GREMLIN Database
BETI - HTH-type transcriptional regulator BetI
UniProt: P17446 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
EcoGene: EG10111
Length: 195 (179)
Sequences: 46749 (37283)
Seq/√Len: 2786.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_A43_T4.1091.00
25_V34_Q4.0511.00
20_E38_R3.5081.00
51_R55_G2.7361.00
22_I30_A2.4111.00
52_D55_G2.1741.00
21_A38_R2.1201.00
17_A38_R2.1011.00
12_R63_D2.0371.00
24_E38_R1.9951.00
89_Q185_R1.9831.00
21_A30_A1.9821.00
21_A34_Q1.9781.00
36_A46_I1.9601.00
21_A25_V1.9081.00
10_R13_Q1.9071.00
11_R59_A1.9051.00
93_G181_N1.8971.00
13_Q17_A1.8841.00
83_S86_Q1.8401.00
17_A20_E1.7971.00
19_L63_D1.7761.00
33_A37_R1.7611.00
138_V142_R1.7351.00
12_R16_D1.7131.00
18_T22_I1.6321.00
15_I59_A1.5801.00
20_E24_E1.5751.00
32_I47_S1.5701.00
134_L138_V1.5451.00
34_Q37_R1.5421.00
32_I43_T1.5171.00
42_S45_I1.4951.00
59_A62_R1.4851.00
34_Q38_R1.4811.00
19_L64_I1.4531.00
18_T56_L1.4421.00
63_D67_Q1.4381.00
134_L151_Q1.4381.00
50_F59_A1.4351.00
9_I13_Q1.4031.00
58_E62_R1.4021.00
181_N185_R1.3831.00
31_T34_Q1.3821.00
138_V150_A1.3771.00
136_N140_E1.3761.00
26_G30_A1.3741.00
19_L60_T1.3691.00
93_G185_R1.3691.00
26_G29_D1.3521.00
62_R125_L1.3471.00
30_A35_I1.3261.00
16_D63_D1.3251.00
45_I48_H1.2991.00
11_R49_Y1.2991.00
156_G160_L1.2881.00
32_I46_I1.2771.00
139_S143_R1.2691.00
41_V45_I1.2581.00
55_G59_A1.2491.00
71_A94_G1.2311.00
43_T47_S1.2211.00
17_A21_A1.2171.00
22_I27_M1.2121.00
25_V29_D1.2061.00
78_A81_Q1.1981.00
140_E145_L1.1971.00
9_I12_R1.1911.00
130_S134_L1.1831.00
89_Q93_G1.1611.00
107_K110_L1.1531.00
138_V141_F1.1431.00
17_A39_A1.1391.00
86_Q90_A1.1341.00
18_T60_T1.1301.00
44_G48_H1.0991.00
15_I50_F1.0971.00
149_Q152_E1.0941.00
35_I56_L1.0901.00
25_V38_R1.0801.00
46_I56_L1.0761.00
20_E104_A1.0751.00
141_F144_E1.0671.00
90_A93_G1.0651.00
182_S185_R1.0621.00
176_D179_R1.0601.00
54_N58_E1.0591.00
45_I49_Y1.0531.00
10_R49_Y1.0471.00
15_I60_T1.0361.00
19_L23_N1.0251.00
136_N139_S1.0211.00
55_G58_E1.0181.00
141_F147_R1.0111.00
16_D20_E1.0041.00
85_E89_Q1.0021.00
128_V132_R1.0001.00
62_R66_S0.9951.00
42_S48_H0.9941.00
87_R139_S0.9941.00
75_R94_G0.9871.00
47_S52_D0.9821.00
27_M57_L0.9811.00
36_A43_T0.9691.00
82_G90_A0.9641.00
59_A63_D0.9561.00
8_S12_R0.9441.00
131_R135_S0.9401.00
111_A114_A0.9381.00
141_F148_E0.9331.00
71_A74_N0.9261.00
63_D66_S0.9231.00
75_R90_A0.9231.00
54_N119_Q0.9151.00
7_Q48_H0.9121.00
15_I63_D0.9101.00
159_A163_G0.9091.00
64_I67_Q0.9081.00
10_R41_V0.9081.00
90_A94_G0.9001.00
94_G97_D0.8961.00
86_Q89_Q0.8931.00
43_T48_H0.8851.00
139_S142_R0.8791.00
102_S105_A0.8781.00
151_Q155_Y0.8741.00
78_A90_A0.8731.00
107_K111_A0.8661.00
73_L77_H0.8651.00
148_E153_A0.8651.00
98_E102_S0.8611.00
70_D74_N0.8611.00
69_R73_L0.8531.00
112_F115_S0.8471.00
32_I53_K0.8471.00
66_S70_D0.8421.00
106_M109_W0.8421.00
178_T181_N0.8331.00
13_Q16_D0.8311.00
138_V151_Q0.8271.00
69_R132_R0.8231.00
58_E121_M0.8161.00
13_Q39_A0.8141.00
93_G97_D0.8141.00
87_R143_R0.8051.00
28_H115_S0.8011.00
37_R43_T0.7971.00
135_S139_S0.7901.00
179_R183_L0.7851.00
7_Q10_R0.7791.00
132_R135_S0.7781.00
23_N104_A0.7751.00
111_A115_S0.7741.00
125_L128_V0.7661.00
168_A171_S0.7661.00
15_I19_L0.7651.00
127_Q131_R0.7651.00
146_P149_Q0.7641.00
14_L39_A0.7621.00
54_N121_M0.7621.00
152_E179_R0.7611.00
108_A112_F0.7581.00
14_L46_I0.7571.00
21_A24_E0.7521.00
107_K115_S0.7501.00
16_D19_L0.7491.00
87_R140_E0.7411.00
73_L136_N0.7411.00
27_M53_K0.7401.00
81_Q87_R0.7381.00
97_D181_N0.7371.00
181_N184_T0.7341.00
135_S138_V0.7271.00
82_G86_Q0.7271.00
183_L187_F0.7231.00
152_E155_Y0.7231.00
25_V30_A0.7201.00
24_E34_Q0.7191.00
167_R170_L0.7151.00
58_E125_L0.7141.00
81_Q86_Q0.7131.00
152_E182_S0.7121.00
103_S107_K0.7051.00
33_A47_S0.7001.00
179_R182_S0.6961.00
10_R45_I0.6891.00
152_E183_L0.6841.00
67_Q70_D0.6831.00
141_F150_A0.6831.00
167_R171_S0.6811.00
177_K180_A0.6801.00
116_S119_Q0.6741.00
120_P124_R0.6721.00
180_A183_L0.6721.00
75_R78_A0.6701.00
150_A154_G0.6641.00
121_M124_R0.6641.00
152_E186_H0.6611.00
140_E143_R0.6601.00
183_L186_H0.6601.00
177_K181_N0.6581.00
73_L132_R0.6571.00
70_D73_L0.6541.00
152_E156_G0.6471.00
160_L163_G0.6471.00
159_A162_D0.6451.00
156_G159_A0.6441.00
123_Y127_Q0.6441.00
133_L140_E0.6391.00
129_S133_L0.6361.00
74_N78_A0.6351.00
115_S119_Q0.6281.00
124_R128_V0.6271.00
162_D167_R0.6241.00
89_Q92_V0.6241.00
83_S87_R0.6211.00
136_N141_F0.6151.00
118_H122_L0.6151.00
134_L155_Y0.6151.00
137_L141_F0.6131.00
182_S186_H0.6131.00
97_D101_V0.6091.00
120_P123_Y0.6081.00
131_R134_L0.6071.00
32_I36_A0.6071.00
74_N94_G0.6071.00
39_A42_S0.6071.00
39_A43_T0.6061.00
178_T182_S0.5961.00
180_A184_T0.5931.00
94_G98_E0.5851.00
19_L67_Q0.5851.00
14_L49_Y0.5841.00
141_F145_L0.5811.00
159_A167_R0.5811.00
27_M30_A0.5781.00
127_Q130_S0.5741.00
92_V95_N0.5721.00
121_M125_L0.5701.00
97_D177_K0.5691.00
118_H121_M0.5671.00
97_D100_Q0.5651.00
146_P150_A0.5641.00
142_R150_A0.5631.00
92_V157_L0.5621.00
175_L179_R0.5611.00
27_M54_N0.5581.00
109_W112_F0.5571.00
22_I57_L0.5551.00
95_N99_T0.5511.00
106_M110_L0.5511.00
10_R42_S0.5451.00
123_Y126_Q0.5441.00
126_Q130_S0.5401.00
78_A82_G0.5361.00
7_Q49_Y0.5321.00
84_A140_E0.5301.00
36_A42_S0.5291.00
128_V131_R0.5281.00
84_A143_R0.5191.00
147_R153_A0.5181.00
163_G166_L0.5121.00
162_D166_L0.5121.00
67_Q71_A0.5121.00
132_R136_N0.5031.00
14_L41_V0.5021.00
36_A41_V0.5021.00
89_Q182_S0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2gfnA 2 0.9487 100 0.199 Contact Map
2np5A 3 0.9385 100 0.201 Contact Map
1ui5A 2 0.9641 100 0.208 Contact Map
4ichA 2 0.9641 100 0.211 Contact Map
2iaiA 2 0.959 100 0.212 Contact Map
2nx4A 2 0.9641 100 0.217 Contact Map
4kwaA 2 0.9641 100 0.221 Contact Map
2xdnA 2 0.9744 100 0.224 Contact Map
4udsA 2 0.9282 100 0.226 Contact Map
2genA 2 0.9436 100 0.228 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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