GREMLIN Database
RSTB - Sensor protein RstB
UniProt: P18392 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11233
Length: 433 (399)
Sequences: 50327 (42486)
Seq/√Len: 2126.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
356_D360_G4.0341.00
355_E416_R3.9611.00
395_H399_L3.6301.00
280_P315_L3.3751.00
349_R420_S3.2991.00
234_L248_L3.2511.00
406_N418_S3.2441.00
353_I416_R2.9511.00
366_R409_T2.9011.00
335_C357_D2.8941.00
315_L401_M2.8011.00
342_S353_I2.7261.00
351_T420_S2.7161.00
338_T357_D2.6671.00
353_I418_S2.6341.00
410_S413_G2.5531.00
344_L351_T2.5361.00
407_C417_F2.5111.00
340_E355_E2.4981.00
351_T418_S2.4971.00
305_K338_T2.4911.00
305_K340_E2.4871.00
362_A365_N2.4861.00
279_E314_A2.4521.00
323_V398_A2.4501.00
394_V405_V2.4221.00
231_R253_S2.4081.00
189_S192_E2.4061.00
408_D416_R2.3741.00
370_F405_V2.3311.00
408_D418_S2.3151.00
342_S355_E2.3041.00
398_A403_G2.2971.00
344_L353_I2.2611.00
409_T415_A2.2441.00
366_R407_C2.2441.00
361_I369_I2.2361.00
307_L342_S2.2181.00
279_E312_Y2.1611.00
365_N368_H2.1251.00
281_D284_L2.1081.00
288_T321_E2.0631.00
231_R252_I2.0541.00
404_T420_S2.0321.00
278_S317_M2.0311.00
307_L340_E2.0031.00
398_A419_F2.0031.00
187_E192_E1.9901.00
368_H371_E1.9661.00
303_R338_T1.9501.00
238_D249_N1.9271.00
323_V397_I1.9081.00
231_R256_E1.9001.00
118_Y121_A1.8921.00
201_M205_I1.8631.00
315_L320_M1.8421.00
297_T332_L1.8411.00
397_I401_M1.8331.00
173_R178_H1.8191.00
293_I325_D1.8181.00
346_S351_T1.7821.00
363_P366_R1.7731.00
256_E260_E1.7661.00
365_N374_V1.7471.00
214_Q218_G1.7281.00
361_I365_N1.7181.00
406_N420_S1.7151.00
399_L404_T1.7121.00
323_V394_V1.6891.00
361_I415_A1.6801.00
368_H374_V1.6781.00
234_L249_N1.6691.00
81_P85_Y1.6611.00
238_D246_Q1.6481.00
277_L314_A1.6441.00
324_L352_L1.6401.00
191_F195_G1.6381.00
329_N333_R1.6321.00
25_L29_F1.6271.00
356_D414_G1.6001.00
210_A214_Q1.5871.00
202_A205_I1.5711.00
188_G192_E1.5651.00
352_L419_F1.5591.00
326_N394_V1.5481.00
283_P287_S1.5441.00
235_E249_N1.5341.00
335_C339_V1.5311.00
316_D319_L1.5291.00
340_E357_D1.4731.00
174_F202_A1.4611.00
153_V157_M1.4591.00
168_E193_R1.4531.00
365_N376_L1.4451.00
230_L252_I1.4411.00
199_N202_A1.4411.00
206_N209_I1.4411.00
370_F407_C1.4321.00
212_K216_I1.4271.00
319_L322_R1.4201.00
195_G199_N1.4131.00
222_E322_R1.4111.00
323_V419_F1.4091.00
398_A405_V1.4011.00
409_T412_L1.3971.00
366_R370_F1.3971.00
334_Y375_R1.3821.00
230_L248_L1.3681.00
171_A174_F1.3601.00
241_S244_E1.3591.00
283_P343_L1.3581.00
319_L397_I1.3431.00
409_T413_G1.3361.00
209_I212_K1.3271.00
229_R233_R1.3191.00
337_S357_D1.3131.00
371_E374_V1.3131.00
182_R203_D1.3111.00
288_T317_M1.3071.00
370_F417_F1.3051.00
168_E172_Q1.3041.00
249_N253_S1.3011.00
317_M321_E1.2991.00
281_D312_Y1.2971.00
362_A411_E1.2901.00
208_L212_K1.2901.00
173_R181_E1.2731.00
396_S399_L1.2711.00
294_Q298_P1.2631.00
218_G372_P1.2471.00
229_R251_D1.2341.00
292_D321_E1.2331.00
231_R249_N1.2271.00
215_L219_I1.2261.00
403_G421_W1.2121.00
275_L316_D1.1981.00
234_L252_I1.1951.00
283_P308_V1.1901.00
349_R404_T1.1861.00
290_L306_T1.1841.00
207_A211_S1.1731.00
198_F201_M1.1691.00
407_C415_A1.1621.00
319_L400_A1.1541.00
369_I407_C1.1421.00
285_W289_H1.1411.00
355_E410_S1.1381.00
157_M161_W1.1381.00
136_L140_A1.1361.00
191_F194_L1.1321.00
370_F395_H1.1231.00
257_A318_R1.1211.00
206_N210_A1.1201.00
178_H181_E1.1131.00
171_A198_F1.1081.00
308_V343_L1.0951.00
287_S306_T1.0941.00
233_R247_A1.0931.00
246_Q250_R1.0921.00
26_V30_T1.0901.00
286_L343_L1.0881.00
260_E264_T1.0811.00
375_R384_T1.0711.00
187_E195_G1.0691.00
32_E36_K1.0681.00
296_V299_D1.0561.00
80_E86_H1.0551.00
224_R260_E1.0491.00
356_D415_A1.0481.00
263_L266_A1.0441.00
289_H325_D1.0401.00
331_A339_V1.0391.00
229_R232_Y1.0391.00
363_P409_T1.0331.00
240_L245_S1.0331.00
172_Q193_R1.0291.00
277_L401_M1.0241.00
327_L417_F1.0241.00
242_A245_S1.0211.00
170_A183_I1.0171.00
182_R202_A1.0091.00
320_M401_M1.0051.00
165_L168_E1.0001.00
192_E195_G0.9991.00
327_L405_V0.9961.00
171_A197_A0.9941.00
222_E326_N0.9941.00
308_V311_H0.9931.00
324_L354_V0.9841.00
251_D254_Q0.9821.00
7_Q189_S0.9741.00
171_A175_G0.9731.00
326_N329_N0.9721.00
40_D44_N0.9661.00
158_R162_Q0.9661.00
182_R199_N0.9621.00
168_E197_A0.9571.00
184_H199_N0.9571.00
240_L243_A0.9561.00
200_Q204_N0.9561.00
289_H293_I0.9541.00
361_I366_R0.9491.00
24_G28_K0.9471.00
231_R235_E0.9431.00
389_L393_I0.9431.00
192_E196_V0.9411.00
46_S49_L0.9401.00
197_A200_Q0.9391.00
398_A421_W0.9381.00
285_W315_L0.9351.00
221_H326_N0.9341.00
369_I417_F0.9331.00
132_H136_L0.9321.00
309_Q344_L0.9281.00
327_L394_V0.9251.00
280_P285_W0.9161.00
124_P128_L0.9131.00
106_Q110_L0.9121.00
214_Q372_P0.9101.00
116_S121_A0.9081.00
115_R118_Y0.9071.00
247_A251_D0.9061.00
150_A154_F0.9061.00
114_P118_Y0.9061.00
284_L288_T0.9061.00
261_E319_L0.9051.00
28_K135_R0.9041.00
346_S420_S0.9021.00
185_F196_V0.9001.00
346_S349_R0.9001.00
151_F155_I0.8991.00
44_N48_Y0.8991.00
160_H163_D0.8991.00
187_E191_F0.8971.00
174_F201_M0.8931.00
289_H321_E0.8901.00
361_I367_E0.8891.00
325_D329_N0.8891.00
51_R55_R0.8871.00
236_M239_N0.8831.00
360_G415_A0.8821.00
334_Y359_P0.8781.00
202_A206_N0.8761.00
292_D325_D0.8751.00
302_V335_C0.8751.00
290_L294_Q0.8711.00
117_H121_A0.8711.00
170_A181_E0.8681.00
372_P396_S0.8671.00
324_L328_L0.8661.00
327_L419_F0.8611.00
361_I407_C0.8601.00
39_L43_M0.8601.00
47_L51_R0.8571.00
29_F32_E0.8571.00
293_I328_L0.8551.00
63_G67_K0.8531.00
323_V401_M0.8531.00
286_L324_L0.8501.00
222_E226_P0.8491.00
248_L252_I0.8471.00
250_R288_T0.8451.00
198_F202_A0.8431.00
289_H328_L0.8421.00
43_M47_L0.8421.00
287_S291_A0.8401.00
252_I256_E0.8391.00
253_S256_E0.8371.00
38_S42_L0.8281.00
257_A261_E0.8271.00
296_V329_N0.8211.00
341_T354_V0.8201.00
36_K40_D0.8181.00
135_R139_I0.8171.00
225_T229_R0.8121.00
175_G200_Q0.8111.00
282_L352_L0.8081.00
233_R251_D0.8071.00
228_V232_Y0.8071.00
276_H316_D0.8051.00
318_R321_E0.8021.00
155_I159_P0.8021.00
255_L259_I0.7991.00
328_L341_T0.7991.00
209_I213_K0.7951.00
208_L211_S0.7951.00
98_G103_L0.7941.00
29_F33_R0.7941.00
293_I329_N0.7931.00
194_L198_F0.7921.00
363_P367_E0.7911.00
106_Q112_R0.7911.00
168_E171_A0.7901.00
163_D167_L0.7861.00
42_L45_S0.7861.00
223_L255_L0.7851.00
282_L350_A0.7851.00
396_S400_A0.7851.00
297_T339_V0.7801.00
275_L319_L0.7801.00
321_E325_D0.7791.00
362_A376_L0.7771.00
107_Y110_L0.7761.00
81_P87_L0.7751.00
302_V306_T0.7741.00
154_F158_R0.7741.00
78_R86_H0.7711.00
277_L315_L0.7691.00
157_M160_H0.7681.00
403_G419_F0.7681.00
395_H404_T0.7671.00
181_E185_F0.7661.00
136_L139_I0.7661.00
283_P310_G0.7661.00
183_I195_G0.7651.00
188_G191_F0.7651.00
159_P162_Q0.7631.00
394_V398_A0.7621.00
110_L113_I0.7611.00
131_L135_R0.7601.00
169_A173_R0.7591.00
193_R196_V0.7561.00
171_A194_L0.7541.00
261_E322_R0.7531.00
15_C19_M0.7531.00
114_P117_H0.7521.00
277_L402_G0.7521.00
216_I219_I0.7471.00
43_M46_S0.7471.00
227_L259_I0.7471.00
35_G38_S0.7461.00
240_L244_E0.7461.00
53_E56_E0.7451.00
375_R386_G0.7441.00
361_I409_T0.7411.00
48_Y51_R0.7381.00
105_D108_T0.7371.00
265_Y392_A0.7351.00
296_V300_K0.7341.00
37_Q40_D0.7331.00
264_T322_R0.7321.00
118_Y122_V0.7311.00
171_A201_M0.7311.00
73_L76_D0.7291.00
39_L42_L0.7281.00
183_I199_N0.7271.00
167_L171_A0.7241.00
356_D359_P0.7221.00
355_E412_L0.7211.00
40_D107_Y0.7211.00
322_R397_I0.7171.00
333_R384_T0.7151.00
210_A213_K0.7131.00
21_L25_L0.7131.00
406_N419_F0.7121.00
221_H225_T0.7111.00
38_S41_D0.7101.00
363_P410_S0.7101.00
81_P84_K0.7071.00
319_L323_V0.7061.00
124_P127_Y0.7061.00
222_E393_I0.7061.00
366_R417_F0.7051.00
195_G198_F0.7041.00
311_H345_L0.7041.00
280_P317_M0.7031.00
224_R256_E0.7021.00
42_L46_S0.7011.00
233_R248_L0.7001.00
108_T112_R0.6981.00
287_S290_L0.6941.00
47_L50_M0.6931.00
175_G204_N0.6921.00
247_A250_R0.6901.00
345_L350_A0.6891.00
366_R408_D0.6881.00
264_T319_L0.6871.00
361_I417_F0.6871.00
172_Q197_A0.6871.00
219_I262_L0.6861.00
52_S56_E0.6851.00
34_A38_S0.6831.00
196_V200_Q0.6831.00
228_V231_R0.6811.00
246_Q249_N0.6791.00
371_E395_H0.6781.00
132_H135_R0.6771.00
218_G222_E0.6771.00
327_L398_A0.6751.00
303_R306_T0.6741.00
393_I397_I0.6731.00
286_L341_T0.6731.00
107_Y112_R0.6731.00
36_K39_L0.6721.00
163_D189_S0.6721.00
189_S193_R0.6711.00
331_A354_V0.6711.00
291_A294_Q0.6711.00
127_Y130_Y0.6711.00
164_M194_L0.6691.00
297_T304_I0.6691.00
162_Q166_K0.6671.00
343_L352_L0.6651.00
254_Q321_E0.6651.00
165_L169_A0.6651.00
133_Q137_L0.6641.00
359_P384_T0.6621.00
50_M53_E0.6611.00
185_F195_G0.6591.00
193_R197_A0.6581.00
72_N75_F0.6581.00
215_L222_E0.6581.00
328_L339_V0.6581.00
201_M204_N0.6571.00
229_R247_A0.6561.00
213_K269_D0.6551.00
280_P314_A0.6531.00
275_L400_A0.6531.00
133_Q136_L0.6521.00
41_D44_N0.6511.00
343_L350_A0.6511.00
139_I143_A0.6501.00
123_G127_Y0.6481.00
295_A299_D0.6481.00
269_D372_P0.6481.00
109_F113_I0.6471.00
40_D43_M0.6471.00
293_I332_L0.6461.00
353_I408_D0.6451.00
204_N207_A0.6451.00
170_A173_R0.6441.00
205_I208_L0.6431.00
123_G126_P0.6421.00
207_A210_A0.6411.00
28_K32_E0.6411.00
263_L267_R0.6411.00
394_V397_I0.6401.00
223_L226_P0.6401.00
181_E184_H0.6401.00
282_L313_A0.6391.00
179_L202_A0.6371.00
297_T300_K0.6371.00
67_K71_L0.6361.00
298_P301_T0.6351.00
365_N378_P0.6341.00
290_L304_I0.6331.00
45_S48_Y0.6301.00
194_L197_A0.6301.00
128_L132_H0.6271.00
302_V332_L0.6271.00
25_L28_K0.6251.00
291_A295_A0.6241.00
307_L344_L0.6241.00
84_K88_D0.6241.00
33_R37_Q0.6231.00
188_G195_G0.6221.00
65_T68_E0.6201.00
285_W320_M0.6191.00
211_S214_Q0.6191.00
284_L287_S0.6191.00
403_G422_P0.6181.00
107_Y111_Q0.6161.00
405_V417_F0.6141.00
295_A298_P0.6141.00
33_R36_K0.6141.00
164_M191_F0.6141.00
360_G414_G0.6131.00
333_R386_G0.6091.00
166_K169_A0.6061.00
159_P163_D0.6061.00
273_N319_L0.6051.00
265_Y396_S0.6051.00
30_T33_R0.6041.00
309_Q342_S0.6041.00
328_L332_L0.6031.00
22_L26_V0.6011.00
149_L153_V0.6011.00
172_Q176_D0.6001.00
112_R121_A0.5991.00
48_Y52_S0.5981.00
287_S308_V0.5971.00
64_K67_K0.5961.00
366_R415_A0.5961.00
288_T292_D0.5951.00
14_V21_L0.5941.00
216_I220_A0.5931.00
349_R422_P0.5931.00
414_G417_F0.5921.00
104_D108_T0.5911.00
262_L373_F0.5901.00
108_T111_Q0.5901.00
167_L198_F0.5891.00
78_R84_K0.5871.00
127_Y131_L0.5861.00
194_L199_N0.5851.00
169_A172_Q0.5851.00
251_D292_D0.5851.00
289_H292_D0.5821.00
106_Q109_F0.5811.00
367_E371_E0.5801.00
297_T301_T0.5801.00
265_Y372_P0.5801.00
339_V354_V0.5801.00
232_Y252_I0.5801.00
309_Q343_L0.5791.00
14_V17_L0.5791.00
12_L153_V0.5781.00
369_I374_V0.5781.00
37_Q41_D0.5771.00
369_I392_A0.5771.00
379_S385_G0.5761.00
197_A201_M0.5761.00
67_K70_D0.5751.00
302_V357_D0.5751.00
16_F19_M0.5731.00
351_T406_N0.5731.00
54_L58_P0.5721.00
189_S195_G0.5711.00
233_R252_I0.5701.00
225_T263_L0.5691.00
336_H357_D0.5691.00
284_L317_M0.5671.00
137_L140_A0.5671.00
137_L141_L0.5671.00
203_D207_A0.5661.00
78_R81_P0.5661.00
375_R385_G0.5661.00
290_L341_T0.5641.00
86_H89_D0.5631.00
392_A396_S0.5611.00
195_G202_A0.5591.00
190_S194_L0.5581.00
41_D45_S0.5581.00
187_E190_S0.5581.00
11_L15_C0.5581.00
162_Q165_L0.5571.00
319_L401_M0.5551.00
172_Q175_G0.5551.00
255_L263_L0.5541.00
297_T302_V0.5531.00
163_D187_E0.5521.00
214_Q396_S0.5491.00
264_T267_R0.5491.00
30_T34_A0.5471.00
138_D141_L0.5451.00
249_N252_I0.5451.00
166_K170_A0.5441.00
224_R255_L0.5421.00
275_L401_M0.5401.00
362_A366_R0.5391.00
143_A147_I0.5391.00
253_S257_A0.5381.00
322_R325_D0.5381.00
313_A350_A0.5381.00
280_P320_M0.5361.00
333_R377_D0.5361.00
223_L227_L0.5361.00
345_L349_R0.5341.00
164_M168_E0.5341.00
285_W321_E0.5321.00
340_E343_L0.5311.00
222_E225_T0.5311.00
13_F16_F0.5301.00
6_I10_L0.5301.00
45_S49_L0.5291.00
163_D166_K0.5281.00
114_P121_A0.5281.00
187_E194_L0.5281.00
225_T232_Y0.5271.00
166_K184_H0.5261.00
213_K216_I0.5251.00
78_R89_D0.5241.00
194_L201_M0.5211.00
222_E258_L0.5201.00
12_L15_C0.5181.00
49_L53_E0.5181.00
215_L218_G0.5181.00
52_S55_R0.5171.00
241_S245_S0.5171.00
163_D171_A0.5161.00
180_N202_A0.5161.00
217_D220_A0.5151.00
10_L13_F0.5121.00
213_K217_D0.5121.00
167_L195_G0.5121.00
223_L259_I0.5121.00
330_N390_G0.5111.00
131_L134_M0.5111.00
300_K335_C0.5091.00
53_E57_I0.5091.00
232_Y236_M0.5081.00
116_S119_V0.5071.00
220_A225_T0.5061.00
117_H120_L0.5021.00
199_N203_D0.5021.00
359_P415_A0.5011.00
331_A335_C0.5011.00
213_K218_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6097 100 0.354 Contact Map
4bixA 2 0.5196 100 0.371 Contact Map
4ctiA 2 0.5266 100 0.389 Contact Map
4q20A 2 0.515 100 0.464 Contact Map
4gczA 2 0.8106 100 0.479 Contact Map
4mpcA 2 0.6813 100 0.483 Contact Map
2c2aA 2 0.5173 100 0.487 Contact Map
3jz3A 2 0.3603 100 0.487 Contact Map
3a0rA 2 0.7367 100 0.492 Contact Map
3d36A 2 0.4919 100 0.495 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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