GREMLIN Database
ARGD - Acetylornithine/succinyldiaminopimelate aminotransferase
UniProt: P18335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10066
Length: 406 (374)
Sequences: 20749 (12266)
Seq/√Len: 634.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
68_K72_E4.3571.00
213_R217_D3.8741.00
364_A398_H3.8151.00
35_R43_E3.4931.00
317_R390_D3.1961.00
176_L211_G3.0891.00
30_K37_W3.0301.00
92_K300_D3.0041.00
317_R386_D2.8071.00
237_D243_H2.7981.00
306_E309_E2.7601.00
310_G314_K2.6381.00
328_Q397_A2.5991.00
62_A304_T2.5921.00
385_E388_D2.5891.00
65_N69_T2.5121.00
92_K303_N2.3441.00
47_F392_G2.3421.00
297_A300_D2.2961.00
172_P178_A2.2801.00
211_G214_E2.2661.00
62_A301_I2.2521.00
35_R388_D2.2431.00
321_H393_M2.2261.00
29_V39_Q2.1891.00
214_E218_Q2.1601.00
360_A363_E2.1551.00
360_A402_K2.1511.00
364_A402_K2.1431.00
60_H301_I2.1351.00
37_W43_E2.1091.00
62_A297_A2.0931.00
313_A386_D2.0671.00
321_H390_D2.0301.00
92_K296_G2.0151.00
133_K186_H2.0141.00
180_K218_Q1.9461.00
89_L295_A1.9391.00
329_Y397_A1.9041.00
391_E395_R1.8841.00
319_V323_Q1.8791.00
64_V68_K1.8721.00
133_K169_I1.8661.00
101_R270_A1.8531.00
360_A364_A1.8241.00
316_Q320_D1.8171.00
38_D42_K1.8111.00
270_A274_S1.7961.00
366_V395_R1.7941.00
42_K365_G1.7931.00
100_E270_A1.7791.00
301_I305_P1.7601.00
191_V224_V1.7491.00
180_K184_D1.7361.00
35_R391_E1.7061.00
84_E88_R1.7031.00
29_V73_T1.6921.00
138_H172_P1.6911.00
96_A303_N1.6811.00
333_S347_K1.6791.00
319_V337_G1.6711.00
321_H324_K1.6631.00
91_R95_E1.6481.00
329_Y401_A1.6431.00
179_V212_L1.6191.00
67_L294_V1.6191.00
174_N205_T1.5911.00
105_M264_S1.5891.00
112_N252_T1.5841.00
237_D312_Q1.5681.00
67_L71_G1.5431.00
32_Q61_P1.5371.00
319_V342_I1.5221.00
92_K95_E1.5201.00
190_V216_C1.5191.00
88_R296_G1.5131.00
192_V212_L1.5121.00
34_S388_D1.4851.00
360_A399_A1.4831.00
314_K317_R1.4811.00
253_S265_A1.4801.00
323_Q326_D1.4631.00
180_K211_G1.4591.00
225_F241_Y1.4561.00
314_K389_I1.4541.00
69_T73_T1.4491.00
207_E210_Q1.4491.00
258_G263_I1.4481.00
177_H181_A1.4421.00
171_V182_V1.4391.00
183_M221_A1.4371.00
122_Y272_I1.4361.00
43_E391_E1.4311.00
135_I187_T1.4251.00
97_T267_L1.4051.00
34_S383_V1.3941.00
397_A401_A1.3941.00
253_S267_L1.3831.00
114_T266_M1.3791.00
134_I189_A1.3731.00
361_G368_V1.3631.00
61_P65_N1.3621.00
213_R216_C1.3591.00
310_G313_A1.3521.00
102_V267_L1.3471.00
325_I397_A1.3461.00
296_G300_D1.3441.00
90_G104_F1.3411.00
213_R223_L1.3411.00
321_H394_Q1.3301.00
94_I102_V1.3291.00
238_L242_M1.3251.00
137_F208_F1.3181.00
122_Y275_A1.3161.00
364_A399_A1.3151.00
297_A301_I1.3101.00
184_D219_H1.3101.00
116_F134_I1.3051.00
136_A170_H1.3001.00
309_E313_A1.2961.00
314_K386_D1.2931.00
237_D242_M1.2921.00
263_I292_C1.2921.00
317_R321_H1.2861.00
65_N68_K1.2831.00
243_H338_M1.2811.00
241_Y251_L1.2761.00
38_D44_Y1.2741.00
321_H397_A1.2731.00
32_Q59_C1.2671.00
325_I393_M1.2611.00
115_A252_T1.2501.00
112_N191_V1.2471.00
119_A224_V1.2461.00
177_H180_K1.2451.00
30_K73_T1.2441.00
384_V389_I1.2391.00
28_P36_I1.2341.00
192_V209_L1.2331.00
88_R300_D1.2331.00
247_T269_T1.2281.00
250_I268_T1.2201.00
190_V212_L1.2111.00
60_H305_P1.2031.00
66_A297_A1.2011.00
56_L301_I1.1991.00
388_D391_E1.1971.00
95_E303_N1.1971.00
257_L263_I1.1931.00
101_R274_S1.1881.00
59_C64_V1.1801.00
244_Y338_M1.1781.00
180_K215_L1.1771.00
64_V72_E1.1741.00
300_D304_T1.1721.00
105_M266_M1.1711.00
210_Q214_E1.1651.00
207_E244_Y1.1531.00
67_L290_L1.1521.00
312_Q316_Q1.1491.00
263_I295_A1.1471.00
176_L215_L1.1441.00
64_V71_G1.1301.00
222_L272_I1.1291.00
123_A188_C1.1271.00
394_Q398_H1.1251.00
104_F292_C1.1211.00
210_Q245_G1.1141.00
233_G308_L1.1131.00
257_L265_A1.0991.00
68_K71_G1.0951.00
151_V168_I1.0891.00
98_F247_T1.0821.00
239_F253_S1.0751.00
151_V191_V1.0721.00
225_F246_V1.0671.00
361_G395_R1.0651.00
391_E394_Q1.0641.00
366_V392_G1.0541.00
250_I266_M1.0511.00
301_I304_T1.0491.00
364_A395_R1.0491.00
27_I39_Q1.0481.00
34_S45_V1.0461.00
361_G399_A1.0441.00
35_R45_V1.0421.00
178_A181_A1.0361.00
386_D390_D1.0291.00
320_D324_K1.0281.00
131_K220_Q1.0221.00
32_Q43_E1.0191.00
29_V84_E1.0141.00
390_D394_Q1.0131.00
172_P175_D1.0101.00
169_I182_V1.0041.00
99_A267_L1.0001.00
123_A130_F0.9991.00
118_L266_M0.9931.00
29_V41_G0.9921.00
111_A252_T0.9881.00
216_C221_A0.9851.00
29_V37_W0.9831.00
180_K214_E0.9831.00
89_L296_G0.9811.00
361_G366_V0.9801.00
96_A238_L0.9761.00
109_T148_T0.9751.00
356_D360_A0.9701.00
32_Q37_W0.9641.00
92_K96_A0.9641.00
62_A300_D0.9611.00
214_E217_D0.9611.00
259_G298_A0.9571.00
132_T186_H0.9501.00
206_P210_Q0.9501.00
173_F204_A0.9491.00
133_K184_D0.9481.00
359_Y363_E0.9461.00
236_G242_M0.9371.00
116_F151_V0.9361.00
183_M187_T0.9351.00
194_P225_F0.9331.00
65_N72_E0.9311.00
308_L311_I0.9311.00
309_E312_Q0.9291.00
189_A224_V0.9271.00
333_S345_E0.9261.00
195_I338_M0.9171.00
180_K219_H0.9141.00
136_A191_V0.9091.00
203_A338_M0.9071.00
45_V388_D0.9061.00
387_A390_D0.9041.00
62_A65_N0.9021.00
209_L244_Y0.8981.00
56_L298_A0.8981.00
345_E374_D0.8961.00
69_T293_A0.8901.00
310_G386_D0.8891.00
232_M302_I0.8871.00
55_A256_A0.8851.00
137_F204_A0.8811.00
163_P167_D0.8801.00
132_T167_D0.8781.00
326_D332_F0.8771.00
133_K187_T0.8761.00
115_A224_V0.8741.00
212_L223_L0.8731.00
27_I87_L0.8731.00
293_A297_A0.8681.00
118_L268_T0.8671.00
302_I308_L0.8661.00
302_I307_V0.8661.00
137_F173_F0.8651.00
207_E211_G0.8631.00
56_L63_L0.8611.00
45_V391_E0.8591.00
315_R319_V0.8521.00
215_L219_H0.8511.00
69_T72_E0.8491.00
63_L294_V0.8441.00
34_S385_E0.8401.00
243_H312_Q0.8401.00
324_K328_Q0.8361.00
261_F291_A0.8361.00
122_Y222_L0.8351.00
47_F384_V0.8331.00
349_Q353_R0.8311.00
39_Q84_E0.8271.00
96_A299_F0.8261.00
119_A189_A0.8241.00
217_D247_T0.8231.00
320_D323_Q0.8221.00
307_V311_I0.8201.00
150_S165_P0.8201.00
85_P293_A0.8171.00
98_F251_L0.8171.00
54_T259_G0.8161.00
133_K167_D0.8141.00
355_R359_Y0.8091.00
94_I99_A0.8071.00
238_L308_L0.8051.00
88_R92_K0.8041.00
109_T145_S0.8041.00
328_Q401_A0.8041.00
324_K397_A0.8011.00
334_D345_E0.8001.00
130_F186_H0.8001.00
321_H389_I0.7931.00
62_A66_A0.7931.00
119_A222_L0.7891.00
384_V392_G0.7871.00
340_L384_V0.7861.00
85_P296_G0.7851.00
93_L267_L0.7841.00
171_V179_V0.7831.00
317_R320_D0.7821.00
343_G375_V0.7791.00
230_C341_L0.7791.00
378_F396_F0.7771.00
349_Q352_G0.7731.00
308_L312_Q0.7691.00
178_A182_V0.7671.00
241_Y246_V0.7651.00
171_V178_A0.7641.00
121_H280_S0.7621.00
45_V392_G0.7591.00
232_M299_F0.7561.00
341_L379_A0.7521.00
211_G215_L0.7481.00
213_R246_V0.7471.00
216_C223_L0.7461.00
398_H402_K0.7431.00
123_A220_Q0.7421.00
194_P209_L0.7421.00
313_A317_R0.7411.00
336_R345_E0.7401.00
138_H170_H0.7371.00
239_F251_L0.7361.00
190_V221_A0.7331.00
89_L292_C0.7331.00
85_P88_R0.7331.00
335_I342_I0.7321.00
358_L370_N0.7321.00
220_Q271_E0.7301.00
33_G383_V0.7251.00
325_I329_Y0.7191.00
47_F366_V0.7191.00
314_K340_L0.7171.00
277_H280_S0.7161.00
337_G342_I0.7151.00
232_M253_S0.7151.00
197_G229_Q0.7141.00
271_E274_S0.7131.00
313_A316_Q0.7121.00
232_M238_L0.7081.00
102_V265_A0.7081.00
238_L303_N0.7071.00
357_F396_F0.7061.00
34_S381_S0.7061.00
85_P292_C0.7041.00
192_V223_L0.7041.00
105_M111_A0.7011.00
119_A250_I0.7011.00
283_S286_G0.7001.00
67_L75_W0.6971.00
348_P352_G0.6961.00
187_T221_A0.6961.00
235_T243_H0.6961.00
210_Q244_Y0.6951.00
116_F191_V0.6941.00
115_A250_I0.6941.00
179_V190_V0.6931.00
52_A379_A0.6901.00
356_D359_Y0.6891.00
82_T87_L0.6871.00
183_M215_L0.6861.00
357_F399_A0.6851.00
183_M219_H0.6841.00
83_N86_A0.6831.00
233_G302_I0.6831.00
357_F376_M0.6761.00
66_A294_V0.6751.00
311_I315_R0.6731.00
269_T272_I0.6711.00
118_L276_F0.6671.00
163_P166_A0.6671.00
45_V366_V0.6651.00
99_A251_L0.6611.00
387_A391_E0.6611.00
73_T84_E0.6601.00
137_F171_V0.6581.00
42_K363_E0.6581.00
85_P89_L0.6571.00
195_I235_T0.6571.00
346_L357_F0.6551.00
92_K299_F0.6541.00
329_Y400_V0.6541.00
253_S257_L0.6531.00
96_A239_F0.6521.00
232_M257_L0.6501.00
315_R337_G0.6501.00
326_D334_D0.6491.00
345_E375_V0.6481.00
204_A207_E0.6481.00
223_L246_V0.6481.00
112_N148_T0.6471.00
63_L259_G0.6461.00
28_P31_G0.6461.00
70_Q73_T0.6431.00
346_L400_V0.6421.00
203_A337_G0.6411.00
392_G395_R0.6411.00
36_I367_M0.6411.00
317_R389_I0.6401.00
86_A90_G0.6401.00
106_N110_E0.6381.00
310_G385_E0.6371.00
34_S384_V0.6371.00
316_Q319_V0.6371.00
357_F361_G0.6361.00
117_K281_H0.6361.00
241_Y248_P0.6361.00
378_F392_G0.6341.00
48_A369_L0.6331.00
107_S110_E0.6311.00
272_I275_A0.6311.00
27_I82_T0.6311.00
217_D223_L0.6301.00
97_T251_L0.6291.00
209_L225_F0.6271.00
206_P244_Y0.6271.00
366_V391_E0.6251.00
331_V347_K0.6241.00
196_Q202_T0.6231.00
361_G396_F0.6221.00
75_W261_F0.6201.00
215_L218_Q0.6191.00
71_G290_L0.6181.00
399_A402_K0.6181.00
268_T273_A0.6181.00
384_V388_D0.6171.00
335_I344_A0.6171.00
43_E395_R0.6151.00
224_V250_I0.6141.00
147_F165_P0.6131.00
197_G341_L0.6131.00
97_T239_F0.6131.00
49_G379_A0.6121.00
70_Q85_P0.6111.00
132_T162_G0.6111.00
254_A264_S0.6111.00
228_V252_T0.6091.00
135_I179_V0.6071.00
31_G74_L0.6061.00
87_L91_R0.6051.00
66_A69_T0.6051.00
395_R399_A0.6051.00
73_T85_P0.6031.00
122_Y271_E0.5991.00
118_L250_I0.5981.00
206_P338_M0.5981.00
175_D178_A0.5961.00
181_A184_D0.5941.00
96_A237_D0.5931.00
196_Q199_G0.5921.00
131_K221_A0.5911.00
108_G228_V0.5901.00
89_L263_I0.5891.00
321_H325_I0.5891.00
59_C71_G0.5881.00
131_K186_H0.5881.00
393_M397_A0.5881.00
94_I100_E0.5871.00
318_F393_M0.5851.00
123_A131_K0.5841.00
344_A396_F0.5821.00
66_A300_D0.5821.00
217_D271_E0.5811.00
359_Y362_A0.5811.00
194_P230_C0.5801.00
311_I382_L0.5791.00
64_V261_F0.5781.00
114_T281_H0.5771.00
311_I340_L0.5771.00
179_V183_M0.5771.00
169_I187_T0.5771.00
120_R163_P0.5761.00
56_L307_V0.5751.00
314_K384_V0.5741.00
49_G381_S0.5741.00
61_P72_E0.5731.00
71_G294_V0.5721.00
176_L180_K0.5691.00
120_R146_L0.5691.00
55_A382_L0.5691.00
48_A367_M0.5681.00
98_F241_Y0.5681.00
31_G36_I0.5661.00
179_V211_G0.5641.00
294_V297_A0.5631.00
28_P81_F0.5621.00
26_F29_V0.5601.00
137_F192_V0.5591.00
395_R398_H0.5591.00
332_F400_V0.5591.00
318_F342_I0.5581.00
32_Q35_R0.5571.00
318_F389_I0.5551.00
185_D219_H0.5541.00
141_F144_R0.5521.00
312_Q315_R0.5521.00
116_F147_F0.5511.00
314_K385_E0.5501.00
177_H211_G0.5481.00
336_R343_G0.5461.00
210_Q213_R0.5461.00
98_F269_T0.5461.00
250_I272_I0.5451.00
326_D335_I0.5441.00
135_I171_V0.5441.00
136_A168_I0.5431.00
376_M396_F0.5421.00
94_I267_L0.5400.99
89_L104_F0.5400.99
55_A302_I0.5390.99
26_F362_A0.5380.99
45_V384_V0.5360.99
88_R91_R0.5350.99
347_K353_R0.5330.99
81_F367_M0.5330.99
354_A370_N0.5330.99
303_N306_E0.5320.99
27_I84_E0.5320.99
155_P159_D0.5320.99
184_D218_Q0.5310.99
63_L298_A0.5310.99
232_M239_F0.5310.99
274_S278_P0.5290.99
396_F400_V0.5290.99
29_V32_Q0.5260.99
389_I393_M0.5250.99
69_T297_A0.5250.99
325_I394_Q0.5240.99
70_Q74_L0.5240.99
238_L302_I0.5230.99
336_R375_V0.5220.99
63_L297_A0.5210.99
28_P74_L0.5190.99
155_P158_S0.5180.99
390_D393_M0.5180.99
135_I182_V0.5170.99
153_G170_H0.5160.99
358_L362_A0.5160.99
251_L267_L0.5150.99
179_V215_L0.5140.99
363_E402_K0.5140.99
369_L372_G0.5120.99
288_N291_A0.5120.99
317_R393_M0.5120.99
199_G202_T0.5100.99
366_V399_A0.5100.99
392_G396_F0.5090.99
305_P310_G0.5090.99
212_L221_A0.5080.99
97_T253_S0.5080.99
310_G389_I0.5070.99
203_A244_Y0.5060.99
222_L250_I0.5050.99
229_Q341_L0.5050.99
274_S277_H0.5040.99
30_K43_E0.5040.99
332_F344_A0.5040.99
362_A367_M0.5030.99
389_I392_G0.5020.99
192_V225_F0.5020.99
135_I169_I0.5010.99
132_T163_P0.5010.99
347_K352_G0.5000.99
139_N199_G0.5000.99
248_P251_L0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z7dA 2 0.9261 100 0.353 Contact Map
4uoxA 3 0.9877 100 0.355 Contact Map
3oksA 2 0.9754 100 0.366 Contact Map
4atqA 7 0.9803 100 0.369 Contact Map
4e3qA 3 0.9901 100 0.374 Contact Map
4jf1A 2 0.9729 100 0.379 Contact Map
4nogA 2 0.9975 100 0.38 Contact Map
4ffcA 4 0.9828 100 0.38 Contact Map
2epjA 2 0.9532 100 0.381 Contact Map
2oatA 3 0.9852 100 0.381 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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