GREMLIN Database
DMSC - Anaerobic dimethyl sulfoxide reductase chain C
UniProt: P18777 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10234
Length: 287 (267)
Sequences: 994 (805)
Seq/√Len: 49.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
97_V125_L7.5861.00
20_V94_F5.3761.00
21_A126_G4.3251.00
83_A86_N3.9131.00
24_F122_T3.3931.00
99_G103_L3.2671.00
68_S71_R3.0271.00
237_A241_W3.0071.00
87_E137_Y2.9031.00
62_S87_E2.8531.00
19_C54_L2.8231.00
26_V164_P2.7681.00
90_S132_M2.7221.00
56_G95_F2.5601.00
14_T87_E2.4781.00
20_V51_L2.4591.00
90_S128_I2.4031.00
65_H87_E2.3551.00
79_V85_S2.3541.00
130_V159_M2.3091.00
14_T137_Y2.2111.00
241_W244_P2.2021.00
87_E132_M2.1461.00
54_L166_L2.0671.00
23_G167_G1.9160.99
229_W241_W1.9070.99
59_F95_F1.8690.99
19_C166_L1.8560.99
261_I265_A1.8480.99
18_Q133_M1.8150.99
55_M129_F1.8080.99
55_M95_F1.7820.99
52_W98_G1.7790.99
7_E14_T1.7760.99
172_S194_V1.7710.99
226_L237_A1.7390.99
223_Y230_R1.7270.99
13_F87_E1.7240.99
72_A85_S1.7110.98
151_T274_F1.7080.98
62_S137_Y1.6760.98
65_H86_N1.6380.98
62_S132_M1.6280.98
65_H137_Y1.6150.98
59_F91_G1.6120.98
149_I153_M1.5980.98
28_A119_L1.5970.98
231_I235_A1.5570.97
7_E13_F1.5510.97
19_C162_G1.5480.97
28_A123_M1.5390.97
58_G128_I1.5350.97
18_Q21_A1.5350.97
15_V267_E1.5290.97
71_R74_N1.5250.97
21_A159_M1.5100.97
235_A239_C1.5030.96
223_Y229_W1.5020.96
14_T62_S1.5020.96
154_G158_T1.4600.96
214_Q218_A1.4580.96
13_F137_Y1.4480.96
85_S206_L1.4140.95
22_G155_F1.4070.95
101_G119_L1.4060.95
162_G166_L1.4030.95
93_I125_L1.3680.94
10_L18_Q1.3640.94
73_F194_V1.3390.93
270_G275_Y1.3360.93
80_G86_N1.3330.93
10_L13_F1.2940.92
62_S65_H1.2930.92
65_H72_A1.2890.92
129_F133_M1.2750.91
226_L241_W1.2710.91
86_N275_Y1.2690.91
23_G51_L1.2300.90
18_Q270_G1.2120.89
10_L62_S1.2120.89
165_L260_F1.2060.89
225_A229_W1.2040.89
91_G129_F1.2000.89
84_L134_V1.2000.89
80_G275_Y1.1990.89
123_M128_I1.1940.89
83_A135_R1.1850.88
100_I268_L1.1610.87
63_M69_P1.1590.87
53_V242_I1.1580.87
87_E151_T1.1480.86
13_F62_S1.1460.86
230_R267_E1.1420.86
8_W19_C1.1410.86
206_L216_A1.1410.86
18_Q267_E1.1390.86
63_M76_L1.1360.86
84_L145_T1.1330.86
60_I177_D1.1270.85
243_A247_K1.1110.85
75_S83_A1.1100.85
91_G133_M1.0960.84
62_S66_L1.0870.83
265_A268_L1.0830.83
84_L87_E1.0720.82
154_G270_G1.0680.82
144_P155_F1.0640.82
198_V202_Q1.0530.81
157_L195_S1.0520.81
14_T132_M1.0470.81
14_T65_H1.0460.81
62_S75_S1.0400.80
236_V262_L1.0390.80
173_L235_A1.0380.80
237_A263_L1.0370.80
182_R193_V1.0340.80
134_V152_P1.0160.79
173_L194_V1.0110.79
83_A136_V1.0070.78
87_E130_V1.0030.78
183_L187_I1.0020.78
62_S84_L0.9960.78
67_G85_S0.9890.77
213_V216_A0.9870.77
29_L33_K0.9850.77
21_A88_I0.9830.77
48_M101_G0.9760.76
120_I124_V0.9750.76
25_I193_V0.9740.76
14_T274_F0.9730.76
65_H91_G0.9700.76
15_V158_T0.9580.75
188_S195_S0.9520.74
88_I94_F0.9500.74
239_C243_A0.9480.74
237_A267_E0.9470.74
27_L166_L0.9460.74
13_F132_M0.9440.74
220_V264_L0.9380.73
51_L56_G0.9220.72
191_A265_A0.9170.71
74_N77_N0.9150.71
158_T267_E0.9140.71
33_K239_C0.9130.71
45_I103_L0.9130.71
13_F17_G0.9120.71
16_F264_L0.9060.71
182_R186_A0.9050.70
183_L186_A0.9040.70
94_F126_G0.9030.70
213_V218_A0.9020.70
184_L192_L0.8940.69
267_E270_G0.8890.69
132_M137_Y0.8830.69
240_L261_I0.8800.68
144_P270_G0.8780.68
31_L105_A0.8750.68
164_P168_Y0.8740.68
200_V261_I0.8720.68
59_F272_G0.8690.67
26_V184_L0.8690.67
230_R234_L0.8640.67
20_V55_M0.8620.67
24_F28_A0.8560.66
14_T145_T0.8560.66
87_E270_G0.8550.66
258_V262_L0.8540.66
75_S133_M0.8540.66
46_A175_G0.8520.66
7_E10_L0.8470.65
191_A194_V0.8470.65
115_R242_I0.8440.65
223_Y226_L0.8430.65
98_G101_G0.8410.65
17_G136_V0.8410.65
78_R81_A0.8390.65
85_S271_R0.8380.64
56_G169_L0.8360.64
72_A136_V0.8350.64
237_A259_S0.8330.64
236_V240_L0.8320.64
13_F91_G0.8310.64
13_F136_V0.8280.64
97_V122_T0.8270.63
67_G71_R0.8270.63
148_S205_E0.8230.63
12_I61_A0.8230.63
173_L261_I0.8210.63
143_V146_W0.8160.62
34_G37_R0.8150.62
74_N86_N0.8100.62
223_Y232_V0.8090.62
168_Y184_L0.8050.61
54_L79_V0.8040.61
242_I257_S0.8010.61
87_E133_M0.8000.61
76_L92_S0.7940.60
7_E18_Q0.7920.60
72_A87_E0.7900.60
182_R192_L0.7890.60
16_F231_I0.7850.59
83_A126_G0.7830.59
193_V204_A0.7810.59
227_M230_R0.7800.59
16_F131_W0.7640.57
105_A122_T0.7630.57
19_C167_G0.7610.57
164_P264_L0.7610.57
10_L87_E0.7600.57
8_W95_F0.7590.57
84_L132_M0.7570.57
103_L107_L0.7540.56
169_L199_S0.7440.55
244_P247_K0.7430.55
23_G194_V0.7410.55
24_F27_L0.7400.55
196_G199_S0.7400.55
156_F160_F0.7380.55
212_S223_Y0.7360.54
92_S99_G0.7350.54
100_I182_R0.7330.54
168_Y181_M0.7290.54
11_M272_G0.7280.54
180_A188_S0.7250.53
18_Q126_G0.7250.53
69_P72_A0.7240.53
86_N133_M0.7230.53
20_V77_N0.7220.53
72_A271_R0.7180.53
58_G124_V0.7160.52
190_L197_V0.7160.52
254_P257_S0.7160.52
55_M61_A0.7150.52
100_I124_V0.7140.52
232_V236_V0.7120.52
20_V58_G0.7110.52
76_L129_F0.7110.52
78_R142_T0.7100.52
159_M238_L0.7080.52
88_I143_V0.7070.52
243_A249_Y0.7060.51
71_R152_P0.7040.51
196_G235_A0.7030.51
50_G235_A0.7030.51
188_S191_A0.6980.51
225_A228_S0.6980.51
235_A261_I0.6960.50
229_W237_A0.6950.50
87_E135_R0.6950.50
75_S90_S0.6940.50
16_F200_V0.6940.50
117_L128_I0.6920.50
231_I236_V0.6920.50
37_R232_V0.6860.49
86_N137_Y0.6850.49
13_F65_H0.6850.49
66_L256_L0.6850.49
106_M176_V0.6850.49
162_G267_E0.6840.49
10_L84_L0.6840.49
94_F98_G0.6820.49
87_E145_T0.6820.49
186_A194_V0.6810.49
234_L238_L0.6800.49
17_G91_G0.6770.48
230_R270_G0.6750.48
16_F54_L0.6750.48
121_V128_I0.6740.48
12_I33_K0.6730.48
50_G173_L0.6710.48
57_I124_V0.6670.47
76_L256_L0.6640.47
112_P235_A0.6610.47
149_I239_C0.6590.47
11_M273_V0.6580.47
32_L232_V0.6560.46
129_F273_V0.6560.46
24_F101_G0.6560.46
215_Q219_L0.6540.46
196_G268_L0.6530.46
86_N129_F0.6520.46
10_L92_S0.6510.46
245_Q248_G0.6500.46
18_Q155_F0.6490.46
123_M127_V0.6460.45
75_S78_R0.6440.45
63_M99_G0.6440.45
27_L198_V0.6430.45
13_F270_G0.6410.45
191_A211_S0.6360.44
16_F66_L0.6360.44
241_W266_G0.6360.44
13_F143_V0.6350.44
102_W167_G0.6260.43
257_S261_I0.6260.43
65_H260_F0.6250.43
186_A257_S0.6220.43
7_E133_M0.6220.43
52_W95_F0.6210.43
91_G275_Y0.6200.43
52_W152_P0.6190.43
84_L101_G0.6150.42
153_M262_L0.6140.42
48_M123_M0.6140.42
262_L268_L0.6140.42
18_Q158_T0.6130.42
89_A129_F0.6120.42
126_G133_M0.6110.42
51_L121_V0.6100.42
186_A258_V0.6100.42
98_G260_F0.6080.42
230_R241_W0.6070.41
86_N135_R0.6060.41
97_V118_W0.6050.41
35_D121_V0.6050.41
201_M242_I0.6030.41
75_S87_E0.6020.41
12_I197_V0.6010.41
87_E129_F0.5990.41
204_A246_L0.5980.41
30_A204_A0.5970.40
230_R273_V0.5960.40
226_L229_W0.5940.40
165_L263_L0.5890.40
124_V232_V0.5880.40
224_G233_L0.5850.39
65_H136_V0.5840.39
130_V151_T0.5800.39
169_L173_L0.5800.39
220_V234_L0.5800.39
67_G274_F0.5800.39
64_L263_L0.5790.39
52_W138_N0.5760.38
8_W122_T0.5740.38
93_I222_D0.5740.38
36_L50_G0.5740.38
71_R234_L0.5740.38
20_V133_M0.5720.38
91_G132_M0.5680.38
177_D185_P0.5660.37
177_D257_S0.5640.37
181_M244_P0.5640.37
14_T91_G0.5600.37
154_G157_L0.5580.37
18_Q51_L0.5580.37
63_M91_G0.5570.37
76_L233_L0.5570.37
140_I144_P0.5560.37
15_V78_R0.5560.37
74_N142_T0.5560.37
216_A219_L0.5550.36
49_F255_L0.5550.36
87_E91_G0.5540.36
142_T152_P0.5520.36
59_F83_A0.5520.36
171_L175_G0.5480.36
8_W166_L0.5480.36
272_G275_Y0.5470.36
229_W269_I0.5450.35
158_T162_G0.5440.35
229_W254_P0.5440.35
59_F72_A0.5430.35
172_S181_M0.5430.35
116_T190_L0.5430.35
171_L230_R0.5400.35
129_F142_T0.5390.35
82_S146_W0.5380.35
173_L239_C0.5370.35
183_L193_V0.5360.35
181_M262_L0.5360.35
159_M163_G0.5350.35
75_S84_L0.5350.35
16_F58_G0.5350.35
272_G277_L0.5340.34
71_R143_V0.5340.34
226_L265_A0.5330.34
103_L232_V0.5330.34
53_V124_V0.5330.34
272_G276_G0.5300.34
122_T204_A0.5300.34
240_L265_A0.5300.34
26_V187_I0.5300.34
85_S137_Y0.5290.34
60_I64_L0.5280.34
182_R194_V0.5260.34
157_L191_A0.5220.33
71_R146_W0.5200.33
60_I258_V0.5170.33
29_L93_I0.5150.33
24_F29_L0.5140.33
21_A155_F0.5140.33
18_Q136_V0.5110.32
158_T270_G0.5090.32
209_I216_A0.5080.32
99_G118_W0.5080.32
130_V136_V0.5040.32
147_Y166_L0.5000.31
117_L255_L0.5000.31
63_M246_L0.5000.31
157_L242_I0.5000.31
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vpzC 2 0.8328 100 0.508 Contact Map
1dc1A 2 0.2091 3.9 0.965 Contact Map
3s8fC 1 0.108 2.8 0.967 Contact Map
2nr9A 2 0.3449 2.1 0.969 Contact Map
3ne5A 3 0.3624 1.9 0.97 Contact Map
3wdoA 1 0.892 1.8 0.97 Contact Map
4pypA 1 0.892 1.5 0.972 Contact Map
3dh4A 3 0.6341 1.5 0.972 Contact Map
2mofA 1 0.1463 1.4 0.972 Contact Map
3iynN 3 0 1.3 0.973 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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