GREMLIN Database
MALI - Maltose regulon regulatory protein MalI
UniProt: P18811 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10557
Length: 342 (322)
Sequences: 34429 (25202)
Seq/√Len: 1404.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
167_M206_A3.4201.00
182_H245_S3.2921.00
15_A47_E3.1741.00
268_Q280_Q3.1661.00
173_L285_A2.7231.00
201_V205_C2.6121.00
182_H283_S2.6101.00
123_G318_M2.5741.00
289_D304_S2.5601.00
171_Q210_K2.3831.00
160_D321_K2.3201.00
35_T39_E2.2841.00
231_A264_K2.2631.00
43_A47_E2.2501.00
39_E43_A2.2141.00
89_A92_A2.1871.00
89_A316_D2.1601.00
235_T265_A2.1451.00
178_I211_F2.1111.00
313_T316_D2.0921.00
168_Q172_L2.0671.00
171_Q206_A2.0451.00
235_T261_G2.0101.00
175_E207_T2.0081.00
171_Q207_T2.0061.00
26_V41_V1.9951.00
90_L315_A1.9951.00
38_G42_N1.9311.00
175_E179_R1.9111.00
170_A174_T1.9001.00
85_G311_G1.9001.00
167_M202_G1.8971.00
27_L45_I1.8931.00
262_L282_V1.8911.00
169_A287_F1.8821.00
230_A257_G1.8801.00
10_H20_V1.8711.00
239_R265_A1.8691.00
170_A248_V1.8281.00
177_L246_A1.8131.00
89_A312_I1.8001.00
304_S337_R1.7951.00
320_Q325_E1.7881.00
174_T204_Y1.7831.00
88_E308_R1.7411.00
175_E211_F1.7411.00
16_A44_A1.7251.00
231_A261_G1.7181.00
15_A44_A1.7101.00
171_Q175_E1.7071.00
306_P309_E1.6741.00
187_W250_Y1.6731.00
85_G308_R1.6551.00
267_R281_Q1.6481.00
234_I258_A1.6451.00
176_H180_N1.6441.00
68_G121_V1.6371.00
268_Q281_Q1.6141.00
186_A244_I1.6041.00
249_C258_A1.5991.00
172_L336_A1.5981.00
89_A93_Q1.5891.00
263_L297_D1.5841.00
313_T332_L1.5801.00
261_G265_A1.5651.00
42_N46_E1.5631.00
150_A314_L1.5361.00
184_R216_H1.5231.00
93_Q319_M1.5221.00
26_V45_I1.5161.00
168_Q171_Q1.5101.00
202_G206_A1.5011.00
309_E313_T1.4981.00
184_R243_T1.4941.00
178_I207_T1.4831.00
165_D168_Q1.4821.00
285_A301_T1.4781.00
221_L236_A1.4761.00
309_E312_I1.4561.00
261_G264_K1.4551.00
12_V44_A1.4501.00
42_N45_I1.4421.00
199_E202_G1.4301.00
176_H179_R1.4131.00
65_G122_D1.4111.00
205_C209_L1.3881.00
89_A315_A1.3791.00
262_L267_R1.3701.00
216_H219_W1.3661.00
235_T264_K1.3571.00
174_T178_I1.3431.00
234_I247_V1.3271.00
174_T203_G1.3271.00
67_I90_L1.3231.00
231_A235_T1.3151.00
169_A336_A1.3151.00
186_A237_L1.3121.00
10_H14_L1.3071.00
207_T210_K1.3051.00
11_D14_L1.2941.00
174_T207_T1.2931.00
65_G95_R1.2901.00
35_T38_G1.2881.00
170_A203_G1.2861.00
235_T239_R1.2851.00
184_R245_S1.2851.00
231_A260_F1.2851.00
182_H246_A1.2751.00
316_D320_Q1.2661.00
15_A48_L1.2651.00
234_I262_L1.2591.00
34_S37_T1.2541.00
25_L30_K1.2471.00
203_G207_T1.2421.00
40_R44_A1.2411.00
319_M323_T1.2391.00
12_V16_A1.2371.00
44_A47_E1.2331.00
175_E210_K1.2311.00
69_L86_L1.2181.00
259_W284_L1.2041.00
236_A240_H1.1991.00
224_T229_Q1.1991.00
100_L112_R1.1981.00
172_L175_E1.1861.00
125_V314_L1.1841.00
9_I20_V1.1841.00
167_M199_E1.1821.00
90_L97_V1.1801.00
100_L116_L1.1791.00
86_L125_V1.1781.00
167_M171_Q1.1711.00
7_I48_L1.1701.00
86_L315_A1.1651.00
37_T40_R1.1651.00
68_G116_L1.1591.00
44_A48_L1.1571.00
204_Y208_L1.1501.00
228_K232_E1.1471.00
308_R312_I1.1441.00
114_S139_M1.1391.00
188_L258_A1.1311.00
12_V48_L1.1271.00
183_Q245_S1.1211.00
257_G261_G1.1211.00
43_A46_E1.1211.00
252_E302_W1.1211.00
185_I208_L1.1121.00
69_L97_V1.0891.00
176_H301_T1.0861.00
167_M203_G1.0851.00
39_E42_N1.0851.00
93_Q316_D1.0841.00
247_V258_A1.0821.00
178_I213_L1.0781.00
26_V33_I1.0771.00
87_T91_E1.0761.00
187_W201_V1.0721.00
206_A210_K1.0721.00
207_T211_F1.0711.00
313_T317_R1.0661.00
91_E108_Q1.0641.00
66_V98_F1.0631.00
233_A236_A1.0591.00
66_V96_M1.0591.00
9_I23_V1.0581.00
311_G315_A1.0551.00
173_L248_V1.0471.00
230_A234_I1.0461.00
249_C255_A1.0451.00
179_R211_F1.0441.00
252_E286_A1.0421.00
29_G38_G1.0421.00
241_N244_I1.0371.00
202_G205_C1.0291.00
226_S229_Q1.0251.00
184_R242_P1.0241.00
55_Q58_A1.0231.00
53_N59_L1.0211.00
312_I316_D1.0201.00
93_Q323_T1.0151.00
110_A114_S1.0141.00
232_E236_A0.9991.00
208_L213_L0.9961.00
318_M322_I0.9891.00
249_C254_I0.9821.00
138_R142_E0.9721.00
221_L233_A0.9681.00
45_I48_L0.9641.00
95_R319_M0.9611.00
168_Q335_P0.9611.00
259_W296_D0.9561.00
215_F218_D0.9551.00
16_A23_V0.9521.00
227_Q260_F0.9491.00
204_Y248_V0.9471.00
185_I246_A0.9451.00
205_C215_F0.9441.00
198_A202_G0.9431.00
180_N283_S0.9381.00
259_W278_F0.9351.00
313_T334_I0.9331.00
114_S118_N0.9321.00
229_Q232_E0.9311.00
173_L303_A0.9301.00
92_A312_I0.9241.00
234_I238_L0.9241.00
317_R332_L0.9231.00
56_A59_L0.9231.00
174_T208_L0.9221.00
164_P306_P0.9131.00
192_S222_E0.9101.00
53_N56_A0.9051.00
125_V318_M0.8981.00
183_Q213_L0.8981.00
178_I183_Q0.8871.00
88_E312_I0.8861.00
69_L83_T0.8821.00
29_G42_N0.8801.00
52_R57_S0.8791.00
67_I125_V0.8781.00
84_A88_E0.8751.00
238_L261_G0.8701.00
86_L311_G0.8681.00
108_Q111_Q0.8671.00
161_T331_N0.8591.00
232_E235_T0.8581.00
268_Q279_E0.8581.00
195_L199_E0.8571.00
164_P336_A0.8531.00
165_D335_P0.8521.00
247_V282_V0.8521.00
162_V317_R0.8501.00
208_L215_F0.8441.00
267_R282_V0.8411.00
82_L150_A0.8401.00
286_A302_W0.8391.00
64_S122_D0.8391.00
26_V42_N0.8391.00
252_E289_D0.8351.00
186_A247_V0.8351.00
190_G225_S0.8341.00
165_D333_I0.8331.00
306_P334_I0.8261.00
163_R333_I0.8241.00
160_D317_R0.8231.00
317_R320_Q0.8191.00
123_G322_I0.8161.00
219_W240_H0.8121.00
168_Q336_A0.8101.00
164_P305_T0.8091.00
66_V119_Q0.8061.00
201_V220_V0.8041.00
184_R219_W0.8041.00
105_D108_Q0.8021.00
206_A209_L0.8011.00
223_C254_I0.8001.00
81_E308_R0.8001.00
289_D293_T0.8001.00
262_L284_L0.8001.00
243_T267_R0.7991.00
315_A319_M0.7991.00
36_A39_E0.7971.00
78_F307_A0.7901.00
18_V41_V0.7871.00
288_T305_T0.7851.00
163_R331_N0.7841.00
166_N200_R0.7831.00
245_S283_S0.7811.00
177_L285_A0.7791.00
8_T11_D0.7741.00
63_Q122_D0.7701.00
252_E255_A0.7701.00
86_L97_V0.7701.00
187_W248_V0.7701.00
234_I261_G0.7701.00
229_Q233_A0.7691.00
193_S198_A0.7691.00
54_R57_S0.7651.00
188_L249_C0.7631.00
36_A40_R0.7621.00
22_T25_L0.7611.00
85_G89_A0.7611.00
306_P337_R0.7601.00
67_I315_A0.7541.00
199_E203_G0.7531.00
189_G201_V0.7531.00
85_G312_I0.7481.00
83_T87_T0.7471.00
21_S25_L0.7451.00
238_L265_A0.7421.00
117_L143_K0.7371.00
234_I237_L0.7371.00
221_L237_L0.7371.00
72_R79_Y0.7371.00
68_G124_V0.7361.00
25_L32_R0.7311.00
88_E92_A0.7291.00
221_L240_H0.7261.00
172_L303_A0.7261.00
256_M296_D0.7231.00
260_F299_P0.7211.00
25_L31_G0.7201.00
51_V118_N0.7181.00
134_D138_R0.7141.00
248_V285_A0.7101.00
160_D330_R0.7091.00
83_T99_L0.7071.00
111_Q114_S0.7061.00
320_Q324_H0.7061.00
213_L216_H0.7041.00
260_F263_L0.7041.00
295_L298_I0.7011.00
294_T298_I0.7001.00
296_D299_P0.6981.00
63_Q323_T0.6951.00
230_A233_A0.6931.00
135_D138_R0.6921.00
236_A239_R0.6911.00
153_A331_N0.6911.00
84_A87_T0.6901.00
87_T97_V0.6901.00
240_H243_T0.6891.00
176_H338_L0.6881.00
289_D339_I0.6861.00
149_F154_S0.6851.00
123_G148_I0.6841.00
87_T101_H0.6811.00
184_R214_P0.6791.00
149_F159_V0.6761.00
39_E46_E0.6741.00
262_L278_F0.6691.00
26_V38_G0.6691.00
108_Q112_R0.6691.00
103_G108_Q0.6681.00
98_F121_V0.6661.00
324_H327_T0.6621.00
107_E111_Q0.6621.00
204_Y215_F0.6601.00
185_I245_S0.6591.00
171_Q203_G0.6551.00
178_I208_L0.6551.00
234_I257_G0.6511.00
240_H244_I0.6511.00
260_F297_D0.6491.00
172_L176_H0.6481.00
147_V159_V0.6481.00
251_N288_T0.6441.00
260_F264_K0.6411.00
223_C229_Q0.6411.00
255_A286_A0.6411.00
148_I318_M0.6321.00
187_W204_Y0.6281.00
117_L145_I0.6281.00
32_R37_T0.6281.00
177_L248_V0.6261.00
141_E158_D0.6251.00
7_I44_A0.6251.00
278_F281_Q0.6231.00
18_V37_T0.6231.00
259_W263_L0.6221.00
293_T302_W0.6221.00
12_V23_V0.6211.00
81_E307_A0.6191.00
225_S250_Y0.6191.00
148_I321_K0.6191.00
10_H60_R0.6181.00
110_A135_D0.6181.00
7_I49_G0.6181.00
76_A253_T0.6171.00
23_V26_V0.6151.00
46_E49_G0.6151.00
84_A308_R0.6151.00
294_T299_P0.6141.00
190_G197_R0.6131.00
125_V150_A0.6131.00
227_Q292_P0.6121.00
262_L265_A0.6111.00
40_R43_A0.6111.00
185_I204_Y0.6111.00
113_F124_V0.6111.00
51_V114_S0.6101.00
176_H285_A0.6101.00
197_R225_S0.6081.00
256_M292_P0.6081.00
82_L307_A0.6061.00
23_V45_I0.6051.00
148_I162_V0.6011.00
304_S339_I0.6011.00
171_Q174_T0.6001.00
141_E147_V0.6001.00
151_S166_N0.5991.00
85_G307_A0.5991.00
320_Q330_R0.5971.00
102_G109_L0.5961.00
287_F305_T0.5951.00
151_S196_T0.5951.00
70_I112_R0.5941.00
256_M290_A0.5931.00
186_A219_W0.5931.00
51_V55_Q0.5931.00
166_N199_E0.5901.00
95_R322_I0.5881.00
308_R311_G0.5861.00
228_K231_A0.5861.00
267_R278_F0.5861.00
123_G314_L0.5851.00
139_M142_E0.5851.00
248_V287_F0.5841.00
84_A103_G0.5781.00
263_L268_Q0.5761.00
189_G222_E0.5761.00
148_I314_L0.5721.00
140_A147_V0.5721.00
267_R279_E0.5711.00
95_R122_D0.5711.00
78_F82_L0.5701.00
67_I123_G0.5691.00
201_V222_E0.5661.00
67_I322_I0.5661.00
25_L33_I0.5651.00
295_L299_P0.5641.00
213_L218_D0.5621.00
251_N254_I0.5621.00
184_R244_I0.5591.00
98_F119_Q0.5591.00
33_I38_G0.5531.00
227_Q257_G0.5511.00
90_L319_M0.5511.00
67_I95_R0.5491.00
317_R321_K0.5481.00
173_L246_A0.5471.00
258_A262_L0.5451.00
148_I317_R0.5441.00
106_G110_A0.5431.00
162_V313_T0.5421.00
29_G32_R0.5411.00
231_A257_G0.5411.00
231_A234_I0.5391.00
197_R250_Y0.5361.00
124_V145_I0.5351.00
218_D240_H0.5351.00
57_S61_G0.5351.00
249_C286_A0.5341.00
153_A161_T0.5341.00
313_T320_Q0.5341.00
205_C220_V0.5321.00
215_F220_V0.5291.00
238_L262_L0.5281.00
16_A26_V0.5281.00
23_V41_V0.5281.00
244_I267_R0.5271.00
333_I336_A0.5271.00
18_V23_V0.5261.00
174_T211_F0.5231.00
66_V122_D0.5221.00
100_L115_L0.5201.00
164_P169_A0.5191.00
180_N245_S0.5181.00
58_A61_G0.5161.00
233_A237_L0.5151.00
121_V124_V0.5151.00
79_Y127_A0.5141.00
77_P253_T0.5121.00
229_Q254_I0.5111.00
64_S95_R0.5111.00
16_A41_V0.5111.00
116_L121_V0.5101.00
135_D139_M0.5101.00
293_T300_V0.5091.00
164_P287_F0.5091.00
306_P310_L0.5071.00
31_G38_G0.5061.00
30_K33_I0.5041.00
76_A79_Y0.5041.00
260_F294_T0.5041.00
301_T338_L0.5041.00
321_K324_H0.5041.00
21_S30_K0.5011.00
290_A302_W0.5011.00
115_L118_N0.5011.00
64_S96_M0.5001.00
11_D15_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dbiA 2 0.7924 100 0.096 Contact Map
2o20A 2 0.7953 100 0.099 Contact Map
2hsgA 1 0.9474 100 0.1 Contact Map
1qpzA 2 0.9532 100 0.107 Contact Map
3bilA 2 0.7339 100 0.107 Contact Map
3kjxA 2 0.962 100 0.109 Contact Map
3jvdA 2 0.7515 100 0.111 Contact Map
3e3mA 2 0.769 100 0.113 Contact Map
4o5aA 2 0.769 100 0.116 Contact Map
3h5oA 2 0.7778 100 0.121 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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