MURC - ECOLI - GREMLIN Contacts

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MURC - UDP-N-acetylmuramate--L-alanine ligase

UniProt:	P17952	Sequences: MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLMNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELLPRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMRVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPARVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKLKPQTPEEEQHD	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10619
Length:	491 (402)
Sequences:	17163 (12676)
Seq/√Len:	632.2

ECOLI - MURC MPL MURD MURE MURF
BACSU - MURD MURC MURE MURF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
191_I	303_V	3.299	1.00
250_Y	299_A	2.882	1.00
262_D	273_T	2.679	1.00
46_I	58_Q	2.499	1.00
301_V	314_I	2.497	1.00
438_I	449_M	2.492	1.00
143_E	320_S	2.491	1.00
120_H	188_M	2.476	1.00
377_M	401_V	2.473	1.00
310_D	313_A	2.451	1.00
189_V	303_V	2.417	1.00
403_T	438_I	2.409	1.00
97_A	100_E	2.395	1.00
261_E	275_L	2.383	1.00
330_F	347_M	2.346	1.00
191_I	299_A	2.339	1.00
403_T	453_V	2.335	1.00
449_M	453_V	2.322	1.00
442_D	445_R	2.298	1.00
440_V	449_M	2.293	1.00
206_D	209_N	2.259	1.00
258_V	302_A	2.240	1.00
140_I	300_A	2.202	1.00
273_T	283_R	2.201	1.00
97_A	101_A	2.184	1.00
285_T	319_E	2.167	1.00
138_S	150_F	2.166	1.00
143_E	317_A	2.134	1.00
211_K	238_E	2.098	1.00
205_G	209_N	2.089	1.00
226_R	306_E	2.068	1.00
231_V	256_A	2.039	1.00
140_I	304_A	2.016	1.00
360_D	364_K	2.008	1.00
449_M	452_P	1.963	1.00
374_N	458_D	1.911	1.00
286_L	297_A	1.897	1.00
454_L	460_I	1.889	1.00
146_L	169_R	1.880	1.00
188_M	225_G	1.848	1.00
405_L	453_V	1.838	1.00
143_E	316_R	1.830	1.00
144_A	313_A	1.818	1.00
61_M	83_V	1.812	1.00
271_H	283_R	1.812	1.00
215_I	242_R	1.802	1.00
423_R	427_R	1.800	1.00
76_V	92_N	1.798	1.00
122_I	307_E	1.770	1.00
137_V	300_A	1.765	1.00
123_A	187_P	1.758	1.00
139_S	320_S	1.756	1.00
124_I	137_V	1.749	1.00
123_A	175_A	1.746	1.00
260_V	298_A	1.720	1.00
282_M	315_L	1.714	1.00
218_L	227_A	1.696	1.00
271_H	285_T	1.686	1.00
211_K	235_V	1.673	1.00
252_F	291_R	1.665	1.00
137_V	303_V	1.652	1.00
395_A	399_T	1.640	1.00
137_V	304_A	1.633	1.00
305_T	311_D	1.626	1.00
276_R	279_K	1.626	1.00
209_N	212_Q	1.626	1.00
74_E	77_R	1.611	1.00
259_R	275_L	1.609	1.00
330_F	349_V	1.600	1.00
272_F	297_A	1.584	1.00
297_A	318_L	1.572	1.00
333_E	347_M	1.559	1.00
405_L	449_M	1.558	1.00
231_V	249_T	1.550	1.00
196_E	357_T	1.543	1.00
374_N	403_T	1.534	1.00
144_A	309_I	1.526	1.00
276_R	305_T	1.526	1.00
138_S	142_A	1.515	1.00
226_R	248_T	1.501	1.00
226_R	246_Q	1.496	1.00
190_A	221_L	1.493	1.00
190_A	217_F	1.488	1.00
189_V	307_E	1.486	1.00
376_V	403_T	1.485	1.00
258_V	305_T	1.481	1.00
386_R	389_D	1.480	1.00
406_M	426_C	1.475	1.00
120_H	170_Y	1.466	1.00
64_G	85_S	1.466	1.00
260_V	263_Y	1.457	1.00
291_R	364_K	1.446	1.00
122_I	137_V	1.444	1.00
48_G	54_N	1.432	1.00
304_A	314_I	1.431	1.00
141_Y	172_I	1.421	1.00
315_L	319_E	1.418	1.00
348_L	451_A	1.417	1.00
181_S	213_T	1.409	1.00
440_V	445_R	1.408	1.00
376_V	453_V	1.398	1.00
132_T	293_N	1.396	1.00
128_H	355_H	1.395	1.00
383_R	467_N	1.391	1.00
424_S	427_R	1.390	1.00
213_T	216_N	1.384	1.00
177_E	203_Y	1.380	1.00
364_K	400_Q	1.377	1.00
273_T	281_P	1.377	1.00
361_A	364_K	1.366	1.00
426_C	439_L	1.364	1.00
287_N	322_Q	1.362	1.00
249_T	257_D	1.362	1.00
170_Y	307_E	1.362	1.00
48_G	53_P	1.358	1.00
423_R	439_L	1.350	1.00
229_M	247_T	1.347	1.00
141_Y	307_E	1.347	1.00
121_G	185_L	1.344	1.00
264_Q	271_H	1.342	1.00
136_M	288_A	1.340	1.00
291_R	368_A	1.338	1.00
378_L	381_P	1.338	1.00
346_A	454_L	1.332	1.00
261_E	273_T	1.323	1.00
221_L	225_G	1.322	1.00
304_A	309_I	1.321	1.00
139_S	317_A	1.320	1.00
95_I	99_H	1.311	1.00
313_A	316_R	1.303	1.00
426_C	430_R	1.302	1.00
110_E	114_E	1.301	1.00
387_T	391_Y	1.297	1.00
96_V	99_H	1.295	1.00
189_V	306_E	1.294	1.00
272_F	294_A	1.293	1.00
391_Y	395_A	1.287	1.00
229_M	249_T	1.274	1.00
228_V	306_E	1.271	1.00
229_M	236_I	1.270	1.00
246_Q	306_E	1.269	1.00
181_S	202_T	1.268	1.00
133_T	193_T	1.267	1.00
230_C	295_L	1.264	1.00
275_L	281_P	1.256	1.00
403_T	436_D	1.255	1.00
120_H	169_R	1.254	1.00
137_V	191_I	1.253	1.00
195_I	211_K	1.253	1.00
316_R	320_S	1.246	1.00
192_V	195_I	1.228	1.00
182_F	185_L	1.221	1.00
386_R	390_L	1.216	1.00
114_E	117_R	1.211	1.00
58_Q	61_M	1.210	1.00
55_P	58_Q	1.209	1.00
68_Y	72_R	1.204	1.00
330_F	333_E	1.197	1.00
136_M	321_F	1.196	1.00
282_M	311_D	1.191	1.00
197_A	388_R	1.189	1.00
266_I	271_H	1.184	1.00
269_Q	285_T	1.183	1.00
212_Q	242_R	1.182	1.00
215_I	239_L	1.181	1.00
261_E	281_P	1.178	1.00
407_L	446_V	1.175	1.00
186_Q	225_G	1.172	1.00
445_R	448_E	1.170	1.00
390_L	393_D	1.167	1.00
248_T	302_A	1.162	1.00
345_T	456_G	1.161	1.00
208_E	212_Q	1.159	1.00
274_L	301_V	1.158	1.00
328_F	366_A	1.158	1.00
58_Q	62_N	1.157	1.00
405_L	446_V	1.147	1.00
131_T	324_T	1.145	1.00
448_E	452_P	1.138	1.00
359_V	463_Q	1.137	1.00
189_V	228_V	1.137	1.00
325_G	329_D	1.131	1.00
316_R	319_E	1.125	1.00
393_D	396_N	1.124	1.00
389_D	393_D	1.119	1.00
252_F	295_L	1.116	1.00
258_V	276_R	1.115	1.00
423_R	426_C	1.112	1.00
48_G	58_Q	1.110	1.00
382_H	385_T	1.104	1.00
232_D	295_L	1.096	1.00
147_D	169_R	1.095	1.00
235_V	238_E	1.094	1.00
248_T	306_E	1.093	1.00
124_I	134_T	1.092	1.00
293_N	296_N	1.091	1.00
312_E	316_R	1.079	1.00
291_R	295_L	1.075	1.00
87_A	96_V	1.074	1.00
141_Y	309_I	1.074	1.00
272_F	284_V	1.067	1.00
238_E	241_P	1.067	1.00
212_Q	216_N	1.066	1.00
228_V	302_A	1.055	1.00
444_A	448_E	1.046	1.00
329_D	350_D	1.042	1.00
140_I	314_I	1.042	1.00
141_Y	170_Y	1.040	1.00
354_H	359_V	1.036	1.00
122_I	303_V	1.036	1.00
216_N	219_H	1.036	1.00
229_M	240_L	1.032	1.00
253_S	291_R	1.030	1.00
392_D	396_N	1.029	1.00
376_V	379_F	1.028	1.00
192_V	218_L	1.026	1.00
392_D	428_T	1.022	1.00
260_V	294_A	1.021	1.00
374_N	455_T	1.021	1.00
231_V	237_R	1.020	1.00
328_F	349_V	1.017	1.00
219_H	242_R	1.016	1.00
175_A	182_F	1.014	1.00
376_V	405_L	1.002	1.00
197_A	200_M	1.000	1.00
188_M	222_P	0.998	1.00
140_I	317_A	0.994	1.00
408_E	441_P	0.992	1.00
146_L	170_Y	0.992	1.00
374_N	402_D	0.990	1.00
376_V	458_D	0.989	1.00
197_A	207_F	0.985	1.00
252_F	260_V	0.981	1.00
309_I	313_A	0.979	1.00
386_R	393_D	0.977	1.00
136_M	297_A	0.977	1.00
359_V	379_F	0.975	1.00
139_S	142_A	0.975	1.00
374_N	378_L	0.973	1.00
207_F	235_V	0.973	1.00
144_A	317_A	0.973	1.00
406_M	439_L	0.970	1.00
256_A	259_R	0.966	1.00
390_L	394_F	0.965	1.00
127_T	198_D	0.965	1.00
128_H	357_T	0.964	1.00
394_F	425_L	0.962	1.00
364_K	397_V	0.960	1.00
386_R	391_Y	0.954	1.00
192_V	239_L	0.952	1.00
405_L	450_L	0.950	1.00
121_G	171_L	0.950	1.00
221_L	227_A	0.948	1.00
193_T	299_A	0.947	1.00
445_R	449_M	0.947	1.00
189_V	226_R	0.945	1.00
376_V	381_P	0.942	1.00
57_T	61_M	0.941	1.00
216_N	220_N	0.940	1.00
209_N	213_T	0.929	1.00
394_F	397_V	0.929	1.00
387_T	424_S	0.925	1.00
377_M	463_Q	0.923	1.00
156_V	160_G	0.923	1.00
232_D	251_G	0.922	1.00
249_T	256_A	0.921	1.00
237_R	249_T	0.920	1.00
251_G	295_L	0.920	1.00
51_L	54_N	0.920	1.00
360_D	393_D	0.916	1.00
333_E	346_A	0.915	1.00
305_T	314_I	0.913	1.00
138_S	148_P	0.908	1.00
455_T	458_D	0.906	1.00
211_K	215_I	0.901	1.00
284_V	315_L	0.899	1.00
387_T	390_L	0.897	1.00
104_P	108_R	0.893	1.00
76_V	82_V	0.889	1.00
438_I	453_V	0.887	1.00
180_A	209_N	0.885	1.00
357_T	361_A	0.883	1.00
450_L	454_L	0.882	1.00
180_A	213_T	0.879	1.00
426_C	437_P	0.878	1.00
388_R	392_D	0.876	1.00
96_V	100_E	0.875	1.00
424_S	428_T	0.875	1.00
139_S	321_F	0.874	1.00
144_A	310_D	0.872	1.00
303_V	307_E	0.871	1.00
178_S	202_T	0.871	1.00
143_E	313_A	0.868	1.00
405_L	440_V	0.867	1.00
362_T	461_L	0.865	1.00
215_I	219_H	0.862	1.00
198_D	355_H	0.859	1.00
208_E	235_V	0.854	1.00
234_P	238_E	0.851	1.00
59_Q	81_V	0.850	1.00
349_V	366_A	0.849	1.00
333_E	344_G	0.848	1.00
346_A	457_N	0.847	1.00
360_D	399_T	0.846	1.00
230_C	250_Y	0.845	1.00
120_H	307_E	0.843	1.00
333_E	345_T	0.838	1.00
301_V	305_T	0.838	1.00
377_M	381_P	0.836	1.00
147_D	167_H	0.836	1.00
440_V	446_V	0.833	1.00
360_D	396_N	0.830	1.00
401_V	404_L	0.822	1.00
105_V	108_R	0.821	1.00
366_A	375_L	0.820	1.00
64_G	86_S	0.817	1.00
233_D	295_L	0.814	1.00
186_Q	222_P	0.814	1.00
90_A	99_H	0.811	1.00
125_A	214_F	0.808	1.00
373_K	458_D	0.808	1.00
135_A	324_T	0.801	1.00
441_P	445_R	0.799	1.00
123_A	217_F	0.799	1.00
93_P	97_A	0.797	1.00
406_M	425_L	0.796	1.00
427_R	430_R	0.796	1.00
347_M	459_L	0.793	1.00
85_S	100_E	0.789	1.00
207_F	211_K	0.788	1.00
311_D	315_L	0.786	1.00
379_F	425_L	0.785	1.00
47_S	79_A	0.785	1.00
45_Q	57_T	0.785	1.00
237_R	241_P	0.784	1.00
326_R	350_D	0.784	1.00
392_D	395_A	0.783	1.00
274_L	298_A	0.783	1.00
230_C	233_D	0.782	1.00
133_T	299_A	0.780	1.00
391_Y	394_F	0.777	1.00
106_I	114_E	0.777	1.00
135_A	155_L	0.775	1.00
139_S	143_E	0.774	1.00
240_L	249_T	0.774	1.00
208_E	211_K	0.774	1.00
405_L	438_I	0.773	1.00
447_A	451_A	0.768	1.00
53_P	58_Q	0.765	1.00
252_F	263_Y	0.764	1.00
53_P	61_M	0.763	1.00
228_V	303_V	0.762	1.00
196_E	207_F	0.761	1.00
374_N	379_F	0.758	1.00
345_T	457_N	0.758	1.00
394_F	398_L	0.756	1.00
232_D	252_F	0.756	1.00
149_T	152_N	0.753	1.00
231_V	236_I	0.751	1.00
425_L	428_T	0.749	1.00
56_V	60_L	0.747	1.00
282_M	312_E	0.745	1.00
131_T	154_G	0.745	1.00
59_Q	83_V	0.744	1.00
266_I	269_Q	0.742	1.00
149_T	168_G	0.741	1.00
427_R	431_G	0.739	1.00
57_T	69_F	0.736	1.00
99_H	105_V	0.736	1.00
265_Q	270_G	0.735	1.00
328_F	365_A	0.734	1.00
203_Y	213_T	0.734	1.00
301_V	311_D	0.732	1.00
279_K	311_D	0.730	1.00
163_A	167_H	0.729	1.00
104_P	114_E	0.728	1.00
193_T	250_Y	0.727	1.00
175_A	187_P	0.725	1.00
82_V	98_A	0.725	1.00
147_D	168_G	0.725	1.00
133_T	300_A	0.724	1.00
115_L	186_Q	0.723	1.00
177_E	213_T	0.723	1.00
180_A	212_Q	0.723	1.00
49_S	68_Y	0.722	1.00
264_Q	283_R	0.721	1.00
231_V	251_G	0.719	1.00
363_I	377_M	0.716	1.00
371_P	459_L	0.715	1.00
425_L	429_I	0.714	1.00
118_F	164_R	0.714	1.00
446_V	450_L	0.714	1.00
266_I	270_G	0.712	1.00
208_E	238_E	0.711	1.00
257_D	277_Q	0.709	1.00
82_V	94_E	0.708	1.00
144_A	304_A	0.708	1.00
59_Q	63_L	0.708	1.00
429_I	432_R	0.707	1.00
111_M	115_L	0.707	1.00
211_K	239_L	0.706	1.00
227_A	243_V	0.705	1.00
121_G	173_A	0.704	1.00
228_V	248_T	0.704	1.00
57_T	60_L	0.704	1.00
212_Q	215_I	0.702	1.00
353_G	463_Q	0.701	1.00
373_K	459_L	0.699	1.00
181_S	209_N	0.698	1.00
109_A	114_E	0.696	1.00
266_I	285_T	0.695	1.00
402_D	455_T	0.694	1.00
227_A	245_R	0.693	1.00
314_I	317_A	0.693	1.00
248_T	258_V	0.689	1.00
349_V	459_L	0.689	1.00
394_F	429_I	0.689	1.00
262_D	265_Q	0.688	1.00
380_Q	464_G	0.686	1.00
267_G	270_G	0.686	1.00
344_G	456_G	0.685	1.00
110_E	184_H	0.683	1.00
197_A	357_T	0.681	1.00
263_Y	294_A	0.681	1.00
309_I	314_I	0.681	1.00
288_A	321_F	0.680	1.00
407_L	471_I	0.678	1.00
124_I	191_I	0.676	1.00
288_A	293_N	0.674	1.00
393_D	397_V	0.672	1.00
381_P	409_V	0.672	1.00
272_F	275_L	0.668	1.00
374_N	381_P	0.668	1.00
75_N	79_A	0.667	1.00
420_A	424_S	0.663	1.00
84_V	94_E	0.663	1.00
407_L	443_P	0.661	1.00
238_E	242_R	0.657	1.00
237_R	240_L	0.656	1.00
389_D	392_D	0.656	1.00
251_G	259_R	0.655	1.00
54_N	58_Q	0.654	1.00
156_V	159_A	0.653	1.00
265_Q	291_R	0.653	1.00
443_P	447_A	0.652	1.00
291_R	294_A	0.650	1.00
180_A	202_T	0.649	1.00
348_L	460_I	0.648	1.00
200_M	205_G	0.647	1.00
290_G	293_N	0.645	1.00
186_Q	220_N	0.645	1.00
105_V	109_A	0.643	1.00
252_F	298_A	0.642	1.00
135_A	156_V	0.641	1.00
353_G	362_T	0.640	1.00
195_I	207_F	0.640	1.00
362_T	463_Q	0.639	1.00
396_N	399_T	0.638	1.00
223_F	244_G	0.637	1.00
312_E	315_L	0.635	1.00
404_L	429_I	0.635	1.00
367_R	375_L	0.635	1.00
108_R	111_M	0.634	1.00
355_H	358_E	0.632	1.00
292_H	361_A	0.631	1.00
294_A	298_A	0.631	1.00
135_A	139_S	0.630	1.00
137_V	172_I	0.628	1.00
378_L	407_L	0.628	1.00
364_K	368_A	0.627	1.00
188_M	224_Y	0.626	1.00
192_V	211_K	0.622	1.00
140_I	144_A	0.622	1.00
301_V	315_L	0.619	1.00
378_L	450_L	0.617	1.00
77_R	101_A	0.616	1.00
326_R	466_G	0.616	1.00
284_V	297_A	0.615	1.00
378_L	462_V	0.614	1.00
138_S	172_I	0.614	1.00
275_L	278_D	0.614	1.00
128_H	196_E	0.613	1.00
50_D	53_P	0.612	1.00
59_Q	62_N	0.612	1.00
84_V	95_I	0.610	1.00
106_I	111_M	0.609	1.00
179_D	202_T	0.606	1.00
141_Y	304_A	0.605	1.00
236_I	240_L	0.604	1.00
426_C	429_I	0.603	1.00
54_N	79_A	0.602	1.00
406_M	437_P	0.601	1.00
122_I	141_Y	0.596	1.00
207_F	210_L	0.596	1.00
60_L	65_A	0.596	1.00
467_N	470_K	0.596	1.00
148_P	172_I	0.595	1.00
134_T	150_F	0.595	1.00
103_I	107_R	0.593	1.00
106_I	110_E	0.593	1.00
73_P	97_A	0.591	1.00
107_R	110_E	0.589	1.00
332_G	347_M	0.588	1.00
366_A	461_L	0.587	1.00
236_I	243_V	0.585	1.00
390_L	397_V	0.584	1.00
276_R	311_D	0.582	1.00
82_V	92_N	0.581	1.00
262_D	283_R	0.580	1.00
328_F	362_T	0.578	1.00
402_D	458_D	0.578	1.00
140_I	309_I	0.576	1.00
360_D	400_Q	0.575	1.00
299_A	303_V	0.575	1.00
428_T	431_G	0.574	1.00
162_H	165_L	0.574	1.00
301_V	318_L	0.574	1.00
178_S	201_D	0.572	1.00
251_G	256_A	0.572	1.00
122_I	170_Y	0.570	1.00
298_A	302_A	0.569	1.00
136_M	300_A	0.567	1.00
375_L	402_D	0.565	1.00
106_I	109_A	0.565	1.00
373_K	457_N	0.565	1.00
243_V	247_T	0.565	1.00
430_R	437_P	0.564	1.00
403_T	449_M	0.564	1.00
134_T	172_I	0.564	1.00
406_M	429_I	0.563	1.00
448_E	451_A	0.562	1.00
398_L	432_R	0.560	1.00
240_L	247_T	0.557	1.00
81_V	106_I	0.556	1.00
378_L	460_I	0.555	1.00
93_P	96_V	0.550	1.00
263_Y	272_F	0.550	1.00
379_F	406_M	0.549	1.00
420_A	439_L	0.549	1.00
181_S	216_N	0.549	1.00
135_A	325_G	0.548	1.00
263_Y	266_I	0.546	1.00
366_A	459_L	0.545	1.00
236_I	239_L	0.544	1.00
408_E	420_A	0.543	1.00
200_M	206_D	0.542	1.00
251_G	254_E	0.542	1.00
128_H	358_E	0.542	1.00
109_A	175_A	0.541	0.99
75_N	78_D	0.539	0.99
124_I	133_T	0.539	0.99
142_A	148_P	0.539	0.99
363_I	401_V	0.538	0.99
378_L	446_V	0.536	0.99
367_R	402_D	0.535	0.99
71_H	85_S	0.535	0.99
353_G	358_E	0.535	0.99
45_Q	66_T	0.534	0.99
231_V	253_S	0.534	0.99
302_A	306_E	0.532	0.99
313_A	317_A	0.532	0.99
377_M	404_L	0.529	0.99
348_L	462_V	0.528	0.99
190_A	224_Y	0.528	0.99
180_A	216_N	0.527	0.99
99_H	102_R	0.526	0.99
91_D	96_V	0.526	0.99
376_V	454_L	0.525	0.99
303_V	306_E	0.525	0.99
92_N	97_A	0.525	0.99
398_L	429_I	0.524	0.99
286_L	318_L	0.524	0.99
125_A	192_V	0.523	0.99
363_I	400_Q	0.523	0.99
447_A	462_V	0.522	0.99
376_V	450_L	0.522	0.99
180_A	203_Y	0.521	0.99
46_I	55_P	0.521	0.99
270_G	294_A	0.521	0.99
101_A	104_P	0.520	0.99
377_M	407_L	0.518	0.99
65_A	68_Y	0.516	0.99
395_A	398_L	0.515	0.99
254_E	259_R	0.515	0.99
388_R	391_Y	0.514	0.99
407_L	440_V	0.514	0.99
218_L	229_M	0.513	0.99
288_A	323_G	0.513	0.99
86_S	89_S	0.513	0.99
360_D	397_V	0.511	0.99
255_D	259_R	0.510	0.99
71_H	75_N	0.510	0.99
182_F	220_N	0.509	0.99
222_P	225_G	0.508	0.99
344_G	451_A	0.507	0.99
132_T	321_F	0.507	0.99
278_D	305_T	0.506	0.99
122_I	189_V	0.505	0.99
207_F	234_P	0.504	0.99
119_R	171_L	0.504	0.99
136_M	140_I	0.501	0.99
72_R	75_N	0.501	0.99
127_T	196_E	0.500	0.99

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4hv4A	1	0.9348	100	0.224	Contact Map
1p3dA	1	0.9348	100	0.237	Contact Map
2x5oA	1	0.8819	100	0.257	Contact Map
3lk7A	1	0.89	100	0.275	Contact Map
1j6uA	1	0.8635	100	0.282	Contact Map
3hn7A	1	0.9022	100	0.287	Contact Map
4bucA	1	0.8452	100	0.305	Contact Map
4c12A	2	0.9185	100	0.333	Contact Map
4bubA	1	0.9063	100	0.343	Contact Map
2wtzA	1	0.9348	100	0.358	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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