GREMLIN Database
MINC - Septum site-determining protein MinC
UniProt: P18196 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10596
Length: 231 (211)
Sequences: 1605 (1175)
Seq/√Len: 80.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_I173_A6.8781.00
169_M173_A5.7751.00
158_I177_A4.5511.00
195_V218_L3.4281.00
57_D60_N3.3901.00
147_V157_L3.0931.00
157_L165_V2.7291.00
132_V138_I2.6821.00
184_Q217_R2.6521.00
5_P31_A2.5131.00
125_T146_I2.4831.00
145_L157_L2.4601.00
33_E71_T2.4051.00
172_R194_L2.3071.00
142_Q160_D2.2651.00
140_A145_L2.2251.00
149_S167_G2.2231.00
60_N63_A2.1991.00
160_D178_S2.1671.00
174_L196_S2.1591.00
181_R199_G2.1511.00
172_R196_S2.0951.00
125_T143_C2.0701.00
132_V155_A2.0411.00
131_P149_S1.9711.00
181_R198_A1.8991.00
205_D216_A1.8731.00
150_H192_A1.8691.00
126_R143_C1.8051.00
143_C159_A1.7891.00
130_T149_S1.7711.00
33_E37_A1.7561.00
151_V155_A1.7451.00
174_L177_A1.7121.00
181_R223_N1.7041.00
200_E220_L1.6271.00
29_H67_A1.6271.00
219_Q228_Q1.6031.00
69_S74_R1.5911.00
166_Y186_F1.5871.00
127_L148_T1.5681.00
10_G14_T1.5460.99
172_R193_E1.5450.99
24_E27_V1.5200.99
150_H167_G1.4940.99
29_H63_A1.4670.99
187_C190_L1.4360.99
144_D161_G1.4150.99
194_L201_Y1.3660.99
76_I82_K1.3620.99
70_A182_E1.3610.99
137_R156_E1.3560.99
134_S169_M1.3500.99
128_I138_I1.3160.98
82_K85_Q1.3120.98
187_C192_A1.3070.98
139_Y160_D1.3030.98
30_Q34_D1.2990.98
151_V169_M1.2960.98
185_I195_V1.2950.98
145_L151_V1.2930.98
66_K70_A1.2670.98
74_R96_P1.2500.98
10_G17_V1.2480.98
15_L28_I1.2330.97
8_L12_S1.2160.97
192_A204_S1.1970.97
169_M187_C1.1880.97
42_F190_L1.1710.97
36_I39_A1.1580.96
165_V186_F1.1580.96
62_S66_K1.1500.96
143_C160_D1.1470.96
151_V173_A1.1450.96
216_A227_V1.1350.96
156_E172_R1.1290.96
140_A160_D1.1270.96
38_Q132_V1.1210.96
152_S187_C1.1190.96
133_R152_S1.1190.96
132_V145_L1.1140.95
221_V226_T1.1140.95
148_T157_L1.1060.95
13_F17_V1.0960.95
39_A42_F1.0930.95
100_E103_E1.0880.95
190_L195_V1.0860.95
73_L78_V1.0810.95
168_M192_A1.0750.94
196_S201_Y1.0750.94
139_Y177_A1.0710.94
25_P63_A1.0570.94
16_S229_P1.0450.94
152_S165_V1.0230.93
25_P60_N1.0130.92
188_T192_A1.0110.92
65_H69_S0.9920.92
136_Q156_E0.9860.91
144_D164_H0.9840.91
157_L169_M0.9810.91
133_R136_Q0.9640.90
159_A163_I0.9600.90
125_T144_D0.9590.90
147_V220_L0.9590.90
51_N145_L0.9480.90
155_A219_Q0.9380.89
61_W93_M0.9330.89
159_A208_P0.9320.89
34_D38_Q0.9310.89
68_V71_T0.9300.89
180_D183_T0.9240.89
25_P67_A0.9230.88
180_D198_A0.9180.88
63_A67_A0.9130.88
33_E70_A0.9120.88
67_A71_T0.9090.88
193_E203_L0.8980.87
168_M189_N0.8910.87
45_H125_T0.8880.86
20_L23_A0.8850.86
129_D148_T0.8820.86
209_A212_Y0.8810.86
153_A204_S0.8790.86
45_H162_N0.8780.86
224_A228_Q0.8770.86
96_P146_I0.8770.86
170_R191_M0.8760.86
203_L206_Q0.8720.85
150_H168_M0.8690.85
219_Q226_T0.8680.85
55_L182_E0.8670.85
14_T206_Q0.8650.85
187_C216_A0.8620.85
202_W227_V0.8610.85
128_I151_V0.8600.85
98_L152_S0.8580.85
48_V80_G0.8540.84
194_L203_L0.8450.84
123_T180_D0.8450.84
150_H195_V0.8430.83
160_D177_A0.8380.83
130_T228_Q0.8370.83
198_A220_L0.8360.83
69_S75_V0.8270.82
218_L227_V0.8230.82
148_T167_G0.8200.82
189_N213_G0.8180.82
202_W205_D0.8160.81
174_L194_L0.8130.81
19_H28_I0.8020.80
95_L102_K0.7980.80
8_L40_P0.7850.79
50_L89_E0.7850.79
130_T157_L0.7800.78
160_D196_S0.7800.78
73_L76_I0.7770.78
30_Q33_E0.7760.78
145_L160_D0.7740.78
85_Q89_E0.7690.77
169_M185_I0.7690.77
196_S203_L0.7670.77
73_L80_G0.7650.77
40_P187_C0.7620.77
26_K63_A0.7600.77
119_T122_V0.7550.76
99_T103_E0.7540.76
148_T217_R0.7540.76
117_Q120_T0.7530.76
190_L204_S0.7480.76
93_M98_L0.7480.76
216_A225_L0.7470.75
27_V30_Q0.7420.75
152_S206_Q0.7400.75
172_R201_Y0.7370.74
135_G170_R0.7330.74
202_W225_L0.7320.74
98_L102_K0.7290.74
21_H28_I0.7250.73
185_I220_L0.7210.73
54_A60_N0.7100.72
17_V203_L0.7100.72
43_L138_I0.7090.72
97_I102_K0.7070.71
97_I101_G0.7020.71
144_D162_N0.6980.70
86_L89_E0.6970.70
29_H33_E0.6940.70
157_L185_I0.6890.69
165_V169_M0.6860.69
156_E164_H0.6820.69
156_E177_A0.6770.68
101_G157_L0.6770.68
50_L61_W0.6770.68
203_L216_A0.6720.67
39_A46_A0.6720.67
35_K67_A0.6700.67
117_Q121_P0.6690.67
93_M97_I0.6680.67
35_K39_A0.6670.67
152_S170_R0.6640.67
8_L35_K0.6630.66
78_V82_K0.6630.66
197_I225_L0.6620.66
6_I14_T0.6610.66
218_L225_L0.6610.66
26_K214_K0.6600.66
35_K190_L0.6570.66
79_S82_K0.6550.65
222_E226_T0.6470.65
129_D149_S0.6460.64
10_G35_K0.6450.64
26_K29_H0.6440.64
132_V163_I0.6390.64
7_E35_K0.6370.63
96_P103_E0.6360.63
12_S16_S0.6350.63
35_K227_V0.6330.63
49_V77_G0.6320.63
32_L78_V0.6300.62
158_I165_V0.6290.62
209_A223_N0.6240.62
147_V151_V0.6230.62
179_G196_S0.6200.61
94_G97_I0.6160.61
87_K90_I0.6140.61
211_F216_A0.6130.60
11_S14_T0.6130.60
188_T215_A0.6080.60
116_A120_T0.6080.60
62_S116_A0.6080.60
139_Y158_I0.6060.60
179_G220_L0.6050.59
116_A119_T0.6050.59
120_T162_N0.6030.59
50_L68_V0.6030.59
13_F155_A0.6000.59
49_V156_E0.5990.59
201_Y207_I0.5990.59
8_L134_S0.5970.58
216_A219_Q0.5950.58
147_V155_A0.5930.58
215_A219_Q0.5930.58
77_G145_L0.5920.58
22_E120_T0.5890.57
88_A97_I0.5870.57
196_S205_D0.5850.57
119_T123_T0.5830.57
86_L90_I0.5820.56
23_A28_I0.5800.56
186_F217_R0.5800.56
37_A71_T0.5750.56
192_A205_D0.5720.55
215_A229_P0.5720.55
5_P28_I0.5720.55
169_M191_M0.5690.55
138_I201_Y0.5670.55
14_T36_I0.5650.54
63_A228_Q0.5630.54
202_W216_A0.5620.54
10_G133_R0.5590.53
207_I211_F0.5570.53
25_P57_D0.5570.53
61_W65_H0.5550.53
134_S152_S0.5530.53
63_A165_V0.5520.53
44_K72_G0.5520.53
24_E29_H0.5510.52
14_T19_H0.5490.52
124_K213_G0.5490.52
9_K161_G0.5480.52
135_G194_L0.5470.52
218_L223_N0.5450.52
127_L131_P0.5430.51
134_S187_C0.5430.51
165_V210_E0.5420.51
127_L157_L0.5380.51
7_E21_H0.5350.50
15_L153_A0.5340.50
10_G135_G0.5320.50
83_D87_K0.5320.50
72_G78_V0.5320.50
211_F227_V0.5310.50
45_H72_G0.5300.50
9_K35_K0.5300.50
39_A43_L0.5300.50
191_M213_G0.5300.50
156_E193_E0.5280.49
46_A177_A0.5270.49
30_Q118_N0.5260.49
137_R145_L0.5240.49
195_V203_L0.5230.49
171_G176_G0.5220.49
132_V219_Q0.5200.48
75_V149_S0.5190.48
54_A229_P0.5180.48
189_N214_K0.5170.48
5_P52_V0.5160.48
135_G152_S0.5150.48
41_A98_L0.5140.48
61_W86_L0.5140.48
170_R204_S0.5140.48
92_K116_A0.5130.48
137_R140_A0.5130.48
196_S199_G0.5120.47
50_L75_V0.5120.47
8_L201_Y0.5080.47
92_K102_K0.5070.47
185_I207_I0.5070.47
181_R200_E0.5060.47
29_H70_A0.5050.46
156_E194_L0.5050.46
37_A121_P0.5020.46
26_K70_A0.5020.46
123_T165_V0.5010.46
54_A68_V0.5000.46
5_P48_V0.5000.46
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1hf2A 2 0.8658 100 0.163 Contact Map
4v02C 2 0.4675 100 0.396 Contact Map
3ghfA 2 0.4329 99.7 0.712 Contact Map
2m4iA 1 0.4069 99.3 0.784 Contact Map
1nktA 3 0.7792 63.6 0.937 Contact Map
2pfuA 1 0.3593 40.7 0.945 Contact Map
2jwkA 2 0.2987 39.8 0.945 Contact Map
4jrbA 1 0.342 15.8 0.955 Contact Map
4kdlB 1 0.2857 13.6 0.956 Contact Map
1uf2K 1 0 13.2 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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