GREMLIN Database
MURC - UDP-N-acetylmuramate--L-alanine ligase
UniProt: P17952 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10619
Length: 491 (402)
Sequences: 17163 (12676)
Seq/√Len: 632.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
191_I303_V3.2991.00
250_Y299_A2.8821.00
262_D273_T2.6791.00
46_I58_Q2.4991.00
301_V314_I2.4971.00
438_I449_M2.4921.00
143_E320_S2.4911.00
120_H188_M2.4761.00
377_M401_V2.4731.00
310_D313_A2.4511.00
189_V303_V2.4171.00
403_T438_I2.4091.00
97_A100_E2.3951.00
261_E275_L2.3831.00
330_F347_M2.3461.00
191_I299_A2.3391.00
403_T453_V2.3351.00
449_M453_V2.3221.00
442_D445_R2.2981.00
440_V449_M2.2931.00
206_D209_N2.2591.00
258_V302_A2.2401.00
140_I300_A2.2021.00
273_T283_R2.2011.00
97_A101_A2.1841.00
285_T319_E2.1671.00
138_S150_F2.1661.00
143_E317_A2.1341.00
211_K238_E2.0981.00
205_G209_N2.0891.00
226_R306_E2.0681.00
231_V256_A2.0391.00
140_I304_A2.0161.00
360_D364_K2.0081.00
449_M452_P1.9631.00
374_N458_D1.9111.00
286_L297_A1.8971.00
454_L460_I1.8891.00
146_L169_R1.8801.00
188_M225_G1.8481.00
405_L453_V1.8381.00
143_E316_R1.8301.00
144_A313_A1.8181.00
61_M83_V1.8121.00
271_H283_R1.8121.00
215_I242_R1.8021.00
423_R427_R1.8001.00
76_V92_N1.7981.00
122_I307_E1.7701.00
137_V300_A1.7651.00
123_A187_P1.7581.00
139_S320_S1.7561.00
124_I137_V1.7491.00
123_A175_A1.7461.00
260_V298_A1.7201.00
282_M315_L1.7141.00
218_L227_A1.6961.00
271_H285_T1.6861.00
211_K235_V1.6731.00
252_F291_R1.6651.00
137_V303_V1.6521.00
395_A399_T1.6401.00
137_V304_A1.6331.00
305_T311_D1.6261.00
276_R279_K1.6261.00
209_N212_Q1.6261.00
74_E77_R1.6111.00
259_R275_L1.6091.00
330_F349_V1.6001.00
272_F297_A1.5841.00
297_A318_L1.5721.00
333_E347_M1.5591.00
405_L449_M1.5581.00
231_V249_T1.5501.00
196_E357_T1.5431.00
374_N403_T1.5341.00
144_A309_I1.5261.00
276_R305_T1.5261.00
138_S142_A1.5151.00
226_R248_T1.5011.00
226_R246_Q1.4961.00
190_A221_L1.4931.00
190_A217_F1.4881.00
189_V307_E1.4861.00
376_V403_T1.4851.00
258_V305_T1.4811.00
386_R389_D1.4801.00
406_M426_C1.4751.00
120_H170_Y1.4661.00
64_G85_S1.4661.00
260_V263_Y1.4571.00
291_R364_K1.4461.00
122_I137_V1.4441.00
48_G54_N1.4321.00
304_A314_I1.4311.00
141_Y172_I1.4211.00
315_L319_E1.4181.00
348_L451_A1.4171.00
181_S213_T1.4091.00
440_V445_R1.4081.00
376_V453_V1.3981.00
132_T293_N1.3961.00
128_H355_H1.3951.00
383_R467_N1.3911.00
424_S427_R1.3901.00
213_T216_N1.3841.00
177_E203_Y1.3801.00
364_K400_Q1.3771.00
273_T281_P1.3771.00
361_A364_K1.3661.00
426_C439_L1.3641.00
287_N322_Q1.3621.00
249_T257_D1.3621.00
170_Y307_E1.3621.00
48_G53_P1.3581.00
423_R439_L1.3501.00
229_M247_T1.3471.00
141_Y307_E1.3471.00
121_G185_L1.3441.00
264_Q271_H1.3421.00
136_M288_A1.3401.00
291_R368_A1.3381.00
378_L381_P1.3381.00
346_A454_L1.3321.00
261_E273_T1.3231.00
221_L225_G1.3221.00
304_A309_I1.3211.00
139_S317_A1.3201.00
95_I99_H1.3111.00
313_A316_R1.3031.00
426_C430_R1.3021.00
110_E114_E1.3011.00
387_T391_Y1.2971.00
96_V99_H1.2951.00
189_V306_E1.2941.00
272_F294_A1.2931.00
391_Y395_A1.2871.00
229_M249_T1.2741.00
228_V306_E1.2711.00
229_M236_I1.2701.00
246_Q306_E1.2691.00
181_S202_T1.2681.00
133_T193_T1.2671.00
230_C295_L1.2641.00
275_L281_P1.2561.00
403_T436_D1.2551.00
120_H169_R1.2541.00
137_V191_I1.2531.00
195_I211_K1.2531.00
316_R320_S1.2461.00
192_V195_I1.2281.00
182_F185_L1.2211.00
386_R390_L1.2161.00
114_E117_R1.2111.00
58_Q61_M1.2101.00
55_P58_Q1.2091.00
68_Y72_R1.2041.00
330_F333_E1.1971.00
136_M321_F1.1961.00
282_M311_D1.1911.00
197_A388_R1.1891.00
266_I271_H1.1841.00
269_Q285_T1.1831.00
212_Q242_R1.1821.00
215_I239_L1.1811.00
261_E281_P1.1781.00
407_L446_V1.1751.00
186_Q225_G1.1721.00
445_R448_E1.1701.00
390_L393_D1.1671.00
248_T302_A1.1621.00
345_T456_G1.1611.00
208_E212_Q1.1591.00
274_L301_V1.1581.00
328_F366_A1.1581.00
58_Q62_N1.1571.00
405_L446_V1.1471.00
131_T324_T1.1451.00
448_E452_P1.1381.00
359_V463_Q1.1371.00
189_V228_V1.1371.00
325_G329_D1.1311.00
316_R319_E1.1251.00
393_D396_N1.1241.00
389_D393_D1.1191.00
252_F295_L1.1161.00
258_V276_R1.1151.00
423_R426_C1.1121.00
48_G58_Q1.1101.00
382_H385_T1.1041.00
232_D295_L1.0961.00
147_D169_R1.0951.00
235_V238_E1.0941.00
248_T306_E1.0931.00
124_I134_T1.0921.00
293_N296_N1.0911.00
312_E316_R1.0791.00
291_R295_L1.0751.00
87_A96_V1.0741.00
141_Y309_I1.0741.00
272_F284_V1.0671.00
238_E241_P1.0671.00
212_Q216_N1.0661.00
228_V302_A1.0551.00
444_A448_E1.0461.00
329_D350_D1.0421.00
140_I314_I1.0421.00
141_Y170_Y1.0401.00
354_H359_V1.0361.00
122_I303_V1.0361.00
216_N219_H1.0361.00
229_M240_L1.0321.00
253_S291_R1.0301.00
392_D396_N1.0291.00
376_V379_F1.0281.00
192_V218_L1.0261.00
392_D428_T1.0221.00
260_V294_A1.0211.00
374_N455_T1.0211.00
231_V237_R1.0201.00
328_F349_V1.0171.00
219_H242_R1.0161.00
175_A182_F1.0141.00
376_V405_L1.0021.00
197_A200_M1.0001.00
188_M222_P0.9981.00
140_I317_A0.9941.00
408_E441_P0.9921.00
146_L170_Y0.9921.00
374_N402_D0.9901.00
376_V458_D0.9891.00
197_A207_F0.9851.00
252_F260_V0.9811.00
309_I313_A0.9791.00
386_R393_D0.9771.00
136_M297_A0.9771.00
359_V379_F0.9751.00
139_S142_A0.9751.00
374_N378_L0.9731.00
207_F235_V0.9731.00
144_A317_A0.9731.00
406_M439_L0.9701.00
256_A259_R0.9661.00
390_L394_F0.9651.00
127_T198_D0.9651.00
128_H357_T0.9641.00
394_F425_L0.9621.00
364_K397_V0.9601.00
386_R391_Y0.9541.00
192_V239_L0.9521.00
405_L450_L0.9501.00
121_G171_L0.9501.00
221_L227_A0.9481.00
193_T299_A0.9471.00
445_R449_M0.9471.00
189_V226_R0.9451.00
376_V381_P0.9421.00
57_T61_M0.9411.00
216_N220_N0.9401.00
209_N213_T0.9291.00
394_F397_V0.9291.00
387_T424_S0.9251.00
377_M463_Q0.9231.00
156_V160_G0.9231.00
232_D251_G0.9221.00
249_T256_A0.9211.00
237_R249_T0.9201.00
251_G295_L0.9201.00
51_L54_N0.9201.00
360_D393_D0.9161.00
333_E346_A0.9151.00
305_T314_I0.9131.00
138_S148_P0.9081.00
455_T458_D0.9061.00
211_K215_I0.9011.00
284_V315_L0.8991.00
387_T390_L0.8971.00
104_P108_R0.8931.00
76_V82_V0.8891.00
438_I453_V0.8871.00
180_A209_N0.8851.00
357_T361_A0.8831.00
450_L454_L0.8821.00
180_A213_T0.8791.00
426_C437_P0.8781.00
388_R392_D0.8761.00
96_V100_E0.8751.00
424_S428_T0.8751.00
139_S321_F0.8741.00
144_A310_D0.8721.00
303_V307_E0.8711.00
178_S202_T0.8711.00
143_E313_A0.8681.00
405_L440_V0.8671.00
362_T461_L0.8651.00
215_I219_H0.8621.00
198_D355_H0.8591.00
208_E235_V0.8541.00
234_P238_E0.8511.00
59_Q81_V0.8501.00
349_V366_A0.8491.00
333_E344_G0.8481.00
346_A457_N0.8471.00
360_D399_T0.8461.00
230_C250_Y0.8451.00
120_H307_E0.8431.00
333_E345_T0.8381.00
301_V305_T0.8381.00
377_M381_P0.8361.00
147_D167_H0.8361.00
440_V446_V0.8331.00
360_D396_N0.8301.00
401_V404_L0.8221.00
105_V108_R0.8211.00
366_A375_L0.8201.00
64_G86_S0.8171.00
233_D295_L0.8141.00
186_Q222_P0.8141.00
90_A99_H0.8111.00
125_A214_F0.8081.00
373_K458_D0.8081.00
135_A324_T0.8011.00
441_P445_R0.7991.00
123_A217_F0.7991.00
93_P97_A0.7971.00
406_M425_L0.7961.00
427_R430_R0.7961.00
347_M459_L0.7931.00
85_S100_E0.7891.00
207_F211_K0.7881.00
311_D315_L0.7861.00
379_F425_L0.7851.00
47_S79_A0.7851.00
45_Q57_T0.7851.00
237_R241_P0.7841.00
326_R350_D0.7841.00
392_D395_A0.7831.00
274_L298_A0.7831.00
230_C233_D0.7821.00
133_T299_A0.7801.00
391_Y394_F0.7771.00
106_I114_E0.7771.00
135_A155_L0.7751.00
139_S143_E0.7741.00
240_L249_T0.7741.00
208_E211_K0.7741.00
405_L438_I0.7731.00
447_A451_A0.7681.00
53_P58_Q0.7651.00
252_F263_Y0.7641.00
53_P61_M0.7631.00
228_V303_V0.7621.00
196_E207_F0.7611.00
374_N379_F0.7581.00
345_T457_N0.7581.00
394_F398_L0.7561.00
232_D252_F0.7561.00
149_T152_N0.7531.00
231_V236_I0.7511.00
425_L428_T0.7491.00
56_V60_L0.7471.00
282_M312_E0.7451.00
131_T154_G0.7451.00
59_Q83_V0.7441.00
266_I269_Q0.7421.00
149_T168_G0.7411.00
427_R431_G0.7391.00
57_T69_F0.7361.00
99_H105_V0.7361.00
265_Q270_G0.7351.00
328_F365_A0.7341.00
203_Y213_T0.7341.00
301_V311_D0.7321.00
279_K311_D0.7301.00
163_A167_H0.7291.00
104_P114_E0.7281.00
193_T250_Y0.7271.00
175_A187_P0.7251.00
82_V98_A0.7251.00
147_D168_G0.7251.00
133_T300_A0.7241.00
115_L186_Q0.7231.00
177_E213_T0.7231.00
180_A212_Q0.7231.00
49_S68_Y0.7221.00
264_Q283_R0.7211.00
231_V251_G0.7191.00
363_I377_M0.7161.00
371_P459_L0.7151.00
425_L429_I0.7141.00
118_F164_R0.7141.00
446_V450_L0.7141.00
266_I270_G0.7121.00
208_E238_E0.7111.00
257_D277_Q0.7091.00
82_V94_E0.7081.00
144_A304_A0.7081.00
59_Q63_L0.7081.00
429_I432_R0.7071.00
111_M115_L0.7071.00
211_K239_L0.7061.00
227_A243_V0.7051.00
121_G173_A0.7041.00
228_V248_T0.7041.00
57_T60_L0.7041.00
212_Q215_I0.7021.00
353_G463_Q0.7011.00
373_K459_L0.6991.00
181_S209_N0.6981.00
109_A114_E0.6961.00
266_I285_T0.6951.00
402_D455_T0.6941.00
227_A245_R0.6931.00
314_I317_A0.6931.00
248_T258_V0.6891.00
349_V459_L0.6891.00
394_F429_I0.6891.00
262_D265_Q0.6881.00
380_Q464_G0.6861.00
267_G270_G0.6861.00
344_G456_G0.6851.00
110_E184_H0.6831.00
197_A357_T0.6811.00
263_Y294_A0.6811.00
309_I314_I0.6811.00
288_A321_F0.6801.00
407_L471_I0.6781.00
124_I191_I0.6761.00
288_A293_N0.6741.00
393_D397_V0.6721.00
381_P409_V0.6721.00
272_F275_L0.6681.00
374_N381_P0.6681.00
75_N79_A0.6671.00
420_A424_S0.6631.00
84_V94_E0.6631.00
407_L443_P0.6611.00
238_E242_R0.6571.00
237_R240_L0.6561.00
389_D392_D0.6561.00
251_G259_R0.6551.00
54_N58_Q0.6541.00
156_V159_A0.6531.00
265_Q291_R0.6531.00
443_P447_A0.6521.00
291_R294_A0.6501.00
180_A202_T0.6491.00
348_L460_I0.6481.00
200_M205_G0.6471.00
290_G293_N0.6451.00
186_Q220_N0.6451.00
105_V109_A0.6431.00
252_F298_A0.6421.00
135_A156_V0.6411.00
353_G362_T0.6401.00
195_I207_F0.6401.00
362_T463_Q0.6391.00
396_N399_T0.6381.00
223_F244_G0.6371.00
312_E315_L0.6351.00
404_L429_I0.6351.00
367_R375_L0.6351.00
108_R111_M0.6341.00
355_H358_E0.6321.00
292_H361_A0.6311.00
294_A298_A0.6311.00
135_A139_S0.6301.00
137_V172_I0.6281.00
378_L407_L0.6281.00
364_K368_A0.6271.00
188_M224_Y0.6261.00
192_V211_K0.6221.00
140_I144_A0.6221.00
301_V315_L0.6191.00
378_L450_L0.6171.00
77_R101_A0.6161.00
326_R466_G0.6161.00
284_V297_A0.6151.00
378_L462_V0.6141.00
138_S172_I0.6141.00
275_L278_D0.6141.00
128_H196_E0.6131.00
50_D53_P0.6121.00
59_Q62_N0.6121.00
84_V95_I0.6101.00
106_I111_M0.6091.00
179_D202_T0.6061.00
141_Y304_A0.6051.00
236_I240_L0.6041.00
426_C429_I0.6031.00
54_N79_A0.6021.00
406_M437_P0.6011.00
122_I141_Y0.5961.00
207_F210_L0.5961.00
60_L65_A0.5961.00
467_N470_K0.5961.00
148_P172_I0.5951.00
134_T150_F0.5951.00
103_I107_R0.5931.00
106_I110_E0.5931.00
73_P97_A0.5911.00
107_R110_E0.5891.00
332_G347_M0.5881.00
366_A461_L0.5871.00
236_I243_V0.5851.00
390_L397_V0.5841.00
276_R311_D0.5821.00
82_V92_N0.5811.00
262_D283_R0.5801.00
328_F362_T0.5781.00
402_D458_D0.5781.00
140_I309_I0.5761.00
360_D400_Q0.5751.00
299_A303_V0.5751.00
428_T431_G0.5741.00
162_H165_L0.5741.00
301_V318_L0.5741.00
178_S201_D0.5721.00
251_G256_A0.5721.00
122_I170_Y0.5701.00
298_A302_A0.5691.00
136_M300_A0.5671.00
375_L402_D0.5651.00
106_I109_A0.5651.00
373_K457_N0.5651.00
243_V247_T0.5651.00
430_R437_P0.5641.00
403_T449_M0.5641.00
134_T172_I0.5641.00
406_M429_I0.5631.00
448_E451_A0.5621.00
398_L432_R0.5601.00
240_L247_T0.5571.00
81_V106_I0.5561.00
378_L460_I0.5551.00
93_P96_V0.5501.00
263_Y272_F0.5501.00
379_F406_M0.5491.00
420_A439_L0.5491.00
181_S216_N0.5491.00
135_A325_G0.5481.00
263_Y266_I0.5461.00
366_A459_L0.5451.00
236_I239_L0.5441.00
408_E420_A0.5431.00
200_M206_D0.5421.00
251_G254_E0.5421.00
128_H358_E0.5421.00
109_A175_A0.5410.99
75_N78_D0.5390.99
124_I133_T0.5390.99
142_A148_P0.5390.99
363_I401_V0.5380.99
378_L446_V0.5360.99
367_R402_D0.5350.99
71_H85_S0.5350.99
353_G358_E0.5350.99
45_Q66_T0.5340.99
231_V253_S0.5340.99
302_A306_E0.5320.99
313_A317_A0.5320.99
377_M404_L0.5290.99
348_L462_V0.5280.99
190_A224_Y0.5280.99
180_A216_N0.5270.99
99_H102_R0.5260.99
91_D96_V0.5260.99
376_V454_L0.5250.99
303_V306_E0.5250.99
92_N97_A0.5250.99
398_L429_I0.5240.99
286_L318_L0.5240.99
125_A192_V0.5230.99
363_I400_Q0.5230.99
447_A462_V0.5220.99
376_V450_L0.5220.99
180_A203_Y0.5210.99
46_I55_P0.5210.99
270_G294_A0.5210.99
101_A104_P0.5200.99
377_M407_L0.5180.99
65_A68_Y0.5160.99
395_A398_L0.5150.99
254_E259_R0.5150.99
388_R391_Y0.5140.99
407_L440_V0.5140.99
218_L229_M0.5130.99
288_A323_G0.5130.99
86_S89_S0.5130.99
360_D397_V0.5110.99
255_D259_R0.5100.99
71_H75_N0.5100.99
182_F220_N0.5090.99
222_P225_G0.5080.99
344_G451_A0.5070.99
132_T321_F0.5070.99
278_D305_T0.5060.99
122_I189_V0.5050.99
207_F234_P0.5040.99
119_R171_L0.5040.99
136_M140_I0.5010.99
72_R75_N0.5010.99
127_T196_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4hv4A 1 0.9348 100 0.224 Contact Map
1p3dA 1 0.9348 100 0.237 Contact Map
2x5oA 1 0.8819 100 0.257 Contact Map
3lk7A 1 0.89 100 0.275 Contact Map
1j6uA 1 0.8635 100 0.282 Contact Map
3hn7A 1 0.9022 100 0.287 Contact Map
4bucA 1 0.8452 100 0.305 Contact Map
4c12A 2 0.9185 100 0.333 Contact Map
4bubA 1 0.9063 100 0.343 Contact Map
2wtzA 1 0.9348 100 0.358 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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