GREMLIN Database
PGPA - Phosphatidylglycerophosphatase A
UniProt: P18200 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10704
Length: 172 (147)
Sequences: 1338 (976)
Seq/√Len: 80.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_S40_M5.1421.00
71_G145_M3.7051.00
42_S98_M3.2591.00
122_I126_W3.2381.00
27_G95_F2.9371.00
79_A144_I2.9331.00
26_V89_S2.9321.00
67_G96_I2.7521.00
43_L117_F2.5251.00
87_H90_I2.1501.00
134_F146_I2.0791.00
134_F150_V2.0301.00
118_V122_I2.0101.00
131_I154_I1.9231.00
97_G152_G1.9171.00
75_C92_W1.8211.00
76_H80_K1.7741.00
98_M102_L1.6901.00
68_I149_I1.6881.00
131_I134_F1.6211.00
135_D139_H1.6151.00
119_I155_S1.6141.00
100_I149_I1.6131.00
68_I96_I1.6051.00
75_C141_G1.5911.00
101_T152_G1.5811.00
138_V146_I1.5230.99
46_I98_M1.4700.99
97_G101_T1.4610.99
79_A141_G1.4520.99
45_A98_M1.4410.99
100_I152_G1.4370.99
24_L74_L1.4350.99
35_I40_M1.3950.99
156_A160_Y1.3930.99
95_F99_W1.3750.99
123_L158_I1.3740.99
101_T155_S1.3630.99
79_A87_H1.3570.99
119_I123_L1.3560.99
101_T116_G1.3560.99
36_V125_M1.3400.99
96_I149_I1.3380.99
49_W113_V1.3310.98
102_L116_G1.2720.98
64_V103_M1.2420.98
109_D112_W1.2400.98
46_I113_V1.2050.97
119_I158_I1.2000.97
67_G99_W1.1940.97
68_I145_M1.1780.97
78_T81_D1.1710.97
142_M146_I1.1690.96
22_H78_T1.1650.96
27_G30_S1.1620.96
45_A99_W1.1460.96
132_R136_R1.1440.96
85_H139_H1.1430.96
130_P133_W1.1400.96
21_W74_L1.1400.96
131_I150_V1.1390.96
119_I159_L1.1370.96
47_P51_L1.1210.96
42_S102_L1.1040.95
110_W114_A1.0730.94
129_W132_R1.0630.94
72_V142_M1.0550.94
68_I142_M1.0500.94
104_A156_A1.0500.94
115_A162_I1.0470.94
21_W77_Q1.0380.93
61_S103_M1.0280.93
30_S41_G1.0250.93
146_I149_I1.0250.93
49_W102_L1.0100.92
41_G45_A0.9900.91
60_Y99_W0.9900.91
85_H90_I0.9890.91
25_A78_T0.9810.91
111_Q115_A0.9750.91
77_Q81_D0.9660.90
27_G44_A0.9510.90
112_W163_G0.9330.89
49_W99_W0.9210.88
71_G92_W0.9180.88
132_R135_D0.9110.88
77_Q80_K0.9090.88
60_Y64_V0.8980.87
65_M69_C0.8920.87
79_A85_H0.8810.86
34_P40_M0.8810.86
49_W60_Y0.8810.86
101_T156_A0.8800.86
59_L62_L0.8800.86
123_L154_I0.8710.85
153_V157_G0.8710.85
28_F32_L0.8630.85
44_A95_F0.8630.85
116_G159_L0.8590.84
22_H81_D0.8590.84
82_M89_S0.8570.84
55_L59_L0.8530.84
72_V141_G0.8530.84
104_A160_Y0.8510.84
129_W154_I0.8480.84
28_F95_F0.8400.83
35_I125_M0.8370.83
26_V32_L0.8300.82
76_H141_G0.8260.82
87_H144_I0.8250.82
22_H32_L0.8220.82
45_A95_F0.8110.81
128_P131_I0.8070.81
43_L47_P0.8040.80
138_V141_G0.7960.80
21_W73_Y0.7920.79
64_V96_I0.7890.79
19_N22_H0.7870.79
123_L151_A0.7860.79
78_T89_S0.7830.79
25_A81_D0.7630.77
47_P50_Y0.7600.76
79_A90_I0.7570.76
105_L109_D0.7550.76
73_Y77_Q0.7540.76
67_G103_M0.7500.76
26_V82_M0.7490.75
30_S44_A0.7480.75
139_H146_I0.7340.74
111_Q114_A0.7330.74
58_Q62_L0.7280.73
70_I74_L0.7220.73
133_W137_N0.7150.72
74_L92_W0.7150.72
30_S40_M0.7130.72
44_A48_F0.7080.71
23_L27_G0.7020.71
112_W116_G0.7020.71
135_D138_V0.7000.70
86_D94_E0.6990.70
33_S36_V0.6980.70
57_W103_M0.6910.69
97_G149_I0.6790.68
119_I162_I0.6730.67
30_S95_F0.6680.67
32_L89_S0.6660.67
51_L54_F0.6660.67
49_W56_P0.6630.66
75_C144_I0.6620.66
66_L70_I0.6590.66
105_L158_I0.6580.66
76_H79_A0.6560.65
134_F137_N0.6510.65
67_G92_W0.6480.64
63_V67_G0.6460.64
68_I72_V0.6440.64
25_A74_L0.6430.64
157_G161_F0.6330.63
68_I152_G0.6250.62
78_T82_M0.6240.62
23_L28_F0.6180.61
160_Y163_G0.6170.61
42_S117_F0.6110.60
97_G113_V0.6100.60
74_L90_I0.6070.59
58_Q61_S0.6030.59
57_W61_S0.5990.58
96_I100_I0.5940.58
46_I102_L0.5910.57
54_F57_W0.5860.57
130_P154_I0.5830.56
149_I153_V0.5830.56
85_H135_D0.5810.56
60_Y63_V0.5780.56
115_A119_I0.5780.56
98_M113_V0.5770.56
46_I117_F0.5750.55
113_V129_W0.5740.55
96_I99_W0.5730.55
43_L46_I0.5720.55
63_V70_I0.5720.55
29_G32_L0.5650.54
105_L116_G0.5650.54
129_W133_W0.5620.54
18_S162_I0.5620.54
49_W53_T0.5610.54
64_V100_I0.5600.53
75_C79_A0.5580.53
53_T107_T0.5580.53
25_A75_C0.5510.52
24_L125_M0.5510.52
48_F51_L0.5500.52
141_G144_I0.5480.52
79_A84_V0.5480.52
44_A47_P0.5470.52
150_V154_I0.5460.52
124_D127_K0.5450.51
111_Q118_V0.5390.51
92_W145_M0.5370.50
62_L165_H0.5310.50
42_S88_G0.5280.49
58_Q66_L0.5270.49
36_V40_M0.5260.49
102_L105_L0.5250.49
161_F165_H0.5250.49
106_P112_W0.5230.49
105_L160_Y0.5220.49
57_W104_A0.5210.48
19_N81_D0.5190.48
64_V99_W0.5190.48
76_H140_G0.5190.48
48_F99_W0.5180.48
50_Y54_F0.5140.47
87_H131_I0.5130.47
71_G74_L0.5110.47
153_V156_A0.5100.47
139_H144_I0.5100.47
52_M104_A0.5070.47
92_W96_I0.5020.46
29_G75_C0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y9iA 4 0.8547 99.9 0.557 Contact Map
1rfzA 4 0.8721 99.9 0.566 Contact Map
1tlqA 4 0.8547 99.9 0.582 Contact Map
4q2eA 2 0.6686 8.7 0.956 Contact Map
2ksfA 1 0.4709 3.7 0.963 Contact Map
2cfqA 1 0.4884 3.7 0.963 Contact Map
2rddB 1 0.1105 3.5 0.963 Contact Map
4us3A 1 0.907 3.3 0.964 Contact Map
2k1eA 3 0.4535 2 0.968 Contact Map
4rp9A 2 0.7907 1.9 0.968 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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