GREMLIN Database
UBIG - Ubiquinone biosynthesis O-methyltransferase
UniProt: P17993 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG11143
Length: 240 (196)
Sequences: 18433 (13630)
Seq/√Len: 973.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_K80_T3.1731.00
146_A206_L2.9181.00
88_F109_Q2.8851.00
65_C83_G2.8751.00
139_Q203_Q2.7471.00
64_G131_M2.4951.00
124_D150_K2.4661.00
82_T123_Y2.4401.00
144_A147_Q2.3661.00
94_A107_Y2.3471.00
84_L110_E2.3391.00
145_C155_V2.3101.00
91_L107_Y2.3031.00
71_A81_V2.2821.00
118_K123_Y2.2641.00
80_T106_D2.2241.00
61_L123_Y2.1981.00
88_F92_Q2.1771.00
91_L109_Q2.1421.00
82_T108_V2.1081.00
149_V153_G2.1051.00
126_V145_C2.0861.00
76_R101_S2.0491.00
93_V96_L2.0441.00
63_V145_C2.0181.00
138_P200_W1.9561.00
126_V149_V1.9291.00
139_Q143_R1.9291.00
60_V74_M1.7921.00
72_E98_A1.7861.00
198_L202_D1.7741.00
98_A107_Y1.7511.00
21_E87_G1.7411.00
63_V112_V1.7291.00
137_D140_S1.7281.00
149_V155_V1.7271.00
55_L58_K1.7121.00
58_K125_V1.7021.00
59_K82_T1.6991.00
139_Q200_W1.6881.00
193_K196_E1.6851.00
144_A148_L1.6311.00
120_A147_Q1.5741.00
72_E97_H1.5681.00
65_C71_A1.5671.00
89_E92_Q1.5301.00
199_G203_Q1.5251.00
85_D91_L1.5121.00
21_E89_E1.4951.00
140_S143_R1.4951.00
71_A83_G1.4931.00
59_K150_K1.4901.00
60_V125_V1.4661.00
91_L95_K1.4541.00
131_M135_V1.4451.00
86_M111_T1.4261.00
82_T106_D1.4251.00
119_H122_Q1.4231.00
135_V141_V1.4011.00
111_T114_E1.3961.00
142_V201_V1.3681.00
149_V206_L1.3661.00
139_Q204_T1.3451.00
73_S76_R1.3431.00
59_K123_Y1.2941.00
49_A77_E1.2931.00
59_K124_D1.2881.00
112_V131_M1.2861.00
128_C131_M1.2851.00
110_E116_A1.2761.00
92_Q95_K1.2711.00
17_I21_E1.2401.00
61_L126_V1.2041.00
58_K79_A1.1911.00
75_A104_Q1.1771.00
57_G79_A1.1741.00
98_A105_V1.1741.00
133_E159_T1.1721.00
59_K122_Q1.1601.00
83_G107_Y1.1571.00
64_G128_C1.1221.00
146_A204_T1.1201.00
108_V118_K1.1151.00
126_V148_L1.1101.00
143_R204_T1.1071.00
116_A144_A1.1011.00
28_W67_G1.0891.00
46_G50_E1.0851.00
26_R29_D1.0821.00
65_C94_A1.0821.00
199_G202_D1.0741.00
84_L115_H1.0671.00
95_K99_L1.0631.00
72_E101_S1.0621.00
198_L211_I1.0611.00
73_S77_E1.0271.00
48_I156_F0.9931.00
196_E199_G0.9911.00
130_E133_E0.9871.00
84_L108_V0.9781.00
46_G73_S0.9771.00
115_H148_L0.9761.00
93_V97_H0.9741.00
83_G94_A0.9721.00
47_Y50_E0.9661.00
60_V81_V0.9481.00
96_L99_L0.9481.00
68_G94_A0.9461.00
92_Q96_L0.9431.00
141_V145_C0.9311.00
41_N44_R0.9231.00
18_A22_A0.9211.00
61_L148_L0.9181.00
72_E76_R0.9141.00
145_C149_V0.9091.00
96_L100_E0.9021.00
58_K124_D0.8981.00
74_M127_T0.8951.00
98_A103_I0.8951.00
60_V127_T0.8941.00
138_P192_I0.8941.00
194_P213_G0.8911.00
143_R147_Q0.8841.00
76_R103_I0.8821.00
82_T118_K0.8811.00
20_F134_H0.8791.00
47_Y51_R0.8711.00
70_L129_M0.8711.00
113_E137_D0.8701.00
112_V135_V0.8591.00
85_D90_P0.8561.00
67_G90_P0.8551.00
130_E158_S0.8541.00
87_G90_P0.8461.00
54_G58_K0.8431.00
71_A105_V0.8391.00
71_A107_Y0.8381.00
125_V153_G0.8381.00
132_L142_V0.8341.00
130_E134_H0.8331.00
70_L127_T0.8321.00
132_L135_V0.8241.00
142_V197_L0.8231.00
62_D65_C0.8201.00
115_H144_A0.8121.00
142_V204_T0.8101.00
20_F133_E0.8101.00
114_E140_S0.8091.00
39_R42_P0.8021.00
28_W97_H0.8011.00
118_K122_Q0.7931.00
132_L141_V0.7881.00
97_H101_S0.7671.00
118_K148_L0.7641.00
122_Q150_K0.7631.00
155_V201_V0.7621.00
200_W204_T0.7601.00
47_Y212_T0.7541.00
24_A28_W0.7521.00
140_S144_A0.7521.00
51_R54_G0.7421.00
69_I73_S0.7251.00
60_V79_A0.7221.00
132_L157_F0.7211.00
125_V154_D0.7201.00
128_C157_F0.7191.00
51_R212_T0.7171.00
98_A101_S0.7161.00
37_L40_I0.7151.00
67_G97_H0.7141.00
181_V184_G0.7011.00
128_C135_V0.6951.00
98_A102_G0.6921.00
120_A144_A0.6921.00
175_E179_R0.6871.00
95_K106_D0.6861.00
134_H159_T0.6861.00
120_A148_L0.6811.00
69_I97_H0.6801.00
62_D83_G0.6791.00
63_V126_V0.6741.00
17_I86_M0.6711.00
55_L79_A0.6711.00
115_H118_K0.6691.00
25_S93_V0.6671.00
52_A125_V0.6661.00
63_V84_L0.6661.00
46_G77_E0.6661.00
115_H123_Y0.6561.00
23_V26_R0.6551.00
70_L74_M0.6551.00
181_V186_H0.6521.00
97_H100_E0.6481.00
20_F23_V0.6461.00
175_E178_L0.6441.00
88_F95_K0.6421.00
68_G107_Y0.6391.00
26_R30_L0.6361.00
38_H41_N0.6361.00
202_D208_E0.6361.00
129_M158_S0.6331.00
37_L41_N0.6311.00
194_P198_L0.6301.00
110_E115_H0.6281.00
75_A103_I0.6271.00
132_L138_P0.6271.00
59_K79_A0.6271.00
64_G135_V0.6241.00
91_L94_A0.6191.00
142_V200_W0.6181.00
45_L49_A0.6171.00
162_R193_K0.6161.00
40_I43_L0.6161.00
189_K192_I0.6151.00
89_E93_V0.6141.00
44_R47_Y0.6121.00
51_R210_H0.6111.00
59_K121_G0.6111.00
72_E75_A0.6101.00
119_H148_L0.6061.00
40_I44_R0.6061.00
65_C85_D0.6041.00
95_K107_Y0.6041.00
133_E160_L0.6021.00
42_P46_G0.6021.00
132_L159_T0.6001.00
72_E107_Y0.5991.00
50_E53_G0.5971.00
121_G151_P0.5911.00
27_W30_L0.5851.00
143_R203_Q0.5841.00
130_E160_L0.5831.00
43_L46_G0.5811.00
157_F201_V0.5801.00
195_A199_G0.5781.00
25_S89_E0.5731.00
45_L73_S0.5731.00
95_K98_A0.5721.00
200_W203_Q0.5711.00
20_F28_W0.5711.00
28_W31_E0.5691.00
128_C145_C0.5681.00
201_V204_T0.5631.00
159_T197_L0.5631.00
53_G154_D0.5591.00
17_I109_Q0.5571.00
78_G81_V0.5561.00
180_M184_G0.5531.00
99_L102_G0.5531.00
25_S96_L0.5531.00
24_A90_P0.5501.00
174_A177_I0.5491.00
36_P40_I0.5491.00
65_C107_Y0.5491.00
72_E103_I0.5471.00
49_A54_G0.5451.00
72_E94_A0.5451.00
208_E211_I0.5411.00
122_Q147_Q0.5391.00
65_C91_L0.5371.00
162_R196_E0.5361.00
70_L133_E0.5351.00
142_V157_F0.5331.00
114_E144_A0.5321.00
196_E200_W0.5321.00
113_E141_V0.5301.00
171_V175_E0.5301.00
100_E103_I0.5291.00
166_S170_A0.5281.00
169_M172_V0.5261.00
62_D134_H0.5251.00
201_V206_L0.5251.00
183_K186_H0.5241.00
173_G176_Y0.5211.00
147_Q150_K0.5181.00
90_P130_E0.5181.00
195_A198_L0.5181.00
128_C141_V0.5151.00
170_A173_G0.5151.00
62_D127_T0.5121.00
21_E88_F0.5111.00
198_L208_E0.5111.00
155_V206_L0.5111.00
176_Y179_R0.5101.00
75_A105_V0.5061.00
41_N45_L0.5051.00
121_G148_L0.5041.00
41_N48_I0.5041.00
160_L189_K0.5021.00
34_F41_N0.5011.00
80_T104_Q0.5011.00
174_A179_R0.5011.00
36_P39_R0.5001.00
34_F37_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4kdcA 1 0.9042 100 0.304 Contact Map
4kdrA 1 0.8625 100 0.34 Contact Map
4obxA 2 0.8417 100 0.417 Contact Map
2o57A 2 0.925 100 0.422 Contact Map
4htfA 2 0.9083 100 0.426 Contact Map
4pneA 2 0.9292 100 0.427 Contact Map
4fsdA 1 0.8167 100 0.432 Contact Map
1y8cA 1 0.8792 100 0.433 Contact Map
3bkxA 2 0.9333 100 0.436 Contact Map
1vl5A 1 0.8042 100 0.437 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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