GREMLIN Database
NARW - Probable nitrate reductase molybdenum cofactor assembly chaperone NarW
UniProt: P19317 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10645
Length: 231 (183)
Sequences: 669 (494)
Seq/√Len: 36.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_F150_L4.6891.00
26_L44_L3.9511.00
106_Y109_L3.8531.00
48_L52_Q3.5971.00
6_V25_A3.2531.00
26_L41_H2.9371.00
89_A93_K2.7961.00
38_D149_A2.6891.00
7_I154_L2.5581.00
42_N146_P2.5431.00
137_G155_L2.5151.00
141_K152_D2.3981.00
23_E44_L2.3911.00
7_I150_L2.3180.99
39_F149_A2.3100.99
4_L157_L2.2270.99
56_C60_D2.1890.99
18_L43_L2.1880.99
92_E97_Q2.1460.99
134_A137_G2.1320.99
42_N54_E2.1170.99
21_C24_D2.1130.99
89_A92_E1.8720.98
110_Y125_G1.8570.98
58_V145_A1.8560.97
39_F43_L1.8360.97
22_K40_T1.8330.97
16_E52_Q1.8070.97
114_L122_A1.7300.96
135_L172_N1.7200.96
36_L150_L1.6720.95
23_E27_A1.5980.94
65_T139_R1.5830.94
87_L90_E1.5670.93
61_R71_E1.5550.93
74_H83_A1.5480.93
98_L109_L1.5190.92
29_I32_D1.5120.92
124_E128_N1.4870.91
22_K44_L1.4840.91
4_L114_L1.4830.91
6_V53_A1.4740.91
90_E125_G1.4560.91
5_K8_G1.4550.91
62_G143_R1.4460.90
9_L21_C1.4320.90
47_P50_D1.4230.90
136_L151_F1.4220.89
170_Q174_E1.3830.88
87_L118_P1.3660.87
16_E20_E1.3650.87
70_F87_L1.3300.86
55_W75_A1.3260.86
163_S168_T1.3000.85
35_M38_D1.2990.85
49_L53_A1.2610.83
65_T136_L1.2390.82
46_A54_E1.2380.82
63_R71_E1.2380.82
74_H87_L1.2300.81
43_L51_K1.2280.81
26_L37_T1.2100.80
73_V132_I1.1990.80
4_L117_L1.1880.79
88_L98_L1.1720.78
34_P38_D1.1580.77
74_H79_D1.1410.76
76_E182_A1.1380.76
88_L92_E1.1340.76
29_I33_A1.1260.75
175_E181_Q1.0860.72
79_D84_M1.0840.72
3_I32_D1.0770.72
135_L179_T1.0740.72
91_Y113_Y1.0700.71
72_H132_I1.0580.70
7_I153_A1.0550.70
84_M103_L1.0460.69
30_R37_T1.0430.69
67_L108_P1.0360.69
54_E147_W1.0350.69
94_V116_V1.0290.68
38_D118_P1.0260.68
49_L84_M1.0150.67
12_E106_Y1.0130.67
139_R178_D1.0080.67
20_E23_E0.9970.66
117_L121_Q0.9950.66
34_P164_S0.9870.65
72_H147_W0.9640.63
25_A28_L0.9560.62
160_S163_S0.9530.62
123_K127_L0.9450.61
5_K24_D0.9420.61
10_L70_F0.9400.61
21_C25_A0.9320.60
67_L135_L0.9290.60
43_L60_D0.9290.60
88_L137_G0.9200.59
98_L113_Y0.9200.59
94_V113_Y0.9110.59
131_P135_L0.9100.59
10_L72_H0.9080.58
4_L96_L0.8990.58
73_V129_V0.8950.57
130_A176_R0.8930.57
49_L65_T0.8890.57
40_T46_A0.8860.57
141_K148_Y0.8710.55
65_T72_H0.8690.55
5_K91_Y0.8640.55
27_A121_Q0.8590.54
28_L31_R0.8420.53
96_L117_L0.8380.52
39_F54_E0.8360.52
127_L135_L0.8300.52
10_L63_R0.8170.50
175_E179_T0.8150.50
52_Q143_R0.8130.50
67_L103_L0.8090.50
8_G21_C0.8090.50
51_K150_L0.8060.50
93_K168_T0.7970.49
6_V29_I0.7970.49
82_Q129_V0.7930.48
85_V184_D0.7890.48
130_A167_V0.7830.48
97_Q181_Q0.7830.48
66_S132_I0.7750.47
27_A31_R0.7720.47
18_L34_P0.7720.47
6_V128_N0.7670.46
5_K96_L0.7670.46
66_S92_E0.7660.46
28_L60_D0.7650.46
8_G19_W0.7650.46
68_L94_V0.7640.46
155_L161_S0.7630.46
165_D168_T0.7630.46
76_E139_R0.7580.45
35_M149_A0.7570.45
71_E145_A0.7540.45
53_A57_E0.7540.45
63_R83_A0.7510.45
15_D144_E0.7490.45
6_V153_A0.7480.44
142_Q166_S0.7410.44
37_T40_T0.7390.44
130_A158_A0.7380.44
169_K173_S0.7380.44
62_G65_T0.7360.43
93_K118_P0.7350.43
17_L20_E0.7330.43
78_R107_L0.7290.43
46_A51_K0.7170.42
29_I115_S0.7130.41
82_Q86_D0.7110.41
38_D101_R0.7090.41
25_A29_I0.7040.41
151_F178_D0.7000.40
20_E120_D0.7000.40
22_K150_L0.6990.40
165_D184_D0.6990.40
37_T43_L0.6980.40
31_R50_D0.6960.40
41_H141_K0.6950.40
90_E110_Y0.6950.40
176_R179_T0.6950.40
71_E130_A0.6900.40
91_Y111_L0.6890.39
147_W161_S0.6830.39
153_A159_G0.6790.39
177_D180_R0.6790.39
74_H91_Y0.6760.38
131_P138_G0.6720.38
86_D143_R0.6660.38
71_E110_Y0.6630.37
181_Q185_A0.6630.37
87_L110_Y0.6620.37
5_K116_V0.6610.37
135_L177_D0.6610.37
107_L171_V0.6580.37
91_Y154_L0.6550.37
148_Y154_L0.6520.36
137_G151_F0.6510.36
43_L118_P0.6500.36
3_I37_T0.6480.36
60_D100_C0.6470.36
137_G160_S0.6420.36
21_C53_A0.6370.35
72_H87_L0.6370.35
96_L116_V0.6340.35
17_L21_C0.6330.35
101_R124_E0.6320.35
82_Q85_V0.6310.35
57_E160_S0.6260.34
132_I182_A0.6210.34
71_E76_E0.6180.34
49_L96_L0.6140.33
4_L70_F0.6120.33
66_S82_Q0.6120.33
138_G142_Q0.6120.33
22_K27_A0.6080.33
83_A103_L0.6070.33
7_I157_L0.6060.33
82_Q180_R0.6060.33
12_E154_L0.6040.33
55_W60_D0.6020.32
36_L40_T0.6010.32
79_D155_L0.5970.32
19_W23_E0.5960.32
106_Y151_F0.5960.32
131_P163_S0.5950.32
41_H54_E0.5940.32
37_T45_N0.5860.31
97_Q174_E0.5850.31
45_N54_E0.5840.31
67_L154_L0.5830.31
5_K28_L0.5820.31
83_A98_L0.5810.31
15_D119_D0.5810.31
64_T176_R0.5810.31
74_H184_D0.5760.30
45_N50_D0.5760.30
17_L146_P0.5750.30
57_E62_G0.5740.30
9_L171_V0.5740.30
43_L150_L0.5740.30
84_M104_P0.5690.30
129_V177_D0.5690.30
30_R34_P0.5650.30
5_K9_L0.5630.30
5_K157_L0.5620.29
130_A181_Q0.5600.29
11_M129_V0.5590.29
68_L108_P0.5590.29
27_A35_M0.5570.29
97_Q115_S0.5570.29
62_G177_D0.5560.29
61_R76_E0.5540.29
70_F86_D0.5540.29
112_E148_Y0.5530.29
143_R184_D0.5530.29
94_V118_P0.5500.29
8_G123_K0.5500.29
122_A166_S0.5480.28
94_V106_Y0.5480.28
32_D153_A0.5450.28
4_L9_L0.5440.28
15_D181_Q0.5430.28
104_P136_L0.5430.28
110_Y129_V0.5410.28
52_Q180_R0.5400.28
55_W147_W0.5360.28
15_D19_W0.5320.27
6_V123_K0.5290.27
179_T182_A0.5270.27
64_T181_Q0.5270.27
48_L66_S0.5270.27
77_S182_A0.5260.27
10_L83_A0.5250.27
56_C75_A0.5240.27
66_S74_H0.5210.27
62_G122_A0.5170.26
34_P41_H0.5160.26
35_M108_P0.5110.26
94_V183_L0.5110.26
61_R131_P0.5060.26
119_D136_L0.5060.26
174_E178_D0.5050.25
56_C110_Y0.5010.25
147_W162_L0.5010.25
26_L30_R0.5000.25
34_P120_D0.5000.25
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o9xA 2 0.645 99.9 0.686 Contact Map
1n1cA 2 0.7446 99.9 0.722 Contact Map
1s9uA 1 0.7446 99.8 0.742 Contact Map
2xolA 2 0.6797 97.6 0.898 Contact Map
3viqB 1 0.329 29.6 0.96 Contact Map
3b02A 2 0.3247 13.8 0.965 Contact Map
2yskA 2 0.5801 13.4 0.966 Contact Map
1rj9A 1 0.4892 8 0.969 Contact Map
2fa5A 2 0.4459 6.6 0.97 Contact Map
2kl4A 1 0.4935 6.6 0.97 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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