GREMLIN Database
DMSB - Anaerobic dimethyl sulfoxide reductase chain B
UniProt: P18776 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10233
Length: 205 (176)
Sequences: 3451 (1926)
Seq/√Len: 145.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
76_T84_M3.0721.00
103_R116_Y2.8811.00
78_V108_A2.8411.00
27_Y131_D2.8161.00
71_E180_N2.6461.00
139_P142_V2.5171.00
106_H123_M2.4891.00
84_M114_P2.3861.00
7_F128_G2.2841.00
84_M94_V2.2231.00
142_V150_L2.1331.00
73_P86_K2.1261.00
130_Y134_A2.1101.00
151_D161_K2.0671.00
6_G155_I1.9691.00
87_R134_A1.9521.00
36_F124_T1.8571.00
78_V104_Y1.8481.00
132_R137_K1.8321.00
138_K143_E1.8181.00
9_I150_L1.8101.00
116_Y123_M1.7841.00
14_C20_C1.7741.00
53_V56_Q1.7701.00
14_C17_C1.7401.00
17_C20_C1.7091.00
91_F128_G1.7071.00
103_R106_H1.7061.00
18_K21_E1.7051.00
28_K127_D1.6831.00
161_K164_D1.6661.00
91_F133_V1.6641.00
85_H93_V1.6521.00
15_T147_L1.6391.00
76_T86_K1.6221.00
79_C105_C1.6221.00
117_N124_T1.6111.00
170_P173_R1.6031.00
155_I159_R1.5911.00
8_F162_H1.5851.00
95_D98_V1.5751.00
4_Q71_E1.5601.00
72_D77_K1.5431.00
87_R93_V1.5361.00
157_E160_K1.5291.00
27_Y132_R1.5001.00
99_C105_C1.5001.00
23_A144_S1.4951.00
79_C99_C1.4891.00
132_R143_E1.4871.00
14_C145_C1.4811.00
85_H95_D1.4801.00
128_G181_I1.4161.00
117_N120_K1.4021.00
17_C145_C1.3501.00
36_F39_I1.3371.00
93_V130_Y1.3301.00
114_P123_M1.3071.00
154_P157_E1.2831.00
72_D178_K1.2661.00
87_R91_F1.2631.00
161_K165_L1.2511.00
153_G157_E1.2391.00
81_S84_M1.2371.00
66_S181_I1.2341.00
8_F184_K1.2291.00
151_D165_L1.2291.00
128_G133_V1.2271.00
160_K163_G1.2231.00
170_P178_K1.2211.00
73_P76_T1.2171.00
9_I64_S1.2071.00
20_C145_C1.2021.00
28_K131_D1.1921.00
99_C102_C1.1761.00
74_A177_T1.1731.00
103_R118_E1.1701.00
12_S184_K1.1631.00
6_G158_L1.1340.99
138_K142_V1.1290.99
151_D162_H1.1090.99
19_T144_S1.1000.99
5_Y154_P1.0950.99
160_K164_D1.0880.99
159_R164_D1.0810.99
39_I45_G1.0790.99
126_C129_C1.0630.99
66_S150_L1.0550.99
94_V123_M1.0440.99
12_S169_A1.0370.99
128_G152_F1.0210.99
27_Y140_I1.0170.99
65_I171_L1.0160.99
166_A182_V1.0160.99
81_S100_I1.0120.99
163_G166_A1.0080.99
133_V152_F1.0070.99
87_R130_Y0.9870.98
164_D168_V0.9770.98
172_P175_H0.9770.98
11_S64_S0.9650.98
93_V127_D0.9620.98
45_G53_V0.9620.98
118_E121_G0.9510.98
163_G167_A0.9450.98
96_E122_H0.9400.98
4_Q180_N0.9380.98
164_D167_A0.9320.98
64_S150_L0.9270.98
170_P175_H0.9230.98
38_R115_Q0.9210.98
86_K92_V0.9180.98
103_R123_M0.9160.98
170_P182_V0.9130.97
176_F183_I0.9110.97
137_K143_E0.9100.97
102_C105_C0.9080.97
104_Y107_M0.9010.97
74_A108_A0.8900.97
40_Y44_G0.8830.97
53_V57_N0.8780.97
7_F142_V0.8780.97
91_F130_Y0.8740.97
83_A98_V0.8610.96
89_D134_A0.8570.96
28_K140_I0.8460.96
79_C102_C0.8460.96
35_S39_I0.8380.96
37_R150_L0.8230.95
37_R42_Y0.8220.95
127_D131_D0.8210.95
19_T22_L0.8210.95
80_P105_C0.8170.95
10_D13_R0.8120.95
81_S85_H0.8080.95
5_Y152_F0.8080.95
54_W57_N0.8050.95
6_G180_N0.8020.95
76_T85_H0.7900.94
81_S102_C0.7890.94
39_I42_Y0.7890.94
37_R41_E0.7830.94
78_V107_M0.7770.94
8_F165_L0.7750.94
23_A140_I0.7730.94
179_P183_I0.7730.94
80_P100_I0.7620.93
94_V114_P0.7530.93
41_E44_G0.7470.92
9_I66_S0.7440.92
132_R140_I0.7400.92
125_K129_C0.7320.92
165_L184_K0.7300.91
36_F40_Y0.7270.91
115_Q124_T0.7240.91
166_A169_A0.7210.91
13_R149_A0.7200.91
5_Y133_V0.7160.91
116_Y121_G0.7140.91
71_E86_K0.7080.90
117_N121_G0.7030.90
78_V84_M0.7000.90
167_A174_A0.6880.89
173_R176_F0.6800.88
104_Y108_A0.6800.88
118_E124_T0.6800.88
15_T146_P0.6750.88
148_R151_D0.6590.87
176_F179_P0.6590.87
80_P99_C0.6580.87
159_R163_G0.6570.87
158_L163_G0.6550.86
177_T180_N0.6510.86
162_H165_L0.6500.86
96_E120_K0.6470.86
34_V37_R0.6470.86
89_D93_V0.6470.86
42_Y45_G0.6420.85
169_A184_K0.6420.85
16_G20_C0.6410.85
116_Y120_K0.6400.85
138_K151_D0.6390.85
7_F64_S0.6390.85
165_L169_A0.6330.85
81_S98_V0.6320.84
35_S38_R0.6310.84
4_Q155_I0.6300.84
38_R45_G0.6270.84
11_S63_L0.6260.84
36_F41_E0.6240.84
41_E60_A0.6200.83
8_F151_D0.6170.83
64_S183_I0.6170.83
4_Q156_D0.6150.83
165_L168_V0.6120.82
106_H116_Y0.6120.82
174_A177_T0.6090.82
153_G158_L0.6090.82
27_Y127_D0.6080.82
19_T26_D0.6080.82
86_K91_F0.6040.82
39_I44_G0.6020.81
64_S68_N0.5950.81
38_R43_A0.5950.81
39_I43_A0.5940.81
71_E178_K0.5940.81
66_S128_G0.5930.80
35_S40_Y0.5910.80
7_F66_S0.5890.80
158_L162_H0.5820.79
51_N56_Q0.5800.79
38_R42_Y0.5800.79
112_G115_Q0.5790.79
19_T146_P0.5760.79
174_A178_K0.5740.78
35_S42_Y0.5730.78
19_T147_L0.5700.78
36_F42_Y0.5690.78
16_G149_A0.5610.77
100_I104_Y0.5580.76
5_Y91_F0.5560.76
139_P150_L0.5560.76
162_H166_A0.5560.76
158_L161_K0.5560.76
31_T34_V0.5550.76
103_R107_M0.5550.76
16_G62_Y0.5520.76
8_F160_K0.5510.75
103_R124_T0.5490.75
9_I183_I0.5480.75
37_R40_Y0.5470.75
124_T127_D0.5430.74
22_L144_S0.5410.74
34_V38_R0.5390.74
21_E39_I0.5390.74
87_R133_V0.5380.74
37_R66_S0.5380.74
100_I105_C0.5350.73
69_H92_V0.5340.73
176_F184_K0.5330.73
5_Y89_D0.5320.73
16_G19_T0.5300.73
8_F166_A0.5300.73
36_F43_A0.5270.72
25_K30_L0.5270.72
154_P160_K0.5270.72
40_Y43_A0.5240.72
171_L174_A0.5240.72
45_G57_N0.5230.72
18_K22_L0.5220.72
37_R44_G0.5200.71
12_S182_V0.5190.71
32_P36_F0.5180.71
33_E37_R0.5170.71
179_P182_V0.5150.71
26_D143_E0.5120.70
80_P102_C0.5110.70
4_Q86_K0.5080.69
175_H179_P0.5070.69
7_F152_F0.5070.69
127_D130_Y0.5020.69
154_P158_L0.5010.68
43_A60_A0.5010.68
33_E40_Y0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2ivfB 1 0.9902 100 0.352 Contact Map
1ti6B 2 0.9463 100 0.364 Contact Map
1kqfB 3 0.9902 100 0.404 Contact Map
2vpzB 2 0.922 100 0.414 Contact Map
1h0hB 1 0.9512 100 0.418 Contact Map
1q16B 2 1 100 0.448 Contact Map
4z3xE 2 0.8049 100 0.576 Contact Map
3mm5B 2 0.9756 99.8 0.681 Contact Map
1jnrB 1 0.678 99.5 0.757 Contact Map
3gyxB 1 0.7073 99.5 0.762 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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