_K1.6350.41
294_Q520_T1.6340.41
75_Q649_A1.6310.41
1093_Q1096_G1.6290.41
1111_S1116_I1.6270.41
853_L856_S1.6250.40
711_V768_L1.6240.40
688_K872_G1.6180.40
544_V550_M1.6080.40
378_A415_L1.5960.39
176_W181_Y1.5930.39
901_S934_K1.5900.39
1145_T1174_S1.5870.39
672_A682_F1.5830.39
875_D881_T1.5820.39
323_P328_I1.5740.39
667_G670_A1.5720.38
133_V840_H1.5710.38
1174_S1177_T1.5690.38
140_M146_C1.5680.38
491_N495_D1.5670.38
328_I474_Y1.5650.38
539_I544_V1.5580.38
590_L604_Q1.5580.38
252_A291_L1.5560.38
662_G695_A1.5560.38
1154_V1158_M1.5520.38
420_L485_R1.5500.38
187_A215_L1.5490.38
200_Y594_F1.5470.38
669_K885_I1.5380.37
488_E492_S1.5340.37
693_R697_E1.5250.37
911_N920_T1.5210.37
1175_E1227_M1.5190.36
255_S539_I1.5180.36
651_R868_D1.5150.36
902_L906_M1.5140.36
540_L544_V1.5100.36
487_L492_S1.5100.36
252_A280_A1.5070.36
698_Q701_S1.5060.36
652_M869_W1.5050.36
335_S562_I1.5030.36
647_V651_R1.4940.36
742_E1177_T1.4930.36
945_I954_V1.4910.35
968_V990_E1.4900.35
252_A257_V1.4890.35
242_A267_F1.4880.35
288_V291_L1.4870.35
549_H1062_R1.4850.35
201_A592_L1.4830.35
141_N180_T1.4800.35
618_W631_P1.4800.35
190_S967_A1.4790.35
137_A141_N1.4740.35
545_N1161_M1.4730.35
1103_E1108_L1.4670.35
611_F709_L1.4650.35
339_M391_S1.4640.34
618_W700_D1.4640.34
975_G983_T1.4620.34
121_L169_L1.4590.34
339_M1039_S1.4570.34
731_L768_L1.4510.34
175_V836_V1.4480.34
315_L481_Y1.4390.34
546_H553_N1.4360.33
668_I671_E1.4330.33
501_P702_S1.4320.33
63_Y70_T1.4320.33
896_Y900_T1.4310.33
827_K900_T1.4280.33
493_A496_Y1.4270.33
370_N397_G1.4270.33
29_N621_E1.4250.33
454_Q492_S1.4240.33
198_V952_S1.4220.33
928_G942_R1.4200.33
401_K880_K1.4180.33
643_I1217_N1.4180.33
140_M176_W1.4150.33
1045_Y1052_R1.4140.33
10_Y13_Q1.4110.33
604_Q1206_W1.4090.33
495_D498_E1.4090.33
646_N655_L1.4040.32
664_N1035_W1.4040.32
204_T321_D1.4030.32
683_T692_L1.4020.32
651_R869_W1.3920.32
813_V816_A1.3880.32
150_K761_I1.3870.32
1144_L1161_M1.3870.32
843_K889_E1.3830.32
663_R686_A1.3810.32
672_A676_G1.3800.32
405_E980_R1.3700.31
891_D894_A1.3670.31
836_V840_H1.3630.31
474_Y563_F1.3600.31
162_N165_E1.3580.31
404_L595_A1.3570.31
474_Y478_L1.3540.31
146_C761_I1.3520.31
354_G1045_Y1.3480.30
488_E491_N1.3470.30
396_W859_E1.3400.30
670_A674_K1.3380.30
286_S289_A1.3370.30
613_N696_C1.3350.30
563_F1044_L1.3330.30
867_L874_C1.3330.30
609_S646_N1.3320.30
594_F604_Q1.3300.30
33_E98_S1.3290.30
549_H967_A1.3280.30
499_I509_Q1.3280.30
684_A873_E1.3240.30
1145_T1226_K1.3140.29
294_Q521_I1.3080.29
197_M799_T1.3070.29
816_A819_S1.3050.29
339_M394_F1.3040.29
231_T1044_L1.3000.29
314_I560_M1.2990.29
282_T289_A1.2930.29
660_Q952_S1.2900.28
688_K880_K1.2870.28
649_A948_A1.2820.28
316_K320_L1.2750.28
561_L858_A1.2710.28
202_A827_K1.2690.28
1038_L1202_A1.2680.28
701_S705_H1.2660.28
975_G984_H1.2660.28
124_E128_Q1.2650.28
48_S62_I1.2640.28
972_Q983_T1.2610.28
1120_S1156_P1.2590.27
671_E682_F1.2580.27
331_C563_F1.2550.27
114_I784_I1.2550.27
166_L782_S1.2500.27
971_W1027_T1.2490.27
1043_Q1046_Q1.2480.27
647_V753_E1.2470.27
877_I881_T1.2430.27
378_A413_T1.2430.27
374_W392_I1.2420.27
140_M150_K1.2400.27
561_L567_V1.2360.27
310_M560_M1.2330.27
121_L139_I1.2280.27
944_L947_T1.2280.27
210_L833_F1.2260.26
652_M866_V1.2250.26
419_L460_L1.2240.26
705_H737_G1.2230.26
684_A688_K1.2210.26
566_C847_V1.2200.26
232_W1042_Q1.2200.26
212_G334_Y1.2190.26
888_V901_S1.2150.26
609_S649_A1.2120.26
311_G563_F1.2110.26
702_S707_R1.2100.26
345_P351_Y1.2060.26
672_A675_A1.2040.26
599_N898_R1.2030.26
1144_L1187_V1.2030.26
247_S1026_Y1.2030.26
389_N729_K1.2010.26
550_M1214_V1.2000.26
342_M354_G1.1980.26
907_D924_I1.1970.26
677_L685_Q1.1960.26
370_N398_E1.1960.26
253_W772_D1.1960.26
946_D950_D1.1910.25
88_H242_A1.1890.25
364_D673_D1.1880.25
718_G1064_P1.1880.25
487_L491_N1.1870.25
502_Y556_G1.1870.25
360_S373_Q1.1850.25
371_N860_L1.1830.25
374_W396_W1.1820.25
647_V754_V1.1800.25
316_K483_L1.1770.25
684_A875_D1.1710.25
657_S1161_M1.1660.25
850_Q884_N1.1650.25
606_N646_N1.1630.25
599_N602_P1.1630.25
609_S655_L1.1620.25
1145_T1228_K1.1610.24
502_Y1060_A1.1580.24
424_D498_E1.1570.24
405_E856_S1.1540.24
124_E148_S1.1530.24
867_L880_K1.1510.24
853_L907_D1.1510.24
897_E938_P1.1500.24
215_L545_N1.1490.24
430_A452_V1.1490.24
651_R870_R1.1460.24
450_V631_P1.1450.24
808_P999_I1.1420.24
869_W876_L1.1400.24
134_L138_S1.1380.24
988_H991_D1.1380.24
726_Y738_I1.1360.24
239_P432_P1.1360.24
937_G941_G1.1350.24
944_L950_D1.1340.24
427_A459_N1.1340.24
899_F1096_G1.1330.24
18_F22_H1.1310.24
799_T995_R1.1280.24
959_A1006_I1.1280.24
970_A1222_I1.1260.23
711_V753_E1.1220.23
678_S681_E1.1220.23
717_L1164_A1.1210.23
247_S847_V1.1200.23
178_I210_L1.1160.23
655_L1197_M1.1150.23
867_L875_D1.1000.23
847_V1226_K1.0990.23
392_I1202_A1.0970.23
362_L385_L1.0950.23
714_S902_L1.0940.23
450_V632_L1.0940.23
666_L846_D1.0940.23
820_R824_E1.0930.23
355_R361_D1.0910.22
326_Y530_H1.0910.22
377_V387_V1.0900.22
207_L214_C1.0890.22
742_E901_S1.0880.22
248_S274_K1.0880.22
660_Q849_L1.0880.22
615_S727_M1.0860.22
505_A515_R1.0860.22
662_G701_S1.0850.22
735_E1179_M1.0850.22
292_C932_Y1.0840.22
876_L885_I1.0790.22
144_Q147_L1.0790.22
827_K896_Y1.0780.22
814_D1166_E1.0780.22
697_E870_R1.0770.22
187_A610_F1.0750.22
251_I255_S1.0750.22
29_N32_W1.0740.22
296_L322_N1.0740.22
164_Q806_I1.0730.22
827_K899_F1.0720.22
838_V893_P1.0710.22
595_A895_T1.0680.22
124_E145_K1.0670.22
121_L1192_P1.0670.22
259_Q287_E1.0650.22
831_K896_Y1.0650.22
669_K684_A1.0620.22
334_Y1031_E1.0610.22
1033_I1036_R1.0550.21
325_D530_H1.0530.21
98_S1162_Y1.0530.21
94_P780_L1.0520.21
591_P906_M1.0500.21
959_A1087_N1.0470.21
532_T621_E1.0460.21
322_N325_D1.0450.21
1075_Q1083_E1.0440.21
536_S569_Q1.0420.21
117_R152_V1.0370.21
396_W915_G1.0320.21
507_G632_L1.0320.21
535_R1099_S1.0310.21
345_P466_N1.0290.21
385_L460_L1.0280.21
326_Y536_S1.0270.21
545_N1042_Q1.0270.21
1053_A1217_N1.0250.21
1045_Y1057_S1.0230.21
334_Y1029_V1.0230.21
99_Y790_T1.0230.21
249_Y1044_L1.0230.21
934_K939_A1.0230.21
98_S621_E1.0230.21
250_I268_F1.0200.21
538_I1059_V1.0200.21
1122_T1126_E1.0200.21
342_M466_N1.0180.21
187_A213_T1.0160.20
326_Y952_S1.0160.20
1204_L1211_Y1.0160.20
147_L150_K1.0160.20
798_N809_L1.0160.20
1080_G1175_E1.0110.20
829_I833_F1.0100.20
583_L589_W1.0090.20
69_V813_V1.0070.20
923_E965_H1.0070.20
570_S1020_V1.0070.20
968_V1007_I1.0070.20
61_K76_T1.0050.20
253_W307_A1.0050.20
784_I818_E1.0020.20
906_M920_T1.0010.20
166_L169_L0.9990.20
1128_T1226_K0.9990.20
239_P575_A0.9980.20
62_I357_I0.9970.20
453_R489_D0.9970.20
121_L124_E0.9960.20
717_L951_A0.9960.20
925_D928_G0.9960.20
669_K673_D0.9950.20
918_W966_V0.9940.20
276_T280_A0.9930.20
141_N753_E0.9930.20
175_V632_L0.9910.20
552_M567_V0.9870.20
227_A1119_I0.9870.20
307_A772_D0.9870.20
59_S75_Q0.9870.20
379_V384_E0.9840.20
319_H474_Y0.9830.20
162_N734_T0.9800.20
406_S415_L0.9770.19
538_I544_V0.9770.19
695_A849_L0.9770.19
698_Q755_E0.9760.19
129_H134_L0.9750.19
592_L945_I0.9740.19
569_Q952_S0.9740.19
485_R1062_R0.9730.19
671_E674_K0.9730.19
429_V834_S0.9730.19
396_W1031_E0.9730.19
709_L765_L0.9730.19
616_S620_Y0.9720.19
320_L474_Y0.9720.19
150_K732_L0.9690.19
898_R938_P0.9660.19
69_V816_A0.9660.19
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170_I518_I0.5180.10
61_K73_I0.5180.10
743_L1089_L0.5180.10
169_L489_D0.5170.10
200_Y1004_R0.5170.10
528_T608_T0.5170.10
320_L323_P0.5170.10
616_S757_Q0.5170.10
109_L323_P0.5160.10
212_G448_N0.5160.10
371_N806_I0.5160.10
521_I1171_I0.5160.10
701_S848_V0.5160.10
353_P1135_V0.5160.10
57_S307_A0.5150.10
376_T717_L0.5150.10
710_F771_L0.5150.10
231_T1217_N0.5150.10
613_N849_L0.5150.10
564_C724_H0.5140.10
1172_P1180_R0.5140.10
276_T686_A0.5140.10
610_F1177_T0.5140.10
702_S717_L0.5140.10
729_K758_T0.5140.10
137_A180_T0.5130.10
732_L1169_M0.5130.10
324_S730_Y0.5130.10
258_P588_G0.5130.10
918_W1054_F0.5130.10
548_Y689_S0.5130.10
66_N1167_R0.5120.10
296_L630_S0.5120.10
583_L1024_A0.5120.10
326_Y532_T0.5120.10
352_V457_V0.5120.10
799_T1168_I0.5120.10
959_A1025_G0.5120.10
592_L651_R0.5120.10
170_I818_E0.5120.10
888_V1126_E0.5120.10
81_T226_P0.5110.10
682_F782_S0.5110.10
355_R864_C0.5110.10
326_Y1023_N0.5110.10
961_E1217_N0.5110.10
279_I780_L0.5110.10
297_A300_Q0.5100.10
495_D639_S0.5100.10
489_D500_K0.5100.10
700_D761_I0.5100.10
375_K391_S0.5100.10
376_T860_L0.5100.10
319_H769_V0.5090.10
521_I1140_A0.5090.10
300_Q959_A0.5090.10
1120_S1151_S0.5090.10
280_A322_N0.5090.10
247_S426_V0.5090.10
88_H1012_W0.5090.10
477_V502_Y0.5090.10
618_W993_K0.5090.10
769_V1038_L0.5090.10
1108_L1126_E0.5090.10
1062_R1155_P0.5080.10
373_Q396_W0.5080.10
151_Q762_E0.5080.10
176_W877_I0.5080.10
688_K1226_K0.5080.10
457_V1081_F0.5080.10
730_Y932_Y0.5080.10
250_I280_A0.5080.10
651_R1198_I0.5080.10
683_T856_S0.5080.10
331_C417_L0.5080.10
257_V1061_Y0.5070.10
600_R1012_W0.5070.10
797_M857_P0.5070.10
898_R943_P0.5070.10
520_T709_L0.5070.10
298_P308_M0.5070.10
342_M376_T0.5070.10
587_T960_P0.5070.10
902_L958_L0.5070.10
130_S138_S0.5070.10
553_N1224_I0.5060.10
809_L1006_I0.5060.10
1129_I1135_V0.5060.10
583_L1153_R0.5050.10
37_R50_H0.5040.10
37_R51_G0.5040.10
202_A829_I0.5040.10
528_T1126_E0.5040.10
267_F614_H0.5040.10
476_L927_L0.5040.10
753_E901_S0.5040.10
875_D880_K0.5040.10
586_Q652_M0.5030.10
914_K1033_I0.5030.10
761_I1145_T0.5030.10
478_L575_A0.5030.10
172_A255_S0.5020.10
169_L350_S0.5020.10
68_L323_P0.5010.10
354_G702_S0.5010.10
169_L1084_K0.5010.10
864_C1045_Y0.5010.10
692_L914_K0.5000.10
601_P974_L0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfA 1 0.7143 100 0.727 Contact Map
1h0hA 1 0.7039 100 0.868 Contact Map
1kqfA 3 0.7039 100 0.873 Contact Map
2vpzA 1 0.5762 100 0.878 Contact Map
2napA 1 0.569 100 0.88 Contact Map
2e7zA 1 0.5722 100 0.881 Contact Map
3ml1A 1 0.6308 100 0.881 Contact Map
1eu1A 1 0.5827 100 0.882 Contact Map
2iv2X 1 0.5441 100 0.884 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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