GREMLIN Database
MUTY - A/G-specific adenine glycosylase
UniProt: P17802 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10627
Length: 350 (334)
Sequences: 2985 (2243)
Seq/√Len: 122.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_T64_D4.7911.00
107_T110_E4.1411.00
15_D176_G3.8011.00
58_R72_E3.6071.00
21_T26_I2.9621.00
247_A260_C2.9171.00
240_H243_E2.8961.00
90_H94_Q2.7571.00
150_A209_I2.7461.00
58_R76_L2.6731.00
176_G179_R2.5981.00
106_E132_K2.5251.00
215_S218_L2.5231.00
215_S219_Y2.4871.00
35_L56_M2.4441.00
29_T32_K2.4201.00
75_H78_T2.3711.00
239_Q305_W2.3311.00
205_Q211_A2.2891.00
53_E57_A2.2781.00
91_K115_P2.2411.00
59_F76_L2.2361.00
198_K201_L2.2341.00
293_T298_H2.1901.00
108_F134_F2.1681.00
71_D332_G2.1421.00
9_Q207_G2.0811.00
111_V126_L2.0491.00
108_F112_A2.0421.00
148_C207_G2.0141.00
95_Q115_P2.0111.00
95_Q99_L1.9731.00
63_T97_A1.9331.00
209_I213_N1.9211.00
239_Q307_P1.9181.00
158_K162_N1.8961.00
29_T33_V1.8811.00
6_F204_L1.8781.00
32_K56_M1.8751.00
127_S181_N1.8681.00
245_L320_A1.8611.00
229_P297_F1.8561.00
230_E300_D1.8521.00
40_L45_V1.8491.00
63_T67_N1.8121.00
150_A219_Y1.8061.00
150_A213_N1.7891.00
148_C204_L1.7761.00
228_L298_H1.7761.00
150_A215_S1.7691.00
27_D33_V1.7501.00
11_L179_R1.7221.00
100_H113_A1.7171.00
15_D179_R1.7151.00
123_G135_P1.7051.00
35_L89_L1.6931.00
153_G163_K1.6811.00
246_L331_V1.6691.00
103_K106_E1.6501.00
110_E113_A1.6301.00
211_A216_W1.6251.00
52_F56_M1.6231.00
231_R297_F1.6121.00
69_P72_E1.6081.00
70_L74_L1.5981.00
84_A88_N1.5891.00
119_R165_W1.5841.00
70_L94_Q1.5821.00
149_Y167_L1.5791.00
50_P53_E1.5701.00
126_L132_K1.5531.00
324_N327_Q1.5501.00
216_W219_Y1.5401.00
112_A119_R1.5351.00
327_Q330_S1.5221.00
126_L134_F1.5201.00
153_G160_V1.5151.00
27_D32_K1.5111.00
70_L90_H1.5041.00
193_T198_K1.5041.00
135_P169_E1.4951.00
335_A338_E1.4801.00
92_A114_L1.4791.00
14_Y182_Q1.4721.00
95_Q100_H1.4711.00
152_S215_S1.4681.00
334_A337_V1.4401.00
151_V167_L1.4381.00
100_H110_E1.4271.00
10_V204_L1.4091.00
11_L15_D1.3981.00
232_T300_D1.3861.00
246_L333_L1.3821.00
92_A95_Q1.3781.00
108_F132_K1.3721.00
104_F111_V1.3711.00
235_F301_I1.3661.00
156_G223_K1.3591.00
73_V90_H1.3571.00
10_V183_A1.3531.00
145_L184_M1.3461.00
186_D190_M1.3441.00
291_R298_H1.3391.00
7_S173_P1.3361.00
65_L73_V1.3321.00
230_E298_H1.3131.00
88_N91_K1.3101.00
126_L130_L1.2921.00
135_P172_T1.2901.00
289_A302_V1.2861.00
250_P253_G1.2831.00
172_T184_M1.2801.00
323_Y331_V1.2741.00
210_A216_W1.2661.00
291_R300_D1.2571.00
106_E130_L1.2551.00
199_C208_C1.2440.99
44_Q47_T1.2380.99
180_F184_M1.2320.99
54_R76_L1.2280.99
91_K94_Q1.2250.99
39_M48_V1.2240.99
32_K52_F1.2230.99
86_A89_L1.2190.99
243_E324_N1.2180.99
146_A164_L1.2160.99
62_V104_F1.2120.99
237_L261_F1.2060.99
49_I53_E1.2050.99
250_P256_G1.2030.99
234_Y304_M1.2030.99
92_A117_V1.2000.99
152_S219_Y1.1920.99
167_L170_Q1.1920.99
97_A100_H1.1910.99
46_A49_I1.1890.99
34_W38_V1.1890.99
152_S221_G1.1860.99
96_V104_F1.1740.99
131_G178_E1.1690.99
10_V184_M1.1680.99
149_Y171_V1.1600.99
94_Q98_T1.1590.99
209_I212_A1.1520.99
108_F122_A1.1410.99
137_L164_L1.1390.99
107_T132_K1.1340.99
303_P340_L1.1230.99
301_I336_P1.1200.99
134_F169_E1.1190.99
248_Q257_G1.1180.99
285_T305_W1.1150.99
111_V134_F1.1080.99
117_V125_I1.1000.99
288_T343_Q1.0980.99
260_C263_Q1.0940.99
67_N97_A1.0880.99
33_V129_S1.0820.99
128_L178_E1.0770.98
202_C208_C1.0690.98
173_P177_V1.0680.98
11_L176_G1.0670.98
266_D269_S1.0660.98
179_R183_A1.0640.98
136_I165_W1.0590.98
199_C202_C1.0580.98
145_L168_S1.0550.98
10_V187_L1.0460.98
168_S180_F1.0370.98
162_N166_S1.0340.98
133_H174_A1.0260.98
111_V125_I1.0240.98
233_G263_Q1.0160.98
321_L331_V1.0140.98
68_A73_V1.0130.98
145_L171_V1.0090.98
187_L203_P1.0030.98
232_T302_V0.9990.98
7_S174_A0.9960.97
242_D325_L0.9920.97
247_A319_N0.9920.97
237_L340_L0.9910.97
59_F68_A0.9900.97
14_Y25_Q0.9900.97
11_L183_A0.9860.97
70_L251_P0.9850.97
123_G136_I0.9840.97
163_K167_L0.9820.97
108_F126_L0.9780.97
71_D248_Q0.9730.97
254_L297_F0.9710.97
8_A12_D0.9610.97
192_C208_C0.9600.97
99_L113_A0.9540.97
259_Y322_W0.9530.97
28_K131_G0.9440.97
177_V181_N0.9420.96
192_C202_C0.9420.96
271_R275_A0.9400.96
158_K161_E0.9310.96
142_K155_P0.9260.96
96_V111_V0.9210.96
59_F72_E0.9170.96
173_P180_F0.9170.96
19_R186_D0.9160.96
192_C199_C0.9060.96
255_W294_F0.9040.96
30_P130_L0.9000.95
157_K160_V0.9000.95
133_H169_E0.8970.95
323_Y328_P0.8800.95
142_K161_E0.8710.95
289_A300_D0.8670.94
239_Q242_D0.8660.94
39_M47_T0.8650.94
253_G256_G0.8640.94
20_K25_Q0.8620.94
335_A339_R0.8560.94
14_Y20_K0.8530.94
254_L294_F0.8390.93
186_D189_A0.8370.93
165_W169_E0.8360.93
156_G224_P0.8360.93
22_L45_V0.8320.93
111_V117_V0.8310.93
6_F148_C0.8300.93
226_Q295_S0.8250.93
141_V186_D0.8250.93
120_S137_L0.8220.93
136_I141_V0.8210.93
73_V86_A0.8200.93
136_I184_M0.8160.92
248_Q319_N0.8140.92
236_L264_F0.8100.92
45_V48_V0.8090.92
294_F297_F0.8080.92
113_A126_L0.8060.92
112_A122_A0.8060.92
317_E320_A0.8030.92
34_W62_V0.8030.92
178_E183_A0.8030.92
163_K166_S0.8030.92
24_W48_V0.7990.92
238_L245_L0.7910.91
9_Q206_N0.7840.91
271_R276_Q0.7800.91
123_G165_W0.7780.91
294_F299_L0.7760.90
249_R253_G0.7750.90
11_L128_L0.7720.90
246_L323_Y0.7720.90
65_L89_L0.7700.90
111_V132_K0.7700.90
35_L86_A0.7690.90
191_I201_L0.7670.90
155_P221_G0.7660.90
28_K128_L0.7650.90
187_L191_I0.7630.90
70_L84_A0.7620.90
259_Y331_V0.7610.90
245_L322_W0.7600.89
75_H331_V0.7590.89
249_R260_C0.7570.89
288_T303_P0.7560.89
69_P90_H0.7560.89
259_Y321_L0.7540.89
62_V96_V0.7540.89
64_D67_N0.7530.89
137_L165_W0.7520.89
28_K33_V0.7510.89
54_R58_R0.7510.89
161_E165_W0.7500.89
109_E113_A0.7460.89
14_Y183_A0.7460.89
235_F260_C0.7450.89
25_Q120_S0.7440.88
11_L14_Y0.7420.88
120_S136_I0.7410.88
136_I168_S0.7380.88
153_G221_G0.7380.88
154_W223_K0.7340.88
290_F301_I0.7330.88
133_H177_V0.7320.88
286_Q304_M0.7300.88
240_H322_W0.7290.87
233_G301_I0.7260.87
204_L207_G0.7240.87
239_Q244_V0.7220.87
119_R161_E0.7220.87
119_R169_E0.7200.87
287_L305_W0.7200.87
145_L164_L0.7180.87
191_I198_K0.7180.87
24_W40_L0.7150.86
243_E327_Q0.7150.86
146_A221_G0.7140.86
144_V187_L0.7130.86
228_L293_T0.7050.86
150_A210_A0.7030.86
339_R343_Q0.7030.86
14_Y179_R0.7020.85
314_C317_E0.7010.85
30_P33_V0.6930.85
270_L273_W0.6900.84
154_W160_V0.6890.84
62_V93_A0.6890.84
35_L92_A0.6840.84
68_A90_H0.6840.84
133_H173_P0.6820.84
92_A111_V0.6810.84
273_W276_Q0.6800.84
200_S214_N0.6800.84
142_K165_W0.6790.83
172_T177_V0.6780.83
111_V130_L0.6730.83
14_Y19_R0.6730.83
142_K164_L0.6690.83
128_L179_R0.6680.82
233_G299_L0.6670.82
78_T338_E0.6660.82
286_Q302_V0.6630.82
261_F341_L0.6620.82
172_T181_N0.6610.82
103_K130_L0.6600.82
38_V125_I0.6590.82
166_S170_Q0.6570.81
235_F337_V0.6560.81
128_L185_M0.6550.81
62_V111_V0.6530.81
149_Y168_S0.6510.81
75_H332_G0.6500.81
12_D16_K0.6500.81
34_W125_I0.6490.81
39_M253_G0.6480.81
35_L76_L0.6480.81
190_M193_T0.6440.80
91_K95_Q0.6430.80
109_E132_K0.6430.80
177_V183_A0.6430.80
267_E271_R0.6420.80
65_L86_A0.6410.80
47_T335_A0.6360.79
154_W157_K0.6350.79
20_K120_S0.6350.79
246_L328_P0.6350.79
54_R57_A0.6340.79
321_L327_Q0.6320.79
171_V180_F0.6310.79
219_Y222_K0.6290.79
164_L168_S0.6260.78
268_E271_R0.6220.78
294_F335_A0.6210.78
233_G297_F0.6180.77
230_E291_R0.6170.77
338_E342_Q0.6150.77
27_D52_F0.6140.77
146_A219_Y0.6130.77
323_Y327_Q0.6090.76
173_P176_G0.6080.76
337_V340_L0.6080.76
197_P208_C0.6070.76
154_W224_P0.6060.76
233_G294_F0.6060.76
104_F126_L0.6050.76
301_I337_V0.6040.76
78_T332_G0.6040.76
84_A256_G0.6030.76
86_A90_H0.6030.76
254_L299_L0.6030.76
62_V97_A0.6020.76
25_Q186_D0.6000.75
151_V164_L0.6000.75
99_L110_E0.5990.75
138_D141_V0.5980.75
261_F340_L0.5970.75
9_Q12_D0.5950.75
294_F337_V0.5950.75
36_S40_L0.5950.75
152_S218_L0.5940.75
255_W337_V0.5920.74
108_F111_V0.5920.74
180_F186_D0.5920.74
69_P86_A0.5920.74
270_L275_A0.5920.74
100_H103_K0.5920.74
36_S45_V0.5920.74
218_L221_G0.5910.74
145_L148_C0.5910.74
244_V341_L0.5910.74
141_V189_A0.5900.74
195_S217_A0.5890.74
70_L87_R0.5870.74
178_E184_M0.5870.74
128_L182_Q0.5870.74
136_I181_N0.5860.74
156_G160_V0.5860.74
59_F90_H0.5840.73
323_Y329_P0.5830.73
249_R256_G0.5830.73
59_F73_V0.5810.73
104_F117_V0.5790.73
255_W296_H0.5790.73
160_V221_G0.5780.73
177_V180_F0.5780.73
235_F340_L0.5770.72
321_L324_N0.5740.72
270_L276_Q0.5740.72
155_P222_K0.5740.72
252_S256_G0.5740.72
234_Y302_V0.5720.72
168_S171_V0.5720.72
133_H172_T0.5710.72
53_E56_M0.5700.72
136_I142_K0.5700.72
292_H296_H0.5700.72
72_E76_L0.5680.71
153_G159_E0.5680.71
222_K225_K0.5650.71
278_Q283_N0.5640.71
141_V190_M0.5630.71
178_E181_N0.5630.71
240_H308_V0.5620.70
19_R25_Q0.5620.70
185_M259_Y0.5620.70
108_F123_G0.5590.70
120_S142_K0.5590.70
127_S135_P0.5590.70
142_K160_V0.5580.70
145_L167_L0.5580.70
144_V186_D0.5570.70
139_G194_R0.5560.70
26_I128_L0.5540.69
260_C337_V0.5540.69
136_I185_M0.5500.69
282_D307_P0.5500.69
93_A104_F0.5480.69
266_D270_L0.5480.69
197_P216_W0.5470.68
24_W45_V0.5440.68
136_I299_L0.5430.68
234_Y266_D0.5390.67
264_F270_L0.5390.67
272_Q275_A0.5390.67
67_N98_T0.5380.67
38_V117_V0.5380.67
129_S132_K0.5370.67
260_C332_G0.5360.67
237_L244_V0.5340.67
19_R179_R0.5330.66
127_S178_E0.5330.66
51_Y54_R0.5330.66
108_F165_W0.5320.66
172_T180_F0.5320.66
98_T101_G0.5310.66
98_T325_L0.5300.66
120_S165_W0.5300.66
197_P202_C0.5290.66
71_D331_V0.5290.66
55_F114_L0.5270.66
109_E112_A0.5270.66
263_Q337_V0.5240.65
70_L91_K0.5230.65
137_L180_F0.5220.65
33_V38_V0.5220.65
299_L337_V0.5210.65
8_A175_V0.5210.65
38_V92_A0.5200.65
36_S39_M0.5190.64
293_T296_H0.5180.64
79_G83_Y0.5180.64
150_A216_W0.5180.64
14_Y22_L0.5160.64
12_D15_D0.5160.64
117_V137_L0.5160.64
273_W277_R0.5160.64
20_K186_D0.5150.64
29_T103_K0.5150.64
6_F180_F0.5150.64
44_Q193_T0.5130.64
229_P256_G0.5130.64
278_Q281_A0.5130.64
51_Y139_G0.5130.64
235_F336_P0.5120.63
283_N286_Q0.5120.63
255_W299_L0.5110.63
239_Q325_L0.5090.63
284_L306_L0.5090.63
95_Q98_T0.5090.63
283_N287_L0.5080.63
287_L303_P0.5070.63
9_Q148_C0.5070.63
25_Q255_W0.5060.62
252_S257_G0.5050.62
120_S186_D0.5050.62
285_T288_T0.5020.62
106_E110_E0.5020.62
7_S177_V0.5010.62
50_P54_R0.5010.62
95_Q114_L0.5010.62
187_L204_L0.5000.62
35_L38_V0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3fspA 1 0.9886 100 0.386 Contact Map
1kg2A 1 0.64 100 0.517 Contact Map
3n5nX 1 0.72 100 0.529 Contact Map
1keaA 2 0.6057 100 0.572 Contact Map
4unfA 1 0.5971 100 0.59 Contact Map
4uobA 1 0.6057 100 0.599 Contact Map
1ornA 1 0.5971 100 0.603 Contact Map
2abkA 1 0.5914 100 0.622 Contact Map
1pu6A 1 0.5343 100 0.719 Contact Map
3n0uA 1 0.5429 100 0.729 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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