DMSC - ECOLI - GREMLIN Contacts

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DMSC - Anaerobic dimethyl sulfoxide reductase chain C

UniProt:	P18777	Sequences: MGSGWHEWPLMIFTVFGQCVAGGFIVLALALLKGDLRAEAQQRVIACMFGLWVLMGIGFIASMLHLGSPMRAFNSLNRVGASALSNEIASGSIFFAVGGIGWLLAMLKKLSPALRTLWLIVTMVLGVIFVWMMVRVYNSIDTVPTWYSIWTPMGFFLTMFMGGPLLGYLLLSLAGVDGWAMRLLPAISVLALVVSGVVSVMQGAELATIHSSVQQAAALVPDYGALMSWRIVLLAVALCLWIAPQLKGYQPAVPLLSVSFILLLAGELIGRGVFYGLHMTVGMAVAS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10234
Length:	287 (267)
Sequences:	994 (805)
Seq/√Len:	49.3

ECOLI - DMSC YNFH NRFD
SULSO - Q97V35

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
97_V	125_L	7.586	1.00
20_V	94_F	5.376	1.00
21_A	126_G	4.325	1.00
83_A	86_N	3.913	1.00
24_F	122_T	3.393	1.00
99_G	103_L	3.267	1.00
68_S	71_R	3.027	1.00
237_A	241_W	3.007	1.00
87_E	137_Y	2.903	1.00
62_S	87_E	2.853	1.00
19_C	54_L	2.823	1.00
26_V	164_P	2.768	1.00
90_S	132_M	2.722	1.00
56_G	95_F	2.560	1.00
14_T	87_E	2.478	1.00
20_V	51_L	2.459	1.00
90_S	128_I	2.403	1.00
65_H	87_E	2.355	1.00
79_V	85_S	2.354	1.00
130_V	159_M	2.309	1.00
14_T	137_Y	2.211	1.00
241_W	244_P	2.202	1.00
87_E	132_M	2.146	1.00
54_L	166_L	2.067	1.00
23_G	167_G	1.916	0.99
229_W	241_W	1.907	0.99
59_F	95_F	1.869	0.99
19_C	166_L	1.856	0.99
261_I	265_A	1.848	0.99
18_Q	133_M	1.815	0.99
55_M	129_F	1.808	0.99
55_M	95_F	1.782	0.99
52_W	98_G	1.779	0.99
7_E	14_T	1.776	0.99
172_S	194_V	1.771	0.99
226_L	237_A	1.739	0.99
223_Y	230_R	1.727	0.99
13_F	87_E	1.724	0.99
72_A	85_S	1.711	0.98
151_T	274_F	1.708	0.98
62_S	137_Y	1.676	0.98
65_H	86_N	1.638	0.98
62_S	132_M	1.628	0.98
65_H	137_Y	1.615	0.98
59_F	91_G	1.612	0.98
149_I	153_M	1.598	0.98
28_A	119_L	1.597	0.98
231_I	235_A	1.557	0.97
7_E	13_F	1.551	0.97
19_C	162_G	1.548	0.97
28_A	123_M	1.539	0.97
58_G	128_I	1.535	0.97
18_Q	21_A	1.535	0.97
15_V	267_E	1.529	0.97
71_R	74_N	1.525	0.97
21_A	159_M	1.510	0.97
235_A	239_C	1.503	0.96
223_Y	229_W	1.502	0.96
14_T	62_S	1.502	0.96
154_G	158_T	1.460	0.96
214_Q	218_A	1.458	0.96
13_F	137_Y	1.448	0.96
85_S	206_L	1.414	0.95
22_G	155_F	1.407	0.95
101_G	119_L	1.406	0.95
162_G	166_L	1.403	0.95
93_I	125_L	1.368	0.94
10_L	18_Q	1.364	0.94
73_F	194_V	1.339	0.93
270_G	275_Y	1.336	0.93
80_G	86_N	1.333	0.93
10_L	13_F	1.294	0.92
62_S	65_H	1.293	0.92
65_H	72_A	1.289	0.92
129_F	133_M	1.275	0.91
226_L	241_W	1.271	0.91
86_N	275_Y	1.269	0.91
23_G	51_L	1.230	0.90
18_Q	270_G	1.212	0.89
10_L	62_S	1.212	0.89
165_L	260_F	1.206	0.89
225_A	229_W	1.204	0.89
91_G	129_F	1.200	0.89
84_L	134_V	1.200	0.89
80_G	275_Y	1.199	0.89
123_M	128_I	1.194	0.89
83_A	135_R	1.185	0.88
100_I	268_L	1.161	0.87
63_M	69_P	1.159	0.87
53_V	242_I	1.158	0.87
87_E	151_T	1.148	0.86
13_F	62_S	1.146	0.86
230_R	267_E	1.142	0.86
8_W	19_C	1.141	0.86
206_L	216_A	1.141	0.86
18_Q	267_E	1.139	0.86
63_M	76_L	1.136	0.86
84_L	145_T	1.133	0.86
60_I	177_D	1.127	0.85
243_A	247_K	1.111	0.85
75_S	83_A	1.110	0.85
91_G	133_M	1.096	0.84
62_S	66_L	1.087	0.83
265_A	268_L	1.083	0.83
84_L	87_E	1.072	0.82
154_G	270_G	1.068	0.82
144_P	155_F	1.064	0.82
198_V	202_Q	1.053	0.81
157_L	195_S	1.052	0.81
14_T	132_M	1.047	0.81
14_T	65_H	1.046	0.81
62_S	75_S	1.040	0.80
236_V	262_L	1.039	0.80
173_L	235_A	1.038	0.80
237_A	263_L	1.037	0.80
182_R	193_V	1.034	0.80
134_V	152_P	1.016	0.79
173_L	194_V	1.011	0.79
83_A	136_V	1.007	0.78
87_E	130_V	1.003	0.78
183_L	187_I	1.002	0.78
62_S	84_L	0.996	0.78
67_G	85_S	0.989	0.77
213_V	216_A	0.987	0.77
29_L	33_K	0.985	0.77
21_A	88_I	0.983	0.77
48_M	101_G	0.976	0.76
120_I	124_V	0.975	0.76
25_I	193_V	0.974	0.76
14_T	274_F	0.973	0.76
65_H	91_G	0.970	0.76
15_V	158_T	0.958	0.75
188_S	195_S	0.952	0.74
88_I	94_F	0.950	0.74
239_C	243_A	0.948	0.74
237_A	267_E	0.947	0.74
27_L	166_L	0.946	0.74
13_F	132_M	0.944	0.74
220_V	264_L	0.938	0.73
51_L	56_G	0.922	0.72
191_A	265_A	0.917	0.71
74_N	77_N	0.915	0.71
158_T	267_E	0.914	0.71
33_K	239_C	0.913	0.71
45_I	103_L	0.913	0.71
13_F	17_G	0.912	0.71
16_F	264_L	0.906	0.71
182_R	186_A	0.905	0.70
183_L	186_A	0.904	0.70
94_F	126_G	0.903	0.70
213_V	218_A	0.902	0.70
184_L	192_L	0.894	0.69
267_E	270_G	0.889	0.69
132_M	137_Y	0.883	0.69
240_L	261_I	0.880	0.68
144_P	270_G	0.878	0.68
31_L	105_A	0.875	0.68
164_P	168_Y	0.874	0.68
200_V	261_I	0.872	0.68
59_F	272_G	0.869	0.67
26_V	184_L	0.869	0.67
230_R	234_L	0.864	0.67
20_V	55_M	0.862	0.67
24_F	28_A	0.856	0.66
14_T	145_T	0.856	0.66
87_E	270_G	0.855	0.66
258_V	262_L	0.854	0.66
75_S	133_M	0.854	0.66
46_A	175_G	0.852	0.66
7_E	10_L	0.847	0.65
191_A	194_V	0.847	0.65
115_R	242_I	0.844	0.65
223_Y	226_L	0.843	0.65
98_G	101_G	0.841	0.65
17_G	136_V	0.841	0.65
78_R	81_A	0.839	0.65
85_S	271_R	0.838	0.64
56_G	169_L	0.836	0.64
72_A	136_V	0.835	0.64
237_A	259_S	0.833	0.64
236_V	240_L	0.832	0.64
13_F	91_G	0.831	0.64
13_F	136_V	0.828	0.64
97_V	122_T	0.827	0.63
67_G	71_R	0.827	0.63
148_S	205_E	0.823	0.63
12_I	61_A	0.823	0.63
173_L	261_I	0.821	0.63
143_V	146_W	0.816	0.62
34_G	37_R	0.815	0.62
74_N	86_N	0.810	0.62
223_Y	232_V	0.809	0.62
168_Y	184_L	0.805	0.61
54_L	79_V	0.804	0.61
242_I	257_S	0.801	0.61
87_E	133_M	0.800	0.61
76_L	92_S	0.794	0.60
7_E	18_Q	0.792	0.60
72_A	87_E	0.790	0.60
182_R	192_L	0.789	0.60
16_F	231_I	0.785	0.59
83_A	126_G	0.783	0.59
193_V	204_A	0.781	0.59
227_M	230_R	0.780	0.59
16_F	131_W	0.764	0.57
105_A	122_T	0.763	0.57
19_C	167_G	0.761	0.57
164_P	264_L	0.761	0.57
10_L	87_E	0.760	0.57
8_W	95_F	0.759	0.57
84_L	132_M	0.757	0.57
103_L	107_L	0.754	0.56
169_L	199_S	0.744	0.55
244_P	247_K	0.743	0.55
23_G	194_V	0.741	0.55
24_F	27_L	0.740	0.55
196_G	199_S	0.740	0.55
156_F	160_F	0.738	0.55
212_S	223_Y	0.736	0.54
92_S	99_G	0.735	0.54
100_I	182_R	0.733	0.54
168_Y	181_M	0.729	0.54
11_M	272_G	0.728	0.54
180_A	188_S	0.725	0.53
18_Q	126_G	0.725	0.53
69_P	72_A	0.724	0.53
86_N	133_M	0.723	0.53
20_V	77_N	0.722	0.53
72_A	271_R	0.718	0.53
58_G	124_V	0.716	0.52
190_L	197_V	0.716	0.52
254_P	257_S	0.716	0.52
55_M	61_A	0.715	0.52
100_I	124_V	0.714	0.52
232_V	236_V	0.712	0.52
20_V	58_G	0.711	0.52
76_L	129_F	0.711	0.52
78_R	142_T	0.710	0.52
159_M	238_L	0.708	0.52
88_I	143_V	0.707	0.52
243_A	249_Y	0.706	0.51
71_R	152_P	0.704	0.51
196_G	235_A	0.703	0.51
50_G	235_A	0.703	0.51
188_S	191_A	0.698	0.51
225_A	228_S	0.698	0.51
235_A	261_I	0.696	0.50
229_W	237_A	0.695	0.50
87_E	135_R	0.695	0.50
75_S	90_S	0.694	0.50
16_F	200_V	0.694	0.50
117_L	128_I	0.692	0.50
231_I	236_V	0.692	0.50
37_R	232_V	0.686	0.49
86_N	137_Y	0.685	0.49
13_F	65_H	0.685	0.49
66_L	256_L	0.685	0.49
106_M	176_V	0.685	0.49
162_G	267_E	0.684	0.49
10_L	84_L	0.684	0.49
94_F	98_G	0.682	0.49
87_E	145_T	0.682	0.49
186_A	194_V	0.681	0.49
234_L	238_L	0.680	0.49
17_G	91_G	0.677	0.48
230_R	270_G	0.675	0.48
16_F	54_L	0.675	0.48
121_V	128_I	0.674	0.48
12_I	33_K	0.673	0.48
50_G	173_L	0.671	0.48
57_I	124_V	0.667	0.47
76_L	256_L	0.664	0.47
112_P	235_A	0.661	0.47
149_I	239_C	0.659	0.47
11_M	273_V	0.658	0.47
32_L	232_V	0.656	0.46
129_F	273_V	0.656	0.46
24_F	101_G	0.656	0.46
215_Q	219_L	0.654	0.46
196_G	268_L	0.653	0.46
86_N	129_F	0.652	0.46
10_L	92_S	0.651	0.46
245_Q	248_G	0.650	0.46
18_Q	155_F	0.649	0.46
123_M	127_V	0.646	0.45
75_S	78_R	0.644	0.45
63_M	99_G	0.644	0.45
27_L	198_V	0.643	0.45
13_F	270_G	0.641	0.45
191_A	211_S	0.636	0.44
16_F	66_L	0.636	0.44
241_W	266_G	0.636	0.44
13_F	143_V	0.635	0.44
102_W	167_G	0.626	0.43
257_S	261_I	0.626	0.43
65_H	260_F	0.625	0.43
186_A	257_S	0.622	0.43
7_E	133_M	0.622	0.43
52_W	95_F	0.621	0.43
91_G	275_Y	0.620	0.43
52_W	152_P	0.619	0.43
84_L	101_G	0.615	0.42
153_M	262_L	0.614	0.42
48_M	123_M	0.614	0.42
262_L	268_L	0.614	0.42
18_Q	158_T	0.613	0.42
89_A	129_F	0.612	0.42
126_G	133_M	0.611	0.42
51_L	121_V	0.610	0.42
186_A	258_V	0.610	0.42
98_G	260_F	0.608	0.42
230_R	241_W	0.607	0.41
86_N	135_R	0.606	0.41
97_V	118_W	0.605	0.41
35_D	121_V	0.605	0.41
201_M	242_I	0.603	0.41
75_S	87_E	0.602	0.41
12_I	197_V	0.601	0.41
87_E	129_F	0.599	0.41
204_A	246_L	0.598	0.41
30_A	204_A	0.597	0.40
230_R	273_V	0.596	0.40
226_L	229_W	0.594	0.40
165_L	263_L	0.589	0.40
124_V	232_V	0.588	0.40
224_G	233_L	0.585	0.39
65_H	136_V	0.584	0.39
130_V	151_T	0.580	0.39
169_L	173_L	0.580	0.39
220_V	234_L	0.580	0.39
67_G	274_F	0.580	0.39
64_L	263_L	0.579	0.39
52_W	138_N	0.576	0.38
8_W	122_T	0.574	0.38
93_I	222_D	0.574	0.38
36_L	50_G	0.574	0.38
71_R	234_L	0.574	0.38
20_V	133_M	0.572	0.38
91_G	132_M	0.568	0.38
177_D	185_P	0.566	0.37
177_D	257_S	0.564	0.37
181_M	244_P	0.564	0.37
14_T	91_G	0.560	0.37
154_G	157_L	0.558	0.37
18_Q	51_L	0.558	0.37
63_M	91_G	0.557	0.37
76_L	233_L	0.557	0.37
140_I	144_P	0.556	0.37
15_V	78_R	0.556	0.37
74_N	142_T	0.556	0.37
216_A	219_L	0.555	0.36
49_F	255_L	0.555	0.36
87_E	91_G	0.554	0.36
142_T	152_P	0.552	0.36
59_F	83_A	0.552	0.36
171_L	175_G	0.548	0.36
8_W	166_L	0.548	0.36
272_G	275_Y	0.547	0.36
229_W	269_I	0.545	0.35
158_T	162_G	0.544	0.35
229_W	254_P	0.544	0.35
59_F	72_A	0.543	0.35
172_S	181_M	0.543	0.35
116_T	190_L	0.543	0.35
171_L	230_R	0.540	0.35
129_F	142_T	0.539	0.35
82_S	146_W	0.538	0.35
173_L	239_C	0.537	0.35
183_L	193_V	0.536	0.35
181_M	262_L	0.536	0.35
159_M	163_G	0.535	0.35
75_S	84_L	0.535	0.35
16_F	58_G	0.535	0.35
272_G	277_L	0.534	0.34
71_R	143_V	0.534	0.34
226_L	265_A	0.533	0.34
103_L	232_V	0.533	0.34
53_V	124_V	0.533	0.34
272_G	276_G	0.530	0.34
122_T	204_A	0.530	0.34
240_L	265_A	0.530	0.34
26_V	187_I	0.530	0.34
85_S	137_Y	0.529	0.34
60_I	64_L	0.528	0.34
182_R	194_V	0.526	0.34
157_L	191_A	0.522	0.33
71_R	146_W	0.520	0.33
60_I	258_V	0.517	0.33
29_L	93_I	0.515	0.33
24_F	29_L	0.514	0.33
21_A	155_F	0.514	0.33
18_Q	136_V	0.511	0.32
158_T	270_G	0.509	0.32
209_I	216_A	0.508	0.32
99_G	118_W	0.508	0.32
130_V	136_V	0.504	0.32
147_Y	166_L	0.500	0.31
117_L	255_L	0.500	0.31
63_M	246_L	0.500	0.31
157_L	242_I	0.500	0.31

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2vpzC	2	0.8328	100	0.508	Contact Map
1dc1A	2	0.2091	3.9	0.965	Contact Map
3s8fC	1	0.108	2.8	0.967	Contact Map
2nr9A	2	0.3449	2.1	0.969	Contact Map
3ne5A	3	0.3624	1.9	0.97	Contact Map
3wdoA	1	0.892	1.8	0.97	Contact Map
4pypA	1	0.892	1.5	0.972	Contact Map
3dh4A	3	0.6341	1.5	0.972	Contact Map
2mofA	1	0.1463	1.4	0.972	Contact Map
3iynN	3	0	1.3	0.973	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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