GREMLIN Database
DMSA - Dimethyl sulfoxide reductase DmsA
UniProt: P18775 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10232
Length: 814 (675)
Sequences: 8370 (5250)
Seq/√Len: 202.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
122_Y137_R5.9831.00
736_I755_A4.8441.00
145_D576_R4.5691.00
743_R812_E4.3311.00
564_K572_E3.7061.00
307_E372_R3.4761.00
299_G356_A3.4741.00
730_D764_G3.4641.00
743_R750_E3.3611.00
150_N153_R3.3221.00
354_E364_A3.2911.00
695_L734_R3.2471.00
555_Q558_K3.1851.00
568_E572_E3.1391.00
303_V307_E3.0901.00
511_V523_A3.0111.00
146_I525_I2.9351.00
147_I525_I2.9241.00
144_Y576_R2.9091.00
312_Q316_D2.8531.00
153_R157_E2.8391.00
729_L763_P2.7801.00
588_T591_E2.7771.00
742_V755_A2.7551.00
302_Y306_T2.7501.00
139_S142_E2.7381.00
296_L360_T2.7201.00
746_N809_V2.7111.00
320_V647_S2.7051.00
726_I755_A2.7001.00
745_F810_Q2.6791.00
154_L162_S2.6791.00
301_A407_L2.6761.00
233_K379_P2.6551.00
745_F812_E2.6421.00
357_S364_A2.6181.00
138_I525_I2.5681.00
238_F297_V2.5481.00
125_K138_I2.5481.00
122_Y562_E2.5321.00
125_K525_I2.5211.00
731_A757_V2.4691.00
721_R754_E2.4601.00
125_K146_I2.4401.00
726_I811_V2.4391.00
266_R373_E2.4381.00
284_E369_K2.4221.00
363_P366_K2.3531.00
366_K369_K2.3361.00
310_V315_L2.3241.00
308_N312_Q2.3211.00
151_M477_M2.3141.00
352_T355_W2.3091.00
144_Y572_E2.2991.00
734_R810_Q2.2741.00
364_A368_I2.2251.00
492_E793_Q2.2211.00
745_F750_E2.1851.00
269_I282_E2.1841.00
738_N757_V2.1761.00
301_A337_Y2.1671.00
232_S235_V2.1501.00
137_R562_E2.1311.00
146_I150_N2.1301.00
736_I742_V2.1271.00
647_S651_E2.1041.00
369_K373_E2.0761.00
313_A317_K2.0761.00
154_L477_M2.0651.00
724_M766_V2.0481.00
74_R89_N2.0321.00
724_M742_V2.0301.00
572_E576_R2.0161.00
231_N414_N2.0141.00
733_K763_P2.0071.00
147_I510_V2.0071.00
753_I768_L1.9891.00
138_I146_I1.9831.00
741_K752_H1.9711.00
286_I370_L1.9541.00
724_M768_L1.9521.00
234_L268_I1.9381.00
302_Y353_P1.9371.00
286_I362_V1.9361.00
560_R563_C1.9341.00
612_E616_Q1.9311.00
292_T359_I1.9181.00
284_E366_K1.8831.00
743_R752_H1.8761.00
234_L373_E1.8721.00
305_I341_I1.8661.00
609_T612_E1.8581.00
125_K136_E1.8521.00
476_K507_E1.8471.00
724_M744_I1.8241.00
121_K561_F1.8201.00
726_I766_V1.8191.00
305_I322_Y1.8181.00
303_V372_R1.7991.00
738_N756_K1.7961.00
307_E368_I1.7831.00
296_L367_I1.7651.00
516_M520_A1.7631.00
354_E368_I1.7511.00
72_P91_G1.7451.00
572_E575_K1.7371.00
303_V353_P1.7331.00
309_L375_G1.7301.00
536_M555_Q1.7181.00
508_L525_I1.7071.00
374_I408_T1.6881.00
191_M196_G1.6881.00
152_Q156_K1.6831.00
695_L766_V1.6821.00
374_I380_A1.6771.00
260_R283_D1.6771.00
124_M526_L1.6751.00
145_D149_T1.6681.00
357_S367_I1.6651.00
357_S363_P1.6611.00
339_A342_L1.6341.00
479_W512_I1.6061.00
407_L652_I1.6041.00
147_I527_L1.6031.00
741_K754_E1.5991.00
700_F767_A1.5991.00
725_W758_T1.5971.00
303_V368_I1.5961.00
530_C565_T1.5951.00
766_V809_V1.5801.00
413_I416_G1.5781.00
729_L732_Q1.5701.00
127_V134_K1.5701.00
737_H740_D1.5671.00
284_E373_E1.5641.00
270_I296_L1.5611.00
506_C509_I1.5601.00
309_L372_R1.5571.00
304_M310_V1.5541.00
138_I142_E1.5521.00
690_N747_D1.5511.00
751_V768_L1.5481.00
695_L730_D1.5451.00
356_A367_I1.5381.00
236_V270_I1.5331.00
151_M510_V1.5311.00
315_L322_Y1.5261.00
124_M137_R1.5061.00
59_I77_V1.4991.00
158_Y476_K1.4941.00
234_L370_L1.4801.00
319_C652_I1.4801.00
112_R715_V1.4741.00
259_A265_A1.4741.00
296_L370_L1.4731.00
303_V309_L1.4731.00
295_A359_I1.4721.00
590_E594_R1.4661.00
127_V136_E1.4631.00
306_T368_I1.4581.00
76_H86_E1.4571.00
75_M82_I1.4531.00
498_E504_K1.4451.00
123_P140_W1.4441.00
445_M448_W1.4391.00
146_I508_L1.4341.00
511_V520_A1.4141.00
480_N509_I1.4081.00
310_V322_Y1.4071.00
142_E146_I1.4061.00
655_Q659_D1.4061.00
372_R376_S1.4011.00
497_H504_K1.3991.00
351_K359_I1.3991.00
587_R591_E1.3971.00
305_I338_K1.3961.00
61_S75_M1.3951.00
695_L810_Q1.3851.00
306_T342_L1.3821.00
288_I362_V1.3801.00
60_W74_R1.3791.00
164_Y475_I1.3691.00
611_E615_K1.3671.00
516_M526_L1.3661.00
554_D614_R1.3621.00
149_T153_R1.3621.00
58_V74_R1.3611.00
236_V370_L1.3591.00
728_P759_P1.3531.00
82_I114_V1.3481.00
142_E525_I1.3451.00
624_P628_H1.3451.00
272_P285_W1.3441.00
461_L465_V1.3411.00
564_K568_E1.3281.00
724_M753_I1.3271.00
337_Y341_I1.3261.00
165_L191_M1.3201.00
127_V132_E1.3151.00
152_Q155_I1.3091.00
575_K580_E1.3091.00
734_R811_V1.3071.00
514_C531_T1.3021.00
305_I310_V1.2961.00
269_I278_G1.2951.00
228_D231_N1.2951.00
155_I163_I1.2921.00
233_K263_S1.2871.00
361_G762_M1.2871.00
300_L374_I1.2851.00
313_A316_D1.2801.00
565_T568_E1.2801.00
351_K355_W1.2751.00
284_E370_L1.2641.00
460_A463_D1.2621.00
377_T380_A1.2561.00
723_E756_K1.2551.00
258_Q261_Q1.2531.00
60_W88_D1.2461.00
450_D454_R1.2441.00
155_I194_C1.2431.00
126_R135_F1.2411.00
304_M375_G1.2401.00
338_K342_L1.2381.00
303_V306_T1.2371.00
118_D712_N1.2361.00
320_V651_E1.2351.00
292_T360_T1.2341.00
286_I366_K1.2341.00
75_M85_V1.2331.00
355_W358_Q1.2311.00
692_Q747_D1.2311.00
324_E339_A1.2271.00
351_K356_A1.2261.00
461_L466_R1.2241.00
744_I768_L1.2191.00
58_V76_H1.2101.00
594_R597_Y1.2101.00
727_N763_P1.2081.00
74_R88_D1.2021.00
768_L787_I1.2011.00
236_V300_L1.2001.00
144_Y564_K1.1981.00
74_R86_E1.1881.00
321_G324_E1.1851.00
233_K378_K1.1851.00
212_G398_T1.1791.00
300_L371_A1.1771.00
512_I569_M1.1761.00
312_Q338_K1.1731.00
477_M510_V1.1711.00
758_T761_M1.1711.00
233_K377_T1.1711.00
568_E575_K1.1691.00
268_I370_L1.1691.00
388_P401_I1.1681.00
463_D466_R1.1661.00
591_E594_R1.1651.00
163_I477_M1.1641.00
309_L376_S1.1631.00
410_N416_G1.1621.00
645_T651_E1.1611.00
303_V367_I1.1601.00
148_A576_R1.1591.00
495_R498_E1.1531.00
692_Q810_Q1.1491.00
297_V401_I1.1431.00
530_C563_C1.1391.00
81_E115_Y1.1381.00
155_I160_N1.1361.00
304_M408_T1.1261.00
56_E78_V1.1211.00
154_L508_L1.1201.00
299_G367_I1.1191.00
237_L240_N1.1181.00
87_T101_V1.1151.00
374_I382_I1.1151.00
288_I292_T1.1151.00
235_V265_A1.1141.00
460_A465_V1.1131.00
492_E495_R1.1081.00
725_W756_K1.1071.00
552_F614_R1.1031.00
235_V256_L1.0971.00
260_R281_R1.0961.00
151_M577_L1.0941.00
315_L652_I1.0921.00
300_L304_M1.0921.00
211_E798_L1.0901.00
766_V811_V1.0871.00
481_Y570_T1.0831.00
154_L507_E1.0821.00
350_A355_W1.0801.00
512_I529_D1.0801.00
462_R466_R1.0781.00
121_K137_R1.0771.00
362_V367_I1.0771.00
274_Y280_G1.0761.00
357_S362_V1.0731.00
190_L577_L1.0641.00
135_F526_L1.0641.00
85_V111_R1.0641.00
593_M597_Y1.0601.00
357_S360_T1.0581.00
300_L370_L1.0551.00
150_N154_L1.0511.00
234_L377_T1.0491.00
159_G162_S1.0471.00
300_L404_L1.0441.00
356_A360_T1.0441.00
365_D368_I1.0441.00
144_Y568_E1.0421.00
147_I508_L1.0351.00
121_K560_R1.0351.00
136_E142_E1.0311.00
114_V557_I1.0301.00
140_W527_L1.0301.00
120_L526_L1.0271.00
594_R611_E1.0251.00
480_N519_S1.0231.00
697_L809_V1.0201.00
632_K636_E1.0181.00
587_R595_H1.0171.00
302_Y352_T1.0151.00
693_Y810_Q1.0151.00
162_S476_K1.0141.00
297_V400_A1.0131.00
724_M811_V1.0121.00
693_Y746_N1.0111.00
58_V86_E1.0101.00
527_L569_M1.0091.00
151_M479_W1.0071.00
320_V649_K1.0061.00
633_A636_E1.0041.00
322_Y407_L1.0011.00
536_M552_F0.9971.00
533_S556_V0.9921.00
613_F618_I0.9891.00
234_L380_A0.9871.00
590_E610_F0.9801.00
338_K341_I0.9791.00
302_Y342_L0.9781.00
403_M652_I0.9771.00
698_T765_V0.9751.00
140_W569_M0.9751.00
237_L267_M0.9731.00
725_W760_R0.9701.00
238_F270_I0.9701.00
342_L350_A0.9690.99
76_H84_Y0.9690.99
448_W451_A0.9680.99
72_P88_D0.9680.99
353_P368_I0.9660.99
163_I194_C0.9610.99
299_G303_V0.9600.99
536_M590_E0.9580.99
268_I373_E0.9580.99
229_I381_F0.9570.99
690_N808_L0.9560.99
289_R762_M0.9530.99
310_V407_L0.9530.99
216_T399_R0.9530.99
590_E614_R0.9510.99
290_P765_V0.9470.99
406_I650_I0.9450.99
727_N761_M0.9440.99
471_L495_R0.9430.99
727_N757_V0.9430.99
460_A466_R0.9430.99
470_K473_V0.9410.99
364_A367_I0.9410.99
322_Y338_K0.9390.99
242_P256_L0.9390.99
144_Y573_L0.9360.99
270_I286_I0.9360.99
726_I736_I0.9350.99
380_A410_N0.9340.99
147_I573_L0.9330.99
75_M533_S0.9300.99
478_I506_C0.9300.99
694_P810_Q0.9280.99
498_E505_K0.9260.99
303_V371_A0.9260.99
494_N498_E0.9260.99
520_A526_L0.9250.99
729_L759_P0.9250.99
748_R807_N0.9230.99
266_R283_D0.9220.99
141_E576_R0.9180.99
319_C406_I0.9180.99
368_I372_R0.9150.99
580_E583_F0.9150.99
447_M450_D0.9140.99
280_G760_R0.9140.99
270_I370_L0.9130.99
610_F614_R0.9120.99
613_F616_Q0.9090.99
550_V608_P0.9060.99
751_V790_L0.9060.99
477_M508_L0.9050.99
294_A397_A0.9040.99
272_P287_P0.9020.99
369_K372_R0.8970.99
479_W573_L0.8940.99
362_V366_K0.8920.99
486_L497_H0.8920.99
315_L407_L0.8890.99
78_V83_K0.8890.99
355_W359_I0.8880.99
270_I288_I0.8880.99
266_R284_E0.8880.99
311_D413_I0.8860.99
557_I560_R0.8850.99
352_T356_A0.8830.99
748_R791_T0.8830.99
230_E255_Y0.8830.99
296_L300_L0.8830.99
689_L808_L0.8830.99
337_Y407_L0.8820.99
484_N708_S0.8820.99
274_Y760_R0.8810.99
530_C559_P0.8790.99
288_I296_L0.8790.99
67_C71_C0.8750.99
631_Y634_F0.8730.99
726_I742_V0.8730.99
529_D569_M0.8720.99
594_R598_A0.8710.99
60_W90_T0.8700.99
616_Q619_F0.8700.99
75_M556_V0.8690.99
63_C67_C0.8650.99
386_W390_R0.8640.99
234_L266_R0.8620.99
63_C71_C0.8620.99
695_L811_V0.8610.99
460_A464_G0.8600.99
441_T451_A0.8570.99
379_P416_G0.8540.99
268_I284_E0.8540.99
536_M589_Q0.8500.99
753_I787_I0.8500.99
444_S447_M0.8490.99
237_L277_T0.8490.99
151_M155_I0.8490.99
306_T353_P0.8480.99
486_L493_I0.8460.99
167_Y170_G0.8440.99
295_A299_G0.8440.99
458_M461_L0.8440.99
731_A736_I0.8440.99
726_I731_A0.8420.99
190_L570_T0.8420.99
259_A263_S0.8400.99
123_P139_S0.8400.99
304_M404_L0.8380.99
299_G355_W0.8360.99
469_D474_P0.8350.98
298_N351_K0.8350.98
274_Y759_P0.8350.98
634_F637_D0.8340.98
299_G358_Q0.8330.98
287_P762_M0.8320.98
57_K80_G0.8290.98
303_V364_A0.8290.98
59_I556_V0.8270.98
517_T520_A0.8260.98
353_P356_A0.8240.98
73_L103_A0.8180.98
124_M516_M0.8160.98
147_I150_N0.8160.98
69_S248_S0.8150.98
713_V716_L0.8100.98
744_I753_I0.8100.98
151_M194_C0.8080.98
486_L500_L0.8060.98
289_R361_G0.8050.98
722_Q772_A0.8040.98
762_M765_V0.8010.98
100_Q258_Q0.7990.98
116_N515_H0.7980.98
125_K142_E0.7970.98
80_G558_K0.7970.98
357_S365_D0.7970.98
744_I809_V0.7960.98
365_D369_K0.7950.98
468_K495_R0.7910.98
212_G402_S0.7890.98
140_W564_K0.7890.98
228_D415_G0.7880.98
646_P651_E0.7880.98
445_M449_T0.7870.98
643_L650_I0.7860.98
728_P732_Q0.7860.98
480_N511_V0.7860.98
518_S773_W0.7850.98
299_G352_T0.7850.98
471_L498_E0.7840.98
619_F623_D0.7810.98
494_N789_V0.7810.98
736_I757_V0.7800.98
243_G277_T0.7790.98
168_G171_T0.7780.98
536_M554_D0.7780.98
461_L464_G0.7780.98
62_A551_I0.7770.98
114_V531_T0.7760.98
323_D338_K0.7760.98
271_D275_T0.7750.98
687_D690_N0.7750.98
122_Y139_S0.7740.98
372_R375_G0.7740.98
315_L319_C0.7730.98
747_D808_L0.7720.98
257_E260_R0.7720.98
446_F450_D0.7720.98
168_G198_L0.7710.97
531_T560_R0.7710.97
130_R133_G0.7660.97
167_Y171_T0.7640.97
148_A152_Q0.7640.97
456_P459_T0.7630.97
235_V259_A0.7620.97
299_G353_P0.7620.97
651_E654_S0.7620.97
236_V382_I0.7610.97
230_E258_Q0.7580.97
366_K373_E0.7580.97
150_N508_L0.7580.97
260_R267_M0.7570.97
690_N694_P0.7560.97
138_I143_A0.7560.97
337_Y652_I0.7560.97
726_I757_V0.7550.97
211_E395_E0.7540.97
302_Y341_I0.7540.97
304_M308_N0.7530.97
471_L505_K0.7520.97
303_V375_G0.7510.97
152_Q577_L0.7510.97
91_G97_G0.7510.97
158_Y162_S0.7470.97
115_Y560_R0.7460.97
190_L573_L0.7460.97
451_A454_R0.7440.97
149_T152_Q0.7440.97
443_I449_T0.7430.97
462_R465_V0.7430.97
630_A633_A0.7430.97
148_A577_L0.7430.97
449_T454_R0.7410.97
445_M450_D0.7410.97
690_N693_Y0.7400.97
234_L374_I0.7400.97
379_P413_I0.7400.97
433_P437_N0.7390.97
452_I455_G0.7390.97
144_Y147_I0.7370.97
208_Q801_G0.7350.97
353_P357_S0.7340.97
59_I75_M0.7320.97
144_Y148_A0.7300.97
274_Y287_P0.7290.96
748_R808_L0.7290.96
353_P364_A0.7280.96
286_I296_L0.7240.96
164_Y478_I0.7240.96
571_S575_K0.7230.96
373_E377_T0.7210.96
459_T463_D0.7190.96
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352_T358_Q0.5560.87
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404_L408_T0.5440.86
696_Q806_T0.5440.86
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509_I519_S0.5440.86
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438_P445_M0.5420.85
271_D278_G0.5420.85
438_P443_I0.5420.85
607_L612_E0.5420.85
746_N810_Q0.5410.85
225_S620_K0.5410.85
154_L163_I0.5410.85
371_A404_L0.5400.85
613_F617_G0.5400.85
445_M451_A0.5400.85
443_I446_F0.5390.85
613_F619_F0.5390.85
153_R156_K0.5390.85
88_D91_G0.5380.85
795_P800_K0.5380.85
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257_E281_R0.5380.85
311_D314_F0.5360.85
207_A801_G0.5360.85
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440_Q445_M0.5350.85
714_D717_K0.5350.85
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271_D285_W0.5340.85
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169_T172_L0.5330.84
109_S713_V0.5330.84
733_K764_G0.5330.84
658_A661_A0.5320.84
453_E458_M0.5320.84
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352_T357_S0.5310.84
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80_G115_Y0.5260.84
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431_R436_E0.5250.84
217_Y411_V0.5250.84
518_S521_K0.5250.84
120_L516_M0.5240.83
356_A359_I0.5240.83
77_V83_K0.5240.83
453_E459_T0.5240.83
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223_G226_P0.5230.83
443_I453_E0.5230.83
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617_G620_K0.5210.83
77_V82_I0.5210.83
125_K147_I0.5210.83
628_H632_K0.5210.83
571_S584_T0.5200.83
595_H598_A0.5200.83
623_D628_H0.5200.83
304_M380_A0.5190.83
589_Q593_M0.5190.83
571_S585_E0.5190.83
133_G136_E0.5190.83
292_T356_A0.5180.83
458_M465_V0.5180.83
272_P698_T0.5180.83
442_S445_M0.5180.83
576_R579_V0.5170.83
180_W184_N0.5170.83
267_M281_R0.5170.83
632_K635_R0.5160.83
723_E754_E0.5160.83
792_T803_P0.5160.83
206_S209_I0.5160.83
627_H631_Y0.5160.83
445_M453_E0.5150.82
244_E703_K0.5150.82
730_D757_V0.5150.82
722_Q769_G0.5140.82
447_M453_E0.5140.82
608_P618_I0.5140.82
141_E564_K0.5140.82
580_E584_T0.5140.82
182_P185_T0.5120.82
393_N397_A0.5120.82
77_V81_E0.5110.82
136_E146_I0.5110.82
375_G380_A0.5100.82
299_G302_Y0.5100.82
388_P398_T0.5100.82
589_Q592_W0.5100.82
266_R376_S0.5090.82
73_L110_M0.5090.82
122_Y561_F0.5090.82
457_E462_R0.5090.82
289_R358_Q0.5080.82
447_M456_P0.5080.82
361_G764_G0.5080.82
194_C579_V0.5080.82
236_V404_L0.5080.82
300_L375_G0.5080.82
242_P277_T0.5070.81
386_W389_Q0.5070.81
318_Y641_N0.5070.81
275_T278_G0.5060.81
187_V198_L0.5060.81
697_L744_I0.5060.81
647_S650_I0.5060.81
589_Q600_S0.5060.81
432_M437_N0.5060.81
687_D747_D0.5060.81
206_S422_E0.5060.81
226_P229_I0.5060.81
479_W510_V0.5050.81
322_Y652_I0.5050.81
399_R653_Y0.5050.81
314_F641_N0.5050.81
727_N734_R0.5050.81
240_N383_S0.5040.81
378_K413_I0.5030.81
445_M456_P0.5020.81
695_L727_N0.5020.81
245_T385_G0.5020.81
442_S447_M0.5020.81
294_A297_V0.5010.81
287_P366_K0.5010.81
728_P758_T0.5010.81
447_M454_R0.5010.81
579_V582_Q0.5010.81
521_K775_D0.5000.81
72_P97_G0.5000.81
491_S802_N0.5000.81
441_T444_S0.5000.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1kqfA 3 0.8882 100 0.232 Contact Map
2vpzA 1 0.844 100 0.234 Contact Map
2ivfA 1 0.887 100 0.248 Contact Map
1h0hA 1 0.887 100 0.267 Contact Map
1q16A 2 0.9423 100 0.267 Contact Map
2e7zA 1 0.8305 100 0.271 Contact Map
2iv2X 1 0.7948 100 0.286 Contact Map
2napA 1 0.8305 100 0.293 Contact Map
1tmoA 1 0.8735 100 0.293 Contact Map
3ml1A 1 0.8747 100 0.294 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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