MUTY - ECOLI - GREMLIN Contacts

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MUTY - A/G-specific adenine glycosylase

UniProt:	P17802	Sequences: MQASQFSAQVLDWYDKYGRKTLPWQIDKTPYKVWLSEVMLQQTQVATVIPYFERFMARFPTVTDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGKFPETFEEVAALPGVGRSTAGAILSLSLGKHFPILDGNVKRVLARCYAVSGWPGKKEVENKLWSLSEQVTPAVGVERFNQAMMDLGAMICTRSKPKCSLCPLQNGCIAAANNSWALYPGKKPKQTLPERTGYFLLLQHEDEVLLAQRPPSGLWGGLYCFPQFADEESLRQWLAQRQIAADNLTQLTAFRHTFSHFHLDIVPMWLPVSSFTGCMDEGNALWYNLAQPPSVGLAAPVERLLQQLRTGAPV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
EcoGene:	EG10627
Length:	350 (334)
Sequences:	2985 (2243)
Seq/√Len:	122.7

ECOLI - MUTY
BACSU - YFHQ
HALSA - Q9HPQ6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
61_T	64_D	4.791	1.00
107_T	110_E	4.141	1.00
15_D	176_G	3.801	1.00
58_R	72_E	3.607	1.00
21_T	26_I	2.962	1.00
247_A	260_C	2.917	1.00
240_H	243_E	2.896	1.00
90_H	94_Q	2.757	1.00
150_A	209_I	2.746	1.00
58_R	76_L	2.673	1.00
176_G	179_R	2.598	1.00
106_E	132_K	2.525	1.00
215_S	218_L	2.523	1.00
215_S	219_Y	2.487	1.00
35_L	56_M	2.444	1.00
29_T	32_K	2.420	1.00
75_H	78_T	2.371	1.00
239_Q	305_W	2.331	1.00
205_Q	211_A	2.289	1.00
53_E	57_A	2.278	1.00
91_K	115_P	2.241	1.00
59_F	76_L	2.236	1.00
198_K	201_L	2.234	1.00
293_T	298_H	2.190	1.00
108_F	134_F	2.168	1.00
71_D	332_G	2.142	1.00
9_Q	207_G	2.081	1.00
111_V	126_L	2.049	1.00
108_F	112_A	2.042	1.00
148_C	207_G	2.014	1.00
95_Q	115_P	2.011	1.00
95_Q	99_L	1.973	1.00
63_T	97_A	1.933	1.00
209_I	213_N	1.921	1.00
239_Q	307_P	1.918	1.00
158_K	162_N	1.896	1.00
29_T	33_V	1.881	1.00
6_F	204_L	1.878	1.00
32_K	56_M	1.875	1.00
127_S	181_N	1.868	1.00
245_L	320_A	1.861	1.00
229_P	297_F	1.856	1.00
230_E	300_D	1.852	1.00
40_L	45_V	1.849	1.00
63_T	67_N	1.812	1.00
150_A	219_Y	1.806	1.00
150_A	213_N	1.789	1.00
148_C	204_L	1.776	1.00
228_L	298_H	1.776	1.00
150_A	215_S	1.769	1.00
27_D	33_V	1.750	1.00
11_L	179_R	1.722	1.00
100_H	113_A	1.717	1.00
15_D	179_R	1.715	1.00
123_G	135_P	1.705	1.00
35_L	89_L	1.693	1.00
153_G	163_K	1.681	1.00
246_L	331_V	1.669	1.00
103_K	106_E	1.650	1.00
110_E	113_A	1.630	1.00
211_A	216_W	1.625	1.00
52_F	56_M	1.623	1.00
231_R	297_F	1.612	1.00
69_P	72_E	1.608	1.00
70_L	74_L	1.598	1.00
84_A	88_N	1.589	1.00
119_R	165_W	1.584	1.00
70_L	94_Q	1.582	1.00
149_Y	167_L	1.579	1.00
50_P	53_E	1.570	1.00
126_L	132_K	1.553	1.00
324_N	327_Q	1.550	1.00
216_W	219_Y	1.540	1.00
112_A	119_R	1.535	1.00
327_Q	330_S	1.522	1.00
126_L	134_F	1.520	1.00
153_G	160_V	1.515	1.00
27_D	32_K	1.511	1.00
70_L	90_H	1.504	1.00
193_T	198_K	1.504	1.00
135_P	169_E	1.495	1.00
335_A	338_E	1.480	1.00
92_A	114_L	1.479	1.00
14_Y	182_Q	1.472	1.00
95_Q	100_H	1.471	1.00
152_S	215_S	1.468	1.00
334_A	337_V	1.440	1.00
151_V	167_L	1.438	1.00
100_H	110_E	1.427	1.00
10_V	204_L	1.409	1.00
11_L	15_D	1.398	1.00
232_T	300_D	1.386	1.00
246_L	333_L	1.382	1.00
92_A	95_Q	1.378	1.00
108_F	132_K	1.372	1.00
104_F	111_V	1.371	1.00
235_F	301_I	1.366	1.00
156_G	223_K	1.359	1.00
73_V	90_H	1.357	1.00
10_V	183_A	1.353	1.00
145_L	184_M	1.346	1.00
186_D	190_M	1.344	1.00
291_R	298_H	1.339	1.00
7_S	173_P	1.336	1.00
65_L	73_V	1.332	1.00
230_E	298_H	1.313	1.00
88_N	91_K	1.310	1.00
126_L	130_L	1.292	1.00
135_P	172_T	1.290	1.00
289_A	302_V	1.286	1.00
250_P	253_G	1.283	1.00
172_T	184_M	1.280	1.00
323_Y	331_V	1.274	1.00
210_A	216_W	1.266	1.00
291_R	300_D	1.257	1.00
106_E	130_L	1.255	1.00
199_C	208_C	1.244	0.99
44_Q	47_T	1.238	0.99
180_F	184_M	1.232	0.99
54_R	76_L	1.228	0.99
91_K	94_Q	1.225	0.99
39_M	48_V	1.224	0.99
32_K	52_F	1.223	0.99
86_A	89_L	1.219	0.99
243_E	324_N	1.218	0.99
146_A	164_L	1.216	0.99
62_V	104_F	1.212	0.99
237_L	261_F	1.206	0.99
49_I	53_E	1.205	0.99
250_P	256_G	1.203	0.99
234_Y	304_M	1.203	0.99
92_A	117_V	1.200	0.99
152_S	219_Y	1.192	0.99
167_L	170_Q	1.192	0.99
97_A	100_H	1.191	0.99
46_A	49_I	1.189	0.99
34_W	38_V	1.189	0.99
152_S	221_G	1.186	0.99
96_V	104_F	1.174	0.99
131_G	178_E	1.169	0.99
10_V	184_M	1.168	0.99
149_Y	171_V	1.160	0.99
94_Q	98_T	1.159	0.99
209_I	212_A	1.152	0.99
108_F	122_A	1.141	0.99
137_L	164_L	1.139	0.99
107_T	132_K	1.134	0.99
303_P	340_L	1.123	0.99
301_I	336_P	1.120	0.99
134_F	169_E	1.119	0.99
248_Q	257_G	1.118	0.99
285_T	305_W	1.115	0.99
111_V	134_F	1.108	0.99
117_V	125_I	1.100	0.99
288_T	343_Q	1.098	0.99
260_C	263_Q	1.094	0.99
67_N	97_A	1.088	0.99
33_V	129_S	1.082	0.99
128_L	178_E	1.077	0.98
202_C	208_C	1.069	0.98
173_P	177_V	1.068	0.98
11_L	176_G	1.067	0.98
266_D	269_S	1.066	0.98
179_R	183_A	1.064	0.98
136_I	165_W	1.059	0.98
199_C	202_C	1.058	0.98
145_L	168_S	1.055	0.98
10_V	187_L	1.046	0.98
168_S	180_F	1.037	0.98
162_N	166_S	1.034	0.98
133_H	174_A	1.026	0.98
111_V	125_I	1.024	0.98
233_G	263_Q	1.016	0.98
321_L	331_V	1.014	0.98
68_A	73_V	1.013	0.98
145_L	171_V	1.009	0.98
187_L	203_P	1.003	0.98
232_T	302_V	0.999	0.98
7_S	174_A	0.996	0.97
242_D	325_L	0.992	0.97
247_A	319_N	0.992	0.97
237_L	340_L	0.991	0.97
59_F	68_A	0.990	0.97
14_Y	25_Q	0.990	0.97
11_L	183_A	0.986	0.97
70_L	251_P	0.985	0.97
123_G	136_I	0.984	0.97
163_K	167_L	0.982	0.97
108_F	126_L	0.978	0.97
71_D	248_Q	0.973	0.97
254_L	297_F	0.971	0.97
8_A	12_D	0.961	0.97
192_C	208_C	0.960	0.97
99_L	113_A	0.954	0.97
259_Y	322_W	0.953	0.97
28_K	131_G	0.944	0.97
177_V	181_N	0.942	0.96
192_C	202_C	0.942	0.96
271_R	275_A	0.940	0.96
158_K	161_E	0.931	0.96
142_K	155_P	0.926	0.96
96_V	111_V	0.921	0.96
59_F	72_E	0.917	0.96
173_P	180_F	0.917	0.96
19_R	186_D	0.916	0.96
192_C	199_C	0.906	0.96
255_W	294_F	0.904	0.96
30_P	130_L	0.900	0.95
157_K	160_V	0.900	0.95
133_H	169_E	0.897	0.95
323_Y	328_P	0.880	0.95
142_K	161_E	0.871	0.95
289_A	300_D	0.867	0.94
239_Q	242_D	0.866	0.94
39_M	47_T	0.865	0.94
253_G	256_G	0.864	0.94
20_K	25_Q	0.862	0.94
335_A	339_R	0.856	0.94
14_Y	20_K	0.853	0.94
254_L	294_F	0.839	0.93
186_D	189_A	0.837	0.93
165_W	169_E	0.836	0.93
156_G	224_P	0.836	0.93
22_L	45_V	0.832	0.93
111_V	117_V	0.831	0.93
6_F	148_C	0.830	0.93
226_Q	295_S	0.825	0.93
141_V	186_D	0.825	0.93
120_S	137_L	0.822	0.93
136_I	141_V	0.821	0.93
73_V	86_A	0.820	0.93
136_I	184_M	0.816	0.92
248_Q	319_N	0.814	0.92
236_L	264_F	0.810	0.92
45_V	48_V	0.809	0.92
294_F	297_F	0.808	0.92
113_A	126_L	0.806	0.92
112_A	122_A	0.806	0.92
317_E	320_A	0.803	0.92
34_W	62_V	0.803	0.92
178_E	183_A	0.803	0.92
163_K	166_S	0.803	0.92
24_W	48_V	0.799	0.92
238_L	245_L	0.791	0.91
9_Q	206_N	0.784	0.91
271_R	276_Q	0.780	0.91
123_G	165_W	0.778	0.91
294_F	299_L	0.776	0.90
249_R	253_G	0.775	0.90
11_L	128_L	0.772	0.90
246_L	323_Y	0.772	0.90
65_L	89_L	0.770	0.90
111_V	132_K	0.770	0.90
35_L	86_A	0.769	0.90
191_I	201_L	0.767	0.90
155_P	221_G	0.766	0.90
28_K	128_L	0.765	0.90
187_L	191_I	0.763	0.90
70_L	84_A	0.762	0.90
259_Y	331_V	0.761	0.90
245_L	322_W	0.760	0.89
75_H	331_V	0.759	0.89
249_R	260_C	0.757	0.89
288_T	303_P	0.756	0.89
69_P	90_H	0.756	0.89
259_Y	321_L	0.754	0.89
62_V	96_V	0.754	0.89
64_D	67_N	0.753	0.89
137_L	165_W	0.752	0.89
28_K	33_V	0.751	0.89
54_R	58_R	0.751	0.89
161_E	165_W	0.750	0.89
109_E	113_A	0.746	0.89
14_Y	183_A	0.746	0.89
235_F	260_C	0.745	0.89
25_Q	120_S	0.744	0.88
11_L	14_Y	0.742	0.88
120_S	136_I	0.741	0.88
136_I	168_S	0.738	0.88
153_G	221_G	0.738	0.88
154_W	223_K	0.734	0.88
290_F	301_I	0.733	0.88
133_H	177_V	0.732	0.88
286_Q	304_M	0.730	0.88
240_H	322_W	0.729	0.87
233_G	301_I	0.726	0.87
204_L	207_G	0.724	0.87
239_Q	244_V	0.722	0.87
119_R	161_E	0.722	0.87
119_R	169_E	0.720	0.87
287_L	305_W	0.720	0.87
145_L	164_L	0.718	0.87
191_I	198_K	0.718	0.87
24_W	40_L	0.715	0.86
243_E	327_Q	0.715	0.86
146_A	221_G	0.714	0.86
144_V	187_L	0.713	0.86
228_L	293_T	0.705	0.86
150_A	210_A	0.703	0.86
339_R	343_Q	0.703	0.86
14_Y	179_R	0.702	0.85
314_C	317_E	0.701	0.85
30_P	33_V	0.693	0.85
270_L	273_W	0.690	0.84
154_W	160_V	0.689	0.84
62_V	93_A	0.689	0.84
35_L	92_A	0.684	0.84
68_A	90_H	0.684	0.84
133_H	173_P	0.682	0.84
92_A	111_V	0.681	0.84
273_W	276_Q	0.680	0.84
200_S	214_N	0.680	0.84
142_K	165_W	0.679	0.83
172_T	177_V	0.678	0.83
111_V	130_L	0.673	0.83
14_Y	19_R	0.673	0.83
142_K	164_L	0.669	0.83
128_L	179_R	0.668	0.82
233_G	299_L	0.667	0.82
78_T	338_E	0.666	0.82
286_Q	302_V	0.663	0.82
261_F	341_L	0.662	0.82
172_T	181_N	0.661	0.82
103_K	130_L	0.660	0.82
38_V	125_I	0.659	0.82
166_S	170_Q	0.657	0.81
235_F	337_V	0.656	0.81
128_L	185_M	0.655	0.81
62_V	111_V	0.653	0.81
149_Y	168_S	0.651	0.81
75_H	332_G	0.650	0.81
12_D	16_K	0.650	0.81
34_W	125_I	0.649	0.81
39_M	253_G	0.648	0.81
35_L	76_L	0.648	0.81
190_M	193_T	0.644	0.80
91_K	95_Q	0.643	0.80
109_E	132_K	0.643	0.80
177_V	183_A	0.643	0.80
267_E	271_R	0.642	0.80
65_L	86_A	0.641	0.80
47_T	335_A	0.636	0.79
154_W	157_K	0.635	0.79
20_K	120_S	0.635	0.79
246_L	328_P	0.635	0.79
54_R	57_A	0.634	0.79
321_L	327_Q	0.632	0.79
171_V	180_F	0.631	0.79
219_Y	222_K	0.629	0.79
164_L	168_S	0.626	0.78
268_E	271_R	0.622	0.78
294_F	335_A	0.621	0.78
233_G	297_F	0.618	0.77
230_E	291_R	0.617	0.77
338_E	342_Q	0.615	0.77
27_D	52_F	0.614	0.77
146_A	219_Y	0.613	0.77
323_Y	327_Q	0.609	0.76
173_P	176_G	0.608	0.76
337_V	340_L	0.608	0.76
197_P	208_C	0.607	0.76
154_W	224_P	0.606	0.76
233_G	294_F	0.606	0.76
104_F	126_L	0.605	0.76
301_I	337_V	0.604	0.76
78_T	332_G	0.604	0.76
84_A	256_G	0.603	0.76
86_A	90_H	0.603	0.76
254_L	299_L	0.603	0.76
62_V	97_A	0.602	0.76
25_Q	186_D	0.600	0.75
151_V	164_L	0.600	0.75
99_L	110_E	0.599	0.75
138_D	141_V	0.598	0.75
261_F	340_L	0.597	0.75
9_Q	12_D	0.595	0.75
294_F	337_V	0.595	0.75
36_S	40_L	0.595	0.75
152_S	218_L	0.594	0.75
255_W	337_V	0.592	0.74
108_F	111_V	0.592	0.74
180_F	186_D	0.592	0.74
69_P	86_A	0.592	0.74
270_L	275_A	0.592	0.74
100_H	103_K	0.592	0.74
36_S	45_V	0.592	0.74
218_L	221_G	0.591	0.74
145_L	148_C	0.591	0.74
244_V	341_L	0.591	0.74
141_V	189_A	0.590	0.74
195_S	217_A	0.589	0.74
70_L	87_R	0.587	0.74
178_E	184_M	0.587	0.74
128_L	182_Q	0.587	0.74
136_I	181_N	0.586	0.74
156_G	160_V	0.586	0.74
59_F	90_H	0.584	0.73
323_Y	329_P	0.583	0.73
249_R	256_G	0.583	0.73
59_F	73_V	0.581	0.73
104_F	117_V	0.579	0.73
255_W	296_H	0.579	0.73
160_V	221_G	0.578	0.73
177_V	180_F	0.578	0.73
235_F	340_L	0.577	0.72
321_L	324_N	0.574	0.72
270_L	276_Q	0.574	0.72
155_P	222_K	0.574	0.72
252_S	256_G	0.574	0.72
234_Y	302_V	0.572	0.72
168_S	171_V	0.572	0.72
133_H	172_T	0.571	0.72
53_E	56_M	0.570	0.72
136_I	142_K	0.570	0.72
292_H	296_H	0.570	0.72
72_E	76_L	0.568	0.71
153_G	159_E	0.568	0.71
222_K	225_K	0.565	0.71
278_Q	283_N	0.564	0.71
141_V	190_M	0.563	0.71
178_E	181_N	0.563	0.71
240_H	308_V	0.562	0.70
19_R	25_Q	0.562	0.70
185_M	259_Y	0.562	0.70
108_F	123_G	0.559	0.70
120_S	142_K	0.559	0.70
127_S	135_P	0.559	0.70
142_K	160_V	0.558	0.70
145_L	167_L	0.558	0.70
144_V	186_D	0.557	0.70
139_G	194_R	0.556	0.70
26_I	128_L	0.554	0.69
260_C	337_V	0.554	0.69
136_I	185_M	0.550	0.69
282_D	307_P	0.550	0.69
93_A	104_F	0.548	0.69
266_D	270_L	0.548	0.69
197_P	216_W	0.547	0.68
24_W	45_V	0.544	0.68
136_I	299_L	0.543	0.68
234_Y	266_D	0.539	0.67
264_F	270_L	0.539	0.67
272_Q	275_A	0.539	0.67
67_N	98_T	0.538	0.67
38_V	117_V	0.538	0.67
129_S	132_K	0.537	0.67
260_C	332_G	0.536	0.67
237_L	244_V	0.534	0.67
19_R	179_R	0.533	0.66
127_S	178_E	0.533	0.66
51_Y	54_R	0.533	0.66
108_F	165_W	0.532	0.66
172_T	180_F	0.532	0.66
98_T	101_G	0.531	0.66
98_T	325_L	0.530	0.66
120_S	165_W	0.530	0.66
197_P	202_C	0.529	0.66
71_D	331_V	0.529	0.66
55_F	114_L	0.527	0.66
109_E	112_A	0.527	0.66
263_Q	337_V	0.524	0.65
70_L	91_K	0.523	0.65
137_L	180_F	0.522	0.65
33_V	38_V	0.522	0.65
299_L	337_V	0.521	0.65
8_A	175_V	0.521	0.65
38_V	92_A	0.520	0.65
36_S	39_M	0.519	0.64
293_T	296_H	0.518	0.64
79_G	83_Y	0.518	0.64
150_A	216_W	0.518	0.64
14_Y	22_L	0.516	0.64
12_D	15_D	0.516	0.64
117_V	137_L	0.516	0.64
273_W	277_R	0.516	0.64
20_K	186_D	0.515	0.64
29_T	103_K	0.515	0.64
6_F	180_F	0.515	0.64
44_Q	193_T	0.513	0.64
229_P	256_G	0.513	0.64
278_Q	281_A	0.513	0.64
51_Y	139_G	0.513	0.64
235_F	336_P	0.512	0.63
283_N	286_Q	0.512	0.63
255_W	299_L	0.511	0.63
239_Q	325_L	0.509	0.63
284_L	306_L	0.509	0.63
95_Q	98_T	0.509	0.63
283_N	287_L	0.508	0.63
287_L	303_P	0.507	0.63
9_Q	148_C	0.507	0.63
25_Q	255_W	0.506	0.62
252_S	257_G	0.505	0.62
120_S	186_D	0.505	0.62
285_T	288_T	0.502	0.62
106_E	110_E	0.502	0.62
7_S	177_V	0.501	0.62
50_P	54_R	0.501	0.62
95_Q	114_L	0.501	0.62
187_L	204_L	0.500	0.62
35_L	38_V	0.500	0.62

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3fspA	1	0.9886	100	0.386	Contact Map
1kg2A	1	0.64	100	0.517	Contact Map
3n5nX	1	0.72	100	0.529	Contact Map
1keaA	2	0.6057	100	0.572	Contact Map
4unfA	1	0.5971	100	0.59	Contact Map
4uobA	1	0.6057	100	0.599	Contact Map
1ornA	1	0.5971	100	0.603	Contact Map
2abkA	1	0.5914	100	0.622	Contact Map
1pu6A	1	0.5343	100	0.719	Contact Map
3n0uA	1	0.5429	100	0.729	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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