GREMLIN Database
CYSH - Phosphoadenosine phosphosulfate reductase
UniProt: P17854 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10189
Length: 244 (207)
Sequences: 4370 (2524)
Seq/√Len: 175.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
201_Y206_D3.5241.00
63_H67_Q3.2981.00
119_K122_E2.8931.00
47_E148_N2.8831.00
37_V153_F2.6751.00
84_P88_R2.5871.00
27_E196_K2.4601.00
131_Y217_T2.4211.00
133_D138_E2.3731.00
63_H193_Y2.3241.00
73_P102_K2.3031.00
44_L151_T2.2351.00
88_R92_E2.1781.00
130_K133_D2.0551.00
36_R169_V1.9801.00
92_E96_K1.9711.00
67_Q197_H1.9261.00
67_Q193_Y1.9181.00
225_M229_E1.8791.00
189_T192_Q1.8711.00
78_D103_V1.8321.00
62_L74_V1.8251.00
56_I194_L1.8111.00
159_E187_N1.7691.00
131_Y214_D1.7541.00
78_D87_Y1.7151.00
104_Y143_A1.7011.00
214_D217_T1.7001.00
84_P215_T1.6691.00
76_L82_L1.6661.00
138_E142_R1.6581.00
33_A64_L1.6511.00
132_N217_T1.6301.00
40_A48_Y1.5961.00
186_D189_T1.5431.00
63_H66_N1.5301.00
92_E200_K1.5161.00
151_T179_V1.4961.00
185_W193_Y1.4841.00
50_L61_S1.4821.00
132_N214_D1.4801.00
39_W43_N1.4691.00
85_E207_E1.4321.00
56_I212_V1.3961.00
219_R233_F1.3861.00
108_E112_W1.3741.00
86_T202_H1.3711.00
50_L65_V1.3661.00
228_E231_R1.3601.00
192_Q196_K1.3601.00
207_E220_K1.3551.00
205_W210_L1.3551.00
167_L183_I1.3521.00
61_S153_F1.3491.00
63_H197_H1.3481.00
170_L179_V1.3441.00
102_K147_L1.3361.00
113_Q117_Y1.3331.00
210_L221_W1.3321.00
40_A179_V1.3301.00
36_R184_D1.3151.00
38_A68_I1.3111.00
158_R183_I1.3071.00
191_Y201_Y1.2891.00
188_R192_Q1.2831.00
96_K198_G1.2811.00
107_T111_A1.2761.00
61_S182_I1.2761.00
156_L167_L1.2751.00
75_I143_A1.2751.00
35_G38_A1.2711.00
44_L177_F1.2511.00
112_W116_R1.2481.00
94_T101_L1.2451.00
37_V65_V1.2421.00
34_E38_A1.2391.00
226_A229_E1.2361.00
154_A180_L1.2301.00
159_E186_D1.2291.00
37_V64_L1.2081.00
54_F90_I1.1951.00
187_N191_Y1.1871.00
34_E64_L1.1851.00
64_L68_I1.1841.00
48_Y151_T1.1761.00
34_E67_Q1.1691.00
117_Y130_K1.1531.00
193_Y197_H1.1531.00
32_D35_G1.1531.00
222_E225_M1.1361.00
59_A93_L1.1301.00
38_A42_D1.1201.00
104_Y146_E1.1191.00
25_N28_L1.1151.00
204_L212_V1.1151.00
167_L171_A1.1071.00
227_E231_R1.1041.00
91_D95_D1.1021.00
60_V190_I1.1021.00
111_A115_A1.0941.00
34_E68_I1.0921.00
201_Y205_W1.0821.00
60_V194_L1.0661.00
64_L193_Y1.0611.00
71_D100_N1.0591.00
172_I177_F1.0591.00
56_I205_W1.0551.00
26_A30_K1.0541.00
65_V72_I1.0491.00
194_L199_L1.0451.00
104_Y142_R1.0451.00
191_Y205_W1.0420.99
92_E95_D1.0350.99
191_Y195_Q1.0350.99
73_P100_N1.0340.99
90_I94_T1.0280.99
73_P147_L1.0230.99
60_V193_Y1.0210.99
25_N29_E1.0050.99
156_L183_I1.0050.99
225_M228_E1.0050.99
70_P99_L0.9890.99
143_A146_E0.9870.99
93_L97_L0.9860.99
81_Y216_H0.9840.99
87_Y90_I0.9800.99
62_L93_L0.9710.99
36_R179_V0.9680.99
107_T138_E0.9650.99
194_L201_Y0.9590.99
156_L180_L0.9570.99
31_L35_G0.9560.99
60_V63_H0.9550.99
41_L44_L0.9470.99
53_S58_A0.9440.99
33_A185_W0.9420.99
158_R184_D0.9410.99
63_H199_L0.9410.99
91_D94_T0.9240.99
187_N210_L0.9210.99
168_P171_A0.9180.99
114_E118_G0.9170.99
187_N227_E0.9140.99
79_T136_K0.9110.99
225_M233_F0.9100.99
55_G58_A0.9080.99
98_K106_A0.9050.99
91_D103_V0.8950.98
56_I191_Y0.8920.98
66_N97_L0.8910.98
63_H97_L0.8820.98
51_S75_I0.8700.98
144_L152_W0.8600.98
80_G105_R0.8570.98
81_Y121_W0.8530.98
94_T100_N0.8530.98
219_R229_E0.8520.98
222_E227_E0.8400.98
77_T104_Y0.8380.98
192_Q195_Q0.8320.98
224_G227_E0.8300.98
130_K134_I0.8290.97
219_R225_M0.8210.97
163_S167_L0.8200.97
107_T142_R0.8170.97
94_T103_V0.8150.97
28_L31_L0.8140.97
48_Y153_F0.8110.97
90_I103_V0.8060.97
35_G39_W0.8040.97
95_D166_N0.8010.97
125_V129_E0.8000.97
223_P227_E0.7970.97
89_F201_Y0.7940.97
60_V185_W0.7800.96
211_S218_T0.7790.96
57_Q160_Q0.7780.96
30_K34_E0.7770.96
169_V183_I0.7750.96
131_Y136_K0.7740.96
92_E203_P0.7690.96
60_V182_I0.7570.96
66_N99_L0.7560.96
225_M231_R0.7540.96
83_F209_Y0.7540.96
109_S138_E0.7420.95
136_K214_D0.7380.95
39_W170_L0.7380.95
108_E116_R0.7380.95
223_P226_A0.7330.95
76_L90_I0.7290.95
75_I104_Y0.7290.95
49_V75_I0.7270.95
162_G165_A0.7230.94
81_Y215_T0.7220.94
51_S210_L0.7160.94
62_L97_L0.7150.94
138_E141_N0.7150.94
113_Q120_L0.7140.94
62_L99_L0.7140.94
80_G106_A0.7120.94
170_L177_F0.7110.94
46_G73_P0.7080.94
52_S59_A0.7050.94
88_R91_D0.7000.93
121_W137_V0.6990.93
59_A89_F0.6950.93
33_A36_R0.6940.93
94_T99_L0.6930.93
131_Y135_N0.6920.93
81_Y110_A0.6910.93
115_A118_G0.6910.93
79_T213_G0.6800.92
56_I160_Q0.6760.92
53_S155_G0.6730.92
83_F204_L0.6720.92
88_R203_P0.6680.92
169_V184_D0.6670.92
85_E88_R0.6650.92
81_Y114_E0.6630.92
168_P183_I0.6610.91
226_A230_T0.6600.91
26_A29_E0.6590.91
225_M230_T0.6580.91
217_T233_F0.6570.91
172_I176_V0.6470.91
117_Y120_L0.6410.90
57_Q205_W0.6410.90
108_E117_Y0.6370.90
113_Q118_G0.6370.90
120_L134_I0.6370.90
104_Y147_L0.6360.90
171_A180_L0.6330.90
100_N147_L0.6300.89
227_E230_T0.6290.89
120_L123_Q0.6280.89
211_S230_T0.6250.89
85_E203_P0.6230.89
97_L199_L0.6210.89
125_V235_L0.6160.88
53_S161_S0.6130.88
76_L87_Y0.6110.88
100_N104_Y0.6090.88
203_P207_E0.6080.88
82_L211_S0.5980.87
96_K200_K0.5970.87
57_Q191_Y0.5950.87
81_Y214_D0.5910.86
105_R110_A0.5900.86
120_L124_G0.5880.86
102_K143_A0.5860.86
224_G228_E0.5860.86
29_E32_D0.5850.86
86_T212_V0.5840.86
54_F59_A0.5820.85
52_S89_F0.5820.85
209_Y220_K0.5810.85
28_L32_D0.5810.85
135_N219_R0.5800.85
221_W225_M0.5790.85
172_I175_G0.5750.85
69_R100_N0.5740.85
54_F160_Q0.5730.84
89_F203_P0.5660.84
33_A40_A0.5650.84
55_G155_G0.5640.83
32_D184_D0.5630.83
53_S214_D0.5630.83
82_L136_K0.5620.83
100_N103_V0.5610.83
142_R146_E0.5610.83
111_A114_E0.5600.83
158_R163_S0.5600.83
50_L58_A0.5590.83
25_N30_K0.5570.83
83_F218_T0.5540.82
77_T211_S0.5500.82
152_W178_K0.5470.82
77_T154_A0.5470.82
165_A183_I0.5460.81
74_V99_L0.5460.81
42_D45_P0.5450.81
50_L59_A0.5450.81
220_K223_P0.5440.81
228_E232_F0.5430.81
144_L176_V0.5400.81
69_R72_I0.5390.81
129_E235_L0.5380.81
143_A147_L0.5350.80
27_E30_K0.5340.80
66_N70_P0.5320.80
88_R95_D0.5310.80
82_L215_T0.5310.80
113_Q135_N0.5310.80
65_V70_P0.5250.79
93_L96_K0.5200.78
79_T217_T0.5200.78
25_N192_Q0.5190.78
62_L66_N0.5180.78
40_A151_T0.5130.77
101_L104_Y0.5130.77
123_Q193_Y0.5110.77
87_Y105_R0.5080.77
204_L209_Y0.5080.77
55_G190_I0.5060.76
42_D165_A0.5050.76
79_T214_D0.5030.76
28_L170_L0.5020.76
30_K196_K0.5010.76
37_V41_L0.5000.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwvA 2 0.8811 100 0.282 Contact Map
2o8vA 2 0.9385 100 0.294 Contact Map
2oq2A 2 0.9672 100 0.296 Contact Map
2goyA 3 0.8689 100 0.343 Contact Map
1zunA 1 0.7131 100 0.41 Contact Map
3fwkA 1 0.8852 100 0.454 Contact Map
2wsiA 1 0.8811 100 0.465 Contact Map
1surA 2 0.8811 100 0.49 Contact Map
2pg3A 2 0.791 99.8 0.695 Contact Map
3k32A 2 0.7623 99.8 0.7 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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